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(Nam Ik Han),(Young Sok Lee),(Hwang Choi),(Jong Young Choi),(Seung Kyu Yun),(Se Hyun Cho),(Jun Youl Han),(Jin Mo Yang),(Byung Min Ahn),(Sang Wook Choi),(Chang Don Lee),(Sang Bok Cha),(Hee Sik Sun),(Do 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2
N/A Background: One of the major morphologic characteristics of hepatitis B is a hepatocellular regeneration which is induced by massive hepatocyte necrosis and associated with proliferative activity of hepatocytes. The purpose of this study is to document the proliferative activity of hepatocytes in various types of hepatitis B by immunohistochemical staining for proliferative cell nuclear antigen-labelling index (PCNA-LI) and electron microscopy. Methods: We studied 83 patients with hepatitis B; 11 cases of acute viral hepatitis, 24 cases of mild chronic hepatitis, 34 cases of severe chronic hepatitis with early cirrhosis and 14 cases of severe chronic hepatitis. The PCNA was tested by immunohistochemical staining using anti-PCNA antibody. Furthermore we evaluated the ultrastructure of acinus-forming hepatocytes (AFH) by electron microscopy. Results : The expression rate and labelling index of PCNA were 27.3% and 5.3±0.9% in acute viral hepatitis, 62.5% and 22.9 ±31.7% in mild chronic hepatits, and then 47.1% and 14.1± 24.2% in severe chronic hepatitis with early cirrhosis, respectively (Figure 1). By contrast, no detectable PCNA expression was noted in AFH. Electron microscopic findings showed that hepatocytes forming a rosette underwent marked degenerative changes with sinusoidal capillarization and increased fine strands of collagen fiber in portal area. Conclusion: The proliferative acitivity of hepatitis B was significantly decreased in severe chronic hepatitis containing AFH. This result suggested that differences in proliferative activity was associated with hepatic cell necrosis and AFH.
Changes in Ginsenoside Composition of White Ginseng by Fermentation
Sung Kwon Ko,Ok Sun Cho,Hye Min Bae,Byung Wook Yang,Byung-Ok Im,Young Tae Hahm,Kyung Nam Kim,Soon Hyun Cho,Jae Young Kim,Sung Hyun Chung,Boo Yong Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
The purpose of the study was to develop a new process to manufacture ginseng extract containing saponin aglycon of high concentration. The process to transform saponin glycosides to saponin aglycon was analyzed by high performance liquid chromatography (HPLC). GCK-1 (open cultured mixture for 1 day at 42℃) had the highest content of protopanaxadiol (0.662%). However, other mixtures (GCK-2, 3, 4, 5, and 6) had less than 0.152% in the content of protopanaxadiol. In case of fermentation by inoculation of Bacillus natto, BNG-5 (B. natto inoculated mixture for 5 days at 42℃) showed the highest content of protopanaxadiol (0.364%). Other mixtures (BNG-1, 2, 3, 4, and 6) also showed the high content of more than 0.2% in protopanaxadiol. B. natto inoculation or open culture fermentation with soybean transformed ginseng saponin glycosides into saponin aglycon.
Nam, Su Bong,Seo, Jung Yeol,Park, Tae Seo,Sung, Ji Yoon,Kim, Joo Hyoung,Lee, Jae Woo,Kim, Min Wook,Oh, Heung Chan Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.1
Background The dorsolateral branch of the posterior intercostal artery (DLBPI) can be easily found while harvesting a latissimus dorsi (LD) musculocutaneous flap for breast reconstruction. However, it remains unknown whether this branch can be used for a free flap and whether this branch alone can provide perfusion to the skin. We examined whether the DLBPI could be reliably found and whether it could provide sufficient perfusion. Methods We dissected 10 fresh cadavers and counted DLBPIs with a diameter larger than 2 mm. For each DLBPI, the following parameters were measured: distance from the lateral margin of the LD muscle, level of the intercostal space, distance from the spinal process, and distance from the inferior angle of the scapula. Results The DLBPI was easily found in all cadavers and was reliably located in the specified area. The average number of DLBPIs was 1.65. They were located between the seventh and eleventh intercostal spaces. The average length of the DLBPI between the intercostal space and the LD muscle was 4.82 cm. To assess the perfusion of the DLBPIs, a lead oxide mixture was injected through the branch and observed using X-rays, and it showed good perfusion. Conclusions The DLBPI can be used as a pedicle in free flaps for small defects. DLBPI flaps have some limitations, such as a short pedicle. However, an advantage of this branch is that it can be reliably located through simple dissection. For women, it has the advantage of concealing the donor scar underneath the bra band.
( Nam-jun Cho ),( Dae-yeon Kim ),( Soon Hyo Kwon ),( Tae Won Ha ),( Hyun Kyu Kim ),( Man Ryul Lee ),( Sung Wan Chun ),( Samel Park ),( Eun-young Lee ),( Hyo-wook Gil ) 대한신장학회 2021 Kidney Research and Clinical Practice Vol.40 No.3
Background: Dipeptidyl peptidase-4 (DPP-4) inhibitor has been reported to have kidney-protective benefits. To elucidate how antidia-betic agents prevent diabetic kidney disease progression, it is important to investigate their effect on the kidney environment in type 2 diabetes mellitus (DM) patients. Herein, we investigated the expression pattern of urinary exosome-derived microRNA (miRNA) in patients taking a combination of DPP-4 inhibitor and metformin (DPP-4 inhibitor group) and compared them with patients taking a combination of sulfonylurea and metformin (sulfonylurea group). Methods: This was a prospective study involving 57 patients with type 2 DM (DPP-4 inhibitor group, n = 34; sulfonylurea group, n = 23) and healthy volunteers (n = 7). We measured urinary exosomal miRNA using the NanoString nCounter miRNA array (NanoString Technologies) across the three groups (n = 4 per each group) and validated findings using real-time polymerase chain reaction. Results: Twenty-one differentially expressed candidate miRNAs were identified, and six (let-7c-5p, miR-23a-3p, miR-26a-3p, miR-30d, miR-205, and miR-200a) were selected for validation. Validation showed no significant difference in miRNA expression between the DPP-4 inhibitor and sulfonylurea groups. Only miR-23a-3p was significantly overexpressed in the diabetes group compared with the control group (DPP-4 inhibitor vs. control, p = 0.01; sulfonylurea vs. control, p = 0.007). This trend was consistent even after adjusting for age, sex, and body mass index. Conclusion: There was no significant difference in urine exosome miRNA expression between diabetic participants taking DPP-4 in-hibitor and those taking sulfonylurea. The miR-23a levels were higher in diabetic participants than in nondiabetic controls.
Evaluation of Usefulness according to Environmental Change of Auditory and Visual in Pediatric X-ray
Sung-Wook Baek(백성욱),Jong-Nam Song(송종남),Jeong Hun Kim(김정훈),Jae-Bok Han(한재복) 한국방사선학회 2017 한국방사선학회 논문지 Vol.11 No.7
성인과 달리 소아의 경우 인지능력과 의사전달이 정확하지 않아 X선 검사에 있어 심리적 불안감으로 인한 움직임은 재검사를 증가시키는 요인 중 하나이다. X선 검사라는 거부감을 최소화하고 의료 서비스의 만족도를 향상하기 위한 방법으로 검사실의 환경을 개선하여 심리적 안정에 도움을 주어 검사과정에서 발생하는 불필요한 재 검사를 비롯한 피폭선량 절감에 긍정적인 방안을 알아보고자 하였다. 실험대상으로는 2017년 5월부터 2017년 8월 까지 본원 일반촬영실에서 만 6개월 이상~만 36개월 미만의 총 186명의 소아를 대상으로 청각과 시각적 환경변화를 모두 적용시키지 않는 평소 검사실을 A 군, 시각적 환경변화는 제외시키고 청각적 환경변화만 적용한 검사실을 B 군, 청각적 환경변화는 제외시키고 시각적 환경변화만 적용한 검사실을 C 군, 청각과 시각적 환경변화를 모두 적용한 검사실을 D 군으로 설정하여 연구를 진행하였다. A 군에서는 재검사 건수가 10 건, B 군 7건, C 군 5건, D 군 2건의 결과를 도출할 수 있었다. 특히 A 군과 D 군에서 통계학적 유의수준 p<0.053으로 유의 하다는 결과를 얻을 수 있었다. 결론적으로 청각과 시각적 환경변화가 소아 심리적 안정에 많은 영향을 미쳤으며, 재검사 건수도 감소하여 의료서비스의 질적 향상 보였다. Unlike adults, cognitive ability and communication are not accurate in pediatric patients. Therefore movement due to psychological anxiety in X-ray photography is one of the factors that increase repeated irradiation. In order to minimize the rejection of X-ray and to improve the satisfaction of medical service, it is necessary to improve the environment of the radiological room to help psychological stability and to find a positive measure for reduction of radiation dose, including unnecessary. The subjects of this study were 186 pediatric patients from May to July, 2017, who were from 6 months to 36 months, The study group was set up a radiological room without auditory and visual environment changes is A group, except for changes in visual environment, the room where only auditory environmental changes were applied was group B, the auditory environment changes were excluded, and the room where only the visual environment change was applied was divided into group C, the auditory and visual environment changes were applied to the D. In group A, 10 retrospectives were obtained, 7 in group B, 5 in group C, and 2 in group D. Especially in group A and group D, statistically significant at p <0.053 In conclusion, hearing and visual environment changes affected the psychological stability of pediatric patient , and the repeated irradiation was reduced, thus improving the quality of medical services.
Erlotinib-Related Spontaneous Pneumothorax in Patient with Primary Lung Cancer
Nam, Hae-Seong,Lee, Hyeon-Jeong,Kim, Min-Su,Park, Sung-Wook,Jeon, Sang-Hoon,Cho, Jae-Hwa,Kwak, Seung-Min,Lee, Hong-Lyeol,Ryu, Jeong-Seon The Korean Academy of Tuberculosis and Respiratory 2010 Tuberculosis and Respiratory Diseases Vol.69 No.6
Spontaneous pneumothorax (SPTx) associated with primary lung cancer is quite rare, but has been reported as the initial presentation or a complication of disease progression. Moreover, chemotherapy-related SPTx in primary lung cancer occurs at a very low frequency, accounting for less than 0.05% of all cases. Here, we report the first case of erlotinib-related SPTx in a patient with advanced lung adenocarcinoma in Korea. After 3 cycles of cisplatin-based chemotherapy as first-line therapy, erlotinib was administered as second-line treatment. Asymptomatic SPTx accompanied by a significant decrease in tumor size was observed in the left lung 7 weeks later. The patient received continuous administration of erlotinib, without additional treatment. This case showed that SPTx can occur in patients with primary lung cancer receiving erlotinib, and asymptomatic chemotherapy-related SPTx in primary lung cancer may not require therapeutic intervention.