전위된 관절내 원위 요골의 관절경을 이용한 고정술

이원용,박병문,임대의,송경섭,홍정우 대한골절학회 2003 대한골절학회지 Vol.16 No.3

목적: 전위된 관절내 원위 요골 골절에 관절경을 이용한 정복술과 경피적 K 강선 및 외고정기기를 이용한 수술법의 결과를 알아보고자 함이다. 대상 및 방법: 2001년 1월부터 8월까지 수술한 11명 12예를 대상으로 하였으며, 평균 추시 기간은 14개월 이었다. 골절의 형태는 AO 분류에 의하면 1예는 B3형, 4예는 C2형, 7예는 C3형 골절이었다. 전예에서 2.7㎜ 관절경을 이용하였으며 추가적인 관혈적 정복은 시행하지 않았다. 경피적 K 강선 고정술 후 외고정 기기를 사용하였다. 관절내 골연골 골편을 제거하였으며 추가적인 수근 골간 인대와 삼각 섬유 연골 손상의 적극적인 처치는 없었다. 고정물 제거 시기는 경피적 K 강선은 술후 4주, 외고정 기기는 7주에 시행하였다. 결과: 평균 수근 관절의 신전 및 굴곡은 정상의 72%였다. 평균 요측 길이는 12.3 ㎜, 전방경사는 5.7°, 척측 경사는 22.4°였다. 평균 관절면의 불일치는 1㎜였다. 술후 구획 증후군의 발생은 없었으며 치료 중 골절 함몰 소견은 없었다. 임상적으로 Gartland와 Werley의 평가에 의하면 8예에서 우수, 3예에서 양호, 1예에서 보통의 결과를 얻었다. 결론: 관절내 분쇄 골절의 치료에서 관절경을 이용한 관절면 정복술은 수술적 연부 조직을 최소화하면서 관절면을 비교적 정확하게 정복함으로 관절면의 불일치를 감소시켜 손상 후 좋은 결과를 얻을 수 있는 효과적인 방법으로 사료된다. Purpose: To investigate the result of arthroscopically assisted reduction of intraarticular fracture of distal radius with percutaneous K-wires and external fixation. Materials and Methods: We reviewed 12 intraarticular distal radial fractures of 11 patients treated arthroscopically assisted reduction in Orthopedic Department of Sung-Ae hospital between January, 2001 and August, 2001. The mean length of follow-up was 14 months. Analysis of them revealed that B3 was 1 case, C2 4 cases and C3 7 cases according to the AO classification. All cases were treated by 2.7 ㎜ arthroscopic devices and percutaneous K-wires pining with external fixationg, but additionally invasive reductional technique was not used. We removed the osteochondral flap but not treated. The K-wires were removed at 4 weeks, external fixation was 7 weeks, respectivley. Result: The mean active range of movement in the affected wrist was total arc of the flextion-extension 72% of the opposite side. Radiographically mean volar tilt, radial inclination and radial length compartment syndrome and fractures collapse were not occured during follow-up period. According to the Gartland and Werley demerit-point system, eleven cases were a excellent or good one was a fair result. Conclusion: Arthroscopically assisted fixation is a useful method for reducing the soft tissue injuies and preventing the articular surface incogruency by anatomically reduction un cases of intraarticular comminution.

중장년층에서의 외상성 견관절 탈구

이광원,류창수,김하용,안재훈,염진섭,김환정,최원식 대한견.주관절학회 2000 大韓肩.주關節學會誌 Vol.3 No.2

초·중등 교과 교육의 정립과 발전을 위한 연구

이경섭,이원희,장원조 한국교육과정학회 1996 교육과정연구 Vol.14 No.3

This paper studies on the identification and development of each subject-centered education in primary and secondary school. Following is the summarizing conclusion. First, is order that each subject-centered content may contribute better to the goals of primary and secondary schools, it is necessary that the goals of the schools and subjects should relate colsely each other. To get the inter-relationship, there are three desirable ways to state the goals of school levels: educational taxonomy, hierarchical order, and each subject-centered. Second, This paper has set up a system of each subject-centered education in accordance with the three following principles. a. Balancing between the system of education and the meta-disciplinary system of each subject. b. Comprising the whole system with the system of education and the sub-system with meta-disciplinary system of each subject. c. Contributing to the practices of educational theory and the theorization of educational practices. Third, development of each subject-centered education calls for a long-term plan. The plan, based on the clarification of obstacles to the development and characterization of each subject, is to revitalize the activities and researches of each subject-centered education, to promote the qualities of experts in the area, to take administrative steps to produce the experts, and to increase exceedingly financial supports to this study.

사람 태아간의 산호성 과립백혈구형성에서 산호성 과립형성에 대한 미세구조 연구

송재섭,김경용,이원복,김동창 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.4

The developmental processes of eosinophilic granule formation were ultrastructural investigation of eosinophilic granulopoiesis in 15 cases of human fetal livers from 8 to 34 weeks of gestation. 1) Numerous vesicles, microgranules and small agranular and granular vacuoles were distributed around the distended Golgi apparatus in myeloblast and eosinophilic promyelocyte. 2) Granular matrix of vacuoles contained small granular vacuoles, serveral vesicles and mutilamellar structures. The granular substance exhibited higher electron density than that of cystic rough endoplasmic reticulum(RER) and was similar partly to that of immature eosinophilic granules. 3) Distended cystic RER was fused to produce matrix of maturing granules with granular vacuoles and immature eosinophilic granules. 4) Immature eosinophilic granule which began to be produced in eosinophilic promyelocyte, had myelin sheath-like structure and debris of vesicles and granular vacuoles and those disappeared immediately. The charicteristic crystalloid inclusions began to develop in immature eosinophilic granule of myelocyte. In summary, it is suggested that vesicles and granular vacuoles as well as RER in the myelocyte and promyelcyte are participating in the formation of immature eosinophilic granules which become mature with the appearance of charicteristic crystalloid inclusion

下顎正中結合과 下顎切齒의 成長變化에 關한 累年的 硏究

심원섭,정규림,이기수 대한치과교정학회 1987 대한치과교정학회지 Vol.17 No.1

The purpose of this longitudinal study was to examine the growth changes of mandibular symphysis and lower incisors with age. The material was 294 lateral cephalometric radiographs taken longitudinally from 6 to 13 year old children, who were not teated orthodontically. The following conclusions seem to be warranted. 1. The sex difference of the measurements of mandibular symphysis and lower incisors were not statistically significant. 2. There were growth increments (2.69mm in boys and 2.08mm in girls) in the total thickness of mandibular symphysis. 3. There were a great change and individual variations on the curvature of anterior border of mandibular symphysis. 4. The chin angle had a tendency to decrease progressively in both sexes. 5. There were growth increments (8.23mm in boys and 7.40mm in girls) in the anterior dental height. 6. The lower anterior teeth tended to incline labially with age.

합성펩타이드를 이용한 영양배엽세포-특이 가토 다클론 항혈청의 제작

이희섭,오재민,김정중,문형배,김원신,이황희 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

Within the last few years, a different approach to generating protein-reactive antibodies has been developed that has several advantages over conventional immunization. This involves synthesizing short peptide sequences, coupling them to immunogenic carrier molecules, and immunizing animals with the conjugates. 3βHSD(3β-hydroxy-5-ene steroid dehydrogenase; EC 1.1.1.145) is the enzyme of the plasma membrane of human trophoblast and it's cDNA sequence was identified by Nickon et al(Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3β-hydroxy-5-ene steroid dehydrogenase. J Reprod Fert 1991;149;156). For the production of trophoblast-specific antibody, we synthesized three oligopeptides that are epitope sites chosen from cDNA sequence of 3βHSD. Oligopetides were coupled with KLH(keyhole limpet hemocyanin) under 25% glutaraldehyde. The trophoblast-specific rabbit polyclonal antisera was produced by conventional methods. This antisera reacts with a 43kDa protein in human placental lysate by Western blotting analysis and The syncytiotrophoblasts and cytotrophoblasts from villi are stained positively with this antisera by immunohistochemistry. Villous trophoblasts were cultured in methionine-free media for 1 hour and [^(35)S]-Methionine for 24 hours. Media and cell lysate were immunoprecipitated with this antisera and 12% SDS-PAGE was performed. In fluorography, bend was not noted in media and 43kDa band was noted in medis and 43kDa band was noted in lysate. It was concluded that anti-3βHSD antibody produced by synthetic peptide was specific to trophoblasts and 3βHSD was membrane-bound protein of trophoblasts.

유기산 완충용액의 불소농도가 상아질의 재광화에 미치는 영향

한원섭,이찬영 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.6

상아질의 재광화에 적당한 불소농도에 대하여는 서로 다른 주장이 존재하므로 불소가 병소 내 무기질의 분포와 수산화인회석 결정성장에 미치는 영향을 분석하기 위하여 이 연구를 시행하였다. 치아절편을 유산완충 탈회용액에 넣어 인공 치아우식을 형성한 후, 재광화 효과를 관찰하기 위해 불소농도가 각각 1, 2, 4 ppm인 유산완충 재광화용액에서 7일간 유지시켰다. 우식 진행과 재광화 양상을 관찰하기 위하여 탈회 2일, 재광화 7일 등 총 9일간 편광현미경으로 관찰하였으며 수산화인회석결정의 변화를 관찰하기 위하여서는 정상상아질, 탈회 2일군, 재광화 7일군의 파절시편을 주사전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 1. 모든 군에서 병소상부의 무기질침착과 병소하부의 무기질소실이 동시에 일어났다. 2. 불소농도가 증가하면 우식 병소의 무기질침착이 증가하였다. 3. 수산화인회석결정이 커졌다. 본실험의 결과에 의하면, 상아질의 우식과 재광화과정이 단순히 탈회 또는 재광화만이 독립적으로 일어나는 과정이 아니고 이 두 과정이 동시에 일어나는 동력학적인 과정이다. 또한 불소농도의 증가와 함께 재광화 양상도 증가하였고, 이러한 재광화는 유기기질망 주위의 수산화인회석결정을 중심으로 진행되었다. The aim of this vitro-study is to evaluate the effects of fluoride on remineralization of artificial dentine caries. 10 sound permanent premolars, which were extracted for orthodontic reason within 1 week. were used for this study. Artificial dentine caries was created by using a partially saturated buffer solution for 2 days with grounded thin specimens and fractured whole-body specimens. Remineralization solutions with three different fluoride concentration (1 ppm. 2 ppm and 4 ppm) were used on demineralized-specimens for 7 days. Polarizing microscope and scanning electron microscope were used for the evaluation of the mineral distribution profile and morphology of crystallites of hydroxyapatite. The results were as follows: 1. When treated with the fluoride solutions, the demineralized dentine specimens showed remineralization of the upper part and demineralization of the lower part of the lesion body simultaneously. 2. As the concentration of fluoride increased, the mineral precipitation in the caries dentine increased. The mineral precipitation mainly occurred in the surface layer in 1 and 2 ppm- specimens and in the whole lesion body in 4 ppm -specimens. 3. When treated with the fluoride solution, the hydroxyapatite crystals grew. This crystal growth was even observed in the lower part of the lesion body which had shown the loss of mineral.

Ice Ball을 이용한 축냉조내에서의 냉각 특성에 관한 연구

박이동,이원섭,이정범 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

The objective of this study was to investigate the characteristics of a cooling water flow in an ice thermal storage tank and th observation was conducted for one turn-over time. In this experiment, the variable parameters were dynamic variables such as inlet flow rate(3steps : 10, 20, 30LPM) and temperature difference between initial storage water temperature in the ice thermal tank and inflow cooling water temperature (2 steps : 5℃, 15℃). The results were as follows ; (1) The mixing was more dominated by inertia force under the condition of high flow rate and decerased with respect to increase of the temperature difference between initial storage water temperature in ice thermal tank and inflow cooling water temperature. (2) Outlet temperature was nearly approached to the cooling water temperature from inlet port when the duration of storage process was reached at about six times of turn -over time. (3) As the flow rate decreased and the temperature difference between initial storage water temperature and inflow cooling water temperature increased, thermal ice storage efficiency was more improved.

마이크로 컴퓨터를 이용한 구형탱크에서의 액위제어

오민,이태희,강원영,신창섭 연세대학교 산업기술연구소 1987 논문집 Vol.19 No.1

The liquid level control of a spherical tank, which changes nonlinearly with the variation of a setpoint, was controlled by a micro-computer using adaptive control theory and the experimentally measured gain value were compared with the theoretically calculated values and experimental results showed that the experimental gain value followed the same pattern of the theoretically calculated value according to the set point change. Also the P-I control using the adaptive control theory showed shorter control time and smaller deviation value than general P-I control.

주의력결핍-과잉운동장애의 비중추신경흥분제 치료의 최신지견

반건호,손소정,이서경,강원섭,조아랑,박진경 경희대학교 2006 慶熙醫學 Vol.22 No.1

Methylphenidate (MPH), amphetamine, and pemoline are cerebrostimulants that have been commonly prescribed for more than half century in the treatment of attention-deficit/hyperactivity disorder (ADHD). The use of such drugs, however, is often followed by untoward effects such as loss of appetite, insomnia, nausea, abdominal pain, vomiting, irritability, and etc. There are also debates about decrements in height and weight percentiles and drug dependency. Thus, in this study, we discussed new therapeutic drugs, non cerebro-stimulants, with possibly less adverse effects and more efficacies. Atomoxetine, highly selective inhibitor of the presynaptic noradrenaline transporter with little or no affinity for other neurotransmitter transporters and receptors, is a non-excitatory drug with a strong possibility to replace CNS excitatory drugs. It is also safer in relation to drug dependency since it does not affect nucleus accumbens or the striatum. Atomoxetine, therefore, can be used in patients who do not respond to the CNS excitatory drugs. Tricyclic antidepressants, imipramine and desipramine are also most extensively studied drugs as ADHD treatment modalities. They also exert inhibitory effect on the reuptake of norepinephrine. The use of these drugs in children, however, is limited because of cardiovascular effects. Bupropion is one of promising drugs in treating prepubertal children with ADHD. It is also useful for comorbid depression and conduct problems. Increasing attention is being given to a narcolepsy drug, modafinil. Modafinil acts on histamine pathway resulting in wakefulness. This effect is similar to that of neuropeptide orexin. Since the effect of modafinil is independent of catecholamine, drug dependency adverse effect is not expected. Recently, some new drugs, such as reboxetine, are reported as safe and efficacious for children with ADHD, but they need long-term safety and controlled studies.