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김영혜 ( Young Hye Kim ),박준선 ( Jun Seon Park ),최상준 ( Sang Joon Choi ),송창훈 ( Chang Hoon Song ),한세준 ( Sei Jun Han ),정혁 ( Hyuk Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
Objective: Burch operation has been effective method for the treatment of stress incontinence. Burch operation is a well-accepted procedure for treating stress urinary incontinence secondary to urethral hypermobility without intrinsic sphincter deficiency and is the reference standard with which other procedures are compared. This study is to evaluate the effectiveness of the Choi`s hook in laparoscopic Burch operation. Methods: This study included 47 patients who had undergone laparoscopic Burch operation from October 2000 through March 2005. Of these 47 patients, 27 patients underwent traditional laparoscopic Burch operation (Group 1) and 20 patients underwent laparoscopic Burch operation with Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament (Group 2). Results: The mean age of patients of Group 1 was 55.6±9.37 years of age and that of Group 2 was 56.0±5.93 years of age. There is no difference in the mean age of patients (P>0.05). The mean operating time was 90.5±15.32 minutes for Group 1 and 38.5±10.14 minute for Group 2. The mean operating time was shorter in Group 2 than Group 1 (P<0.05). There was no difference in recurrence rate and complication rate between Group 1 and Group 2 (P>0.05). Conclusion: We performed laparoscopic Burch operation with the Choi`s Hook on anchoring the endopelvic fascia to the Cooper`s ligament. When we compared traditional laparoscopic Burch operation with laparoscopic Burch operation with Choi`s Hook, we could shorten the operation time using the Choi`s Hook.

골반 장기 탈출증 및 질궁탈출증 환자에서 시행한 질식 천골가시 인대 고정술에 대한 임상적 고찰
최상준 ( Sang Joon Choi ),김태중 ( Tae Jung Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
Objective : To assess the therapeutic results and complications of the transvaginal sacrospinous ligament suspension for the treatment of vault prolapse following hysterectomy and pelvic organ prolapse. Methods : A retrospective analysis was performed fro

정상 임신과 자궁내 발육제한 , 임신성 고혈압 환자의 태반에서 고사와 bcl - 2 발현에 관한 연구
최상준(Sang Joon Choi),문현주(Hyun Ju Moon),박성훈(Sung Hun Park),이경(kyung Lee),안태규(Tae Gyu Ahn),송창훈(Chang Hoon Song),한세준(Sae Jun Han),정혁(Hyuk Jung),임성철(Sung Chul Lim),박창수(Chang Soo Park) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
Objective : Placenta is organ which is growing from early pregnancy and which is senescent in late pregnancy. During senescent process, apoptosis has been correlated with gestational weeks and birth weight. Methods : Formalin fixed paraffin embedded tissues from 30 term pregnancy normal placental samples, 13 second trimester placental samples, 15 first trimester placental samples, 10 placental samples of intrauterine growth restriction and 8 placental samples of pregnancy induced hypertension. Light microscopy, electron microscopy, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate marker nick end-labeling staining were used to identify apoptosis. Immunohistochemical stain was performed by microprobe system(Fisher Co) Results : Apoptosis has been demonstrating within placental tissue. Quantification of apoptosis(medians) was as follows; first trimester (n=15)1.84±1.24, second trimester(n=13)1.13±0.97, term pregnancy(n=30)2.11±1.52, intrauterine growth restriction(n=10)3.30±1.07, PIH(n=8) 3.11±1.25. Incidence of apoptosis was significantly higher in placental samples from term pregnancy than second trimester (p<0.05, Kruskal Wallis u test) and also higher in placental samples of intrauterine growth restriction than term pregnancy (p<0.05, Mann-Whitney u test). bcl-2 expression was maximal during the second trimester (p<0.05,Kruskal Wallis u test) and no statistic significance between term pregnancy and intrauterine growth restriction and between term pregnancy and PIH. Conclusion : These data suggest that programmed cell death(Apoptosis) is a naturally occurring physiologic process in the human placenta and that the period of maximal placental growth, second trimester is associated with an increased expression of cell survival factors.

자궁경부암에서 E-cadherin/β-catenin 복합체의 발현
최상준 ( Choi Sang Joon ),한세준 ( Han Se Jun ),정혁 ( Jung Hyuk ),안태규 ( Ahn Tae Gyu ),송창훈 ( Song Chang Hun ),임성철 ( Lim Sung Chul ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.7
Objective : The objective of this study was to determine relationship between alteration of expression of E-cadherin, β-catenin and tumor progression, clinical stage, lymph node metastasis, age of patients with uterine cervical cancer. Methods : The authors evaluated the immunohistochemical expression pattern of E-cadherin and β-catenin in relationship with tumor stage and clinicopathologic parameters in 71 cervical neoplasia including 36 cases of squamous cell carcinoma (SCC), 10 cases of microinvasive SCC, 22 cases of squamous cell carcinoma in situ, and 3 cases of severe dysplasia. Results : There were aberrant expression in 76.1% of E-cadherin (54 of 71) and 74.6% of β-catenin (53 of 71) in the cervical cancer. There was positive correlation of aberrant expression of E-cadherin with tumor progression and clinical stage (<0.005). There was positive correlation of aberrant expression of β-catenin with tumor progression and clinical stage (<0.005). Conclusion : These results suggest that degree or the pattern of E-cadherin, β-catenin, and E-cadherin/β-catenin complex may be related to histologic grade and clinical stage of uterine cervical cancer.

