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- 저자 : Weller, Evan (검색결과 44 건)
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Weller Andrew E.,Ferraro Thomas N.,Doyle Glenn A.,Reiner Benjamin C.,Berrettini Wade H.,Crist Richard C. 한국유전학회 2024 Genes & Genomics Vol.46 No.9
Background Schizophrenia is a mental disorder that causes considerable morbidity, whose risk largely results from genetic factors. Setd1a is a gene implicated in schizophrenia. Objective To study the gene expression changes found in heterozygous Setd1a± knockout mice in order to gain useful insight into schizophrenia pathogenesis. Methods We mined a single-cell RNA sequencing (scRNAseq) dataset from the prefrontal cortex (PFC) and striatum of Setd1a± mice and identified cell type-specific differentially expressed genes (DEGs) and differential transcript usage (DTU). DEGs and genes containing DTU found in each cell type were used to identify affected biological pathways using Ingenuity Pathway Analysis (IPA). Results We identified 273 unique DEGs across all cell types in PFC and 675 unique gene peaks containing DTU. In striatum, we identified 327 unique DEGs across all cell types and 8 unique gene peaks containing DTU. Key IPA findings from the analysis of DEGs found in PFC and striatum implicate processes involved in protein synthesis, mitochondrial function, cell metabolism, and inflammation. IPA analysis of genes containing DTU in PFC points to protein synthesis, as well as cellular activities involving intracellular signaling and neurotransmission. One canonical pathway, ‘EIF2 Signaling’, which is involved in the regulation of protein synthesis, was detected in PFC DEGs, striatum DEGs, and PFC genes containing DTU, drawing attention to its importance in schizophrenia pathophysiology. Conclusion Processes involving protein synthesis in general and the ‘EIF2 Signaling’ pathway in particular could be targets for the development of new research strategies and biomarkers in schizophrenia. Background Schizophrenia is a mental disorder that causes considerable morbidity, whose risk largely results from genetic factors. Setd1a is a gene implicated in schizophrenia. Objective To study the gene expression changes found in heterozygous Setd1a± knockout mice in order to gain useful insight into schizophrenia pathogenesis. Methods We mined a single-cell RNA sequencing (scRNAseq) dataset from the prefrontal cortex (PFC) and striatum of Setd1a± mice and identified cell type-specific differentially expressed genes (DEGs) and differential transcript usage (DTU). DEGs and genes containing DTU found in each cell type were used to identify affected biological pathways using Ingenuity Pathway Analysis (IPA). Results We identified 273 unique DEGs across all cell types in PFC and 675 unique gene peaks containing DTU. In striatum, we identified 327 unique DEGs across all cell types and 8 unique gene peaks containing DTU. Key IPA findings from the analysis of DEGs found in PFC and striatum implicate processes involved in protein synthesis, mitochondrial function, cell metabolism, and inflammation. IPA analysis of genes containing DTU in PFC points to protein synthesis, as well as cellular activities involving intracellular signaling and neurotransmission. One canonical pathway, ‘EIF2 Signaling’, which is involved in the regulation of protein synthesis, was detected in PFC DEGs, striatum DEGs, and PFC genes containing DTU, drawing attention to its importance in schizophrenia pathophysiology. Conclusion Processes involving protein synthesis in general and the ‘EIF2 Signaling’ pathway in particular could be targets for the development of new research strategies and biomarkers in schizophrenia.
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Permeability Prediction Based on Geoelectrical Parameters
( Andreas Weller ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
Many attempts have been made to correlate electrical and hydraulic conductivity because electrical current and fluids flow in a similar way through the pore space. The electrical conductivity is mainly controlled by the porosity whereas the fluid flow additionally depends on the pore size. Porosity and pore size are independent parameters that cannot be separated from a conventional resistivity measurement that provides only the resistivity amplitude at a single frequency. The induced polarization (IP) method, which is an extension of the conventional resistivity survey, investigates the low frequency dispersion of electrical conductivity that originates from capacity-like behavior of porous material. Charge polarization occurs in the electrical double layer that forms at the boundary between solid minerals and the pore filling fluid. IP parameters like the normalized chargeability or the imaginary part of electrical conductivity depend on the specific surface area per unit pore volume, which is inversely proportional to the pore size. An IP measurement enables the separation of volume conduction, which is related to porosity, and surface conduction that is controlled by the pore size. Various IP models for permeability prediction have been proposed and tested using comprehensive sets of samples. In the case of the sandstone samples, the electric formation factor exerts the primary control on permeability, and the imaginary conductivity was found to be of less importance. The opposite was observed for the unconsolidated samples, in which the imaginary conductivity was the most important term for permeability prediction. This study was supported by "The SEM projects; 2018002440005".
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Chinese Approaches to Ethnic Diversity
Robert P. Weller 고려대학교 민족문화연구원 2011 Cross-Currents Vol.- No.1
The two books reviewed here clarify how China addresses the problem of internal diversity. All states have to address this issue to some extent. Multiethnic empires like the Qing chose a strategy that recognized the separate political, legal, and social rights of communal groups (Mongols, Tibetans, Han Chinese, and the rest), as long as those groups accepted the overarching authority of the emperor. The Qing also drew in part on a far older Chinese vision of the imperium as a set of increasingly distant tribute zones, where people became less politically integrated and less civilized as one moved out from the center. While not all Chinese dynasties viewed themselves in this way, the Qing shared this broad mode of governance with many other empires in world history.
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