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Wenbo Zhao,Xianye Qin,Bing Han,Biao Liu,Peichao Lian,Shuisheng Wu 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6
The catalytic synthesis of dimethyl carbonate from methyl carbamate and methanol was investigated in a batch reactor. All of the homogeneous Brönsted acid catalysts show favorable catalytic activity. As homogeneous Brönsted acid catalyst is difficult to separate after reaction, it is converted to heterogeneous catalyst by grafting sulfonic acid groups to MCM-41 with three different methods. Their catalytic activity investigation indicated that sulfonic acid groups grafted by sulfonating with chlorosulfonic acid directly showed activity near to that of homogeneous sulfuric acid catalyst. It was further selected as a model catalyst to investigate the effect of acid amount on its catalytic activity. The results indicated that its activity was positively correlated with its acid amount.
An Immunological Hypothesis of Fu’s Subcutaneous Needling Acupuncture
Wenbo Xu,Jidong Wu,Ping Xu 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.3
Fu’s subcutaneous needling (FSN) is a novel acupuncture approach. Although it has been popularized and widely used by acupuncture practitioners, theoretical research on its mechanism of action remains lacking. This study establishes an immunological hypothesis for the efficacy of FSN basis existing knowledge in biomedical science, histology and physiology, and traditional acupuncture mechanisms. The theoretical inference indicates that FSN treatment may affect the body's immune system through subcutaneous connective tissue, similar to triggering a cobweb-like system. This article also proposes possible clinical implications of this theory, which require further studies to validate.
Caspase-3 inhibitor inhibits enterovirus D68 production
Wenbo Huo,Jinghua Yu,Chunyu Liu,Ting Wu,Yue Wang,Xiangling Meng,Fengmei Song,Shuxia Zhang,Ying Su,Yumeng Liu,Jinming Liu,Xiaoyan Yu,Shucheng Hua 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
Study of Deflection of Buried HDPE Corrugated Pipeline under the Uneven Settlement of Soil
Wenbo Gu,Kai Wu,Liyuan Tong,Songyu Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1
This paper aims to study the deflection of high-density polyethylene (HDPE) corrugated pipeline subjected to differential settlements of the ground using the finite difference method-discrete element method (FDM-DEM) coupling simulation method in 3D. Various physical characteristics of the pipeline, including diameters, corrugations, and elastic modulus have been investigated. Soil particles with different shapes are considered. The variation of soil settlement of soil particles with three different shapes under the uneven settlement condition is studied. The soil arching effects, including positive soil arch and negative soil arch, have been respectively analyzed. The results reveal that the change in pipe corrugation influences the stiffness of the pipe and the friction between the pipe and soil to some extent, which also causes the change of vertical deflection of the pipe. The soil composed of four particles is easier to form soil arch, which makes the soil more self-stabilized, thus alleviating the circumferential deformation of the pipeline.
Haijun Wu,Weikang Jiang,Wenbo Lu 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.7
The moment of diagonal form fast multipole boundary element for the Helmholtz equation in essence is the surface integration of exponential function on an element. In this paper, the moment for a linear triangular element can be integrated analytically by transforming the coordinates from global Cartesian coordinates to local area coordinates. The derived analytical moment evaluation is compared with the classical numerical calculation, and results show that analytical method makes the moment calculation efficient, stable, and accurate.
Photocatalytic oxidation of gas-phase Hg0 by carbon spheres supported visible-light-driven CuO–TiO2
Jiang Wu,Chaoen Li,Xiantuo Chen,Jing Zhang,Lili Zhao,Tianfang Huang,Tao Hu,Chong Zhang,Bu Ni,Xiao Zhou,Pankun Liang,Wenbo Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-
A simplified approach for the fabrication of CuO/TiO2@C is demonstrated. In this study, low cost CuO/TiO2@C photocatalysts (CSs loading 0.25–2 wt.%) were prepared, characterized and evaluated for gasphaseHg0 oxidation. The obtained CuO/TiO2@C photocatalysts were used to remove gaseous elementalmercury under UV light and LED respectively, and the optimum doping of content of CSs was determined. The results showed that the CuO/TiO2@C photocatalysts were highly efficient in oxidizing Hg0, reachingabove 64% when the CSs doping reached 0.5 wt.%. We have proposed that the probable mechanism bywhich CuO/TiO2@C photocatalysts remove gaseous elemental mercury: with CSs doping, CSs can act assensitizer and transfer electrons to the semiconductors, triggering the formation of very reactive radicalsto improve photocatalytic efficiency.
Study on the progressive collapse resistance of CP-FBSP connections in LCFST frame structe
Qingqing Xiong,Wenbo Wu,Wang Zhang,Zhihua Chen,Hongbo Liu,Tiancheng Su 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.3
When the vertical load-bearing members in high-rise structures fail locally, the beam-column joints play an important role in the redistribution of the internal forces. In this paper, a static laboratory test of three full-scale flush flange beam-reinforced connections with side and cover plates (CP-FBSP connection) with double half-span steel beams and single Lshaped columns composed of concrete-filled steel tubes (L-CFST columns) was conducted. The influence of the side plate width and cover plate thickness on the progressive collapse resistance of the substructure was thoroughly analyzed. The failure mode, vertical force-displacement curves, strain variation, reaction force of the pin support and development of internal force in the section with the assumed plastic hinge were discussed. Then, through the verified finite element model, the corresponding analyses of the thickness and length of the side plates, the connecting length between the steel beam flange and cover plate, and the vertical-force eccentricity were carried out. The results show that the failure of all the specimens occurred through the cracking of the beam flange or the cover plate, and the beam chord rotations measured by the test were all greater than 0.085 rad. Increasing the length, thickness and width of the side plates slightly reduced the progressive collapse resistance of the substructures. The vertical-force eccentricity along the beam length reduced the progressive collapse resistance of the substructure. An increase in the connecting length between the beam flange and cover plate can significantly improve the progressive collapse resistance of substructures.
Xie Mengxiao,Wu Zhijiao,Ying Shuai,Liu Longfei,Zhao Chenhui,Yao Chunlei,Zhang Zhiwei,Luo Can,Wang Wenbo,Zhao Dan,Zhang Jing,Qiu Wen,Qiu Wen 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Glomerular mesangial cell (GMC) proliferation is a histopathological alteration in human mesangioproliferative glomerulonephritis (MsPGN) or in animal models of MsPGN, e.g., the rat Thy‐1 nephritis (Thy-1N) model. Although sublytic C5b-9 assembly on the GMC membrane can trigger cell proliferation, the mechanisms are still undefined. We found that sublytic C5b-9-induced rat GMC proliferation was driven by extracellular signal‐regulated kinase 1/2 (ERK1/2), sry-related HMG-box 9 (SOX9), and Cyclin D1. Here, ERK1/2 phosphorylation was a result of the calcium influx-PKC-α-Raf-MEK1/2 axis activated by sublytic C5b-9, and Cyclin D1 gene transcription was enhanced by ERK1/2-dependent SOX9 binding to the Cyclin D1 promoter (−582 to −238 nt). In addition, ERK1/2 not only interacted with SOX9 in the cell nucleus to mediate its phosphorylation at serine residues 64 (a new site identified by mass spectrometry) and 181 (a known site), but also indirectly induced SOX9 acetylation by elevating the expression of general control non-repressed protein 5 (GCN5), which together resulted in Cyclin D1 synthesis and GMC proliferation. Moreover, our in vivo experiments confirmed that silencing these genes ameliorated the lesions of Thy‐1N rats and reduced SOX9 phosphorylation, acetylation and Cyclin D1 expression. Furthermore, the renal tissue sections of MsPGN patients also showed higher phosphorylation or expression of ERK1/2, SOX9, and Cyclin D1. In summary, these findings suggest that sublytic C5b-9-induced GMC proliferation in rat Thy-1N requires SOX9 phosphorylation and acetylation via enhanced Cyclin D1 gene transcription, which may provide a new insight into human MsPGN pathogenesis.
Meng Fanchao,Wu Yuying,Li Wenbo,Hu Kaiqi,Zhao Kai,Yang Huabing,Gao Tong,Sun Yue,Liu Xiangfa 한국물리학회 2022 Current Applied Physics Vol.39 No.-
Evolution of the heat-resistant phases and deformation behavior of α-Al matrix of four alloys have been characterized by SEM and EBSD. The strengthening mechanisms influenced by morphology and distribution of the heat-resistant phases were described. And the strain contouring of the α-Al matrix after deformation was rendered. The heat-resistant phases with block-like as reticular or semi-reticular network distribution exist in grain boundary can effectively provide elevated-temperature strength for alloys, while the strain contouring of α-Al matrix is mainly concentrated in the area with fewer intermetallic phases. It is shown that intermetallic phase evolution corresponds to extrusion treatment and the formation of eutectic Si and primary Si, highly interconnected networks of intermetallic phases exist in the alloy in which the primary Si and the eutectic Si are simultaneously present or disappeared. And only the disappearance of the primary Si and the extrusion treatment will destroy the network structure of the intermetallic phases. A reticular or semi-reticular microstructure is more capable of matching strength and plasticity and facilitating uniform deformation of the α-Al matrix. And the destruction of this microstructure is allowed to accommodate more plastic strain before failure.