여호와의 증인 환자에서 산과적 출혈 후 무수혈 치료 2예

김재령,여소진,이해혁,김정식,김태희,남계현,이권해,이임순,박진화,황경호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Jehovah's Witness comprise a unique obstetric population. Their refusal of blood stems from an interpretation of a literal translation of the Bible, and it is this belief that puts them at an increased risk of morbidity and mortality if hemorrhage occurs. We report two cases of a Jehovah's Witness who bled massively due to obstetric hemorrhage, refused blood transfusion and had profound anemia. The patients were treated with recombinant human erythropoietin, parenteral iron and oxygen. And they were treated on an intensive care unit with intermittent positive pressure ventilation. We reviewed with literature considering the therapy for acutely anemic patients who refuse transfusion to decrease the duration of the most severe anemia.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

-본문참고-

Design and Implementation of a Directory System for Disease Services

Yeo, Myung-Ho,Lee, Yoon-Kyeong,Roh, Kyu-Jong,Park, Hyeong-Soon,Kim, Hak-Sin,Park, Jun-Ho,Kang, Tae-Ho,Kim, Hak-Yong,Yoo, Jae-Soo The Korea Contents Association 2010 International Journal of Contents Vol.6 No.1

Recently, biological researches are required to deal with a large scale of data. While scientists used classical experimental approaches for researches in the past, it is possible to get more sophisticated observations easily with the convergence of information technologies and biology. The study on diseases is one of the most important issues of the life science. Conventional services and databases provide users with information such as classification of diseases, symptoms, and medical treatments through the Web. However, it is hard to connect or develop them for other new services because they have independent and different criteria. It may be a factor that interferes the development of biology. In this paper, we propose integrated data structures for the disease databases. We also design and implement a novel directory system for diseases as an infrastructure for developing the new diseases services.

협동학습 과정에서의 언어적 행동과 화학 문제 해결력 사이의 관계

노태희,전경문,여경희 한국과학교육학회 2000 한국과학교육학회지 Vol.20 No.2

본 연구에서는 협동학습에서의 언어적 행동과 화학 문제 해결력 사이의 관계를 조사하였다. 고등학교 2학년 학생을 대상으로 사전 화학 성취도의 측면에서 이질적인 3인 1조의 소집단을 구성한 후, 협동학습 환경에서 4단계 문제 해결 전략을 사용하도록 하였다. 이러한 소집단 문제 해결 과정에 대해 녹화 및 녹음을 실시하였다. 학생들의 화학 문제 해결력은 문제 해결 전략 수행 능력 검사로 측정하였다. 언어적 행동은 크게 정보 주기, 정보 받기, 질문하기, 부정하기로 유형화하였고, 총 16개 하위 범주로 세분하였다. 학생들이 가장 많이 나타내는 언어적 행동은 정보 제공하기의 하위 범주인 제공이었다. 언어적 행동과 문제 해결력 사이의 부분 상관을 조사한 결과, 7개 범주에서 유의미한 정적 상관이 나타났으며, 제공 범주가 문제 해결력과 가장 밀접하게 관련 있는 것으로 조사되었다. 그러나 선행 연구에서 보고되지 않은 교정, 정당화, 제공 명료화, 명료화 등에서의 상관도 유의미하였다. 하위 수준 학생들은 정보를 주거나 받는 언어적 행동과 문제 해결력 사이의 관련성이 높았으나, 상위나 중위 수준의 경우 언어적 행동이 문제 해결력을 향상시키지 못하는 경향이 있었다. This study investigated the relationships between verbal behaviors and chemistry problem solving ability in cooperative learning. Based on the previous chemistry achievement, 11th-graders were assigned heterogeneously into three-membered groups. Small cooperative group problem solving processes in using 4 stage-problem solving strategy were audio/video taped. Students' chemistry problem solving ability was then measured by a problem solving strategy performance test. Their verbal behaviors were classified into giving information, receiving information, asking questions, and disagreeing. These were further coded into 16 subcategories. Providing, a subcategory of giving information, was the most frequent behavior. In studying partial correlation between verbal behaviors and problem solving ability, 7 categories were found to have significantly positive relationships. Providing showed the highest correlation with the problem solving ability as reported previously. Moreover, this study also revealed significant correlations in the categories of clarifying provided, correcting, justifying, and clarifying. In the case of low-ability students, the verbal behaviors of giving or receiving information were strongly correlated with problem solving ability. However, these verbal behaviors did not enhance the problem solving ability of high- and medium-ability students.

자궁경부암 세포주들과 Nude mouse 에 이종이식한 자궁경부암 세포에서 아데노바이러스와 리포펙틴을 이용한 종양억제 유전자 ( p53 ) 의 이입율

여경아(Kyeong A Yeo),정재은(Jae Eun Jung),이혜영(Hye Young Lee),이방현(Bang Hyon Lee),김태형(Tae Hyung Kim),천병수(Byeung Soo Cheung),노민석(Min Suk Rho),이준모(Joon Mo Lee),남궁성은(Sung Eun Namkoong),박용석(Yong Seok Park),김종국(Ch 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6

Background: The classical treatment of the cervical cancer is surgery, radiotherapy, chemotherapy. Even though the improvement of treatment successful rate, conventional therapy has some limitations. Recent cutting edge of cancer therapy has been developed in gene level including understand the biological characteristics of the cancer cells, enhance the human immune response, suppress the cancer cell proliferation. Therefore, the gene therapy is proposed to new treatment strategy. Purpose: The transfection efficiency of cervical cancer cell lines and cervical cancer cell line xerografted nude mouse was investigated by transfection of liposome and infection of adenovirus mediated suppressor(p53) and reportor(LacZ) gene. Method: The cervical cancer cell lines was used in this study were CaSki, SiHa (HPV16 positive, wild type p53 gene), HeLa, He]aS3(HPV18 positive, wild type p53 gene) and C33A, HT3(HPV negative, mutant p53). Direct plasmide and AdCMVp53 gene transfection was performed by using liposome system (pRcCMVLacZ / lipofectin, FuGene 6, Ca-phosphate). LacZ gene was used as the reportor gene for the transfection efficiency evaluation. Expression of p53 in cell lines and tumor tissue was confirmed by western blot and immunohistochemical staining. Xenografted nude mouse of SiHa cell line was infected by AdCMVp53 and AdCMVLacZ. Transfection efficiency was observed by same as above. Results: In cervical cancer cell lines, gene transfection using liposome system(pRcCMVLacZ/lipofectin, FuGene 6, Ca-phosphate)revealed different transfection efficiency, especially pRcCMVLacZ in Fugene 6 showed 18-40% of high transfection efficiency in 6 cervical cancer cell lines by X-gal staining and AdCMVp53 showed 95-98% of the high transfection efficiency in HeLa, C33A. AdCMVp53 was significantly expressed at 2-5days after injection xenografted nude mouse on the western blot and transfection efficiency was 19.79±5.36, 26.26 ± 11.69, 14.77±3.98,15.99 ±6.43%(day1-5). AdCMVLacZ were found to immunohistochemistry analysis, in vivo transFection efficiency was 61.26±4.66, 59.63±9.12, 29.46±14.33, 31.73±22.64%(day 1-5) at ×200 and 88.68.65, 70.85±20.94, 40.75±25.44, 48.21±10.97% (day 1-5) at ×400. Conclusion: As a results , adenovirus-mediated transfection efficiency was higher in vivo experiment compared to cell lines. These high efficiency of adenovirus-mediated suppressor gene(p53) could become a significant meaningful data gene therapy strategy both transgenic mice and cervical cancer cell lines.

Inverse Relationship between Adipocyte Differentiation and Ceramide Level in 3T3-L1 Cells

Choi, Kyeong-Mi,Lee, Youn-Sun,Choi, Mi-Hwa,Sin, Dong-Mi,Lee, Seunghyun,Ji, So-Young,Lee, Mi Kyeong,Lee, Yong-Moon,Yun, Yeo-Pyo,Hong, Jin-Tae,Yoo, Hwan-Soo Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.6

<P>Adipocyte differentiation has been a target in anti-obesity strategies and is known to be closely related to lipid metabolism. Ceramide, a major sphingolipid metabolite, has been implicated in differentiation. In this study, we investigated whether ceramide biosynthesis is related to adipogenesis in 3T3-L1 cells. Preadipocytes can be differentiated synchronously by a mixture of adipogenic inducers including 3-isobutyl-1-methylxanthine, dexamethasone and insulin. The number of lipid droplets and the triglyceride content, which are differentiation biomarkers, gradually increased during adipogenesis. Interestingly, ceramide and sphingosine contents in the differentiated cells were decreased compared to those in preadipocytes. When the preadipocytes were treated with an 3-isobutyl-1-methylxanthine- or dexamethasone- or insulin-deficient mixture of inducers, the cellular ceramide levels were significantly increased compared with those in cells treated with the complete set of inducers. When preadipocytes were treated with 0, 0.1 or 1 μg/ml insulin along with 3-isobutyl-1-methylxanthine and dexamethasone, the ceramide levels were decreased and the triglyceride content was increased in a concentration-dependent manner. When the cells were treated with epigallocatechin gallate, an adipocyte differentiation inhibitor, during adipogenesis, the ceramide levels of adipocytes were increased and the fat content was decreased. In conclusion, our findings demonstrate that cellular ceramide levels are inversely correlated with adipocyte differentiation.</P>

담낭염과 동반된 결핵성 담낭관 림프절염

허태길 ( Tae Gil Heo ),홍성우 ( Seong Woo Hong ),장여구 ( Yeo Goo Chang ),이우용 ( Woo Yong Lee ),오행진 ( Haeng Jin Ohe ),최경운 ( Kyeong Woon Choi ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2021 대한소화기학회지 Vol.78 No.4

Tuberculosis of the cystic duct lymph node is very rare. Only four cases have been reported in the literature. This paper presents the case of a young male patient with a tuberculous cystic duct lymph node and chronic cholecystitis, who was diagnosed with cystic duct stones and a gall bladder polyp preoperatively. (Korean J Gastroenterol 2021;78:245-248)

문제 해결 전략에서 협동학습의 효과

노태희,전경문,여경희 한국과학교육학회 1999 한국과학교육학회지 Vol.19 No.4

본 연구에서는 분자 수준의 그림을 강조하고 4단계 문제 해결 전략을 제시하는 수업에서 협동학습의 효과를 조사하였다. 고등학교 세 학급(130명)을 선정하여 개별적으로 전략을 사용하는 집단(St : Strategy), 협동학습 환경에서 전략을 사용하는 집단 (St-Co: Strategy-Cooperative learning), 그리고 통제 집단으로 무선 배치하였다. 수업 처치 후 학생들의 객관식 문제 해결력, 전략 수행 능력, 수업 참여도에 대한 인식을 비교하였고, 학생들이 선호하는 수업 유형도 조사하였다. 객관식 문제 해결력에서는 집단간에 유의미한 차이가 없었으나, 전략 수행 능력에서는 수업 처치와 사전 성취 수준 사이의 상호작용 효과가 유의미하였다. 단순 효과를 분석한 결과, St 집단의 중위 수준 학생들이 St-Co 집단보다 전략을 더 잘 수행한 것으로 나타났다. 그러나 수업 참여도에 대한 인식 검사에서는 St 집단의 점수가 통제 집단보다 유의미하게 낮았고, 학생들이 가장 선호하는 수업도 St-Co인 것으로 조사되었다. The effect of cooperative learning in a heuristic approach (four stage-problem solving strategy) that also emphasized molecular level representation was studied. Three high school classes (N=130) were randomly assigned to St group (using strategy individually), St-Co group (using strategy in cooperative group), and control group. After instruction, students' multiple-choice problem solving ability, strategy performing ability, and the perception of involvement were compared. Students' preferred instruction type was also examined. Although multiple-choice problem solving ability were not different significantly, a significant interaction between the treatment and the previous achievement level was found in strategy performing ability. Analysis of simple effects indicated that the medium-level students in the St group performed better than those in the St-Co group. In the perception questionnaire of involvement, however, the scores of the St group were significantly lower than those of the control group. The instruction type that students most preferred was also St-Co.

조직공정성 유형별 불공정성 인식이 반응행동(EVLN)에 미치는 영향

손태원(Tae-Won Sohn),공도훈(Dohoon Gong),여경태(Kyeong-Tae Yeo) 한국인사관리학회 2014 조직과 인사관리연구 Vol.38 No.1

This paper aims to examine the causal relationship between organizational justice types and EVLN as responses to employee's perceptions of unfairness. At first, this article reviewed the literatures of organizational justice, examined organizational justice could be classified into 3 or 4 types of justice(distributiveㆍproceduralㆍinteractional(interpersonalㆍinformational)) by assessing measurement scales of organizational justice and applied these scales to Korean employees. Hirschman's EVLN model which categorizes dissonance response behaviors as Exit, Voice, Loyalty, and Neglect was used. In order to perform this study, the data of Korean General Social Survey(year 2000, 2009) were analyzed. Overlapping data of 2000, 2009 about perceptions of unfair treatments, personnel decision making and its procedures, actions after personnel decision making and about dissonance response behaviors were tested to strengthen the validity of this study. Hypotheses were verified through the factor analyses and multiple regression analyses. The effects which each organizational justice type had on dissonance response behaviors were different by their types. Unfair perception in procedural justice was positively related with most of the dissonance response behaviors, exit had positive relation with distributive injustice dominantly, and direct voice was negatively related with interactional(informational) injustice. By investigating the changes between year 2000 and 2009 from post-hoc compara- tive analysis, this article verified that there had been noticeable improve- ment in perception of organizational justice, though unfairness perceptions were serious as before. And this article examines that exit, indirect voice had decreased in 2009 compared with 2000 and direct voice took precedence of exit in 2009 unlike in 2000. Finally this paper derives some implications for personnel management and labor-management policy direction. 본 연구는 분배공정성, 절차공정성, 상호작용(대인ㆍ정보)공정성 등 조직공정성 유형별 불공정성 인식이 각각의 반응행동들과 어떤 관련이 있는지를 밝히는데 목적이 있다. 특히 불공정 인식시의 행동에 대해 하나의 변수만 고려하기 보다는 Hirschman 등의 EVLN 모형을 적용하여 각 공정성 유형들이 이탈(Exit), 항의(Voice), 충성(Loyalty), 태만(Neglect) 등의 반응행동에 미치는 영향을 연구했다. 분석의 타당성을 높이기 위해 한국종합사회조사(KGSS)의 데이터 중에서 직장으로부터의 대우불공정에 대한 인식, 인사 관련 의사결정에 관한 인식, 인사정책 결정후의 조치 사항에 대한 인식, 불공정 대우시의 행동유형 등에 대한 설문이 공통적으로 이루어진 2000년과 2009년의 데이터를 비교 연구했다. 먼저 각 조직공정성 유형별, 특히 상호작용공정성과 대인ㆍ정보공정성에 대한 측정 방법에 대한 선행연구를 살펴보고, 각 유형별 공정성인식과 반응행동인 EVLN의 측정방법에 대한 타당성과 신뢰성을 검증한 후 가설을 수립하고 요인분석 및 다중회귀분석을 통하여 가설을 검증했다. 검증 결과 각 조직공정성 유형별로 EVLN에 미치는 영향은 상이한 것으로 나타났다. 특히, 절차공정성은 대부분의 EVLN과 통계적으로 유의미한 관계가 있다는 점, 이탈행동은 분배불공정성인식과 특별한 관련이 있다는 점, 직접적 항의는 상호작용(정보)불공정성과는 부(-)의 유의미한 관계를 가지는 점 등을 발견할 수 있었다. 특히 사후분석을 통해 변수들간의 관계를 2000년과 2009년 두 시점에서 분석, 비교해 본 결과, 불공정하다고 인식하는 정도는 여전히 높지만 유형별 공정성 인식은 개선이 되고 있었다. EVLN에서도 '이직'이나 '노조를 통한 고발'의 경우는 각각 유의미한 수준에서 줄어들고 있었으며, 2009년은 2000년에 비해 '이직'보다는 '공식적 이의제기'를 더 많이 고려하는 것으로 나타났다. 이러한 점들을 통해 조직ㆍ인사 관리에서의 시사점과 나아가 한국의 노사 정책 현황과 방향을 고찰해 본 점은 의의가 있다.

충남지역 농업용 하천수와 지하수 변동조사

윤여욱(Yeo-Uk Yun),김민경(Min-Kyeong Kim),이종은(Jong-Eun Lee),이진일(Jin-Il Lee),최문태(Moon-Tae Choi),남윤규(Yun-Kyu Nam) 한국토양비료학회 2015 한국토양비료학회 학술발표회 초록집 Vol.2015 No.12