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송근영,강길,박정희,김경종,민영돈,박치영,임성철 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Gastric small cell carcinoma(SCC) is defined as poorly-differentiated neuroendocrine tumor of the stomach, and their morphologic and biologic features arc similar to those of the lung. It is known that this tumor has poor prognosis even in early pathologic stage, It acounts for only 3% of all gastrointestinal SCC. that has been reported only 33 cases outside and 6 cases inside of the comitiy. Most of these reports are related to advanced gastric SCC. as pathologic stage IIIb or IV. This report describes a case of early gastric SCC. pathologic stage Ib.
영구자석 동기발전기의 정주파수 정전압 출력에 관한 연구
우정인,조용길,황정원,송호신 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2
The permanent magnet machines have the advantages of high efficiency and power density, features very improtant for air-borne applications with their requiement of no external dc supply for rotor excitation, in addition, a very lower synchronous reactance thus making it a stiff source of power with a higher steady state and more transient capability than ist counterpart, the wound rotor type. In this paper, The permanent magnet synchronous machine is taken as a power source in the variable speed constant frequency power conversion scheme with converter-inverter system. All digital routines are excuted in the sampling time of 100 micro second by a DSP Board (TMS320c25) with A/D converters, which is detect the load current, capacitor current and DC link voltage at a sudden load change and to compute the predicted current. In one sampling interval, two optimal space voltage vectors as well as tow zero voltage vectors are employed so that the capacitor current may follow the reference. As a result, sinusoidal output constant voltage is obtained while swiching frequency is constant, and experimental results are presented, which shows the effectiveness of the proposed control method.
원인 미상의 급성 간염에서 Erythrovirus B19 감염에 관한 연구
정길만(Gil Man Jung),오성남(Sung Nam Oh),김효정(Hyo Jung Kim),김윤홍(Yoon Hong Kim),연종은(Jong Eun Yeon),김종헌(Jong Hun Kim),송진원(Jin Won Song),송기준(Ki Joon Song),백낙주(Nak Joo Baek),이명석(Myung Sek Lee),김재선(Jae Seon Kim) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Background/Aims: Erythrovirus B19 is associated with erythema infectiosum in children and acute arthropathy in adults. Moreover, it causes transient aplastic crisis in hemolytic anemia, chronic anemia in immunocompromised patients, and nonimmune fetal hydrops in pregnant women. Recently, acute hepatitis or fulminant hepatitis in children and adults has been reported infrequently in association with erythrovirus B19 infection. Therefore, we tried to evaluate the relationship between erythrovirus B19 and acute hepatitis of unknown etiology. Methods: Patient group included 70 patients with acute NANBNC hepatitis of unknown etiology, who were admitted to Korea University Guro Hospital from March 1995 to May 1999 (mean age, 48 years; M:F=1:1.7). Control group included 30 patients with chronic liver disease of unknown etiology admitted during the same period. (mean age, 49 years/ M:F=1.1:1). Nested PCR for erythrovirus B19 DNA was performed for sera of the patient and control groups. Results: Among the patient group, only one case was positive for erythrovirus B19 DNA PCR. The nineteen-year- old young man died of fulminant hepatitis of unknown etiology. Among the control group, none was positive for erythrovirus B19 DNA. Conclusions: These results suggest that erythrovirus B19 may be a cause of acute hepatitis of unknown etiology in Korea. In the future, a largescale investigation will be needed to clarify the role of erythrovirus B19 in young patients with acute or fulminant hepatitis of unknown etiology. ( Korean J Gastroenterol 2002; 39: 356-360)
Ryu, Ha-Jung,Jung, Ho-Youl,Park, Jung-Sun,Ryu, Gil-Mi,Heo, Jee Yeon,Kim, Jae-Jung,Moon, Song-Mean,Kim, Hung-Tae,Lee, Jong-Young,Koh, Insong,Kim, Jun-Woo,Rho, Jae Kyun,Han, Bok-Ghee,Kim, Hyungtae,Park, S.Karger 2006 International archives of allergy and immunology Vol.139 No.3
<P><I>Background and Methods:</I> Numerous genetic studies have mapped asthma susceptibility genes to a region on chromosome 5q31-33 in several populations. This region contains a cluster of cytokines and other immune-related genes important in immune response. In the present study, to determine the genetic variations and patterns of linkage disequilibrium (LD), we resequenced all the exons and promoter regions of the 29 asthma candidate genes in the chromosome 5q31-33 region. <I>Results:</I> We identified a total of 314 genetic variants, including 289 single nucleotide polymorphisms (SNPs), 22 insertion/deletion polymorphisms and 3 microsatellites. Standardized variance data for allele frequency revealed substantial differences in SNP allele frequencies among different ethnic groups. Interestingly, significant ethnic differences were observed mainly in intron SNPs. LD block analysis using 174 common SNPs with a frequency of >10% disclosed strong LD within most candidate genes. No significant LD was observed across genes, except for one LD block (CD14-IK block). Gene-based haplotype analyses showed that 1-5 haplotype-tagging SNPs may be used to define the six or fewer common haplotypes with a frequency of >5%, regardless of the number of SNPs. <I>Conclusion:</I> Overall, our results provide useful information for the identification of immune-mediated disease genes in the chromosome 5q31-33 region, as well as valuable evidence for gene-based haplotype analysis in disease association studies.</P><P>Copyright © 2006 S. Karger AG, Basel</P>
Lee, Sarah,Jung, Eun Sung,Do, Seon-Gil,Jung, Ga-young,Song, Gwanpil,Song, Jung-min,Lee, Choong Hwan American Chemical Society 2014 Journal of agricultural and food chemistry Vol.62 No.9
<P>Metabolite profiling of three blueberry species (<I>Vaccinium bracteatum</I> Thunb., <I>V. oldhamii</I> Miquel., and <I>V. corymbosum</I> L.) was performed using gas chromatography–time-of-flight-mass spectrometry (GC-TOF-MS) and ultraperformance liquid chromatography–quadrupole-time-of-flight-mass spectrometry (UPLC-Q-TOF-MS) combined multivariate analysis. Partial least-squares discriminant analysis clearly showed metabolic differences among species. GC-TOF-MS analysis revealed significant differences in amino acids, organic acids, fatty acids, sugars, and phenolic acids among the three blueberry species. UPLC-Q-TOF-MS analysis indicated that anthocyanins were the major metabolites distinguishing <I>V. bracteatum</I> from <I>V. oldhamii</I>. The contents of anthocyanins such as glycosides of cyanidin were high in <I>V. bracteatum</I>, while glycosides of delphinidin, petunidin, and malvidin were high in <I>V. oldhamii</I>. Antioxidant activities assessed using ABTS and DPPH assays showed the greatest activity in <I>V. oldhamii</I> and revealed the highest correlation with total phenolic, total flavonoid, and total anthocyanin contents and their metabolites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2014/jafcau.2014.62.issue-9/jf405272b/production/images/medium/jf-2013-05272b_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf405272b'>ACS Electronic Supporting Info</A></P>
절수에 의한 mongolian gerbil 종뇌 및 간뇌에서 dopamine성 면역반응세포의 분포변화
송치원,이경열,박일권,정주영,권효정,이철호,현병화,이근좌,송운재,정영길,이강이,김무강,Song, Chi-won,Lee, Kyoung-youl,Park, Il-kwon,Jung, Ju-young,Kwon, Hyo-jung,Lee, Chul-ho,Hyun, Byung-hwa,Lee, Geun-jwa,Song, Woon-jae,Jung, Young-gil,Lee 대한수의학회 2000 大韓獸醫學會誌 Vol.40 No.1
Nowadays, mongolian gerbil is notably utilized for the research of brain and water deprivation because of a congenital incomplete willis circle structure in the brain, audiogenic seizure in low noise, and special cholesterol metabolism without water absorption for a long time. In this study, we are intend to identify the morphological changes of the catecholaminergic neuron of brain according to the time lapse in the condition of long term water deprivation. 55 mongolian gerbil were divided 10 groups(control, 1, 2, 3, 4, 5, 10, 15, 20, 42th day water deprivation group), of which each group include 5 mongolian gerbils and 5 normal mongolian gerbils in control group were also used for brain atlas as a control. The brains were observed by the immunohistochemical stain using the TH, DBH and PMNT antibody. The results were as followings; 1. The nerve fibers of the TH-immunoreactive neuron were observed only in the and corpus striatum of the telencephalon. 2. Intensity of the immunostain of the nerve fiber in the cerebral cortex and corpus striatum was decreased gradually day by day after water deprivation. 3. The TH-immunoreactive nerve cells were observed in the paraventricular and periventricular nucleus of the 3rd ventricular in the hypothalamus of mongolian gerbil but the number of nerve cells were decreased from the first day of the water deprivation to the 10th day and increased until the 20th day, after than redecreased from the 20th day by the continuous water deprivation. The number of nerve fibers in this area were increased in the first day, but decreased from the 2nd day of water deprivation. The shape and density of the dopamine secreting cells in the brain of mongolian gerbil by the immunoreactive stain were changed in the continuous water deprivation. In this results, we can conclude that dopamine concerned in the water metabolism of mongolian gerbil, and mongolian gerbil could be used as an animal model for the research of water deprivation.
Raynaud 증후군을 위한 Reserpine, Procaine 의 동맥주사와 성상교감신경절 차단
송선옥,최규택,전재규,정정길 대한통증학회 1988 The Korean Journal of Pain Vol.1 No.1
Efforts from many different approaches have been made to cure Raynaud's phenomenon, auch as a dorsal sympathectomy, topical injection of nitroglycerin, phentolamin and procaine, and oral or parentral administration of various drugs. However, there has been no successful management proven yet. In recent years, it was reported that intra-arterial administration in normal subjects as well as patients with Raynaud's syndrome has demonstrated a significant rise in blood flow to the hands. We used intermittent stellate ganglion blocks in conjunction with intra-arterial injections of reserpine and procaine in 10 patients suffering from finger necrosis. The stellate ganglion block was performed in a paratracheal approach by injection of 1% lidocaine purposely mixed with adrenaline followed by the adminiatration of reserpine 1 mg and procaine 50 mg through a butterfly needle inserted in the radial or brachial artery. The administration of reserpine and procaine was done only twice at intervals of 1 week because of the development of suspected arteriosclerosia. The stellate ganglion block was carried out once a week for about 3 months, then once a month as needed for 6 to 12 months. As the procedure was carried out and the necrotic tissue sloughed off, oozing appeared and new granulation tiseue was observed. 5 out of 10 patients were healed completely and the rest improved considerably but were not followed to the end, We concluded that the intra-arterial administration of reserpine and procaine helped initiate and accelerate increasing blood flow to the hand and the stellate ganglion block continued to help revascularixation by dilating the peripheral beds.