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정해관,이민석,이현경,임문환,김용탁,이성우,임현술,황선보,오연희,배철성,심재철,김승현,도은형,윤혜원 東國大學校醫學硏究所 1995 東國醫學 Vol.3 No.-
동국대학교 의료원 산부인과에서는 1991년 10월 1일부터 1994년 12월 31일까지 약 39개월동안 자궁외 임신으로 진단된 79명의 환자에게 골반경 수술을 시행하였다. 골반경수술은 수술후 입원기간의 단축, 개복으로 인한 불필요한 출혈의 방지 및 수술시간의 단축, 수술후 유착감소 및 반복수술의 용이성, 미용상의 효과가 좋았다. 특히 비파열성 자궁외 임신에서 골반경을 이용한 난관개구술과 MTX 국소투여법 같은 보존적 치료는 매우 효과적이었다. 그리고 난관파열이 되어 어느정도 복강내출혈이 있는 파열성 자궁외 임신에서도 골반경수술의 장점을 살리면서 시술을 할 수 있을 것으로 생각된다. Prevalence of extrauterine pregnancy has increased. With the availability of the rapid quantitative B human chorionic gonadotropin titers and more accurate sonograms, the diagnosis of probable extrauterine pregnancy is being made earlier and often before tubal rupture. Salpingectomy at the time of laparotomy has been the standard treatment for tubal pregnancy, even when the tube was not ruptured. Recently conservative surgery via salpingotomy/salpingostomy or fimbrial expression has been advocated. The pelviscopy is an essential tool in making the diagnosis and, given certain criteria, can be useful for management as well. Pelviscopic management of extrauterine pregnancy has been described extensively in last several years. These methods have been associated with low morbidity, early recovery, and short hospital stay. Although the role of medical therapy for extrauterine pregnancy is still uncertain, medical therapy of early, unruptured extrauterine pregnancy can be safe and cost effective and even result in improved fertility, compared with the standard surgical therapy. Conservative treatment of unruptured type tubal pregnancy, which have been diagnosed early, salpingotomy and salpingostomy and MTX local injection are highly effective. We have experienced 80 cases of pelviscopic surgery in 79 patients with extrauterine pregnancy. Among the procedures, salpingectomy was peformed most frequently(78.5%). Salpingotomy was also performed(12.5%), salpingectomy was performed(1.3%), pelviscopy guided MTX local injection was performed(1.3%), and fimbrial expression was performed(1.3%). Of 79 patients, complication occurred in 7 patients. In one patient with liner salpingotomy, additional pelviscopic salpingectomy was needed for bleeding control from previous salpingotomy sites. Hospital stay was averaged 3.8 days. Pelviscopic treatment of extrauterine pregnancy was simple and effective with fast recovery even in patients with pelvic adhesions due to prior operations, ruptured extrauterine pregnancies with moderate intraperitoneal free blood.
정석원,김한규,황용순,천태상,이화동 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.7
The ocurrence of complications after brain tumor surgery often lead to fate. To decrease the incidence of complications, it is desirable to identify patients at risk as early as possible prior to surgery. It can be achieved by determining preoperatively those factors known to be of prognostic relevance in the development of such postoperative complications. The prognostic factors may be differ considerably depending on the population studied but the homogeneous population studied in this analysis may help to contribute to the reference guide in identifying those factors. Authors have retrospectively analysed the major complications developed after performing on 150 brain tumor surgeries during last five years to identify the prognostic factors.
천막 상부 신경 교세포종에 대한 과분할 방사선치료의 효과에 대한 임상적 분석
정석원,김한규,황용순,이화동,염하용 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.12
Fractionation dose and number have been known as radiation factor affecting the radiation complication and the effectiveness in radiotherapy for brain tumors. In this study hyperfractionation technique with 115cGy/fraction 2 fractions daily 5days/wk, upto 5750-6900cGy to partial brain volume was compared with conventional fractionation technique with daily 200cGy/fraction 5 fractions/wk, upto 5400-6000cGy, in regarding to the effectiveness of hyperfractionated radiotherapy and eraly and later radiation reavtion. The survival period was longer in hyperfractionated irradiated group particularly if the tumors were located in the posterior portion of brain, however there was no singificant statistics due to small number of patients. Mean survival period for glioblastoma multiforme was 11.8 months in hyperfractionated group vs 8.7 months in conventional fractionated group and for high grade astrocytoma 36month in hyperfractionated group, but in conventional fractionated group all was died in 18 months. Actue radiation reaction occurred less frequently in hyperfractionated group, 15.8% vs 47.8% in conventional fractionated group(p<0.024). Alopecia was developed in 31.6% of the hyperfractionated group vs 82.6% of the conventional fractionated group(p<0.0031). One case of later radiation necrosis in cancer region was suspected in the hyperfractionated group but we has been in a dilemma for confirmatory diagnosis in present available diagnostic technique. The hyperfractionated irradiation technique was proven to be superior to conventional fractionated technique regarding the radiation reaction and the effectiveness of the treatment.
사과 추출물의 구취억제효과에 대한 Polyphenol Oxidase의 영향
조상원(Sang-Won Cho),곽기석(Ki-Suk Kwak),이주항(Joo-Hang Lee),윤영수(Young-Soo Yun),구연숙(Yeun-Suk Gu),지청일(Cheong-Il Ji),이두석(Doo-Seog Lee),이양봉(Yang-Bong Lee),김선봉(Seon-Bong Kim) 한국식품영양과학회 2001 한국식품영양과학회지 Vol.30 No.6
본 연구는 사과의 구취억제인자를 구명하기 위한 기초자료로써 사과 추출물의 획분에 따른 사과에서 추출한 PPO의 methyl mercaptan에 대한 구취억제활성을 조사하였다. 사과를 착즙하여 구취억제활성을 측정해 본 결과, 사과 고형분의 농도가 증가함에 따라 구취억제활성이 증가하는 경향을 나타내었다. 사과의 저분자획분에 PPO를 첨가한 경우, 저분자획분의 농도증가 및 반응시간에 따른 methyl mercaptan에 대한 구취억제활성이 증가하는 경향을 나타내었다. 이상의 결과는 사과에서 추출한 PPO에 의한 갈변반응의 중간체로 생성되는 o-quinone이 methyl mercaptan과 결합하여 methyl mercaptan을 비휘발성으로 전환시켜 구취억제활성을 나타내는 것으로 생각된다. Deodorizing activity of polyphenol oxidase (PPO) extracted from apples was investigated by measuring the changes of methyl mercaptan as an indicator of halitosis in human mouths. In the studies of apple extracts on deodorizing activity, the deodorizing activity was increased with the amount of apple extracts. In the cases of adding PPO to the low molecular fraction of apple extracts, the deodorizing activities were increased with the amount of the low molecular fraction of apple extracts and the reaction time of the extracts with PPO. Deodorizing activities of PPO is thought that o-quinone as an intermidiate produced by an oxidative reaction of PPO during enzymatic browning reactions may react with methyl mercaptan to form a non-volatile and sulfur-containing compound.
말기 환자를 치료하는 의사의"호스피스정보제공" 의무화에 대한 정당성
정하윤 ( Ha Yoon Cheong ),손명세 ( Myoung Sei Sohn ),허대석 ( Dae Seog Heo ),이원희 ( Won Hee Lee ) 한국의료윤리학회 2010 한국의료윤리학회지 Vol.13 No.2
This article identifies the two key functions that doctors should perform prior to accepting terminally ill patients` requests for hospice care. In the first place, doctors caring for terminally ill patients should inform relevant family members of the patient`s condition, provide patients and family members with information on hospice care, and offer patients an opportunity to choose to receive hospice care or not. Secondly, doctors should consult with other medical professionals concerning patients` choices and, when appropriate, provide hospice care needs for terminal patients and their families. In order to perform these two functions effectively, doctors caring for terminally ill patients should be provided with due information on hospice care. This article reviews the relevant moral justifications for providing hospice care and argues that it not only satisfies both medical and ethical objectives but is also in terminal patients` best interests.
이종,김한규,정석원,황용순,천태상,이화동 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.7
Two cases of primary intracranial teratomas are presented. One case is right cerebellopontine angle malignant teratoma of 3years old female and the other case is left frontal benign teratoma of 40 years old male. We reviewed the literatures and discussed these cases in the point of the rare sites and pathological characteristic of teratoma.