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Apo-1/Fas (CD95) Gene Polymorphism in Korean Hepatocellular Carcinoma Patients
Kim, Sung-Soo,Hong, Seung-Jae,Ahn, Yun-Gul,Kim, Bong-Seog,Yuh, Young-Jin,Han, Kye-Young,Lee, Hee-Jae,Chung, Joo-Ho,Yim, Sung-Vin,Cho, Jae-Young,Park, Yeon-Hee The Korean Society of Pharmacology 2003 The Korean Journal of Physiology & Pharmacology Vol.7 No.1
It is well known that different expression of Apo-1/Fas (CD95) plays important roles in various tumors and hepatocellular carcinoma (HCC) pathogenesis. Apo-1/Fas mediated apoptosis is one of the important pathways of apoptosis and is known to mediate apoptotic cell death by fas ligand (FasL). To examine the possible relationship between Apo-1/Fas gene polymorphism and HCC susceptibility, MvaI restriction fragment length polymorphism (RFLP) of Apo-1/Fas gene was examined in 94 Korean HCC patients and 240 control subjects. No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the HCC. It is, therefore, concluded that Apo-1/Fas gene polymorphism is not associated with HCC susceptibility. Further studies are needed in order to clarify the relationships between genotypes of Apo-1/Fas gene and HCC pathogenesis.
단보 : 인체 혈장중 라베프라졸의 정량을 위한 LC-MS/MS 분석법 검증 및 단일 용량 투여에 의한 약물동태 연구
탁성권 ( Sung Kwon Tak ),서지형 ( Ji Hyung Seo ),류주희 ( Ju Hee Ryu ),최상준 ( Sang Joon Choi ),이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),이진성 ( Jin Sung Lee ),홍승재 ( Seung Jae Hong ),임성빈 ( Sung Vin Yim ),이경태 ( 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.1
원보 : 파스틱 정(R)(나테글리니드 90mg)에 대한 글루나테 정(R)의 생물학적 동등성
탁성권 ( Sung Kwon Tak ),이진성 ( Jin Sung Lee ),최상준 ( Sang Joon Choi ),서지형 ( Ji Hyung Seo ),이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),류주희 ( Ju Hee Ryu ),홍승재 ( Seung Jae Hong ),임성빈 ( Sung Vin Yim ),이경태 ( 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.2
Choi, Han-Sung,Jung, Kyung-Hee,Lee, Seung-Chul,Yim, Sung-Vin,Chung, Joo-Ho,Kim, Youn-Wha,Jeon, Woo-Kyu,Hong, Hoon-Pyo,Ko, Young-Gwan,Kim, Chul-Ho,Jang, Ki-Hyo,Kang, Soon-Ah The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.1
This study evaluated whether or not bovine colostrum (BC) is able to treat or prevent intestinal barrier damage, bacterial translocation, and the related systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) in an intestinal ischemia/reperfusion (I/R)-injured rat model. Fifty Sprague-Dawley rats were used. The rats' intestinal I/R injuries were induced by clamping the superior mesenteric artery for 30 minutes. After 3 hours of reperfusion and then twice daily reclamping during the experiment, the experimental group was given BC (4 mL/kg/day) perorally, and the other groups received 0.9% saline and low fat milk (LFM) after intestinal I/R injury. Seventy-two hours later we assessed (1) intestinal damage and intestinal permeability, (2) enteric bacterial count and bacterial translocation, (3) serum albumin, protein, and hepatic enzyme levels, (4) pathologic findings of ileum and lung, (5) activity of oxygen-free radical species, and (6) pro-inflammatory cytokines (tumor necrosis factor-$\alpha$ and interleukin-$1{\beta}$). Intestinal damage, intestinal permeability, and bacterial translocation to other organs were significantly reduced in rats fed with BC after I/R when compared to rats fed LFM/saline after I/R (P <.05). In the evaluation of acute lung injury, neutrophils were found only in the lungs of the saline-fed group after I/R, and the wet/dry ratio of the lung tissue was significantly reduced in the BC-fed group after I/R compared to other I/R groups. A marked difference was found between LFM/saline-fed groups and BC-fed groups regarding malondialdehyde (P < .05) and pro-inflammatory cytokines (P < .01). In conclusion, BC may have beneficial effects in treating and preventing intestinal barrier damage, bacterial translocation and the related SIRS and MODS in the intestinal I/R-injured rat model.
Association between cytochrome P450 promoter polymorphisms and ischemic stroke
KIM, SU KANG,YIM, SUNG-VIN,LEE, BYUNG-CHEOL Spandidos Publications 2012 Experimental and therapeutic medicine Vol.3 No.2
<P>The human cytochrome P450 (CYP) superfamily includes at least 57 genes that encode enzymes with diverse metabolic and biosynthetic functions. This study was conducted in order to investigate the associations between polymorphisms in CYP superfamily genes (CYP11B2, CYP17A1, CYP2B6, CYP2C9, CYP2E1 and CYP7A1) and ischemic stroke (IS). Six single nucleotide polymorphisms (SNPs) of CYP superfamily genes were selected and genotyped by direct sequencing in 121 patients with IS and 321 control subjects. The genetic data were analyzed using SNPStats and SPSS 18.0. Multiple logistic regression models (codominant 1, codominant 2, dominant, recessive and log-additive) were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs) and p-values. The rs179998 SNP of CYP11B2 was significantly associated with IS (p=0.0336 in a log-additive model). The rs3813867 SNP of CYP2E1 was significantly associated with smoking in IS (p=0.0336 in a log-additive model). The rs1799998 SNP of CYP11B2 and rs3808607 of CYP7A1 were related to diabetes mellitus in IS (p<0.05). CYP11B2, CYP2E1 and CYP7A1 SNPs were associated with IS in the population studied. Further study is required to confirm these associations and to determine their biological significance.</P>
Yoo, Jung-Hwa,Yim, Sung-Vin,Lee, Byung-Cheol Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><B>Background</B></P><P> Bojungikki-tang (BJIKT) is a widely used traditional herbal formula in China, Japan, and Korea. There have been reports that several herbs among BJIKT have interactions with antiplatelet drugs, such as aspirin. This study aimed to assess whether BJIKT interacts with aspirin in terms of pharmacokinetics (PK) and pharmacodynamics (PD) in healthy subjects and ischemic stroke patients.</P><P><B> Methods</B></P><P> The phase I interaction trial was a randomized, open-label, crossover study of 10 healthy male subjects, and the phase III interaction trial was a randomized, placebo-controlled, parallel study of 43 ischemic stroke patients. Each participant randomly received aspirin + BJIKT or aspirin + placebo. For PK analysis, plasma acetyl salicylic acid (ASA) and salicylic acid (SA) were evaluated, and, for PD analysis, platelet aggregation and plasma thromboxane B<SUB>2</SUB> (TxB<SUB>2</SUB>) were measured.</P><P><B> Results</B></P><P> In the PK parameters, mean area under curve, maximum concertation, and peak concentration time of ASA and SA were not different between two groups in healthy subjects and ischemic stroke patients. In the PD profiles, TxB<SUB>2</SUB> concentrations and platelet aggregation were not affected by coadministration of BJIKT in healthy subjects and ischemic stroke patients.</P><P><B> Conclusions</B></P><P> These results suggest that coadministration of BJIKT with aspirin may not result in herb-drug interaction.</P>
Genotoxicity studies of substance-P by using short-term assay
Hong, Hyun Sook,Yim, Sung-Vin,Son, Youngsook THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRP 2016 MOLECULAR AND CELLULAR TOXICOLOGY Vol. No.
Substance-P (SP) can function of mobilizing mesenchymal stem cells (MSCs) from the bone marrow to the circulation and exert anti-inflammatory effects by increasing anti-inflammatory M2-type macrophage and regulatory T cells in the circulation. The preclinical efficacy of SP was demonstrated in a variety of conditions including ischemia damages, but its safety was not assessed. In this study, we assessed the genotoxicity of SP by using in vitro bacterial reverse mutation assay, chromosomal aberration assay, and in vivo micronucleus test. The maximum test dose of SP was <TEX>$250{\mu}g/mL$</TEX> in a cell-based assay and 16.6 mg/kg for an in vivo test. Ames test revealed SP did not increase in the number of revertant colonies. An in vitro chromosomal aberration assay with Chinese hamster lung cells showed that SP was not clastogenic even at the maximum dose applied. In vivo micronucleus test also demonstrated that SP did not induce micronuclei formation in the bone marrow cells of male ICR mice. Taken together, our results suggest that SP is not mutagenic to bacterial cells. Moreover, SP does not cause chromosomal damage in mammalian cells either in vitro or in vivo.