난소절제후 Estrogen을 투여한 흰쥐 대동맥에서 Protein Kinase C-α와 Fas 발현의 변화

이왕수,이상엽,안지현,송영빈,김학진,이광재,유재격,김상욱,김태호,김치정,류왕성 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.3

Estrogen is believed to decrease coronary artery disease. Protein kinase C-α(PKCα)appear to be important in signal conduction pathways. Estrogen treatment increases catalytic activity of PKCα,and activation of PKCαcan modulate estrogen receptor levels and responsiveness. And it was reported that activation of PKC can protect cells from apoptosis induced by Fas ligation. But the beneficial effect of estrogen on PKCαwas not clearly demonstrated. The objective of this study was to evaluate the role of PKCαafter ovariectomy and estrogen therapy in rat aorta. The results were summarized as below: 1. The significant pathological changes were not observed in the rat aorta irrelevant to ovariectomy and estrogen therapy. 2. The expression of Fas was decreased in the aorta of estrogen-treated rats than that of ovariectomized rats without estrogen therapy. 3. Increased expression of PKCαwas more marked in the aprta of estrogen-treated rats than that of ovariectomized rat without estrogen therapy. In conclusion,PKCαmay be important in signal conduation pathway on the effect of estrogen. Activation of PKCαby estrogen reduced Fas expression, suggesting that PKCαactivation may play a role in protection against atherasclerosis. Further studies are needed to elucidate the role of PKCαafter estrogen therapy.

암센서용 TiO2/Au/CNT 나노복합물의 전기화학적 검출

홍성미, 김홍일, 김한주, Wang, Xuemei, 박수길 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

Demand of rapid detection for cancer, it is necessary that high sensitivity, specificity, low cost, and simple method. CNT and metal nano materials are widely used to elecate efficient. CNT have various advantage, and can be composed with metal nano materials. Especially, Titanium oxide and gold nano particles are focused on sensor for detection of cancer, it can elecate electron transition feeiciency between electrode surface and target materials, and biological functionalization of CNT. It means that nano material is composed each other. In this study, electrodes are considered materialsd and their chracteristic for cancer sensor.

쑥, 진피, 두충이 고지혈증 흰쥐의 체내 지질대사에 미치는 영향

김지현,왕수경 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

본 연구는 생후 4주된 Sprague-Dawley rats을 1% cholesterol, 30% lard를 첨가조제한 고지방 식이로 3주간 사육하여 고지혈증을 유발시킨 후 쑥, 두충, 진피를 섬유질원으로 하여 식이중 총 식이섬유 함량이 10%가 되도록 조제한 식이로 흰쥐를 6주간 사육했을 때의 체내 지질대사에 미치는 영향을 cellulose군과 비교 관찰하였다. 그 결과 실험 동물의 총 식이섭취량에 있어서 cellulose군, 진피군이 쑥군, 두충군보다 유의적으로 높았고, cellulose군과 진피군 비교에서는 대조군인 cellulose군이 높았다. 체중 증가량은 cellulose군이 나머지 세 군에 비해 유의적으로 높았다. 지방 흡수율은 두충군이 LDL-콜레스테롤은 쑥, 두충, 진피군이 cellulose군에 비해 비해 유의적으로 낮았고, 특히 두충군이 가장 낮았다. 중성지방은 cellulose군에 비해 세군이 유의적의로 낮았고, HDL-C/TC에 있어서는 cellulose군에 비해 나머지 세 군이 유의적으로 높았다. 두충, 쑥, 진피군 중에서는 두충군이 가장 높은 경향을 보였다. 혈당에 있어서는 통계적 유의차는 없었지만 쑥, 진피군이 다소 낮은 경향을 보였고, cellulose군이 가장 높았다. 간의 총지질과 총콜레스테롤 함량은 cellulose군이 다른 세 군에 비해 유의적의로 높았고, 중성 지방에 있어서는 cellulose군이 유의적으로 낮았다. 변의 총지질과 총콜레스테롤 농도는 두충, 쑥군이 celluloserns, 진피군에 비해 유의적의로 높았고, 진피군도 cellulose군에 비해 다소 높은 경향을 보였다. 중성지방은 진피군에 비해서 대른 세 군이 유의적으로 높았고 수분을 포함한 변중량, 건중량에 있어서는 cellulose군에 비해 쑥, 진피군이 유의적의로 높았으며 두충군도 cellulose군에 비해 다소 높은 경향을 보였다. 수분함유량은 진피군이 유의적으로 높았고, 두충군, 쑥군이 cellulose군에 비해 높았다. 이상의 연구 결과 진피는 혈중 총지질, 총콜레스테롤 수준 저하, 그리고 배변에 효과적이고 두충은 혈중의 HDL-콜레스테롤 증가, 총콜레스테롤 감소에 효과적의로 나타나 진피, 두충이 우수한 지질 대사 개선 효과를 나타내는 것으로 보인다. 이러한 결과로 보아 cellulose와 같은 불용성 식이섬유보다 수용성과 불용성 식이섬유를 동시에 함유하고 있는 식품 자체가 고지혈증·동맥경화의 예방이나 치료에 효과가 있을 것으로 기대된다. This study was performed to investigate the influence of dietary foods from three Chinese medicinal herbs(Mugwort, Dried orange peel and Duchung) on lipid metabolism in rats. Male rats of Sprague-Dawley strain were divided into four dietary groups(Cellulose(CL), Mugwort(MW), Dried orange peel(OP), Duchung(DC)) after three weeks of hyperlipideniic dieting and were fed ad libiturn each of the experimental diets for six weeks. The fiber sources of the experimental diets were prepared by drying and milling mugwort, orange peel, duchung and cellulose. Each of the fiber sources was mixed into the diet to achieve 10 8% levels of total dietary fiber. Levels of apparent fat absorption exhibited a significant decrease in the MW and DC groups. The OP group also showed a decreasing trend, but to a lesser extent. The levels of serum total lipid were not significantly different among the four experimental groups. Total serum cholesterol levels were significantly lower in the OP group than in both the CL and MW groups. Serum TC; and LDL-cholesterol levels were significantly higher in the CL group than other groups. Serum HDL-cholesterol levels were significantly lower in the CL group than in the other groups. Total lipid and total cholesterol in liver were significantly higher in the Cl, group than in other groups and TG in liver was significantly lo\w in the CL group than in the other groups. Total lipid and total cholesterol in feces displayed a significant increase in the MW and DC groups when compared with the CI, group. The OP group also showed an increase compared to the CL group. (Korean J Nutrition 30(8) : 895~903, 1997)

청소년의 체형인식과 체중조절에 관한 실태 조사

김윤정,임영희,왕수경,윤은영,구난숙 대전대학교 생활과학연구소 1998 생활과학연구 Vol.4 No.-

This purpose of this survey was to investigate status recognition and weight contrast of high school students and college in Taejon. These results were summarized as follows: In the heights and weights those of male 178.74±6.31cm and 65.49±9.44kg, those of female were 162.09±4.36cm and 51.95±5.95kg. By broca index, 53.7% of subjects were normal, 38.2% were lean, 5.3% were overweight and 2.8% were obese. 44.4% of male have recognized their body form as normal, 30.5% of female have recognized their body form as overweight, 47.8% of lean groups answered that they were normal. In normal groups, 46.2% answered normal and 28.9% answered some fatty. 46.8% of normal group in female misunderstood that they were some fatty. In spite of not to weight control, lean and normal group answered that they were weight control. Weight control methods were used diet therapy (66.2%). therapy+exercise(22.8%) and exercise(9.0%). Reason to select therapy of weight control were one's recommendation(45.8%) and by mass media(3.8%). Weight loss and period of weight control were 1.9days, 0.4kg in high school students, 7.3days, 0.7kg in college students, and 3.8days, 0.5kg in male, 5.7days, 0.6kg in female. The results of weight control, 65.0% were failed. The reason of failure in weight control, 42.4% answered because of hungry.

理想社會에 관한 韓國人의 傳統的 觀念 : 靜庵 趙光祖의 理想社會論을 中心으로 A Study on Cho Kwang-jo's View

金旺洙 연세대학교 인문과학연구소 1994 人文科學 Vol.72 No.-

Even though the concept of utopia refers to "the best place to live" or "the wonderful place that does not exist in real world," it can be defined as "the best place that can be realized in this world." Because of the orientation toward the possibly realized best place to ive in this world, human history shows endless endeavors to achieve utopia. This sometimes serves as an engine for social renovation. Without exception, utopian thoughts have existed in Korean society. Even during the stable Yi-dynasty, there were diverse sets of utopian thoughts. Among them, Cho Kwang-jo´s idea was the typical and representative thought on utopia with Confusianistic idea. Cho Kwang-jo, who was a politician with a belief that national goals and individual ideals should be congruent, emphasized morality based on the Greatest ancestors´ guidence. His idea was the model of Confusianistic thought on utopia which gave a new perspective during the Yi-dynasty. This paper examines the philosophical base of Cho Kwang-jo´s view on utopia and analyzes the content of his view in a systematic way. By so doing, this paper intends to show the aspect of utopian thought created and maintained by the ruling class in traditional Korean society.

활성탄소섬유를 이용한 휘발성유기화합물의 흡착특성 연구

김정수,차왕석 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-

One of the most inportant technical issues of recent years is the effective and economical removal of Volatile Organic Compounds(VOCs) in air. The present study examined the adsorption characteristics of common and toxic VOCs including Methyl Ethyl Ketone(MEK), acetaldehyde and toluene in the gas phase using commercial activated carbon fibers(ACFs). First of all, the adsorption equilibrium capacity as a function of initial VOC's concentration and adsorbate sorts was investigated in a packed bed reactor. As for the effect of the initial VOC's concentration, the adsorption equilibrium capacity increased with increasing initial concentration of VOC's, but reached a constant value beyond a certain concentration. The adsorption equilibrium capacity increased with increasing molecular weight of adsorbate, but decreased with temperature.

矮小條蟲(Hymenolepis nana)에 대한 Albendazole의 영향에 관한 電子顯微鏡的 硏究

王辰聲,金洙鎭,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3

Newly developed albendazole (Zentel®) is a broad spectrum anthelmintic with high activity against intestinal nematodes as well as trematodes and cestodes infections. The present study was undertaken to observe the morphological changes of Hymenolepis nana which obtained from experimentally infected mice after treatment with albendazole. For this study 20 mice were artificially infected with eggs and 16 of them were given albendazole (1×100mg/kg) four weeks after infection. The worms were collected from the small intestine of the mice which were autopsied at 1 and 2 hours after treatment. The fine structure of the collected worms were studied by means of scanning and transmission electron microscopies. The findings were compared with those of untreated worms. The results are as follows: 1. The worms obtained from non-treated mice showed that the whole surface is covered with many microtriches. Microtriches of H. nana may be divided into three anatomical regions; a base, junctional region and cap. Tegumental layer showed well developed syncytium which included a lot of number of discoidal secretory bodies. 2. Many blebs were formed on the surface of the damaged tegument of the worm at 1 hour after treatment with albendazole. The bleb was packed by plasma membrance and included matrix which uniform electron density. Some bleb surface has microtriches. 3. The destruction of tegumental syncytium was recognized at 2 hours after treatment with albendazole. Therefore the blebs on the worm sufrace caused to the death by the tegumatal bursing.

악안면 영역에 발생한 혈관종 환자의 외과적 치험례

김일규,박형준,최진호,장금수,김왕식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Hemangiomas are benign tumors in blood vessels that occur by traumatic or congenital origin. Lesions are appeared early in life, with 73% present at birth and 85% developing by the end of the first year. Head & neck hamangiomas represent about 25%∼33% of all hemangiomas. Kaban & Mulliken divided vascular birthmarks into two major categories : hemangioma and vascular malformation. Case 1 was diagnosed as cavernous hemangioma and the mass was excised completely and defected space was reconstructed with fat tissue. Case 2 was diagnosed definitely as traumatic A-V malformation by post-op histopathological examination and the mass was excised completely. This report describes two cases that were successfully treated by complete surgical excision for hemangioma in maxillofacial region.

대학생들의 다이어트 식습관 실태 조사

김연정,문진아,왕수경 대전대학교 기초과학연구소 2010 自然科學 Vol.21 No.-

대전대학교 교양과목으로 개설된 ‘식생활과 다이어트’ 교과목을 수강하는 남녀 학생 151 명을 대상으로 다이어트 경힘과 함께 그들의 식습관을 알아온 결과는 다음과 같다 조사대상자는 남학생 81 명과 여학생 70명으로 총 151 명이었다. 남학생들의‘식생활과 다이어트’ 수강동기는 식생활 전반에 대해 공부하고 싶다는 응답이 여학생들은 특히 다이어트에 관심이 있어서 라고 응답한 학생이 가장 높아 유의적 차이를 보였다 여학생 중 51 .4%, 남학생 중54.3%는 다이어트에 대한 경험이 있었으며, 다이어트 해 본 시기는 남학생은 대학교 때 여학생은 고등학교 때가 가장 높게 나타나 유의적 차이를 보였다. 다이어트 정보는 남학생과 여학생 모두 인터넷과 경험 있는 친구 나 선배를 통해서가 가장 높게 나타났다. 남녀 학생의 평균 운동 시간은 유의적 차이를 보여 남학생은 주 1 - 3시간 운동하는 학생이 가장 많았고 여학생들의 주 1 시간미만 운동하는 학생이 많았다. 식생활 태도에 대한 조사에서 아침 식사를 하지 않는 학생이 남녀 각각 19.6%. 18.6%로 나타났다. 남학생이 여학생보다 과식하는 경향을 보였으며 간식을 먹는 횟수는 여학생이 많았다. 조사대상자 자신의 식생활의 개선점으로 남녀 학생이 각각 56 .4%와 47.0%가 불규칙한 식사로 답하였다. 이상의 결과로 남녀 학생들이 다이어트에 대한 관심도가 높았고 식습관에 문제가 있어 “식생활과 다이어트”과목을 수강함으로써 식습관과 다이어트 과목을 통한 영양교육이 효과가 있을 것으로 본다. In th is study, 151 students(male were 81 and female were 70enrolled in ‘' Food and Diet course were asked about their diet experiences and food habits . In the question asking the reasons for taking this‘' Food and Diet'class , most male subjects answered they enrolled 'to learn about overall knowledge’, whereas female students answered ' special interest in diet’' led to taking th is class. 67 .1 %of women and 64.2% of men said they put effort to maintain weight. Also , 51 .4%of female and 54.3% of male have experience of diet. The period of diet was most frequent in University for men (33 .3%) and in high school for women (47.1 %). Diet information was gathered from internet of from friends with previous experiences for both genders . It showed students gain little through reading nutrition related books , percentage was low for men and women (3 .7%. 1.4%, respectively). For diet methods. 40% of the subjects in total said they do diet through exercise. Female subjects showed that they've tried many different methods such as yoga and diet therapy . 53 .1 % of male and55.7% of female answered the diet was effective and lost weight. In the questionnaire about the dietary life and habits. percentage of the subjects who do not eat breakfast was 19.6% for men and 18.6% for women. The frequency of excessive eating and taking snacks was higher in men and it showed statistically meaningful result. From above results , we can conclude that the interest in diet was high in both gender and they both have problems regarding eating habits. 80 by taking ‘' Food and Diet’' class , it is predicted that this course will have educational effect on students 'eating habits and their diet.

여객선의 화재 안전 평가 : 화재, 연기 통제와 대피 분석

김수웅,왕진,권영섭 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.1

여객선 화재 발생시, 대참사를 피하기 위한 가장 중요한 수단중의 하나는 승객들이 신속하고 안전하게 탈출 하는 것이다. 할 수 있는 여러 연기 확산 예방조치들 중 하나는 연기의 확산을 간단하고 믿을 수 있는 방법으로 통재하는 것이다. 이러한 방법은 사람들이 연기와 접할 수 있는 지역을 최소화 할 수 있고, 연기로부터 탈출할 수 있는 가시성을 보장할 수 있게 된다. 이 연구에서는 여객선 화재 안전에 실질적인 적용성과 실용성에 도달하기 위한 필요한 작업들을 다루고 있고, 화재 안전성 평가에 대한 가능성을 제공한다. 여객선에서 화재, 연기 통재와 대피 분석을 연구하기 위해 제안된 방법은 현재 이용 가능한 정보와 새로운 위험 평가 기술을 사용하였다. 제안된 방법을 설명하기 위해 사례 연구가 수행 되었다. 마지막으로 앞으로 여객선 안전 분야중의 화재 안전성 평가의 연구 진행 방향에 대해 자세히 설명했다.