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Sung, Pil Soo,Choi, Hee Baeg,Kim, Su-Yeon,Hong, Sung Woo,Park, Chung-Hwa,Song, Myeong Jun,Lee, Sung Won,Yoo, Chan Ran,Choi, Sang Wook,Han, Nam Ik,Kim, Tai-Gyu,Yoon, Seung Kew The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Natural killer (NK) cells play an important role in innate immunity, especially in the response to viral infections, such as hepatitis C virus (HCV). Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that mediate innate immunity. KIRs are also involved in acquired immunity, because some KIRs are expressed on the surface of certain subsets of T cells. In this study, the frequency of KIR genes, <I>HLA-C</I> allotypes, and combinations of KIR genes with their <I>HLA-C</I> ligands were evaluated in two different groups of the Korean population: controls and patients with chronic HCV infection. The study population consisted of 147 Korean patients with chronic HCV infection. The frequency of KIR2DS2 in patients with chronic HCV infection was 9.5% which was significantly lower than 19.5% of the control (<I>P</I> < 0.01). However, there were no significant differences in the frequency of other KIR genes, <I>HLA-C</I> allotypes or different combinations of KIR genes with their <I>HLA-C</I> ligands. This study can contribute to the further prospective study with a larger scale, suggesting the assumption that <I>KIR2DS2</I> might aid in HCV clearance by enhancing both the innate and acquired immune responses of people in Korea.</P>
RPL36 as a prognostic marker in hepatocellular carcinoma
Song, Myeong Jun,Jung, Chan Kwon,Park, Chung‐,Hwa,Hur, Wonhee,Choi, Jung Eun,Bae, Si Hyun,Choi, Jong Young,Choi, Sang Wook,Han, Nam Ik,Yoon, Seung Kew Blackwell Publishing Asia 2011 Pathology international Vol.61 No.11
<P>Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non‐tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non‐tumors. RPL36 expression correlated significantly with serum levels of albumin (<I>P</I>= 0.044) and prothrombin time (<I>P</I>= 0.026), which reflect liver synthetic function. Moreover, expression of RPL36 was found to be higher in patients with early tumor stages (I/II) (<I>P</I>= 0.038) or without portal vein thrombosis (<I>P</I>= 0.005). In univariate analysis, patients with RPL36 expression revealed better overall survival (<I>P</I>= 0.037). By multivariate survival analysis, RPL36 expression was found to be an independent prognostic factor for overall survival (<I>P</I>= 0.026). Our data suggest that RPL36 may be involved in the early stage of hepatocarcinogenesis, and it can be used as an independent and potential prognostic marker for resected HCC.</P>