발열이 있는 호중구 감소증 환자에서의 위험도 예측인자

정중식,권운용,김규석,임용수,이중의,서길준,윤여규 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Most febrile neutropenic patients are treated in an aggressive manner. However, identification of low-risk patients may enable clinicians to administer risk-based treatment. The object of this study is to certify the factors associated with increased risk at the time of visiting the emergency department. Methods: This is a retrospective study. We reviewed the medical records of 101 febrile neutropenic patients who had visited the emergency department of Seoul National University Hospital from January 1998 to August 1999. We assumed 22 risk prediction factors that could be assessed at admission to the emergency department and 5 factors that could be assessed during treatment course. To find independent risk-prediction factors, we analyzed these factors respectively by using multiple regression analysis. Results: Tachycardia(aOR=136.5), altered mentality(aOR=28.8), decreased renal function(aOR=20.1), and significant comorbidity(aOR=17,2) are the independent factors associated with higher mortality. Altered mentality(aOR=31.6) and decreased renal function(CCr < 75㎖/min, aOR=5.4) are those associated with a higher incidence of septic shock. Independent factors associated with persistent(more than 3 days) fever are the early(within 10 days) onset of fever after last chemotherapy(aOR=8.8) and the existence of new pulmonary infiltrates on a simple chest X-ray(aOR=4.3). Conclusion: The stability of vital signs, the change of mentality, the renal function, the existence of significant comorbidity, the existence of new pulmonary infiltrates, and the rate of neutropenia are clinically useful risk-prediction factors in febrile neutropenia at the time of visiting the emergency department.

회장에 장폐색을 유발한 Anisakiasis 1예

박수헌,서정민,문인성,백남종,심규식,김부성 대한소화기내시경학회 1990 Clinical Endoscopy Vol.10 No.2

Anisakiasis refers to the infestation of humans by species of marine nematode larvae belonging to the subfamily Anisakiae. An acute abdominal symptom may occur after ingestion of raw marine fish containing nematode larvae of the genus Anisakis. Migration of the parasite into the wall of gtomach, small intestine or, less commomly, the colon elicits a striking eosinophilic granulomatous tissue response. A 39 year old man was visited St. Vincent Hospital because of abdominal distension and tenderness. The plain abdominal X-ray showed ileus pattern suggesting intestinal obstruction. Hence we presented a case of intestinal Anisakiasis combined with intstinal obstruction.

SUH 동조방법에 대한 부하외란의 영향

위규식(Kyu Sik Wie),서병설(Byung Suhl Suh),윤인섭(En Sup Yoon) 대한전자공학회 1984 대한전자공학회 학술대회 Vol.1984 No.10

富平地域의 中生代 火成岩類

Kyu Sik Suh(徐圭植),Hee In Park(朴喜寅) 대한자원환경지질학회 1986 자원환경지질 Vol.19 No.3

In the Bupyeong district, Mesozoic pyroclastic rocks, intrusive breccia, granites and felsic porphyries comprise a volcano-plutonic complex, overlying and intruding the Precambrian Gyeonggi gneiss complex. pyroclastic rocks, consisted mainly of rhyolitic welded tuffs, form a topographic circular structure about 10 kilometers in diameter. Granites and felsic porphyries which intruded the pyroclastic rocks are distributed in the inner side and also along the outer margin of the circular structure. K-Ar ages of two granite bodies(biotite), 162 and 148±7 Ma, and that of the intrusive rhyolite (whole rock), 121±6 Ma indicate that a series of volcano-plutonic igneous activity occurred between Jurassic and early Cretaceous age. Petrochemical characteristics suggest that the pyroclastic rocks, granites and felsic porphyries were originated from the comagmatic source. From the evidences of field occurrence, petrochemical and geochronological characteristics of igneous rocks and the geologic structures, it is believed that the igneous rocks in the Bupyeong district were formed during a Jurassic to early Cretaceous resurgent caldera evolution.

富平銀鑛床의 鑛體胚胎場所

Kyu Sik Suh(徐圭植),Hee In Park(朴喜寅) 대한자원환경지질학회 1987 자원환경지질 Vol.20 No.2

The geology of the Bupyeong mine area is consisted of Precambrian Gyeonggi gneiss complex and Mesozoic igneous rocks; i.e., pyroclastic rocks, intrusive breccia, granite and felsic porphyries which were formed during a Jurassic to early Cretaceous resurgent caldera evolution. Granites are not observed on the surface and in the underground of the mine. Bupyeong silver deposits occur as stockworks of base metal sulfides- minor silver minerals-quartz - carbonate veinlets, hosted by pyroclastic rocks and intrusive breccia at the southwestern margin of the caldera. Silver occurs mainly as native silver, and other silver minerals, minor in quantity, are argentite, tetrahedrite-freibergite, pyrargyrite, polybasite, canfieldite and dyscrasite. The average grade of silver ore is about 180g/t Ag. Discrimination of silver ore from the country rocks depends largely on the chemical analyses of rock samples taken every two meters from tunnels, diamond-drilling cores and mining stopes, because silver minerals are hardly observed in the ore by crude eye, and silver orebodies do not properly coincide with the concentrated zone of base metal sulfides which were precipitated at the earlier stage than the stage of precipitation of native silver. General characteristics of the loci of the silver orebodies are as follows; (1) The host rocks of orebodies are pyroclastic rocks and intrusive breccia. (2) Many of the orebodies are distributed around Gyeonggi gneiss complex. Especially where the paleotopography of gneiss complex shows a gradual slope, the basal stratigraphic horizon of the pyroclastic rocks unconformably overlying the gneiss complex offered a favorable loci of high grade ore. (3) N5°W to N15° E-striking faults played an important role in the localization of the orebodies. (4) Conduits of intrusive breccia within the gneiss complex, through which the intrusive breccia intruded into the upper pyroclastic rocks, exist beneath most of the main orebodies. This suggests that the conduits of intrusive breccia served as channelways for the migration of ore fluids.

한국에서의 원발성 담즙성 간경변증

서정민(Jeong Min Suh),심규식(Kyu Sik Shim),양영상(Young Sang Yang),윤승규(Seung Kew Yoon),한준열(Joon Yeol Han),안병민(Byung Min Ahn),이창돈(Chang Don Lee),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park),김부성(Boo Sung 대한내과학회 1996 대한내과학회지 Vol.50 No.2

Objectives: Primary biliary cirrhosis(PBC) is a relatively common autoimmune liver disease in western country. But it is rare in Asia. Only 11 cases of PBC has been reported so far in Korea. We have experienced 7 cases of PRC recently. The aim of the present study is to assess the clinical characteristics of PHC in Korea. Methods: We ana1yzed 18 cases of PBC for the distribution of age and sex, initial symptoms and signs, associated disorders, frequency of autoantibodies, and pathologic stage. Results: Of 18 patients, the ratio of male to female was 1: 3.5 and the average age was 52.8 years old. Pruritus(77.8%) was the most frequent clinical symptom followed by jaundice(61.1%), chronic fatigue(44.4%), xerostomia and xerophthalmia(22.2%), and general weakness(16.7%). Associated disorders were Sjogres`s syndrome(22.2%), Behcet`s syndrome, (5.6%), bronchial asthma(5.6%), pleural effusion (5.6%), and bicuspid valve stenosis (5.6%), Detected autoantibodies were antimitochondrial antibody(100%), fluorescent antinuclear antibody(50%), rheumatoid factor(44.4%), and smooth muscle antibody(5.6%). The pathologic stages based on morphologic findings were stage 1(16.7%), stage 1-2(11.1%), stage 2 (27.8%), stage 2-3(22.2%), stage 3(16.7%), and stage 3-4(5.6%). Conclusion: The clinical characteristics of PBC in Korea are similar to those of western country`s cases. But the male to female ratio in Korea is higher than in western countires

위선암 2789예의 생존율 및 예후인자

서광욱(Kwang Wook Suh),김충배(Choong Bai Kim),김명욱(Myung Wook Kim),지훈상(Hoon Sang Chi),조장환(Chang Hwan Cho),김병로(Byong Ro Kim),민진식(Jin Sik Min),이경식(Kyong Sik Lee),김춘규(Choon Kyu Kim),황규철(Kyu Chul Whang) 대한외과학회 1991 Annals of Surgical Treatment and Research(ASRT) Vol.41 No.2

면역 억제제를 투여한 동종 흰쥐 비장내 분리 간세포 이식 : 이식 간세포 생존 및 급성간부전 치료 효과 Survival of Transplanted Cells and Threapeutic Effect of Acute Hepatic Failure

서정민,정규원,김부성,조세현,선희식,박두호,한남익,이창돈,김성수,윤승규 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6

Background/Aims: Recent studies have shown that purified hepatocyte may be immunogenic. We evaluated the survival of transplanted hepatocyte in rat spleen and the therapeutic effect of dimethylnitrosamine(DMNS) induced acute hepatic failure with or without immunosuppression after injecting the isolated allogenic hepatocyte into rat spleen. Methods: Rat hepatocyte were prepared according to a modification method of two step ex vivo perfusion of collagenase digestion. Isolated allogenic hepatocytes(2×10^7 cells) were injected into the spleen of normal or hepatic-failed Sprague-Dawley rats with or without cyclosporin(CsA) treatment for 2 wks. Results: Transplanted hepatocytes in allogenic normal rat spleen without CsA immunosuppression were undetected in 2 to 4 days, but detected for at least 14 days in cases using CsA immunosuppression. However, groups with allogenic hepatocytes transplantation(2×l0^7 cells/rat) at 24 hr after DMNS were enhanced by the survival rate significantly without CsA administration (p$lt;0.05), and also tended to have enhanced survival rate with CsA(p=0.56) compared to that of the controls. Furthermore, hepatocytes transplantation with or without CsA adminstration ameliorated serum level of albumin but not transaminase, bilirubin at 3 and 7 ciays in the rat with DMNS-induced hepatic failure compared to that of controls. Conclusions: This data demonstrate that isolated and transplanted allogenic hepatocytes into the splenic parenchyma may be immunogenic, and rejected rapidly without CsA administration, but also reduced the mortality of the acute hepatic failure with or without CsA administration. Therefore, understanding the possible mechanism by which transplanted hepatocytes into the spleen reduced mortality of experimental acute hepatic failure requires further study.

韓國企業의 海外投資實態와 多國籍化에 관한 硏究

徐淙圭,洪忠植 同德女子大學校 1983 同大論叢 Vol.13 No.1

International Business can be difined as either private or govermental business relationship conducted across national boundaries. In the case of private firms, these transactions are for profit. The diferences between domestic and international business are centered primarily in the careas of currencies, interest rates, inflations, taxation systems, governmental restrictions, languages, and cultures. An increasing portion of the foreign sales of firms is being made from controlled foreign production facilities. this is termed direct foreign investment. Direct overseas investment has traditionally been considered as an international capital movement that moves abroad when the anticipated return is higher overseas than at home. In this point of view, a national extension of domestic business brings certainly about an internation alization of firms. As one begins to operate internationally, however, the pratices must be changed to corespond with the different environmental variales present abroad. therefore investment firms in a foreign country have to map out the special international strategies for the international management. The determination of an overall strategies for the international management must by dynamic. the changes of conditions and results do not always conform to expectations. a strategy must, therfore, be flexible enough to let a company (1) respond to new opportunities and (2) eliminate participation in these activities with inadequate expected contributions. Because the international objectives of firm should not be substantially different from those that guide actions domestically. The direct foreign investments of Korean firms have been annually enlarged from 1968. these direct investments are expected to be expanded with the growth of trade. The multinationalization of our firms should be ready for a few basic strategies in the field of advanced planning, process of international organization, and the international project planning.

Methamphetamine and MDMA (3,4-methylenedioxymethamphetamine) Induce Apoptosis in Both Human Serotonergic and Dopaminergic Cell Lines

( Kyu Bong Kim ),( Soo Kyung Suh ),( Bo Kyung Lee ),( Byung Kyu Kim ),( Jae Hee Kim ),( Eui Sik Han ),( Chang Won Park ),( Jong Won Kim ),( Kwang Jin Kim ),( Sun Hee Lee ) 한국응용약물학회 2003 Biomolecules & Therapeutics(구 응용약물학회지) Vol.11 No.4

N/A Methamphetamine(METH)and 3,4-methylenedioxymethamphetamine(MDMA) have become popular recreational drugs of abuse in many countries. Although the neurotoxic damage caused by METH and MDMA is characterized by degeneration of the dopaminergic and serotonergic systems in brain, the molecular and cellular mechanisms remain to be clarified. Therefore, the purposes of this study were to confirm the capability of METH and MDMA to induce apoptosis and to clarify the action of its molecular mechanism by using serotonergic JAR cells and dopaminergic SK-N-SH cells. METH and MDMA were dose-dependently cytotoxic to human serotonergic JAR cells and dopaminergic SK-N-SH cells. The morphological change of apoptosis was found in Giemsa staining and TUNEL and further verified in DNA fragmentation analysis. Immunoblotting analysis revealed proteolytic cleavage of caspase-3 and -9 and change of bcl-2 and bax proteins. These results suggest METH and MDMA may induce caspase-dependent apoptosis via the mitochondrial cell death pathway and METH and MDMA-induced neurotoxicity may happen to broadly and independently of both dopaminergic and serotonergic systems.