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Incomplete autophagy promotes the replication of Mycoplasma hyopneumoniae
Wang Zhaodi,Wen Yukang,Zhou Bingqian,Tian Yaqin,Ning Yaru,Ding Honglei 한국미생물학회 2021 The journal of microbiology Vol.59 No.8
Autophagy is an important cellular homeostatic mechanism for recycling of degradative proteins and damaged organelles. Autophagy has been shown to play an important role in cellular responses to bacteria and bacterial replication. However, the role of autophagy in Mycoplasma hyopneumoniae infection and the pathogenic mechanism is not well characterized. In this study, we showed that M. hyopneumoniae infection significantly increases the number of autophagic vacuoles in host cells. Further, we found significantly enhanced expressions of autophagy marker proteins (LC3-II, ATG5, and Beclin 1) in M. hyopneumoniae-infected cells. Moreover, immunofluorescence analysis showed colocalization of P97 protein with LC3 during M. hyopneumoniae infection. Interestingly, autophagic flux marker, p62, accumulated with the induction of infection. Conversely, the levels of p62 and LC3-II were decreased after treatment with 3-MA, inhibiting the formation of autophagosomes, during infection. In addition, accumulation of autophagosomes promoted the expression of P97 protein and the survival of M. hyopneumoniae in PK- 15 cells, as the replication of M. hyopneumoniae was downregulated by adding 3-MA. Collectively, these findings provide strong evidence that M. hyopneumoniae induces incomplete autophagy, which in turn enhances its reproduction in host cells. These findings provide novel insights into the interaction of M. hyopneumoniae and host.
miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
Wang Huiling,Fang Qian,You Shuo,Wu Yaqin,Zhang Chaojie 한국유전학회 2023 Genes & Genomics Vol.45 No.1
Background Substantial evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), play a vital role in human cancer. Phosphoserine aminotransferase 1 (PSAT1) is a serine biosynthesis-related member of the aminotransferase family and is closely associated with worse prognosis in triple-negative breast cancer (TNBC). Objective The present study elucidated the molecular mechanisms underlying PSAT1 regulation by miRNAs in TNBC. Methods After collecting breast cancer and para-cancerous tissues, expression and functional testing of microRNA-195-5p (miR-195-5p) and PSAT1 were implemented both in vivo and in vitro. Results Abnormally low miR-195-5p expression was confirmed in TNBC tissues and cells. The specific targeting effect of miR-195-5p on PSAT1 was screened. Our observations revealed that biological tumor behavior was inhibited after miR-195-5p upregulation and this inhibition could be reversed by PSAT1 overexpression both in vivo and in vitro. Conclusion Our study revealed the regulatory axis of miR-195-5p/PSAT1 in TNBC, suggesting a promising targeted therapy for clinical application.
Space Deformation of Parametric Surface Based on Extension Function
Wang, Xiaoping,Ye, Zhenglin,Meng, Yaqin,Li, Hongda Society for Computational Design and Engineering 2002 International Journal of CAD/CAM Vol.1 No.1
In this paper, a new technique of space deformation for parametric surfaces with so-called extension function (EF) is presented. Firstly, a special extension function is introduced. Then an operator matrix is constructed on the basis of EF. Finally the deformation of a surface is achieved through multiplying the equation of the surface by an operator matrix or adding the multiplication of some vector and the operator matrix to the equation. Interactively modifying control parameters, ideal deformation effect can be got. The implementation shows that the method is simple, intuitive and easy to control. It can be used in such fields as geometric modeling and computer animation.
PREPARATION AND PROPERTIES OF HNT–SiO2 COMPOUNDED SHEAR THICKENING FLUID
YAN WANG,YAOFENG ZHU,YAQIN FU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8
A novel shear thickening fluid (STF) obtained from a halloysite nanotube (HNT) and SiO2 compounded system was successfully prepared using HNT and nano-SiO2 as dispersed phases and polyethylene glycol 200 (PEG200) as the dispersion medium. The steady rheological behavior of the STF was investigated using a high-speed rotational rheometer, and the dispersion states of SiO2 and HNT in PEG200 were characterized by field emission scanning electron microscopy and transmission electron microscopy. Results show that HNT and SiO2 coexisted in the compounded system, and presented a special state that was both uniformly dispersed and partially enriched. The shear thickening effect of the STF was significantly enhanced by the enrichment of SiO2loaded on the surface of HNTs in the compounded system.
Test Analysis and Study on Cutting Destruction Properties of Solid Ice-snow Road
Li Yaqin,WuWenfu,Wang Junfa,Qiu Xinwei 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.5
Build cutting resistance measurement system based on single-chip microcomputer and high speed camera in order to analysis cutting destruction of solid ice-snow. The experimental model has been built according to the rotating orthogonal experiment methods when tests, take the cutting resistance as objective function, A significant factor in the depth of cutting, rake angle as well as tool installation angle as influencing factors, and analysis found that the relationship between the primary and secondary factors were setting angle>density>cutting depth. By comparing theoretical models and experimental models found both the maximum error is about 8.7%, the minimum error is about 12.8%, the median error of about 12%, which verified the availability of theoretical model. Affecting the snow removal efficiency of parameters were carried out the optimal tests study, and found that the best setting angle of cutting tool is from 46°to 52°on the condition that the temperature is lower than -15°C, the thickness of snow and ice is less than 35mm, and rake angle -10°~ -9°.Optimal combination of parameters meet not only the job requirements but also provide a valuable reference for the optimum design of snow removal tool structure and process parameters, and the overall design of a prototype in the future.
Zhang Feng,Wang Yaqin,Miao Wenfei,Liu Zhaoming,Oh Won-Chun 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.5
Modified tourmaline (TM) minerals were prepared using hydrothermal method, followed by surface coating with sorbitan monostearate (SPAN-60), as well as characterization of FTIR, XRD, zeta potential, and antibacterial property analysis. The as-synthesized TM particles were incorporated with polyethersulfone (PES) substrate of thin-film composite forward osmosis (TFC-FO) membrane for alleviated structural resistance and biofouling tendency based on two different approaches, polymer blending into and polymer coating onto the inorganic deposited layer, respectively. To investigate the micromorphology of the prepared membranes, SEM was used to obtain the surface and cross-section images, and elemental mapping with EDS was applied to analyze the dispersion state of TM particles in PES matrix. In comparison to the control membrane, the water flux in FO mode of the nanocomposite membranes significantly increased with TM loading content, which is attributed to the optimization of microstructure and enhancement of inner osmotic pressure resulted from the ions released by TM. More importantly, the results showed TM endowed antibacterial activity in the membrane when TM deposited layer combined with the bottom surface of substrate. It is confirmed by our work that TM is a versatile additive for FO membrane with high performance.