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Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease
Sim, Yun Su,Lee, Jin Hwa,Kim, Ki Uk,Ra, Seung Won,Park, Hye Yun,Lee, Chang-Hoon,Kim, Deog Kyeom,Shin, Kyeong-Cheol,Lee, Sang Haak,Hwang, Hun Gyu,Ahn, Joong Hyun,Park, Yong Bum,Kim, Yu-Il,Yoo, Kwang Ha The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3
Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036-1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376-29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388-34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.
문혜연,Sim Gyu Hun,Kim Hyeon Jin,Kim Keunpil,Kang Hyun Ah 한국미생물학회 2022 The journal of microbiology Vol.60 No.1
We evaluated the Cre-lox and CRISPR-Cas9 systems as markerrecycling tools in Saccharomyces cerevisiae recombinants containing multiple-integrated expression cassettes. As an initial trial, we constructed rDNA-nontranscribed spacer- or Ty4- based multiple integration vectors containing the URA3 marker flanked by the loxP sequence. Integrants harboring multiple copies of tHMG1 and NNV-CP expression cassettes were obtained and subsequently transformed with the Cre plasmid. However, the simultaneous pop-out of the expression cassettes along with the URA3 marker hampered the use of Cre-lox as a marker-recycling tool in multiple integrants. As an alternative, we constructed a set of CRISPR-Cas9-gRNA vectors containing gRNA targeted to auxotrophic marker genes. Transformation of multiple integrants of tHMG1 and NNV-CP cassettes by the Cas9-gRNA vector in the presence of the URA3 (stop) donor DNA fragments generated the Ura- transformants retaining multiple copies of the expression cassettes. CRISPR-Cas9-based inactivation led to the recycling of the other markers, HIS3, LEU2, and TRP1, without loss of expression cassettes in the recombinants containing multiple copies of tHMG1, NNV-CP, and SfBGL1 cassettes, respectively. Reuse of the same selection marker in marker-inactivated S. cerevisiae was validated by multiple integrations of the TrEGL2 cassette into the S. cerevisiae strain expressing SfBGL1. These results demonstrate that introducing stop codons into selection marker genes using the CRISPR-Cas9 system with donor DNA fragments is an efficient strategy for markerrecycling in multiple integrants. In particular, the continual reuse of auxotrophic markers would facilitate the construction of a yeast cell factory containing multiple copies of expression cassettes without antibiotic resistance genes.
Yuk, Sim Bum,Lee, Jae Moon,Namgoong, Jin Woong,Sakong, Chun,Hwang, Tae Gyu,Kim, Se Hun,Lee, Woosung,Kim, Jae Pil Applied Science Publishers 2019 Dyes and pigments Vol.171 No.-
<P><B>Abstract</B></P> <P>Perylene diimides (PDIs) have been used in various industries, especially in devices such as organic light-emitting diodes, organic semiconductors, and thin-layer organic photovoltaics, because of their excellent optical and electrical properties and outstanding thermal stability. In addition, PDIs are suitable for black matrix and black bank materials, which require wide and strong absorption of visible light, for use in display panels. Research has been conducted to apply solution-processed PDI on the black matrix and black bank film fabrication. However, due to the low solubility of PDI, industrially required optical properties have not been achieved. In this study, diphenyl-linked PDI dimers were synthesized and evaluated on their optical properties and thermal stability for solution-processed black matrix. The solubility of the synthesized dimers was improved compared to that of monomers as intermolecular interaction reduced by two PDI cores in a molecule that is rotated at a specific angle. Five kinds of dimeric and monomeric PDIs were synthesized with bay substituents of different electron donating power. The absorption range of the dyes was red-shifted as the electron donating power of the substituents increased, and the fluorescence of the dyes was quenched by intramolecular charge transfer (ICT). In a solution state, dimers showed enhanced absorbance and thermal stability and enlarged absorption range as compared to the monomers. Hybrid-type black matrices using dimeric PDIs and carbon black showed high thermal stability, flat surface condition, and low dielectric constant. Additionally, the optical density of the black matrices, which was not satisfactory in the previous study, was greatly improved (up to 2.755) because of the increased dye content due to highly soluble dimeric PDIs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly soluble dimeric perylene dyes were synthesized and used as colorant of black matrix. </LI> <LI> The optical and physical properties of the dimers were measured in comparison with the monomers. </LI> <LI> A higher optical density was obtained than the previous studies due to enhanced solubility of the dyes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
SIMD를 이용한 HEVC 하다마드 트랜스폼의 고속 구현
유종훈(Jong-Hun You),조현호(Hyun-Ho Jo),심동규(Dong-Gyu Sim) 한국방송·미디어공학회 2011 한국방송공학회 학술발표대회 논문집 Vol.2011 No.11
본 논문에서는 SIMD(Single Instruction Multiple Data) 프로세서를 사용한 HEVC 부호화기의 하다마트 트랜스폼 고속화를 제안한다. 본 논문에서는 MMX와 SSE 레지스터를 사용하여 하다마드 트랜스폼을 SIMD 연산으로 대체함으로써 메모리 접근 횟수와 명령어의 수를 줄여 부호화기를 고속화 하였다. 또한, HEVC의 10비트 입력에 따른 SIMD 구조의 비효율적인 구현을 해결하기 위하여 하다마드 트랜스폼의 입력 픽셀 비트수를 감소시키는 IBDD(Internal Bit Depth Decreasing)를 제안했다. HEVC 부호화기에 하다마드 트랜스폼을 SIMD 연산으로 대체한 결과 부호화 효율의 저하 없이, 부호화기의 수행 시간은 10% 감소되었다.
Determinants of Nicotine Dependence in Chronic Obstructive Pulmonary Disease
( Yun Su Sim ),( Jin Hwa Lee ),( Ki Uk Kim ),( Seung Won Ra ),( Hye Yun Park ),( Chang-hoon Lee ),( Deog Kyeom Kim ),( Kyeong-cheol Shin ),( Sang Haak Lee ),( Hun Gyu Hwang ),( Joong Hyun Ahn ),( Yong 대한결핵 및 호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.3
Background: Smoking cessation is the most powerful intervention to modify progress of chronic obstructive pulmonary disease (COPD), and nicotine dependence is one of the most important determinants of success or failure in smoking cessation. We evaluated nicotine dependence status and investigated factors associated with moderate to high nicotine dependence in patients with COPD. Methods: We included 53 current smokers with COPD in the Korean Obstructive Lung Disease II cohort enrolled between January 2014 and March 2016. Nicotine dependence was measured by using Fagerstrom test for nicotine dependence (FTND). Cognitive function was assessed by Korean version of Montreal Cognitive Assessment. Results: The median FTND score was 3, and 32 patients (60%) had moderate to high nicotine dependence. The median smoking amount was 44 pack-years, which was not related to nicotine dependence. Multiple logistic regression analysis revealed that high education status (odds ratio, 1.286; 95% confidence interval, 1.036-1.596; p=0.023), age <70 (odds ratio, 6.407; 95% confidence interval, 1.376-29.830; p=0.018), and mild to moderate airflow obstruction (odds ratio, 6.969; 95% confidence interval, 1.388-34.998; p=0.018) were related to moderate to high nicotine dependence. Conclusion: Nicotine dependence does not correlate with smoking amount, but with education level, age, and severity of airflow obstruction. Physicians should provide different strategies of smoking cessation intervention for current smokers with COPD according to their education levels, age, and severity of airflow obstruction.
Developed of Automotive Bolt Supply and Automatic Quantity Feeder for Productivity Improvement
Byeong Ro Min,Mueng Gyu Park,Se Hun Oh,Kwee Bo Sim,Se Bu Oh 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-
The existing bolt quantity detection method is inconvenient for the operator to use in the field because the bolts are placed on the plate in order to grasp the total quantity and the thread is inserted and aligned in the holes. In this study, we developed a device that automatically detects the quantity of bolts by detecting the bolts to improve the convenience and assembly speed of workers. The objective of this study is to apply the optimum bolt quantity detector to the field by analysis after laboratory experiment using the designed bolt quantity detector. Experimental design has 81 experimental specimens of 3, 5, 7 in diameter and 5, 7, 10 mm in length, and 10, 15, 20, 25, 30, 35, 40, 50° of the angle of the alignment part. Each experimental specimen was measured 100 times and then the mean value was applied to find the optimum angle. After 100 measurements of the diameter and length of a bolt, the number of repetition was the lowest for the average value when the bolt diameter was 5. In the development of machine bolt quantity detector, the length was more important than the diameter of the bolt.
IgA 신증 환자들에서 스테로이드와 안지오텐신 2 수용체 차단제의 병합 투여 효과
이상훈 ( Lee Sang Hun ),심재준 ( Sim Jae Jun ),이상호 ( Lee Sang Ho ),이태원 ( Lee Tae Won ),김명재 ( Kim Myeong Jae ),양문호 ( Yang Mun Ho ),임천규 ( Im Cheon Gyu ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5
배 경 : IgA 신증 환자들에서 고용량의 스테로이드 치료가 단백뇨 감소 및 신보호 효과가 있으며, 안지오텐신 Ⅱ 수용체 차단제 (ARB) 투여도 도움이 된다는 보고들이 있다. IgA 신증 환자들에서 이 두 가지 약제를 병합 투여함으로써 단백뇨 및 신기능에 부가적 효과가 있는지를 전향적 연구로 알아보고자 하였다. 방 법 : 신생검으로 IgA 신증을 진단 받고 1일 1 g 이상의 단백뇨와 혈청 크레아티닌이 2.0 ㎎/dL 이하인 42명의 환자를 무작위로 스테로이드와 ARB의 병합 투여군과 ARB 단독 투여군 으로 나누어 추적 관찰하였다. 결 과 : 병합 투여군은 18명, ARB 단독 투여군은 20명이 추적 관찰되었으며 추적기간은 각각 15.4±3.5 및 19.8±7.4개월이었다. 24시간 단백뇨량은 병합 투여군이 치료 전 4.67±5.33 g에서 0.78±0.99 g으로, ARB 단독 투여군이 4.31±2.85 g에서 1.38±1.09 g으로 유의하게 감소하였다. 추적 후 완전 관해율은 병합 투여가 44%로서 ARB 단독 투여의 10%에 비해 유의하게 높았다. 혈청 크레아티닌은 두 군 모두 치료 시작 전과 후에 통계학적으로 유의한 변화는 없었으며 (병합 투여군: 1.33±0.38 ㎎/dL->1.33±0.46 ㎎/dL, ARB 단독 투여군 : 1.08±0.39 ㎎/dL->1.32±0.79 ㎎/dL), 두 군 사이에도 차이가 없었다. 신기능 악화 증례도 병합 투여군이 1명 (5%), ARB 단독 투여군이 5명 (25%)이었다. 부작용으로는 병합 투여군에서 1예의 당뇨병과 1예의 당불내성이 발생하였다. 결 론 : 두 치료법 모두 단백뇨 감소에 효과적이었으며, 스테로이드와 ARB의 병합요법에서 완전 관해율이 더 높았다. 두 치료법의 신기능 보존 효과의 여부는 더 장기적인 추적 관찰이 필요하다고 생각된다. Background : It has been reported that prednisolone (PDL) therapy favorably influences proteinuria and renal function in the patients with IgAN in whom ARB as well as ACE inhibitor has an anti-proteinuric effect. Therefore, we did a controlled prospective trial to test the effect of treatment with PDI, (daily high- dose for 6 months) and ARB in proteinuric adult patients with IgAN. Methods : Forty-two patients with proteinuria ≥1.0 g/day and serum Cr ≤2.0 mg/dL were randomized to treatment with PDL and ARB and to that with ARB alone. Results : The follow-up period lasted 15.4±3.5 months in combination group (n=18) and 19.8±7.4 months in ARB group (n=20). Proteinuria was significantly reduced in the both groups (ARB group: from 4.31±2.85 g to 1.38±1.09 g vs. combination group: from 4.67±5.33g to 0.78±0.99 g). The rate of complete remission was 10% in ARB group and 44% in combination group at the final follow-up (p<0.05). There were no differences of mean serum Cr between groups before and after treatment. The number of patient with aggravation in renal function was five (25%) in ARB group and one (5%) in combination group. Conclusion : This study shows that the urinary protein excretion was effectively reduced by both groups and the rate of complete remission was higher in combination group than in ARB group. Long-term follow-up may be helpful to define the effect on the renal function in IgAN patients.