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환율 변동성 예측 모형의 실증분석 -원/달러 환율을 중심으로-
최생림 ( Sang Rim Choi ),형남원 ( Nam Won Hyung ) 한국국제경영학회 2003 國際經營硏究 Vol.14 No.1
Various volatility forecasting models were tested and compared using shor-term and long-term Korean won/US dollar exchange rates. EWMA model, like in other previous research, shows better estimates than GARCH-type time series models in short-term. In long-term analysis, the relative dominance of EWMA model decays rapidly and the power of FIGARCH model, among other GARCH models, proves to be superior due to its long memory reflecting mechanism.
소기숙,최회강,박소영,고강훈,김성남,이옥자,윤민영,문형철,김성철,이정훈,나원경,So, Ki-suk,Choi, Hoi-kang,Park, So-young,Koh, Kang-hun,Kim, Sung-nam,Lee, Ok-ja,Yun, Min-young,Mun, Hyung-chul,Kim, Sung-chul,Lee, Jung-hun,Na, Won-kyung 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1
Objective: Recently scolopendrid aquacupuncture has been a good effect on pain control but it has not been known about clinical safety. So, In order to prove the clinical safety of scolopendrid aquacupuncture, We have observed the physical reac-tion and clinical pathology test after scolopendrid aquacupuncture treatment. Methods: We analyzed physical reaction and clinical pathology test before and after Scolopendrid aquacupuncture treatment of 30 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results & Conclusions: The results were summarized as follows. 1) The distribution of sex was 14 males and 16 females, and the average of patients age was 46.2 years. 2) The distribution of symptom was lumbago, lumbago with radiating pain, nuchal pain and knee joint pain. 3) In the 30 patients treated with Scolopendrid aquacupuncture, hematologic test did not show remarkable change. 4) In the 30 patients treated with Scolopendrid aquacupuncture, Liver function test(AST, ALT, ALP) showed a slight decrease on the contrary, and abnormal rate showed a decrease of 1.0%(from 3.3% to 2.3%) compared with previous study. 5) In the 30 patients treated with Scolopendrid aquacupuncture, Renal function test(BUN, Cr) and abnormal rate(from 2.5% to 2.0%) showed a slight decrease on the contrary. 6) In the 30 patients treated with Scolopendrid aquacupuncture. Electrolyte were normal range before & after treatment. 7) In the results of the Urine analysis of 30 patients, Leukocyte, Protein. Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aquacupuncture treatment, and the rest almost made no difference. 8) In the Physical reactions, all of the patients complained of pain of body partially, only one patient showed reddish and itch, but symptoms like those were entirely disappeared within 24 hours and whole body pain, swelling, headache, dizziness, fatigue and nausea was not observed.
( Hyung Ki Kim ),( Yoon Jun Kim ),( Woo Jin Chung ),( Soon Sun Kim ),( Jae Jun Shim ),( Moon Seok Choi ),( Do Young Kim ),( Dae Won Jun ),( Soon Ho Um ),( Sung Jae Park ),( Hyun Young Woo ),( Young Ku 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.1
Background/Aims: This retrospective study assessed the clinical outcome of a transjugular intrahepatic portosystemic shunt (TIPS) procedure for managing portal hypertension in Koreans with liver cirrhosis. Methods: Between January 2003 and July 2013, 230 patients received a TIPS in 13 university-based hospitals. Results: Of the 229 (99.6%) patients who successfully underwent TIPS placement, 142 received a TIPS for variceal bleeding, 84 for refractory ascites, and 3 for other indications. The follow-up period was 24.9±30.2 months (mean±SD), 74.7% of the stents were covered, and the primary patency rate at the 1-year follow-up was 78.7%. Hemorrhage occurred in 30 (21.1%) patients during follow-up; of these, 28 (93.3%) cases of rebleeding were associated with stent dysfunction. Fifty-four (23.6%) patients developed new hepatic encephalopathy, and most of these patients were successfully managed conservatively. The cumulative survival rates at 1, 6, 12, and 24 months were 87.5%, 75.0%, 66.8%, and 57.5%, respectively. A high Model for End-Stage Liver Disease (MELD) score was significantly associated with the risk of death within the first month after receiving a TIPS (P=0.018). Old age (P<0.001), indication for a TIPS (ascites vs. bleeding, P=0.005), low serum albumin (P<0.001), and high MELD score (P=0.006) were associated with overall mortality. Conclusions: A high MELD score was found to be significantly associated with early and overall mortality rate in TIPS patients. Determining the appropriate indication is warranted to improve survival in these patients. (Clin Mol Hepatol 2014;20:18-27)
Choi, Jong-Whan,Yeh, Byung-Il,Han, Dong-Pyou,Lee, Hyean-Woo,Sohn, Joon Hyung,Jung, Seun-Ho,Kim, Hyun-Won Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.6
To investigate conformational information of a low oxygen affinity recombinant hemoglobin (rHb) containing $96Val{\rightarrow}Trp$ mutation at the ${\alpha}96$ position, we ave produced rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr$), using the Escherichia coli expression system and site-directed mutagenesis. The oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Phe$) is similar to that of human normal adult hemoglobin (Hb A). However, the oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Tyr$) showed much lower oxygen affinity than Hb A which is similar to that of rHb (${\alpha}96Val{\rightarrow}Tyr$), providing an opportunity as a potential candidate for a hemoglobin-based blood substitute. Both rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr)$ showed high cooperativity in oxygen binding. IH-NMR spectroscopy shows that both rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr$) have very similar tertiary structure around the heme pockets and uaternary structure in the ${\alpha}_1/{\beta}_2$ subunit interface ompared to Hb A. The low oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Tyr$) has been suggested to be due to a hydrogen bond caused by an extra hydroxyl group not present in rHb (${\alpha}96Val{\rightarrow}Phe$). However, investigation of the carbonmonoxy form of rHb (${\alpha}96Val{\rightarrow}Phe$) and (${\alpha}96Val{\rightarrow}Try$) in the presence of inositol hexaphosphate at low temperature suggests that low oxygen affinity of (${\alpha}96Val{\rightarrow}Try$) may arise from a mechanism different to that of rHb (${\alpha}96Val{\rightarrow}Trp$).
A rare case of multiple cutaneous larva migrans
( Won Choi ),( Joon Soo Lim ),( Kyoung Geun Lee ),( Hyung Jin Hahn ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Cutaneous larva migrans is caused by larvae of nematodes such as hookworms which can penetrate into the skin. When directly contacted with soil which is contaminated with the larvae, the infestation can occur. The predilection sites are known as the exposed area such as feet and forearms, and clinically presented as irregularly linear, elevated burrow. A 4-year-old boy presented with multiple linear migratory elevated erythematous papuloplaques on both extremities, abdomen and perianal area with itching. Skin biopsy specimens from lesion of left thigh showed traces of hookworm in epidermis, perivascular infiltration with lymphocytes and some eosinophils in dermis. The patient traveled Vietnam 2 weeks before visit and played with his father burying his body in the sand of beach which might be contaminated. He was treated with topical ivermectin and oral albendazole and showed considerable improvement. In our literature review, the parasite can be found 1 to 2 cm ahead of the visible track within a burrow located in the upper layers of the epidermis but often not observed in the biopsies. With typical lesions and contact history of sand, he was finally diagnosed with cutaneous larva migrans. Herein we report a case of cutaneous larva migrans with literature review.
A rare case of primary cutaneous plasmacytosis on left mandibular area
( Won Choi ),( Joon Soo Lim ),( Kyoung Geun Lee ),( Hyung Jin Hahn ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Cutaneous plasma cell infiltration can be seen in various disorders, including amyloidosis, lupus erythematosus, scleroderma, plasma cell neoplasm and infectious diseases such as syphilis and deep fungal infections. Above all, primary cutaneous plasmacytosis is regarded as a rare benign proliferation of plasma cells which can present as reddish papuloplaques or nodules without other systemic involvement. A 44-year-old man presented with asymptomatic irregular surfaced erythematous nodule on left mandibular area. Skin biopsy specimens showed multiple plasma cells and lymphoid cell infiltration in entire dermis. There were no fungal organisms identified in PAS and GMS stainings. Immunohistochemical stainings showed positive for CD 138 but no light chain restriction on Kappa and lambda light chains suggesting of no monoclonality. He has no evidence of other organ involvement or infection including VDRL in laboratory tests. Multiple myeloma was ruled out by normal findings of calcium level, renal function, level of complete blood counts and imaging of bones. Extramedullary plasmacytoma was excluded because of no monoclonality. He was finally diagnosed with primary cutaneous plasmacytosis based on histological findings and was treated with surgical excision. Herein we report a rare case of primary cutaneous plasmacytosis on left mandibular area.
A rare case of mucinous nevus on the buttock
( Won Choi ),( Joon Soo Lim ),( Kyoung Geun Lee ),( Hyung Jin Hahn ),( Ki Bum Myung ),( Seung Hyun Cheong ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Mucinous nevus is a rare benign entity classified as a cutaneous mucinosis or connective tissue nevus. The principal site is known as trunk and clinically presented as asymptomatic growing grouped papuloplaques with unilateral distribution at birth or early adulthood. The band-like amorphous mucin deposition in the upper dermis is regarded as its own histologic features. A 11-year-old boy presented with asymptomatic multiple papuloplaques on left side of buttocks. Skin biopsy specimens from his lesion of left buttock showed orthokeratosis, acanthosis and slight papillomatosis in epidermis and also amorphous bluish materials in papillary dermis. These materials were proven as mucin by staining of alcian blue. In this case, the patient showed verrucous lesions on left side of buttock near the anus which is known as uncommon sites. We firstly suspect this findings as condyloma accuminatum, but it was ruled out by negative findings of HPV-PCR and band-like deposition of mucin in upper dermis without abnormal findings such as large vacuolated epithelial cells Therefore, we emphasize the importance of skin biopsy including staining of mucin to confirm mucinous nevus near the anus which can be misdiagnosed as condyloma accuminatum. Herein, we report a rare case of mucinous nevus on left buttock area.
Preparative and Stereoselective Synthesis of the Versatile Intermediate for Carbocyclic Nucleosides
Choi, Won-Jun,Moon, Hyung-Ryong,Kim, Hea-Ok,Yoo, Byul-Nae,Lee, Jeong-A,Shin, Dae-Hong,Jeong, Lak-Shin 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14
The preparative and stereoselective synthesis (45-50% overall yields) of the target compound 17 has been accomplished from D-ribose. The bulky protecting groups such as TBDPS and Trityl enforced the facial selectivity during Grignard reaction to give the tertiary β-allylic alcohol 16 as the sole product, which was oxidatively rearranged to the key molecule 17 in excellent yield.