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Inhibitory Effects of an Aqueous Extract of Gynura procumbens on Human Mesangial Cell Proliferation
이희제,이병철,정주호,Sumali Wiryowidagdo,전완주,김성수,김현숙,최면 대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.4
Gynura procumbens (Lour.) Merr. has been used in some parts of Southeast Asia as a folk medicine to treat kidney diseases, diabetes mellitus, and hyperlipidemia. The present work was undertaken to prove the mechanisms of G. procumbens in the management of glomerular diseases. We investigated the effect of an aqueous extract of G. procumbens on cell proliferation, DNA synthesis, and the expressions of TGF-β1, PDGF-BB, CDK1, CDK2, and CDK4 in fetal bovine serum-activated human mesangial cells (MCs). The G. procumbens extract inhibited proliferation, DNA synthesis, expressions of PDGF-BB, CDK1, and CDK2 mRNA, and expression of TGF-β1 protein in MCs. The inhibitory effect of G. procumbens on MC proliferation may be mediated by suppression of PDGF-BB and TGF-β1 expressions and the modulation of CDK1 and CDK2 expression. Therefore, G. procumbens shows promise as an adjunct therapy in preventing progressive renal diseases.
Squeeze-film damping of flexible microcantilevers at low ambient pressures: theory and experiment
Lee, Jin Woo,Tung, Ryan,Raman, Arvind,Sumali, Hartono,Sullivan, John P IOP 2009 JOURNAL OF MICROMECHANICS AND MICROENGINEERING - Vol.19 No.10
<P>An improved theoretical approach is proposed to predict the dynamic behavior of long, slender and flexible microcantilevers affected by squeeze-film damping at low ambient pressures. Our approach extends recent continuum gas damping models (Veijola <A article='0960-1317/14/7/034'>2004 <I>J. Micromech. Microeng.</I> <B>14</B> 1109–18</A>, Gallis and Torczynski 2004 <I>J. Microelectromech. Syst.</I> <B>13</B> 653–9), which were originally derived for a rigid oscillating plate near a wall, to flexible microcantilevers for calculating and predicting squeeze-film damping ratios of higher order bending modes at reduced ambient pressures. Theoretical frequency response functions are derived for a flexible microcantilever beam excited both inertially and via external forcing. Experiments performed carefully at controlled gas pressures are used to validate our theoretical approach over five orders of the Knudsen number. In addition, we investigate the relative importance of theoretical assumptions made in the Reynolds-equation-based approach for flexible microelectromechanical systems.</P>
Inhibitory Effects of an Aqueous Extract of Gynura procumbens on Human Mesangial Cell Proliferation
Hee Jae Lee,Byung-Cheol Lee,Joo-Ho Chung,Sumali Wiryowidagdo,Wanjoo Chun,Sung-Soo Kim,Hyunsook Kim,Myeon Choe 대한생리학회-대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.20 No.3
<I>Gynura procumbens</I> (Lour.) Merr. has been used in some parts of Southeast Asia as a folk medicine to treat kidney diseases, diabetes mellitus, and hyperlipidemia. The present work was undertaken to prove the mechanisms of <I>G. procumbens</I> in the management of glomerular diseases. We investigated the effect of an aqueous extract of G. procumbens on cell proliferation, DNA synthesis, and the expressions of TGF-β1, <I>PDGF-BB, CDK1, CDK2, </I>and CDK4 in fetal bovine serum-activated human mesangial cells (MCs). The G. procumbens extract inhibited proliferation, DNA synthesis, expressions of <I>PDGF-BB, CDK1,</I> and <I>CDK2 </I>mRNA, and expression of TGF-β1 protein in MCs. The inhibitory effect of G. procumbens on MC proliferation may be mediated by suppression of PDGF-BB and TGF-β1 expressions and the modulation of <I>CDK1 </I>and <I>CDK2</I> expression. Therefore, <I>G. procumbens </I>shows promise as an adjunct therapy in preventing progressive renal diseases.
Inhibitory Effects of an Aqueous Extract of Gynura procumbens on Human Mesangial Cell Proliferation
Lee, Hee-Jae,Lee, Byung-Cheol,Chung, Joo-Ho,Wiryowidagdo, Sumali,Chun, Wan-Joo,Kim, Sung-Soo,Kim, Hyun-Sook,Choe, Myeon The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.4
Gynura procumbens (Lour.) Merr. has been used in some parts of Southeast Asia as a folk medicine to treat kidney diseases, diabetes mellitus, and hyperlipidemia. The present work was undertaken to prove the mechanisms of G. procumbens in the management of glomerular diseases. We investigated the effect of an aqueous extract of G. procumbens on cell proliferation, DNA synthesis, and the expressions of $TGF-{\beta}1$, PDGF-BB, CDK1, CDK2, and CDK4 in fetal bovine serum-activated human mesangial cells (MCs). The G. procumbens extract inhibited proliferation, DNA synthesis, expressions of PDGF-BB, CDK1, and CDK2 mRNA, and expression of $TGF-{\beta}1$ protein in MCs. The inhibitory effect of G. procumbens on MC proliferation may be mediated by suppression of PDGF-BB and $TGF-{\beta}1$ expressions and the modulation of CDK1 and CDK2 expression. Therefore, G. procumbens shows promise as an adjunct therapy in preventing progressive renal diseases.
Antihypertensive Effects of Gynura procumbens Extract in Spontaneously Hypertensive Rats
Hye Kyung Kim,Mi-Ja Kim,Hee Jae Lee,Sumali Wiryowidagdo 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
Aqueous extracts of Gynura procumbens(Lour.) Merr. were orally administered to spontaneously hyperten-sive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procum-bens(Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not givenGPE (P. .05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphatekinase, and increased nitric oxide (NO), a known vasodilator, compared with the nonGPE-administered SHR group (P..05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hyperten-sion through increasing NO production in blood vessels.