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Prognostic Value of Combined Biomarkers in Patients With Heart Failure: The Heartmarker Score
van der Stam Jonna A.,Bouwmeester Sjoerd,van Loon Saskia L. M.,van Riel Natal A. W.,Dekker Lukas R.,Boer Arjen-Kars,Houthuizen Patrick,Scharnhorst Volkher 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.3
Background: Heart failure (HF) biomarkers have prognostic value. The aim of this study was to combine HF biomarkers into an objective classification system for risk stratification of patients with HF. Methods: HF biomarkers were analyzed in a population of HF outpatients and expressed relative to their cut-off values (N-terminal pro-B-type natriuretic peptide [NT-proBNP] >1,000 pg/mL, soluble suppression of tumorigenesis-2 [ST2] >35 ng/mL, growth differentiation factor-15 [GDF-15] >2,000 pg/mL, and fibroblast growth factor-23 [FGF-23] >95.4 pg/mL). Biomarkers that remained significant in multivariable analysis were combined to devise the Heartmarker score. The performance of the Heartmarker score was compared to the widely used New York Heart Association (NYHA) classification based on symptoms during ordinary activity. Results: HF biomarkers of 245 patients were analyzed, 45 (18%) of whom experienced the composite endpoint of HF hospitalization, appropriate implantable cardioverter-defibrillator shock, or death. HF biomarkers were elevated more often in patients that reached the composite endpoint than in patients that did not reach the endpoint. NT-proBNP, ST2, and GDF-15 were independent predictors of the composite endpoint and were thus combined as the Heartmarker score. The event-free survival and distance covered in 6 minutes of walking decreased with an increasing Heartmarker score. Compared with the NYHA classification, the Heartmarker score was better at discriminating between different risk classes and had a comparable relationship to functional capacity. Conclusions: The Heartmarker score is a reproducible and intuitive model for risk stratification of outpatients with HF, using routine biomarker measurements.
SUSTAINING GALAXY EVOLUTION: THE ROLE OF STELLAR FEEDBACK
JAVADI, ATEFEH,VAN LOON, JACCO TH.,KHOSROSHAHI, HABIB The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We have conducted a near-infrared monitoring campaign at the UK InfraRed Telescope (UKIRT), of the Local Group galaxy M33. The main aim was to identify stars in the very final stage of their evolution, and for which the luminosity is more directly related to the birth mass than the more numerous less-evolved giant stars that continue to increase in luminosity. The pulsating giant stars (AGB and red supergiants) are identified and their distributions are used to derive the star formation rate as a function of age. These stars are also important dust factories; we measure their dust production rates from a combination of our data with Spitzer Space Telescope mid-IR photometry. The mass-loss rates are seen to increase with increasing strength of pulsation and with increasing bolometric luminosity. Low-mass stars lose most of their mass through stellar winds, but even super-AGB stars and red superginats lose ~40% of their mass via a dusty stellar wind. We construct a 2-D map of the mass-return rate, showing a radial decline but also local enhancements due to agglomerations of massive stars. By comparing the current star formation rate with total mass input to the ISM, we conclude that the star formation in the central regions of M33 can only be sustained if gas is accreted from further out in the disc or from circum-galactic regions.
STAR FORMATION HISTORY AND DUST PRODUCTION: NGC147 AND NGC185
GOLSHAN, ROYA HAMEDANI,JAVADI, ATEFEH,VAN LOON, JACCO TH.,KHOSROSHAHI, HABIB G. The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
NGC147 and NGC185, paired satellites of the Andromeda galaxy, possess the same order of mass and analogous structures, but they show different star formation and different amounts of interstellar gas and dust. Therefore, we present the first reconstruction of the star formation history of NGC147 and NGC185. Asymptotic Giant Branch stars are highly evolved stars that are brightest in K-band. This maximum K-band magnitude is related to the birth mass of stars. As a result, we have found a 9.9 Gyr old single star formation epoch for NGC185 followed by relatively continuous star formation. NGC147, however, has passed through two star formation episodes; one is as old as ~6 Gyr and the other is as recent as ~850 Myr. Asymptotic Giant Branch stars are also important dust factories; by fitting Spectral Energy Distributions to observed near and mid infrared data for each star, we were able to measure the dust production rates of individual stars; on order of $10^{-5}M_{\odot}yr^{-1}$. Hence, we estimate the total mass entering the interstellar medium to be $1.06{\times}10^{-4}M_{\odot}yr^{-1}$ and $2.89{\times}10^{-4}M_{\odot}yr^{-1}$ for NGC147 and NGC185.
Left abomasal displacement between the uterus and rumen during bovine twin pregnancy
Bart Pardon,Geert Vertenten,Pieter Cornillie,Stijn Schauvliege,Frank Gasthuys,Gunther van Loon,Piet Deprez 대한수의학회 2012 Journal of Veterinary Science Vol.13 No.4
Here, we describe two cases of left displaced abomasum (LDA) in Holstein cattle at 6 and 9 months of twin gestation. Clinical examination revealed signs of proximal ileus with marked abdominal distension, but no ping sounds. An unusually high position of the gravid uterine horn on the left side was observed with ultrasound. Left exploratory laparotomy confirmed that the abomasum was displaced to the left and entrapped between the rumen and twin gravid uterine horn. A left surgical approach was necessary to correct the condition. Both animals recovered and gave birth to healthy twins. The present cases indicate that the subomental position of a heavy twin gravid uterine horn is a possible mechanical cause of LDA.
Protein Co-Ingestion Strongly Increases Postprandial Insulin Secretion in Type 2 Diabetes Patients
Ralph J.F. Manders,Dominique Hansen,Antoine H.G. Zorenc,Paul Dendale,Joris Kloek,Wim H.M. Saris,Luc J.C. van Loon 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.7
The capacity of nutritional protein to induce endogenous insulin secretion has been well established. However, it is not known whether such a response is applicable in a diverse population of type 2 diabetes patients. The aim of the present study was to assess the impact of co-ingesting either intact or hydrolyzed protein with carbohydrate on postprandial plasma insulin and glucose responses in type 2 diabetes patients. Sixty longstanding, male, type 2 diabetes patients participated in a study in which we determined postprandial plasma insulin and glucose responses after ingesting a single bolus of carbohydrate (0.7 g/kg: CHO) with or without an intact protein (0.3 g/kg: PRO) or its hydrolysate (0.3 g/kg: PROh). Results showed that protein co-ingestion strongly increased postprandial insulin release, with the insulin response + 99 – 41 and + 110 – 10% greater in the CHO+ PRO and CHO+ PROh experiments when compared with the CHO experiment. The insulinotropic properties of protein co-ingestion were evident in nearly all patients, with 58 out of 60 patients responding > 10% when compared with the insulin response following carbohydrate ingestion only (CHO). The concomitant plasma glucose responses were 22 – 32 and 23 – 36% lower in the CHO+ PRO and CHO+ PROh experiments, respectively. We conclude that protein co-ingestion represents an effective dietary strategy to strongly augment postprandial insulin release and attenuate the postprandial rise in glucose concentration in type 2 diabetes patients.