필리핀 여행 후 발생한 쯔쯔가무시병 1예

김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.

Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예

김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.

2003년도 해양스포츠 체험활동을 통한 소아건강교실 사례 발표

김현주,이상엽,이가영,곽현,이남수,김혜선,김윤진,김인주,김용기,대학비만학회 부산분과학회 일동 대한비만학회 2003 The Korean journal of obesity Vol.12 No.4

유도 허벅다리걸기 기술발휘 시 받기의 자세와 저항수준에 따른 운동학적 특성 분석 사례연구[Ⅰ]

김의환,윤현,김성섭 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

E. H. KIM, H. YOON, S. S. KIM. A Case Study on Kinematical Traits Analysis when Performing of Uchimata(inner thigh reaping throw) by Posture and Voluntary Resistance Levels(VRL) of Like in Judo[ I ]. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 235-257, 2004. The purpose of this study was to analyze the kinematical traits variables when performing Uchimata(inner thigh reaping throw) by Voluntary Resistance Levels(VRL) and two postures of Like in Judo. The subjects, who were one male judoka(YH) for 1992 Barcelona Olympic Games, and one male trainee Y. I. University representative member(SDK) and were filmed on two S-VHS 16 mm video cameras(60fields/sec.),that posture of Like were Shizenhontai(straight defensive posture) and Jigohontai(straight natural posture), VRL of like were 0% and 100%. The kinematical variables were temporal(total time-required:TR), potures and COG variables etc., The data of this study collection were digitized by SIMI Motion Program computed the mean values and the standard deviation calculated for each variables. When performing according to each posture and VRL, from the data analysis and discussion, the conclusions were as follows : 1. Temporal variables : total time-required(TR) when performing Uchimata was shown the shortest time YH than SDK by each posture and VRL. TR of each posture were shown the shorten trends or equal in DP by lower than NP, In existence and / or nonexistence of VRL was shown the shorten trends in VRL 0% than 100% of Like. 2. Posture variables : In attacking right knee angle, YH was performing flexion(147→103degree) from Tsukuri(set-up) to Kake(execution) in regardless of postures and VRLs, SDK was performing not exchange extension and flexion in VRL 100%, and extension(120i142degree) in VRL 0%, respectively. In supporting left knee angle, YH was perfoinring extension(1194163degree) from Tsukuri(set-up) to Kake(execution) in regardless of postures and VRLs, SDK extension(934 139degree), respectively. In attacking right hip angle, from Tsukuri to Kake, YH was performing extension(1334 169degree), except in VRL 0%(156 i137degree) NP, SDK was performing flexion(159i126degree) accept in VRL 100%(149 i152degree) NP, In left hip angle, from Tsukuri to Kake, YH was performing flexion NP(70, 50degree) more than DP(27, 57degree), SDK was performing flexion DP(73, 52degree) more than NP(34, 20degree). 3. COG variables : When performing Uchimata, vertical COG variables was shown YH(:2-8cm), SDK(:15-24cm) lower than Uke's COG level position, in existence and / or nonexistence of postures and VRL, during Kake as maximum force point of throwing techniques in Judo.

장기적 흡인 배액법을 이용한 척추 후방 기기 고정술 후 감염의 치료

김용민,김동수,최의성,손현철,박경진,김융성 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

연구 목적 : 척추경 나사못을 이용한 척추 후방 기기 고정술 후 심부 감염이 발생한 증례 들을 대상으로 관련 인자를 분석하고 Hemo-vac을 이용한 장기간의 폐쇄성 흡인 배액법을 통한 치료와 그 결과에 대해 알아보고자 하였다. 대상 및 방법 : 1996년 5월부터 2001년 8월까지 척추후방기기고정술 후 심부 감염이 발생 한 5례를 연구 대상으로 하여 전신 질환 동반, 감염의 발현 양상을 조사하였고, 창상 세척 등 감염 수술 후 장기적 배액법을 이용한 치료 과정 및 최종 결과를 후향적으로 분석하였다. 결 과 : 당뇨와 비만이 술후 심부 감염의 위험요인으로 분석되었다. 수술 환부로부터의 배농, 발열 등 감염 증상은 술후 평균 18.8(8-36)일에 발현되기 시작하였다. 일인당 단 1회의 세척술이 실시되었고 고정기기는 제거하지 않았다. 이후 평균 19.2일간의 지속적 흡인 배농 및 평균 43.6일간의 항생제 정맥투여에 이은 평균 33.8일간의 경구투여로 심부감염은 특별한 합병증 없이 모두 치료되었으며 양호한 임상적 결과와 후외방 골융합을 얻을 수 있었다. 결 론: 척추 후방 기기 고정술 후 발생한 심부 감염에 대해 창상의 세척 및 육아조직 제 거 후 항생제 투여와 Hemo-vac을 이용한 장기간의 장기적 흡인 배액법은 감염의 조절과 척추의 안정성을 동시에 얻을 수 있는 유용한 방법중 하나인 것으로 생각되었다 Purpose: Various treatment modalities have been applied to control deep infection after spinal instrumentation. Validity of removing implants to control the infection is still contro- versial because it may cause loss of spinal stability. Analysis of the inherent risk factors associated with deep infection and the efficacy of management with long-term suction drainage without removal of implants. Materials and Methods : Fiye cases of postoperative deep infection after posterior spinal fixation from May 1996 to August 2001 were investigated on combined general ill- ness, features of infection, various profiles on the management of infection with surgical irrigation and debridement followed by long-term suction drainage, and final outcomes. Results :Remarkable risk factors were diabetes and obesity. Evidences of infection such as discharge from the wound, dehiscence, or fever were observed on the average of 18.8th day postoperatively By only one additional surgical procedure for each patient followed by long-term suction drainage for mean 19.2 days and administration of intravenous antibiotics for average of 43.6 days, deep infections were controlled successfully without removal of implants and without any grave complications. All achieved favorable clinical results and posterolateral fusion. Conclusion : Irrigation and debridement accompanied by long-term suction drainage using Hemo-vac and administration of susceptible antibiotics seemed to be one of the effective methods to control deep infection after posterior spinal instrumentation and main than the postoperative stability of spine.

비혈연간 동종골수이식에 의해 치료된 중증 재생불량성빈혈 1예

김현중,이홍기,이방훈,이창근,이종태,정현식,김원석,윤성수,강원기,박근칠,김대식,고영혜,박찬형 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

비혈연간 동종골수이식은 혈연간 동종골수이식이 불가능한 환자에서 기존의 면역역제요법으로 효과가 없었던 경우나 재발한 경우에 적응증이 될수 있다. 이식 거부와 이식편대숙주병의 발생이 골수 이식의 성공률을 감소시키므로, 보다 강력한 conditioning regimen의 사용과 T cell이 제거된 골수를 사용하는 것이 필요하다. 기존의 high dose corticosteroid나 cyclosporine에 대하여 불응성인 이식편대숙주병의 치료를 위해서 ATG와 Mycophenolate mofetil (Cellcept®) 의 사용이나 Tacrolimus, Methotrexate와 같은 다른 면역억제제치료를 고려해 볼 수 있다. It is known that allogenic bone marrow transplantation is the most effective treatment for aplastic anemia. However, this treatment is only applicable to a minority of patients because the proportion of patients who have HLA-matched siblings about 25% to 30% of all the aplastic anemia patients. In the case of the absence of HLA-matched donor, unrelated allogenic bone marrow transplantation is considered. However, (because of severe acute and chronic GVHD and graft failure) the success rate of this approach is only 20~30%. Recently, it was reported that increased immunosuppressive condition combined with T cell depletion of the marrow graft would result in greater success. There was no case of successfully treated aplastic anemia patient by unrelated allogenic bone marrow transplantation in Korea. Here, we report a case of severe aplastic anemia successfully treated with unrelated allogenic bone marrow transplantation.

Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes

Sung‑Soo Kim,Sang In Lee,Hyun‑Seok Jin,Sangjung Park 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Vitamin D (Vit. D) is used extensively during tuberculosis treatment. Low levels of serum Vit. D increase the risk of active tuberculosis development. Altered expression of the proteins involved in Vit. D metabolism impairs cathelicidin production, thereby increasing the host susceptibility to tuberculosis. Objective We are trying to investigate whether single nucleotide polymorphisms (SNPs) in LRP2, CUBN, and VDR genes could afect tuberculosis development. Methods We included participants of the Korean Association Resource (KARE), part of the Korean Genome and Epidemiology Study (KoGES), and used their recorded data. A total of 8840 people (4182 men and 4658 women) were eligible subjects. The 5-kb regions from the ends of transcripts of GC, LRP2, CUBN, and VDR genes were amplifed to select 13, 47, 70, and 15 SNPs, respectively. For association analysis and statistical analysis, PLINK version 1.07 and PASW Statistics version 18.0 were used. Results Signifcant correlation was observed in 11, 2, and 1 SNPs in LRP2, CUBN, and VDR genes. The efect of rs6747692 of LRP2 on transcription factor binding was confrmed using RegulomeDB. We confrmed that rs2239182 of VDR is located in the genomic eQTL region and can afect transcription factor binding and gene expression. Conclusions Genetic polymorphisms in genes encoding proteins involved in Vit. D metabolism infuence immune system components. Therefore, such polymorphisms may infuence the susceptibility to Mycobacterium tuberculosis invasion and alter the defense mechanisms against Mycobacterium tuberculosis infection. The correlation between genetic variation and tuberculosis development can provide new guidelines for the management of tuberculosis.

골반 경사로 인한 요추부 측만증에서 신발 높이기의 효과

김용민,김동수,최의성,손현철,박경진,김융성 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2

Ta 상·하부 전극을 가진 Ta₂O_(5) 박막 커패시터의 전기적 특성

김현주,송재성,김인성,박문흠,김상수 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-

The electrical characteristics of Tazodtantdum pentoxide) films sputtered on Ta/Ti/SiO₂/p-Si substrate were investigated. Ta(tantalum1 was used for the bottom and top electrode for the purpose of simplifying the manufacturing process in IPD's(integrated passive devices). Dielectric materials deposited on Ta/Ti/SiO₂/p-Si were annealed at 700 ℃ for 60 sec in vacuum. The XRD results showed that as-deposited Ta had a highly preferred orientation, but Ta₂O_(5) film possessed amorphous structure, which was transformed to crystalline by rapid thermal annealing. We compared the C-F, C-V, and 1nJ-E of both as-deposited and annealed dielectric thin films deposited on Ta bottom electrode. From this results, we concluded that the leakage current could be reduced by heat treatment and dielectric constant was high than Ta₂O_(5) deposited on Pt, Au, etc.. Therefore, Ta as electrode material is thought that is suitable as material to replace the precious metal electrodes and to simplity the fabrication process of the Ta₂O_(5) MIM capacitor.