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(Sang Ah Chang),(Bong Yun Cha),(Soon Jib Yoo),(Yo Bae Ahn),(Ki Ho Song),(Je Ho Han),(Jong Min Lee),(Hyun Sik Son),(Kun Ho Yoon),(Moo Il Kang),(Kwang Woo Lee),(Ho Young Son),(Sung Ku Kang) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2
N/A Background : It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. Methods : About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. Results : In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. Conclusion : These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
Quality Characteristics of Beef by Different Cooking Methods for Frozen Home Meal Replacements
Kwang Il Kim,Sang Yoon Lee,In Guk Hwang,Seon Mi Yoo,Sang Gi Min,Mi Jung Choi 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.4
Blanching beef for use in home meal replacements (HMR) is an important process that determines the final quality of the beef after the cooking process. Thermal pretreatment also minimizes the change in quality during the main cooking process or storage. In this study, beef samples were washed and sliced, then treated by immersion in boiling water (1-10 min), steaming (1-10 min), or pan-frying in oil (30-240 s). The color after each thermal treatment showed higher L* and b* values and lower a* values compared with the raw beef, except for the pan-frying thermal treatment. The total color difference (ΔE) and pH value were significantly increased by panfrying (p<0.05). There was no significant difference in the shear force of the beef samples, except for the sample pan-fried for 210 s. The nutritional content of beef was measured as the moisture, protein, fat, and ash contents, which were 69.96, 16.64, 3.49, and 1.13%, respectively, in raw beef. After thermal treatment, the crude protein and fat contents were increased, whereas the moisture and ash contents decreased. The mineral content, including Na, Mg, Fe, and Ca was highest after pan-frying. The heat treatment decreased microorganisms in all the samples. The total bacteria count in raw beef was 4.5-4.7 Log CFU/g, whereas the bacteria count decreased to 2.2- 2.8 Log CFU/g after blanching. Thermophilic bacteria, coliform, mold, and yeast not detected in any thermally treated sample.
Ion Exchange Characteristics of Rhodium from a Simulated Radioactive Liquid Waste
Yoo, Jae Hyung,Lee, Sung Ho,Kim, Kwang Rag,Shon, Jong Sik,Chung, Hong Suk 한국공업화학회 1999 Journal of Industrial and Engineering Chemistry Vol.5 No.4
Radioactive liquid waste contains significant quantities of platinum group metals such as palladium (Pd), rhodium (Rh) and ruthenium (Ru). There are many techniques, such as solvent extraction, precipitation, ion exchange, and adsorption methods, for the separation and recovery of Rh. In this study, batch and column experiments were carried out to investigate the ion exchange and elution characteristics of Rh from a simulated radioactive liquid waste by commercial cation and anion exchange resins such as Dowex 50W, IRN 78 and Dowex 1 ×8. The effects of the ionic group of resins, the solution temperature, and the concentration of nitric acid were investigated. Also, the elution characteristics of Rh by various eluents were studied.
Yoo Wonbeak,Choi Hyunji,Son Young Hoon,Lee Jaemin,Jo Seongyea,Jung Dana,Kim Yeon Jeong,Koh Sang Seok,Yang Yong Ryoul,Kwon Eun-Soo,Lee Kwang-Pyo,노경희,Kim Kyung Won,Ko Yousun,Jun Eunsung,Kim Song Cheol,K 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Cancer cachexia is a highly debilitating condition characterized by weight loss and muscle wasting that contributes significantly to the morbidity and mortality of pancreatic cancer. The factors that induce cachexia in pancreatic cancer are largely unknown. We previously showed that pancreatic adenocarcinoma upregulated factor (PAUF) secreted by pancreatic cancer cells is responsible for tumor growth and metastasis. Here, we analyzed the relation between pancreatic cancer-derived PAUF and cancer cachexia in mice and its clinical significance. Body weight loss and muscle weight loss were significantly higher in mice with Panc-1/PAUF tumors than in those with Panc-1/Mock tumors. Direct administration of rPAUF to muscle recapitulated tumor-induced atrophy, and a PAUF-neutralizing antibody abrogated tumor-induced muscle wasting in Panc-1/PAUF tumor-bearing mice. C2C12 myotubes treated with rPAUF exhibited rapid inactivation of Akt-Foxo3a signaling, resulting in Atrogin1/MAFbx upregulation, myosin heavy chain loss, and muscle atrophy. The neutrophil-to-lymphocyte ratio and body weight loss were significantly higher in pancreatic cancer patients with high PAUF expression than in those with low PAUF expression. Analysis of different pancreatic cancer datasets showed that PAUF expression was significantly higher in the pancreatic cancer group than in the nontumor group. Analysis of The Cancer Genome Atlas data found associations between high PAUF expression or a high DNA copy number and poor overall survival. Our data identified tumor-secreted circulating PAUF as a key factor of cachexia, causing muscle wasting in mice. Neutralizing PAUF may be a useful therapeutic strategy for the treatment of pancreatic cancer-induced cachexia.
Kwang Hyun Yoon,Won Woong Kim,Ji Young Yoo,Eun Jeong Ban,Hai Young Son,Sang-Wook Kang,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Cheong Soo Park 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.4
Purpose: During the past decade, various endoscopic thyroid surgeries have been conducted, each with its own benefits. The incorporation of robotic systems to endoscopic thyroid surgery has improved the visualization and precision of endoscopic techniques. We previously reported our initial experience with robotic modified radical neck dissection (MRND) of papillary thyroid carcinoma (PTC) with lateral neck node metastasis (LNM). The aim of this study was to compare surgical outcomes of robotic vs. conventional open MRND of PTC with LNM using propensity score matching. Methods: From January 2008 to February 2011, 515 patients with PTC with LNM were enrolled. One hundred patients underwent robotic MRND, and 415 patients underwent conventional open MRND. These two groups were retrospectively compared with respect to their clinicopathological characteristics, surgical outcomes, and surgical completeness. Furthermore, to avoid selection bias, propensity score matching analysis was used to compare surgical outcomes of each group without any compounding factors. Results: The operative time for the robotic MRND was longer than for the open MRND (297.9±60.2 min vs. 212.1±55.6 min, P=0.089). However, the mean numbers of retrieved lymph nodes and mean hospital stay after surgery were similar in the two groups (36.0±12.9 vs. 40.8±13.3, P=0.235), (6.1±1.6 days vs. 6.1±2.1 days, P=0.577). The complication rates were similar between the two groups, and there was no statistical difference in postoperative thyroglobulin levels between groups (0.51±0.83 ng/ml vs. 0.89±2.46 ng/ml, P=0.593). Conclusion: According to our study, robotic MRND shows similar surgical outcomes to conventional open MRND after case-matched analyses. We suggest that robotic MRND is an acceptable alternative as an operative method for PTC with LNM, resulting in excellent cosmesis and patient satisfaction.
Isolation and Characterization of the Mutans Streptococci from the Dental Plaques in Koreans
Yoo, So-Young,Park, Seon-Joo,Jeong, Dong-Ki,Kim, Kwang-Won,Lim, Sung-Hoon,Lee, Sang-Ho,Choe, Son-Jin,Chang, Young-Hyo,Park, In-Soon,Kook, Joong-Ki The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.3
Mutans streptococci have been implicated as cariogenic bacteria in dental caries because they can produce high levels of dental caries-causing lactic acid and extracellular polysaccharide. The aim of this study was to isolate and characterize the mutans streptococci from the dental plaque obtained from Koreans. The dental plaque samples were collected from the anterior and molar teeth of both jaws in 155 subjects (aged 2 to 33.2 years, average age $13.7{\pm}4.7\;years$). The samples were diluted by 100-fold in $1{\times}\;PBS$ and plated on mitis-salivarius bacitracin (MSB) agar plates. The mutans streptococci grown on MSB plates were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) targeting dextranase gene (dex). The mutans streptococci were identified at the species level using a 16S rDNA sequencing comparison method. The biochemical tests were carried out to biotype the mutans streptococci. Ninety-five strains of the mutans streptococci out of 358 colonies, which were derived from 141 subjects, were isolated. Of them, 77 strains and 18 strains were Streptococcus mutans and Streptococcus sobrinus, respectively. The biotyping data showed that 62, 1, 20, 10, and 2 strains were biotypes I, II, IV, V and variant, respectively. Of the two strains of variant biotype, one strains was similar to biotype IV except that it was positive to the arginine hydrolysis test. We considered this one strain a new biotype, and classified it as biotype VII. In conclusion, S. mutans and its biotype I was most frequently isolated in Korean dental plaque. The mutans streptococci strains isolated in this study might be useful for the study of the pathogenesis and the prevention of dental caries.
( Yoo Jin Lee ),( Soo Rim Kim ),( Yeo Jung Moon ),( Sei Kwang Kim ),( Sang Wook Bai ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
To demonstrate the significance of bladder outlet obstruction (BOO) on preoperative urodynamic studies (UDS) in women who had diagnosed pelvic floor dysfunction including pelvic organ prolapsed (POP) and stress urinary incontinence (SUI). We reviewed the medical records of 80 patients with POP including SUI and 80 patients with only SUI who underwent preoperative urodynamic studies at Yonsei University Health system from January 2006 to March 2012. Comparisons were made between the patients with and without BOO on preoperative urodynamic studies. On these studies, the patients` baseline demographics including the age, body mass index (BMI), menopause, history of previous pelvic surgery, cystoscopic findings such as bladder trabeculation and the parameters of the urodynamic study such as Qmax (mL/sec), Pdet (cmH2O), postvoidal residual volume (PVR, mL), maximal cystometric capacity (MCC, mL), and prevalence of detrusor instability (DI), site and stage of POP, preoperative and postoperative urinary symptoms were reviewed retrospectively. Statistical analysis was performed using two sample T test, Fisher`s Exact Test, univariate and multivariate logistic regression. The analysis included 160 patients (POP including SUI group, n=80; SUI group, n=80). Among the 80 patients with POP including SUI, 30 patients had BOO and 50 patients did not. Similarly, in SUI group, 30 patients with BOO and 50 patients without BOO were included in this study. From the comparison of the two groups with and without BOO, there were no significant differences in age, BMI, history of previous pelvic surgery, menopause, prevalence of DI, postoperative urinary symptoms. In 30 patients with BOO of the POP including SUI group, the mean Qmax was lower than those 50 patients without BOO (12.3 mL/sec vs 25.5 mL/sec, p<0.001). Patients with BOO had higher mean Pdet (33.6 cmH2O vs 21.5 cmH2O, p=0.001), lower mean MCC (406.9 mL vs 454.0 mL, p=0.006), and higher mean PVR (41.4 mL vs 21.1 mL, p=0.016). In SUI group, the mean Qmax was significantly lower in 30 patients with BOO (13.5 mL/sec vs 25.4 mL/sec, p<0.001). The mean value of the Pdet was significantly higher with BOO (33.1 cmH2O vs 25.5 cmH2O, p=0.015). Patients who had difficult labor were associated with BOO (p=0.040) and preoperative urinary frequency was significantly associated with BOO (p=0.011). In the univariate analyses, among the 60 patients with BOO, menopause (p=0.046, Odds ratio (OR)=0.47) and cystoscopic bladder trabeculation (p=0.006, Odds ratio (OR)=4.79) were associated with BOO and the association with Qmax (p<0.001, OR=0.56) and Pdet (p<0.001, OR=1.05) approached highly significance. In the multivariate model, the association with Qmax (p<0.001, OR=0.52) and Pdet (p=0.004, OR=1.09) remained strongly significant. The presence of BOO on preoperative urodynamic studies is associated with Qmax, Pdet, MCC, PVR, and bladder trabeculation. However, there was no correlation with BOO and prevalence of DI or preoperative and postoperative urinary symptoms.