Application of Antioxidant Transgenic Mice

Sun?Uk Kim,Hee-Young Yang,Sun-Hee Ahn,Suhee Kim,Dae?Yeul Yu,Dong?Seok Lee,Tae-Hoon Lee 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8

영·유아 언어, 인지, 사회·정서 발달 평가도구 문항 개발을 위한 예비연구

이종숙,신은수,박은혜,김영태,유영의,최일선,유흥옥 이화여자대학교 교육과학연구소 2009 교육과학연구 Vol.40 No.3

본 연구는 만 2~5세 영·유아의 발달 상태를 객관적으로 평가함과 동시에 발달이 지연된 영·유아를 선별할 수 있는 발달평가도구 문항을 개발하기 위한 예비연구이다. 이를 위해 문헌고찰 및 발달관련 평가도구들을 비교 분석하여 발달지표를 선정하고, 만 2세~5세까지의 영·유아의 언어, 인지, 사회·정서발달영역을 교사관찰에 기초하여 평가할 수 있는 문항을 개발하였다. 연구대상은 대도시, 중소도시, 읍면 소재지 별로 표집 된 만 2세부터 5세까지 총 13개 유아교육기관에 다니는 435명의 영·유아들이며, 본 연구에서 최종 개발된 평가도구의 문항은 총 141문항이다. 평가도구 문항은 언어, 인지, 사회·정서발달영역별로 영·유아의 행동과 언어를 중심으로 교사가 관찰하고, 관찰하기 어려운 문항에 대해서는 단서와 kit를 제시하여 평가할 수 있도록 구성하였다. 개발된 평가도구 문항의 적절성을 알아보기 위하여 내용 타당도와 내적 신뢰도를 살펴본 결과 비교적 양호한 것으로 나타났다. This was a preliminary study to construct a developmental rating scale for understanding children's objective developmental levels and screening developmental disabilities. For this purpose, a developmental indicator was selected by a literature review and comparative analysis of related developmental assessment tests. An assessment scale based on teacher's observations to measure language, recognition, and social-emotional developmental areas was developed. The subjects were 435 young children aged 2 to 5 who lived in both urban and rural areas. A trial test consisted of 141 assessment items in the language, recognition, and social-emotional developmental domains. The developmental scale was evaluated by teachers who observed children's behavior and language, and used clues and kits. Tests on validity and reliability for confirming the appropriateness of the developed assessment scale showed that content was relatively valid and internally consistent.

간암 환자에 합병된 Citrobacter braakii 패혈증 1례 보고

이해미,배성하,이수남,이정우,신아영,류시영,이수연,윤문희,한선영,한남익,이영석,유진홍 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Citrobacter species is a gram-negative bacilli that can cause opportunistic infections in immunocompromised hosts. Citrobacter braakii refers to the genomospecies 6 of the Citrobacter freundii complex. There are no detailed studies on infections caused by this newly identified specific genetic species in Korea. We herein report a case of a patient with hepatocellular carcinoma who, after undergoing transcatheter arterial chemoembolization, developed biloma which later progressed to C.braakii sepsis and did not respond to treatment. To our knowledge, this is the first reported case in Korea on C. braakii infection resulting in septic shock in a patient with malignancy in Korea.

법천리출토 생선뼈에 대한 잔존지방산 분석(2)

유혜선,정영주 국립중앙박물관 2000 박물관보존과학 Vol.2 No.-

This study is an analysis of residual fatty acid of the unidentified 26 fish bone samples which were excavated from Bupchon-ri in Wonju, Kangwon province. The purpose of this study is to identify fish kind by comparing the residual fatty acid analysis with the reference data of croaker, shark, herring and weakfish. Fatty acid was separated by gas chromatography and distribution pattern was analyzed by calculating composition of each sample. Principal component analysis(PCA), one of multivariate analysis method was used to understand fatty acid distribution data. 江原道 原州市 富論面 法泉里古境(4號境)에서 출토된 생선뼈 중 종류를 확인 할 수 없었던 생선뼈 26점에 대한 잔존지방산 분석을 실시하였다. 앞서 분류한 4종류의 생선(조기, 상어, 준치, 민어)뼈에 대한 잔존 지방산 분석 기준 데이터와 비교하여 어류종류를 확인하고자 하였다. 분석은 가스크로마토그라피(Gas chromatography)를 이용하여 지방산을 분리하였고, 각각의 含量을 계산하여 시료별 지방산 분포패턴을 확인하였다. 지방산분포 데이터의 해석을 위해서 多變數分類法 중 주성분분석법을 이용하였다.

Cis-AB 혈액형 4례

이영진,최유선 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

The ABO groups are important for blood transfusion and inheritance. The child is receive ABO gene by each parents' ABO gene in chromosome 9. But rare blood groups show unusual inheritance of ABO group on the same chromosome by cross over or mutation. The cis AB group is unusual genetic transmission which have AB and O group child from AB and O group parents. So cis AB group give rise to paternity problem, and discrepancy between cell and serum group. I experienced 4 cases of cis AB and report cases with some literature.

관절강내 Ketorolac-Bupivacaine과 Morphine-Bupivacaine의 슬관절경 수술후 진통효과

최유선,채영남 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Background: Systemic Ketorolac has been used effectively to manage postarthroscopic knee pain. However, reports on intraarticular injection of ketorolac for pain relief were few. We examined the effect of analgesia in intraarticular administration of ketorolac compared to morphine after knee surgery. Methods: In randomized grouping, we studied 40 patients undergoing endoscopic knee surgery. The patients in group KB(n=23) received 30㎎ of ketorolac mixed with 20㎖ of 0.25% bupivacaine; those in group MB(n=17) received 5㎎ of morphine mixed with 20㎖ of 0.25% bupivacaine. We compared visual analogue score for pain, the number of patients for supplemental analgesics and the side effects of drug between two groups. Results: There was no significant difference between two groups in the pain score and the eeds for supplemental analgesics. Conclusion: Intraarticular ketorolac had no advantage compared to intraarticular morphine. So, we would caution against the wide spread use of intraarticular NSAIDs until their safety and efficacy can be established.

저용량 Droperodol 의 지속적 정맥내 주사가 방사선 치료로 유발된 구토에 대한 효과 : As a Substitution for Granisetron for the Treatment of Gastrointestinal Symptoms from Palliative Radiation Therapy

문성록,박수경,정영표,김태요,최유선 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Background: Radiation therapy in palliative cancer management leads mainly to nausea, vomiting, dyspepsia and anorexia. Several agents have been used to treat above symptoms and sings. We assessed the usefulness of continuous intravenous infusion of low-dose droperidol, compared to granisetron for the control of gastrointestinal symptoms due to radiation therapy. Method: We devided 30 patients who developed gastrointestinal symptoms after undergoing palliative radiation therapy due to metastatic bone pain in two groups. In group G(n=15), the patients were injected granisetron(3㎎) and then injected it, 3㎎ per day. In group D(n=15), the patients were injected low-dose droperidol(0.25㎎) and then infused continuously at low-dose(1㎎/day) by the disposable continuous infusion pump. Result: There were no significant differences in the patient's satisfaction, improvement of appetite and incidences of side effects between two groups. Conclusion: The continuous intravenous infusion of low-dose droperidol can substitute for serotonin-receptor antagonist for the treatment of gastrointestinal symptoms during radiation therapy for cancer patients.

관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

아로마 요법이 뇌졸중환자의 자율신경계와 스트레스에 대한 신체 저항도에 미치는 효과

신유선,조영숙,정유진 대한기초간호자연과학회 2004 Journal of korean biological nursing science Vol.6 No.2

Purpose : The purpose of this study is to determine effects of aromatherapy on the activity and balance of autonomic nervous system and on physical resistance to stress. Methods : This research is a primitive experimental design which attempts to analyze aromatherapy EKG monitoring on real-time basis. Lavender & Chamomile, each 30 drops, were blended with 100ml Sweet Almond oil. Subjects was laid relaxed, and had insides of his wrists and ankles attached with electrodes for EKG. Right after applied with essential oil onto his philtrum and parotid, started on EKG monitoring. Results : The activities of parasympathetic and sympathetic nerve were changed as time elapsed, with significant differences(p=.000). In multiple comparison, the value was significantly different (p<.05).The balance of autonomic nerve was changed, becoming close to the normal level in accord with applicable international standards(1.5)(p=.011). In multiple comparison, the value showed a significant difference(p<.05). Physical resistance to stress increased with the passage of time, but not statistically significant. Conclusions : This suggests that aromatherapy can be used as a nursing intervention which aims at alleviating symptoms related to the imbalance of autonomic nerve system such as headache, hot flashes, irregular heartbeat, nervousness, depression and anxiety.

항산화 및 미생물의 성장에 대한 해양성 심층수의 영향

김유정,정일선,최영주 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-

해양심층수의 첨가에 따른 항산화력과 된장에서 분리한 Bacillus, 석유분해균인 Sphingomonas 및 효모의 증식을 측정하였다. Bacillus와 Sphingomonas 경우는 KDMW와 다나수의 첨가에 의해서 균주의 생육이 증가되었을 뿐만 아니라 정지기 및 사멸기에 도달하는 시간도 연장되는 것으로 보아 심층수에 있는 미네랄이 이러한 생리활성을 나타내는 것으로 추정된다. 효모의 경우는 심층수의 첨가에 의하여 대조구와 별다른 차이를 보이지 않고 있다. 항산화력의 경은 KDMW를 50%까지 첨가 했을 경우는 25% 항산회력을 나타냈지만 60% 이상 첨가하면 오히려 항산회력이 현저히 감소하였다. 다나수의 경우는 40 - 100% 범위내에서 약 20%의 유사한 활성을 나타냈다. Korean deep mineral water (KDMW) has a similar mineral composition with deep sea water KDMW has demonstrated its usefulness and attracted in the medical fields. KDMW intake improves antioxidant activity and the growth of fermentation related strains. The antioxidant activity was increased up to 23% by the addition of 40% KDMW. The growth rate of Bacillus sp. on medium containing KDMW(40%) was faster than that of the strain on the medium without it. These results suggest that the minerals in KDMW play an important role for activation of immune system and the microbial growth. In addition to, it is considered that the study on the effects of abundant minerals of deep mineral water in the fermentation will by continued.