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Sol Ji Ahn,Chang Ik Yoon,Pill Sun Paik,Tae-Kyung Yoo,Namsun Park,Eun Sook Lee,Jung Eun Choi,Joon Jeong,Hyun Jo Youn,Woo-Chan Park 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.6
Purpose: This study was performed to identify the risk of mortality in patients diagnosed with human epidermal growth factor receptor 2 (HER2)-positive ductal carcinoma in situ (DCIS). Methods: We selected 2,592 patients with HER2-positive DCIS from Korean Breast Cancer Society (KBCS) database between January 1997 and December 2019. Patients who received neoadjuvant chemotherapy were excluded. Logistic regression analysis was used to determine the association between clinical factors and overall death after adjusting for tumor and clinical characteristics. Mortality data were modified using the Statistics Korea data. Results: Thirty deaths (1.2%) were identified out of 2,592 patients in the KBCS database. In the univariate logistic regression analysis, older age, higher body mass index (BMI), type of breast surgery (mastectomy), estrogen receptor-negative, progesterone receptor-negative, and exposure to endocrine therapy were significant clinical factors associated with death. In the multivariate analysis, age (hazard ratio [HR], 1.062; 95% confidence interval [CI], 1.015–1.111; P = 0.006), BMI (HR, 1.179; 95% CI, 1.032–1.347, P = 0.016), breast surgery type (mastectomy vs. lumpectomy; HR, 0.285; 95% CI, 0.096–0.844; P = 0.024), and endocrine therapy (HR, 0.314; 95% CI, 0.099–0.995; P = 0.049) were significant risk factors for mortality. Conclusion: Advanced age, higher BMI, mastectomy, and the absence of endocrine therapy were factors associated with poor survival of patients with HER2-positive DCIS. This finding requires further validation combined with additional analysis of large databases.
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Vitamin D Deficiency in Chronic Hepatitis C Patients: Cause or Result?
( Sol Ji Park ),( Dae Won Jun ),( Sang Bong Ahn ),( Jae Yoon Jung ),( Joo Hyun Sohn ),( Seok-yong Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tons of reports showed prevalence of vitamin deficiency is high in chronic hepatic C patients (CHC). But there is no clear mechanism of vitamin deficiency in CHC. We investigate to find risk factor affecting serum vitamin D level in CHC treatment population. Methods: Fifty-eight CHC patients treated with pegylated-interferon and ribavirin. Serum vitamin D, amount of ultra violet exposure, and HCV-RNA PCR level were evaluated. Results: Forty three (74.1%) among 58 subjects showed vitamin D deficiency (≤20ng/mL) at the baseline. Serum vitamin D level did not change after treatment (16.9 ng/ml vs 17.6 ng/ml, p=0.524). Sustained viral response (SVR) was achieved by 86.2% (50 patients), while 13.8% (8 patients) failed to SVR. Serum vitamin D level did not different after treatment in both SVR (17.1ng/mL vs 17.5ng/mL, p=0.711) and non-SVR group (16.0ng/mL vs 18.1ng/mL, p=0.419). SVR was not different according to baseline vitamin D level. SVR failure was 33.3% in vitamin D < 10 ng/ml, 11.8% in vitamin D < 20 ng/ml, 6.7% in vitamin D ≥ 20 ng/ml. SVR was not risk factor regarding normalization of serum vitamin D level. Estimated amount of UV exposure was risk factor for normalization of serum vitamin D level in multivariate analysis. Conclusions: Serum vitamin D level did not changed after successful treatment in patients with CHC. Only amount of UV exposure was risk factor for normalization of serum vitamin D level.
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Sol In Suk,Lee Eun,양현종,Lee Yong Ju,Yum Hye Yung,Lee Mi-Hee,Chu Mi Ae,Moon Hui jeong,김효빈,서주희,Shim Jung Yeon,Ahn Ji Young,Jang Yoon Young,Chung Hai Lee,Chung Eun Hee,Kim Kyunghoon,김봉성,김철홍,Park Yang,신미용 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.3
Background: Human coronaviruses (HCoV) cause mild upper respiratory infections; however, in 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged, causing an acute respiratory disease pandemic. Coronaviruses exhibit marked epidemiological and clinical differences.Purpose: This study compared the clinical, laboratory, and radiographic findings of children infected with SARS-CoV-2 versus HCoV.Methods: SARS-CoV-2 data were obtained from the Korea Disease Control and Prevention Agency (KDCA) registry and 4 dedicated coronavirus disease 2019 (COVID-19) hospitals. Medical records of children admitted with a single HCoV infection from January 2015 to March 2020 were collected from 10 secondary/tertiary hospitals. Clinical data included age, sex, underlying disease, symptoms, test results, imaging findings, treatment, and length of hospital stay.Results: We compared the clinical characteristics of children infected with HCoV (n=475) to those of children infected with SARS-CoV-2 (272 from KDCA, 218 from COVID-19 hospitals). HCoV patients were younger than KDCA patients (older than 9 years:3.6% vs. 75.7%; P<0.001) and patients at COVID-19 hospitals (2.0±2.9 vs 11.3±5.3; P<0.001). Patients with SARS-CoV-2 infection had a lower rate of fever (26.6% vs. 66.7%; P<0.001) and fewer respiratory symptoms than those with HCoV infection. Clinical severity, as determined by oxygen therapy and medication usage, was worse in children with HCoV infection. Children and adolescents with SARS-CoV-2 had less severe symptoms.Conclusion: Children and adolescents with COVID-19 had a milder clinical course and less severe disease than those with HCoV in terms of symptoms at admission, examination findings, and laboratory and radiology results.
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군병원 간호장교들의 표준주의지침 수행도에 미치는 영향요인
최지안 ( Ji Ahn Choi ),이현옥 ( Hyun Ok Lee ),노솔아 ( Sol A No ),김수진 ( Su Jin Kim ) 국군간호사관학교 군건강정책연구소 2012 군진간호연구 Vol.30 No.2
Purpose: This study aimed to identify the influencing factors on the nursing officer``s compliance with the standard precautions as a way to come up with measures to improve their compliance in military hospitals. Method: Using a structured survey, data were collected from 324 nursing officers working in military hospitals. Data were collected data were analyzed with SPSS 12.0. Results: The results were as follows: 1) 23.1% of the subjects had been exposed to patients`` blood or other body fluids and injured by needles or other sharp tools used on patients for the last year; 2) The mean score of the ``knowledge of standard precautions`` is 22.9(88.1%) out of 26. The subjects demonstrated the lowest scores on ``reusable gloves or gowns that can be used after being cleaned; 3) The mean score of the ``attitudes towards standard precautions`` was 13.6(85.1%) out of 16; 4) The mean of the ``level of safety environment for the compliance with standard precautions`` was 5.1(72.9%) out of 7; 5) The mean score of the ``compliance with standard precautions`` was 49.7(82.8%) out of 60; 6) The most influential factors of nursing officers`` compliance with the standard precautions were ``safety environment`` and ``report of exposure of the source of infection``. Conclusion: It would be necessary to create a safer environment to improve compliance with the standard precautions in the military hospitals.
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초등학생의 ACE 유전자 다형성에 따른 신체구성 및 체력 특성과 복합운동의 효과
정솔지(Sol Ji Jung),안나영(Na Young Ahn),홍창배(Chang Bae Hong),박정화(Jung Hwa Park),박주식(Ju Sik Park),김기진(Ki Jin Kim) 한국발육발달학회 2009 한국발육발달학회지 Vol.17 No.4
The purpose of this study analyzed the comparisons of body composition, physical fitness, and 12-week combined exercise training-mediate changes according to angiotensin-converting enzyme(ACE) insertion(I)/deletion(D) polymorphism in elementary school students. 145 subjects were divided into 3 groups as II, ID, DD genotype groups based upon ACE I/D polymorphism. Height, body weight, lean body mass, body circumferences(upper arm, hip, thigh) increased significantly(p<.05) after 12-week combined-exercise training in all groups. BMI and WHR decreased significantly(p<.05) after 12-week combined-exercise training in all groups, but there were not significantly different among all groups. Muscular strength, endurance, and power increased significantly(p<.001) after 12-week combined-exercise training in all groups. Flexibility and cardio-respiratory endurance increased significantly(p<.05) after 12-week combined-exercise training in all groups. Power change was significantly(p<.05) higher in DD genotype than II genotype after 12-week combined-exercise training. In conclusions, there were positive results in body composition and physical fitness after 12-week combined-exercise training in all groups. Especially, 12-week combined exercise training-mediate changes of muscular strength and power showed a high tendency in DD genotype. We need further studies for an accurate comparison of exercise training-mediate changes according to ACE I/D polymorphism.
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Park, Sol Ji,Shin, Soojeong,Koo, Ok Jae,Moon, Joon Ho,Jang, Goo,Ahn, Curie,Lee, Byeong Chun,Yoo, Young Je Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.1
Transplantation of islet cells into diabetic patients is a promising therapy, provided that the islet cells are able to evade host immune rejection. With improved islet viability, this strategy may effectively reverse diabetes. We applied 2% calcium alginate to generate small and large capsules to encapsulate porcine neonatal pancreatic cell clusters (NPCCs) using an air-driven encapsulator. After encapsulation, the viability was assessed at 1, 4, 7, 14 and 28 days and secretion of functional insulin in response to glucose stimulation were tested at days 14 and 28. Selective permeability of the small alginate capsules was confirmed using various sizes of isothiocyanate-labeled dextran (FITC-dextran). Encapsulation of NPCCs was performed without islet protrusion in the small and large capsules. The viability of NPCCs in all experimental groups was greater than 90% at day 1 and then gradually decreased after day 7. The NPCCs encapsulated in large capsules showed significantly lower viability ($79.50{\pm}2.88%$) than that of naive NPCCs and NPCCs in small capsule ($86.83{\pm}2.32%$, $87.67{\pm}2.07%$, respectively) at day 7. The viability of naive NPCCs decreased rapidly at day 14 ($75.67{\pm}1.75%$), whereas the NPCCs encapsulated in small capsules maintained ($82.0{\pm}2.19%$). After 14 and 28 days NPCCs' function in small capsules ($2.67{\pm}0.09$ and $2.13{\pm}0.09$) was conserved better compared to that of naive NPCCs ($2.04{\pm}0.25$ and $1.53{\pm}0.32$, respectively) and NPCCs in large capsules ($2.04{\pm}0.34$ and $1.13{\pm}0.10$, respectively), as assessed by a stimulation index. The small capsules also demonstrated selective permeability. With this encapsulation technique, small capsules improved the viability and insulin secretion of NPCCs without islet protrusion.
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