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G. Suresh,M. R. Ramesh,M. S. Srinath 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8
This paper reports on a study of the high-temperature tribological performance of self-lubricating nickel-based compositeclad. A porous and crack free clad containing matrix, reinforcement, and lubricant phase is developed on titanium 31 alloyusing microwave irradiation. The microstructure of both NiCrSiB/WC and NiCrSiB/WC/Ag/BaF2 clad revealed very goodmetallurgical bonding with the substrate. The average microhardness of NiCrSiB/WC and NiCrSiB/WC/Ag/BaF2 clad is710.58 HV and 650.25 HV respectively, is comparatively higher than the titanium 31 substrate (320 HV). The addition of Agand BaF2solid lubricants in the clad endowing clad to operate at a broad temperature range. Compared with the NiCrSiB/WCclad, solid lubricant encapsulate clad has shown very low friction coefficient and wear rates. The sliding wear characteristicsof the clad were investigated by varying load and temperatures. The results revealed that oxide phases (NiO and Cr3O)andlubricant phases (Ag and BaWO4)formed at low and high temperatures are adequate to reduce delamination and material loss.
The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
Suresh, Bharathi,Lee, Junwon,Kim, Kye-Seong,Ramakrishna, Suresh Hindawi Publishing Corporation 2016 Stem cells international Vol.2016 No.-
<P>Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation. There are two switches: an E3 ubiquitin ligase enzyme that tags ubiquitin molecules to the target proteins for proteolysis and a second enzyme, the deubiquitinating enzyme (DUBs), that performs the opposite action, thereby preventing proteolysis. In order to maintain stemness and to allow for efficient differentiation, both ubiquitination and deubiquitination molecular switches must operate properly in a balanced manner. In this review, we have summarized the importance of the ubiquitination of core stem cell transcription factors, such as Oct3/4, c-Myc, Sox2, Klf4, Nanog, and LIN28, during cellular reprogramming. Furthermore, we emphasize the role of DUBs in regulating core stem cell transcriptional factors and their function in stem cell maintenance and differentiation. We also discuss the possibility of using DUBs, along with core transcription factors, to efficiently generate induced pluripotent stem cells. Our review provides a relatively new understanding regarding the importance of ubiquitination/deubiquitination of stem cell transcription factors for efficient cellular reprogramming.</P>
Medical student’s perception to different types of set induction in anatomy lectures
Suresh Narayanan,Suresh Narayanan,Nachiket Shankar,Vimala Ananthy 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.3
Set induction refers to the process of using a thought-provoking statement, interesting fact, or an audio-visual stimulus at the beginning of lecture to gain student’s attention and give an overview about the lecture topic. In the present study, students were introduced to three types of set induction namely narratives, food-based analogies and humor-based images or activities at the beginning of anatomy lecture and their response to it is collected and analyzed. The objective of the study is to estimate the difference in a questionnaire-based perception score between the three different types of set induction; estimate sex differences in the questionnaire-based perception score. Students rated the validated, 7-item perception questionnaire using a 5-point Likert scale. Students felt that food-based analogies and humor-based images were more interesting, motivated them to participate in lecture-discussion than the narrative set induction. The familiarity of set induction varied between all the three different types of set induction. There was no significant difference in the perception of different types of set induction between male and female undergraduate students. Based on the student’s feedback, it could also serve as a memory aid and ease the students learning experience. Majority of students responded positively to the use of set induction and recommended for its use in future classes.
T. Suresh,P. Suresh,M. Prabu 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.2
In several research studies, many experiments have been conducted on non-traditional Electric Discharge Machining (EDM)and also investigated how different EDM process parameters influence the surface quality and productivity. EDM is a materialremoval process in which desired shape can be obtained by generation of spark. EDM process parameters play the vital role toimprove the surface finish and productivity simultaneously. This paper presents the effects of EDM machining parameter suchas Discharge ON Time, Discharge OFF Time, and Wire Feed, and their interactions on the Material Removal Rate (MRR) andSurface Roughness (SR) during the machining of magnesium matrix composites (MgZE41A) reinforced with Ag and LiAlO2. The hybrid composite of 97Mg+1.5Ag+1.5 LiAlO2 combination is selected for manufacture using powder metallurgy techniqueas it has a high wear resistance. Analysis of Variance (ANOVA) is adopted to study the influencing process parameters for eachresponse. Desirability function analysis (DFA) tool is adopted to find the optimal EDM process parameters which would reducethe surface roughness and improve the material removal rate simultaneously. From the analysis results it has been found thatdesirability ‘D’ of 0.55 gives the better results.
Suresh Bandari,Subash Jadav,Basanth Babu Eedara,Raju Jukanti,Prabhakar Reddy Veerareddy 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.1
The purpose of this investigation was to enhance the dissolution rate of loratadine using polyethylene glycol 6000 (PEG) solid dispersions (SDs). The solubility behavior of loratadine in the presence of polyethylene glycol 4000and polyethylene glycol 6000 in water showed linear increase with increasing concentrations of PEG, indicating AL type solubility diagrams. SDs of loratadine with PEG 6000 were prepared at 1 : 1, 1 : 3, 1 : 5, 1 : 7 and 1 : 9 ratios by the solvent evaporation method. Solid dispersions were characterized for drug content, dissolution behavior and for physicochemical characteristics. The dissolution rate of loratadine was enhanced rapidly with increasing concentrations of PEG 6000 in SDs. Fourier transform infrared (FTIR) studies showed the stability of loratadine and the absence of a well-defined loratadine - PEG 6000 interaction. Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRD) studies revealed the amorphous state of loratadine in SDs of loratadine with PEG 6000 which was further confirmed from scanning electron microscopy (SEM) studies. The flow properties of the blend, physical characteristics and disintegration time of the tablets formulated indicated that PEG 6000 SD can be used to formulate fast release loratadine tablets.
A JITTER FREE ALL DIGITAL PHASE LOCKED LOOP
Suresh,Maya,Mourad,Samiha 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1
A digital Phase Locked Loop (PLL) is easier to implement, has good dynamic range, initializes quickly and has higher noise immunity compared to an analog PLL However, a digital PLL usually has high jitter. This paper describes the design of a fitter free digital PLL that has been prototyped in an ACTEL FPGA. The digital PLL consists of a phase detector, a loop filter and a digital controlled oscillator. The phase detector produces an output proportional to the phase difference between the output clock and the incoming clock The output of the loop filter counter is compared to that of the digital controlled oscillator (DCO) The DCO produces the output signal which is aligned to the incoming frequency signal. The frequency range is 0.25 MHz to 15 MHz and the lock frequency range is ± 20 KHz