함평만 갯벌 조간대의 식생분포 및 현존량

이승호,이점숙,김종욱,김하송,임병선 木浦大學校 沿岸環境硏究所 1998 沿岸環境硏究 Vol.15 No.1

함평만 조간대 염생식물조사를 위하여 염생식물군락이 형성된 6개지역을 선정하여 식생분포 및 현존량을 조사하였다. 우점군락은 퉁퉁마디군락(Salicoenia herbacea community), 칠면초군락(Suaeda japonic community), 나문재군락(Suaeda asparagoides community), 좀보리사초군락(Carex pumilalini community), 가는갯능쟁이군락(Atriplex gmelini community), 갯개미취군락(Aster tripolium community), 갯잔디군락(Zoysia sinica community), 해홍나물군락(Suaeda maritima community), 갯질경군락(Limonium tetragonun community), 갈대군락(Phragmites communis community), 실망초군락(Erigeron bonariensis community)으로 구분되었다. 염생식물 군락의 생산량은 1,680∼2,170 g.d.w./㎡으로 갈대군락이 가장 높았고, 갯잔디 군락이 310∼500 g.d.w./㎡으로 가장 낮았다. The coastal vegetation was classified by the Braun-Blanquet's method and the biomass was investigated at the wetland of Hampyung-Man. The vegetation of the study area was classified with 11 coastal communities as follows: Salicornia herbacea community, Suaeda japonica community, Suaeda asparagoides community, Carex pumilalini community, Atriplex gmelini community, Aster tripolium community, Zoysia sinica community, Suaeda maritima community, Limonium tetragonun community, Phragmites communis community, Erigeron bonariensis community, Biomass was highest in Phragmites communis community (1,680∼2,170 g.d.w./㎡) and lowest in Zoysia sinica community (310∼500 g.d.w./㎡).

저항을 이용한 프로판-공기 혼합가스의 점화한계 개선에 관한 연구

이춘하,오종용,옥경재,지승욱,이광식,심광렬 한국화재소방학회 2004 한국화재소방학회논문지 Vol.18 No.1

본 논문은 IEC형 불꽃점화 시험장치를 이용하여 저압 유도회로의 최소 점화한계를 프로판-공기 5.25 Vol.%의 혼합 가스에 대하여 실험적으로 구하였으며, 또한 유도회로의 인덕턴스 L에 안전소자로서 저항을 병렬접속하였을 경우 프로판-공기 5.25 Vol.%의 혼합 가스에 대한 점화한계 개선효과를 관찰하였다. 그 결과, 최소 점화한계는 전류의 크기에 따라 좌우되었다 또한, 전원으로부터 공급되는 에너지는 인덕턴스에 우선 축적되고. 그 초과분의 에너지가 폭발성 가스의 점화원으로 작용하였다. 점화한계 개선효과는 인덕턴스가 300 mH일 때, 최고 330%의 개선효과가 나타났으며 인덕턴스가 클수록 점화한계 개선효과가 크게 나타났다. 또한 병렬로 접속한 저항의 크기가 적을수록 점화한계 개선 효과가 크다. 본 연구결과는 본질안전 방폭형 전기기기의 연구개발을 위한 기본자료로 활용할 수 있을 뿐만 아니라 이들 기기의 방폭성능에 대한 시험자료로도 활용이 가능할 것으로 사료된다. This paper describes the minimum ignition limits for propane-air 5.25 Vol.% mixture gases in low voltage inductive circiuts. The improved effects on the ignition limit are studied by parallel safety components(resistors) for propane-air 5.25 Vol.% mixture gas in low voltage inductive circuits. The experimental devices used in this test are the IEC type spark ignition test apparatus. The minimum ignition limits are controlled by the values of current in inductive circuit. Energy supplied from elect source is first accumulated at the inductance, it's extra energy is working as ignition source of the explosive gas. The improved effects on the ignition limit are respectively obtained as the maximum rising rate of 330% by composing parallel circuits between inductance and resistor as compared with disconnecting inductance with the safety components. The more values of inductance increase the higher improved effects of ignition limit rise. The less values of resistor the higher improved effects of ignition limit rise. It is considered that the result can be used for not only data for researches and development of intrinsically safe explosion-proof machines which are applied equipment and detectors used in dangerous areas but also for datum for its equipment tests.

환경친화적 수용성 대전방지제의 합성 및 그 응용에 관한 연구

조승현,하진욱 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2

Water soluble anti-static coating composition(AS-2001), multi-functional(anti-static and slip-stop)and anti-static functional paint coating agents were formulated. Firstly, the multi-functional coating agents were formulated with AS-2001 and slip stop(SㆍS) with water-born polyurethane. The additive of multi-functional coating agent varied from 5 to 12 wt%, depending on the amount of polyurethane used. The optimum amount of coating agent was 10 wt%, The ratio of coating composition AS-2001: SㆍS was 8:2. The surface resistance and friction factor of coated layer were 10^(9)Ω/㎠ and 0.88 in optimum condition, respectively. Secondly, the anti-static functional paint was formulated with AS-2001 and water soluble paint. The additive amounts of AS-2001 are varied from 5 to 20 wt% depending on the amount of water soluble paint. Results showed that the surface resistance of coated gypsum board decreased up to 10^(6)Ω/㎠ as the amount of coating agent increased. However, water soluble paint was aggregated in 20wt% addition of AS-2001, causing coating problems. Anti-static and anti-stain effects were excellent even though 5 wt% of AS-2001 was added in the board.

건전지의 본질안전 방폭성 평가에 관한 연구

지승욱,이광식,이동인,박원주,이춘하,김하호 嶺南大學校 工業技術硏究所 1997 工業技術硏究所論文集 Vol.25 No.1

Ignitability of explosive gas mixture by spark of dry cell in case of short circuit by accident was studied for the purpose of evaluation of intrinsically safe characteristics of dry cell that manufactured in Korea. IEC type spark test apparatus, 21±2[vol%] of hydrogen-air mixture, and dry cell that produced in Korea was used for the experiment. The result of this research could be used for design, manufacturing and using the intrinsically safe electrical apparatus.

위선암에서 p53과 EGFR 및 PCNA 발현에 관한 연구

강현욱,양승하,강상균 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Expression of oncogene in the gastric adenocarcinoma was considered as a determinant factor of cancer progression or prognosis by some authors, however, the results were so fluctuated according to the authors that there was no uniform agreement in their clinicopathological correlation as well as in its practical application. To evaluate correlation between the pathologic finding and the expression of p53, EGFR and PCNA, immunohistochemical studies were performed on paraffin-embedded sections of 84 gastric adenocarcinomas. Pathologic findings were classified as 4 subgroups by their histologic types, differentiation, invasion and lymph node metastasis. The correlation of PCNA labelling index with various clinicopathologic factors and oncogene expression was studied. The results were as follows; 1. p53 expression was seen in 47cases(55.56%) of gastric carcinoma, and correlation between p53 expression with tumor type, differentiation, invasion and lymph node metastasis was not proved. EGFR positive expression was found in 37(44.05%) cases and was increased in advanced gastric carcinoma, and cases of lymph node metastasis. 2. Co-expression of p53 and EGFR was observed in 18 cases(33.33%), suggesting existence of both oncogene in the same case, while both negative cases were 18 cases(33.33%) that suggest the possibility of presence of the other factors. 3. PCNA labelling index was higher in advanced gastric carcinoma and in cases of lymph node metastasis, but there was no statistical significance. 4. There was no statistical significance between PCNALI and p53 expression. 5. PCNALI and EGFR expression was parallel with pathologic finding such as differentiation, progression and metastasis of the carcinoma, these results suggest that there was significant correlation between PCNALI and EGFR. 6. PCNALI was statistically significant between two groups of both p53 and EGFR positive and both negative. 7. PCNALI showed statistical significance between EGFR positive and negative groups in cases of lymph node metastasis. In summary, the value of p53 expression as a prognostic factor was still doubtful but EGFR and PCNA expression tended to be associated with tumor progression and seemed to be objective and reliable prognostic factors, respectively. Combined method of EGFR and PCNA thought to be more helpful in preoperative decision or prediction of prognosis in gastric carcinoma.

Fosfomycin의 항균효과 및 capillary electrophoresis에 의한 측정법에 관한 연구

윤효인,박승춘,이규승,권진욱,조준형,신광순,김무열,허강준,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

Fosfomycin, a low molecular antibiotic, is to be easily synthesized, therefore to be possibly used in veterinary sectors due to econimic reasons. In this study, we determined the antibacterial activities of fosfomycin against some domestic animal-origin pathogens, and its combined effects with some important antibacterials available. We also compared detection methods of fosfomycin from various measuring instruments. The results obtained through this experiment were as follows: 1. Antibacterial activities of fosfomycin against the pathogens used in this experiment were appeared fairly low. We found the antobacterial activities depanded on the kinds of media and the addition of some material thereins, which suggests the importance of appropriate medium so as to judge the antibacterial activity of fosfomycin. 2. Fosfomycin showed varying antibacterial effects in combination with other antibacterials, which should be taken into consideration when combining other antobacterials especially in the clinical settings. Of the combined antivacterials, fosfomycin had synergistic effects in combination with amoxicillin but antagonistic effects with oxytetracyline. 3. Conventional detection methods using HPLC, GC and spectrophotometer were not appropriate to measure fosfomycin. Capillary electrophoresis by the way of the indirect ultraviolet detection method was good enough to detect fosfomycin in the range of expected concentration in tissues, with the limit of quantitation (LOQ) of 1.25 ㎍/㎖. We recommend the eletrophoresis method could be used to detect fosfomycin, thereby being able to set the optimal dosage for animals and providing the measures in relation with the residual concentration in the meat.

정상과 만성염증성 활막배양세포에서 Corticotropin releasing hormone(CRH)이 cyclooxygenaase-1(COX-1)과 cyclooxygenase-2(COX-2) mRNA발현에 미치는 영향

정운원,이승관,이창규,조경진,김성욱,하주희,서장훈 高麗大學校 倂設 保健大學 保健科學硏究所 2000 保健科學論集 Vol.26 No.1

Corticotropin-releasing hormone(CRH) is a major regulator of the hypothalamic-pituitaryadrenal axis(HPA). In inflammatory stress, the cytokines TNF-, IL-6 stimulate the production of CRH, a 41 amino acids neuropeptide, in the hypothalamus. The release of CRH leads to pituitary production of adrenocorticotropic hormone, followed by glucocorticoid secretion by the adrenal cortex. Glucocorticoids suppress namy components of the inflammatory process. Recently, CRH and CRH receptor were reported to be located in the periphery such as Immune system and chronic inflammatory sites as rheumatoid arthritis (RA). Cyclooxygenase consisted of two isoforms, COX-1 and COX-2, converts arachdonate to prostaglandins(PGs) which are important mediators of inflammation. insymoviocyte in RA, it was described that COX-2 mRNA was markedly increased by inflammatory agents, PMA or IL-1 and COX-1 transcripts were not modulated. We examined the modulation of COX by immune CRH in cultured normal and rheumatoid synoviocytes. Our results were shown that COX-1 mRNA expression decreased with the each stimulation of PMA and IL-1 in normal synoviocyte. In RA synoviocyte, PMA and IL-1 were increased mRNA expression of COX-1. In simultaneous treatment with CRH, PMA group was decreased, but IL-1 group was increased mRNA expression of COX-1. COX-2 mRNA expression was slightly increased by the treatment with PMA and highly increased by IL-1. After CRH treatment, PMA and IL-1 addictively increased COX-2 mRNA expression. We think that these results are contributed to the influence of increased cANP by CRH on the promoter of COX-2 in normal and synoviocytes. Because many cytokines, neuropeptides, and signal transduction pathways are involved in chronic inflammation, the exact role of CRH on inflammation is not fully elucidated. To achieve this goal, further experiments are needed.

아동의 눈-사지 협응과 물체조작 기술의 관계

김선진,한동욱,박승하,김용호 한국스포츠심리학회 2003 한국스포츠심리학회지 Vol.14 No.2

본 연구의 목적은 아동의 눈-사지 협응 능력과 물체조작 기술의 차이를 알아보고, 두 변인군의 관계를 구명하는 데 있다. 피험자는 남?여 5-10세의 아동 186명을 대상으로 하였다. 눈-사지 협응 능력은 예측 타이밍 능력, 추적 능력, 전신 반응 능력을 측정하여 분석하였으며, 물체조작 기술은 TGMD(Test of Gross Motor Development)에서 제시한 받기, 던지기, 치기, 차기, 튀기기 기술을 평가하였다. 먼저 눈-사지 협응 능력과 물체조작 기술의 연령과 성별에 따른 특성을 알아보기 위해 이원 변량분석을 실시한 결과, 5세의 아동 집단은 전반적으로 수행능력이 6세, 7세, 8세, 9세, 10세의 아동에 비하여 수행능력이 떨어졌으며, 10세의 아동은 다른 연령 집단에 비하여 우수한 수행능력을 나타냈다. 이러한 결과는 5-6세, 9-10세의 연령 시기가 눈-사지 협응 능력과 물체조작 기술이 변화되는 시기임을 나타내주고 있으며 이는 연령에 따른 특징을 보여주는 것이다. 다만 눈-사지 협응 능력과 다르게 물체조작 기술에 있어서는 성별에 따른 수행 능력이 9세와 10세의 연령 집단에 있어서 상반된 특징이 나타났다. 즉 남자 아이들의 경우, 9세의 연령 집단과 비교하여 10세의 연령 집단은 물체조작 기술의 수행 능력이 급격하게 증가한 반면에 여자 아이들은 수행 능력이 떨어지는 특징을 보였다. 또한 눈-사지 협응과 물체 조작 기술간의 관계를 알아보기 위해 정준 상관분석을 실시한 결과, 두 과제간 상관계수 .599로 통계적으로 유의한 상관관계를 보였다. 이러한 결과를 바탕으로 눈-사지 협응 능력과 물체조작 기술의 관계를 설명해 주는 각 변인들의 상대적 기여도를 살펴보면, 눈-사지 협응 능력에서 손과 발을 사용한 예측 타이밍 능력이 추적 및 전신 반응 능력보다 높은 기여도를 보였다. 또한 물체조작 기술에 있어서는 받기와 튀기기 능력이 눈-사지 협응 능력과 물체조작 기술의 상관관계를 설명하는데 많은 기여를 하는 것으로 나타났다. The purpose of this study was to investigate the difference of eye-limb coordination and the object-control skills with age and sex, and examine the relationship between two-variable groups. For this experiment, 186 children with the age of 5 to 10(99 boys and 87 girls) participated in the study. The eye-limb coordination ability(anticipation timing ability, pursuit ability and reaction ability) and the object-control skill(catching skill, throwing skill, striking skill, kicking skill, bouncing skill) suggested in TGMD(Test of Gross Motor Development)were tested. The two-way ANOVA was used to present the characteristics of the eye-limb coordination ability and the object-control skills according to age and sex. As a result, children with the age of 5 demonstrated the lowest performance while children with the age of 10 showed high performance significantly among age groups. The children with the age of 5 to 6 and 9 to 10 were found to be two critical periods of change with age. However, unlike the eye-limb coordination ability, there was a distinctive feature in the object-control skills of the age 9 and 10 over sex. 10 year-old boys showed a radical progress, but the 10 year-old girls showed a decline on the object-control skills compared with the 9 year-old. A canonical correlation analysis was used to examie the relationship between the eye-limb coordination and the object-control skills for the early childhood. The relationship revealed significantly showing canonical correlation with coefficient .599. Overall, the results indicated the eye-limb coordination ability such as anticipation timing ability with hand and foot showed higher role than pursuit and reaction ability. In addition, the object control skills such as catching and bouncing ability contributed importantly in explaining the relationship between the eye-limb coordination ability and the object control skill.

자동차 공조용 핀형 열교환기의 성능특성에 관한 연구

홍경한,전상신,이승재,박찬수,권일욱,김재열,김병철,하옥남 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4

Fin-tube type(Fin-type) heat exchanger has been tested in order to replace the heat exchanger of parallel flow type(P.F-type) which is now widly used in automobile air conditioning system. The following conclusions are drawn by the comparison of the characteristics of the heat exchangers. Evaporator and condenser capacities and COP(Coefficience of performance) were varied as with the compressor speed, outdoor air temperature and air flow rate changed, which much influenced on the characteristics of the air conditioning system. Evaporator and condenser capacities were increased with increasing compressor speed and outdoor air temperature. Evaporator and condenser pressures of Fin- type were decreased by 7% and 5% respectively compared with those of P.F-type. The COP of Fin-type was decreased with increasing outdoor air temperature and compressor speed. The COP of P.F-type was decreased by 14% compared with that of Fin-type.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.