담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

The prediction of the tooth size in the mixed dentition for Korean

Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 대한소아치과학회지 Vol.33 No.2

이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

Influenza流行特性의 數學的 모델 解析

崔震永,鄭亨煥,李承煥 東亞大學校 1975 東亞論叢 Vol.12 No.2

As a systematic study for prevailent states of influenza mathematic models for influenza were derived. They were analysed by means of digital computer under the conditions of changing the average number of contacts per carrier, β, from 1 to 9, for the eight types of communities [first type : the initial distribution of population of population, s(0)=8,900 susceptibles, c(0)100 carriers, i(0)=1,000 immunes; second type: s(0)=7,900, c(0)=100, i(0)=2,000; third type : s(0)=6,900, c(0)=100, i(0)=3,000; fourth type: s(0)=5,900, c(0)=100, i(0)=4,000; fifth type : s(0)=4,900, c(0)=100, i(0)=5,000; sixth type : s(0)=3,900, c(0)=100, i(0)=6,000; seventh type: s(0)=2,900, c(0)=100, i(0)=7,000; eight type : s(0)=1,900, c(0)=100, i(0)=8,000;] in Seoul In conclusion, the outcomes of this study are summarized as follows. (1) The number of carriers of influenza becomes maximum within approximately 2 weeks after the attack of diseases and about 70 percent of all cases in the contagious period is infected with influenza within 1 to 3 weeks in Seoul. (2) The more influenza does prevail, the smaller the value of Cmax becomes while the contagious period becomes sligity longer. (3) It can be estimated that the number of the initial immunes, I(0), is about 40 to 50 percent of the total population and β is approximately 6 in Seoul. (4) If the number of the immune, I(0), is 10 percent, the infectious rate of influenza will be 88 percent, while the Cmax occurs from 1 to 1.5 week. (5) The contagious period is more than 6 or 7 weeks in the rural area and the Cmax in this area is later than in Seoul and less in number. (6) The curve of influenza epidemic in Seoul area is similar to fourth type in Fig.3. (7) If the number of the immune, I(10), is 70 percent in β=5 and 80 percent in β=6, the curve of influenza epidemic is unusual. The authers believe that the method to analyse the influenza model in this paper will be helpful to study of other epidemics. It will also contribute to public health management and the preventive policy decision against epidemics.

再開發地區指定의 設定基準에 관한 硏究

崔昌煥,吳錫氣,安相哲 동아대학교 공과대학 부설 한국자원개발연구소 1982 硏究報告 Vol.6 No.1

This study is for the establishment standard on the blighted degree in urban renewal area. The factors of establishment standard is population density, ratio of a building site, size of a building site, diffusion ratio of road, ground coverage, volume ratio of building, dwelling space of a person, total floor space per building, and others. As a result of this study, the standard of renewal area appointment is as follows. 1) Population density … over 300 person per hectare. 2) Ratio of a building site … over 70 percent. 3) Size of a building site … under 120㎡ 4) Diffusion ratio of the road … under 25 percent. 5) Ground coverage of a building … over 55 percent. 6) Volume ratio of a building … over 120 percent. 7) Dwelling space of a person … under 20㎡ 8) Total floor space per a building … under 80㎡ 9) Age of building … over 40 years.

韓國의 都市規模別 計劃人口 密度에 관한 硏究

崔昌煥,吳錫氣,安相哲 동아대학교 공과대학 부설 한국자원개발연구소 1977 硏究報告 Vol.2 No.1

Population is concentrated urban region in Korea. It is leading to over-massed dwelling of urban region and was made worse by the residential environment. This study is comparison of population density by the city size of the Master Plan in Korea. Analytical method decide ranking at thirty-five cities of Korea by the census in 1975 and it divided into city size which is Metropolis (over a million), Large City (300-1,000 thousand), Middle Town (100-300 thousand) and Small Town (under 100 thousand persons). In this study, population density for possible developing area was computed by the presumption of population in 1986. The results of this study are summerized as follows: 1). Population plan was underestimated in Metropolis (Seoul, Busan and Daegu) by policy agreement. 2). The possible developing area's population density will proper in under-a million's city. 3). The Metropolis cause an advance in the population density of possible developing area in 1936 and will bring about a change for the worse of residential environment. (362persons/ha.) 4). A plan of solution to a population density's rising is necessary re-enforcement of re-completed master plan and the plan of arrangements for residential area must be considered in the plan of re-completed master plan.

말초동맥질환에 있어서 혈장 호모시스테인 농도의 의미

최동현,이상목,고석환,홍성화,오수명,윤충,박호철 대한혈관외과학회 2004 Vascular Specialist International Vol.20 No.1

작업관련 상지의 근골격계 질환 선별 및 감시를 위한 미국 NIOSH-style 설문지와 Nordic-style 설문지의 타당도 비교

최원준,성낙정,강영중,한상환 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 작업관련 근골격계 질환의 선별검사에 사용되는 두 종류의 증상설문지(NIOSH 스타일 설문지,노르딕 스타일 설문지)의 결과를 신체검사 결과와 비교하여 타당도를 평가하고,활용방안에 대하여 검토하고자 수행되었다. 방법: 인천에 위치한 3개의 제조업 사업장 근로자 208명을 대상으로 NIOSH 스타일 설문지와 노르딕 스타일 설문지를 작성하도록 하고,신체검사를 시행하였다. 신체 검사 소견과 과거병력을 바탕으로 한 환례정의를 최적기준으로 하여 두 설문지의 민감도,특이도,양성예측도,음성예측도,일치도를 구하여 타당도를 조사하였다. 결과: NIOSH 스타일 설문지는 민감도 59.5%, 특이도 68.0%, 양성예측도 68.0%, 음성예측도는 59.5%로 조사되었다. 카파계수(Kappa coefficient)로 나타낸 일치도는 0.27(95% confidence interval 〔CI〕=0.14∼0.40)이었다. 노르딕 스타일 설문지는 민감도 73.9%, 특이도 68.0%,양성예측도 72.6%,음성예측도 69.5%로 조사되었다. 카파계수로 나타낸 일치도는 0.42(95% CI=O.30∼0.54)이었다. NIOSH 스타일 설문지와 노르딕 스타일 설문지의 일치도는 카파계수 0.43(95% CI= 0.31∼O.55)로 나타났다. 증상강도의 합계점수가 2점 이상인 경우를 기준으로 했을 때,노르딕 스타일 설문지의 민감도는 72.1%,특이도는 70.1%이었다. 결론: 두 설문지 모두 적절한 타당도를 가지고 있는 것으로 평가되었다. NIOSH 스타일 설문지는 증상의 빈도,지속기간,강도를 조사할 수 있고 이에 따라 다양한 양성기준을 설정할 수 있다. 노르딕 스타일 설문지는 민감도가 높은 편이고,증상의 강도를 설문항목에 포함시킬 경우 양성기준을 다양화하기 쉽다는 점과 문항이 간단하고 작성하기 쉽다는 점을 장점으로 들 수 있다. 조사 목적과 작업장의 특성에 따라 두 설문지를 적절하게 활용할 수 있을 것으로 기대된다. Objectives: The study aimed to compare the validity of two questionnaires (NIOSH- and Nordic-style) which are used for the screening and surveillance of neck and upper extremity work-related musculoskeletal disorders. To evaluate the validity, clinical examination was used as the reference. Methods: Two types of questionnaire were filled out by 208 workers from three different plants in Incheon, Korea. Workers underwent clinical examination by three occupational physicians. The presence of a symptom or sign in at least one body region was regarded as positive in both results of questionnaire and case definition using clinical examination. Validity was evaluated by sensitivity, specificity, positive predictive value, negative predictive value and agreement (Kappa coefficient). For the Nordic-style questionnaire, the sum of the symptom scores was used to yield the ROC curve. Results: The results of the NIOSH-style questionnaire were sensitivity 59.5%, specificity 68.0%, positive predictive value 68.0%, negative predictive value 59.5%, and Kappa coefficient 0.27(95% confidence interval [CI]=0.14∼0.40). The results of the Nordic-style questionnaire were sensitivity 73.9%, specificity 68.0%, positive predictive value 72.6%, negative predictive value 69.5%, and Kappa coefficient 0.42 (95% CI=0.30∼0.54). For the Nordic-style questionnaire, sensitivity was 72.1 % and specificity was 70.1 % based on the sum of the symptom scores≥2. Conclusions: Both questionnaires demonstrated appropriate validity for the screening and surveillance of work-related musculoskeletal disorders. The selection of questionnaire may depend on the purpose of investigation and characteristics of the work place.

3個의 耕耘날을 利用한 平衡振動式 耕耘裝置(Ⅴ) : 運動解析과 要因分析

金成泰,金容煥,崔圭洪,金成泰 慶尙大學校 1988 論文集 Vol.27 No.1

This is the fifth part of series of reports on the study on a blanced-type oscillating tillage implement using triple blades system. Previous reports were made on the characteristics of power requirement and vibration with which tillage implements were oscillated parappep and perpendicular to the travelling direction. In this paper, the locus and motion analysis of the tillage blade and factor analysis were carried out. Obtained results are as follows : 1. The loci od the blade edge were described as helix curve at vertical oscillation and as lacerated curve at horizontal oscillation to the soil bin movement. 2. The motion equations of blade edge are estimated as follows. Vertical forced vibration ?? ?? Horizontal forced vibration ?? ?? 3. The multiple regression equations for resultant oscillating acceleration draft, specific resistance, and torque were established by using frequency, amplitude, life angle of tillage blade, and velocity of carriage as indepentent vibrations, respectively. 4. By reducing the velocity ratio is increased providing higher effect of the reduced draft. But this effect contradicted to achieve the reduced osillating acceleration. Both effects should be considered simultaneously to find out the optimum operating condition. 5. The reduction effect of the oscillating acceleration was slightly favoured to the horizontal forced vibration type, but traction efficiency could be lowered due to the increased slippage. Therefore, it can be concluded that the vertical forced vibration type is more appropriate considering overall performances. 6. From the experimental results, the optimum operating conditions of the vertical forced vibration type are recommended as follow ; life angle 30 degree, operation velocity 0.15 metre per second, amplitude 4-6 millimetre, and frequency 22.5 hertz.

Chlorambucil이 수컷 생쥐의 Sertoli 세포의 미세구조에 미치는 영향

최인장,장성익,김덕훈,이인환 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

This study was investigated the effect of chlorambucil (Leukeran) on the Sertoli cell of male mouse by electron microscope. Chlorambucil suspended in the 0.5N sodium bicarbonate (pH 8.0) was injected into the male mouse by intraperitoneal at doses level (16mg/kg) for one week, 3 weeks, respectively. The results were as follows; 1. One week after adminstration of chlorambucil, swelling and their inner cristae distruption of some mitochondria, mild vacuolation of cytoplasm, moderate dilation of smooth endoplasmic reticulum (SER) were presented. But, lipid droplet and secondary lysosome were severely increased. 2. After 3 weeks, the dilation of SER and vacuolation of some cytoplasm, the swelling and inner cristae destruption of most mitochondria were appeared. The lipid droplet and lysosome were midly increased. 3. After 5 weeks, most mitochondria were swelling and their membrane were almost disrupted. The dilation of SER and vacuolation of most cytoplasm were almost severely increased. But lipid droplet and lysosome were not observed. As a results, the duration of the chlorambucil administration is longer, the degeneration of the cytoplasm organelles is increased in comparison with control group. On the other hand, nucleus is not degenerated.