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위암세포에 의한 종양침윤 림프구의 면역반응 억제기전에 관한 연구
박정규,송규상,서광선,최정목,배진선,장일성,윤완희,노승무,조은경,백태현 大韓免疫學會 1995 大韓免疫學會誌 Vol.17 No.3
Tumor-infiltrating lymphocytes ('1°ILs) interact most closely with tumor cells and thus are more likely to reflect tumor host interactions accurately. But it is unknown whether such T cells are nonspecific inflammatory cells or a subset of specific host immune responses. In this study, there was no clear correlation between the infiltration of T lymphocytes in stomach cancer and the overexpression of c-ErbB-2 or increasing class I MHC expression on tumor cells. A positive correlation was seen between the presence of TILs in the tumor and tumors with diploidy by flow cytometric DNA analysis. The proliferative responses of Ills stimulated with IL-2, anti-CD3 mAb, or both were examined. When compared to normal mucosal-associated lymphoid tissue lymphocytes, the proliferative response of TILs to high dose IL-2 was minimal. A similarly poor response to anti-CD3 mAb plus IL-2 was also observed. The freshly isolated TILs exhibit reduced ability to proliferate in response to IL-2, anti-CD3 mAb or both. The microenvironment of the tumor suppresses the proliferative capacity of the TILs. The mechanism of this suppression remains unknown. It could be mediated by suppressor cells, by soluble substances within the tumor, or both. To examine this question, supernatants of stomach cancer cells (SNSNU-1) were tested for the presence of immunosuppressive factors. Human peripheral blood T-cells and tumor-draining lymph node lymphocytes (TDLNL) were incubated for 3 days with SNSNU-1 and then assessed for proliferative responses to PMA, anti-CD28 mAb, or both and for the inducibility to express IFN- r or IL-4 mRNA to PMA. Peripheral blood T-cells pretreated with SNSNU-1 were unable to proliferate in response to PMA, anti-CD28 mAb or both. SNSNU-1 also produces inhibitory activities of TDLNL proliferative response to PMA or anti-CD28 mAb and PMA (49%, 52%, respectively). In contrast, culture supernatants obtained from HEp-2, K562 or Daudi showed normal proliferative responsiveness of peripheral blood T-cells and TDLNL by PMA, anti-CD28 mAb or both.
강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-
과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.
Effect of Testosterone Supplementation on Cognition in Elderly Men: A Systematic Meta-Analysis
Seung Wan Hong(Seung Wan Hong),Yoon Jeong Cho(Yoon Jeong Cho),Jae Hyuck Lee(Jae Hyuck Lee),Young Sung Suh(Young Sung Suh),Dae Hyun Kim(Dae Hyun Kim) 대한임상노인의학회 2023 대한임상노인의학회지 Vol.24 No.1
Background: Cognitive function is an important issue in aging societies. Testosterone levels and cognitive function are known to be correlated; however, the clinical conclusions remain controversial. This study aimed to investigate whether testosterone supplementation improve cognitive function in adult men through a systematic meta-analysis. Methods: A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The PubMed, Cochrane Library, and Embase databases were searched. Literature search, study identification, and data extraction were performed between December 2019 and March 2021. Results: A total of 15 studies were included in the meta-analysis. The sample sizes of the selected studies varied from 11 to 493. There were no significant differences in cognitive speed (standardized mean difference [SMD]=−0.05; 95% confidence interval [CI], −0.26 to 0.16), immediate verbal memory function (SMD=0.07; 95% CI, −0.05 to 0.20), immediate visual memory function (SMD=−0.01; 95% CI, −0.15 to 0.13), working memory function (SMD=−0.04; 95% CI, −0.42 to 0.35), delayed memory function (SMD=−0.02; 95% CI, −0.14 to 0.10), executive function (SMD=0.03; 95% CI, −0.08 to 0.15), perception (SMD=−0.13; 95% CI, −0.37 to 0.11), cognitive inhibition (SMD=−0.13; 95% CI, −0.49 to 0.23), visual attention (SMD=−0.02; 95% CI, −0.16 to 0.11), and cognitive status scores (SMD=−0.02; 95% CI, −0.18 to 0.14). Conclusion: The findings of this study indicate that there is a lack of evidence that testosterone administration has an effect on preventing cognitive decline. Therefore, testosterone use to prevent cognitive decline may not be recommended.
서승완(Seung Wan Suh),곽아름(Ah Reum Gwak),임재아(Jae-A Lim),이지윤(Jiyoon Lee),박수미(B.A. Su Mi),이준영(Jun-Young Lee),정희연(Hee Yeon Jung),손보경(Bo Kyung Sohn),최삼욱(Sam-Wook Choi),김대진(Dai Jin Kim),최정석(Jung-Seok Choi) 한국중독정신의학회 2015 중독정신의학 Vol.19 No.1
Objectives : Although Internet Gaming Disorder (IGD) is an important phenomenon, its impact on subjective happiness is less appreciated. This study aimed to compare the quality of life (QOL) and psychosocial well-being of individuals with IGD with those of individuals with alcohol dependence (AD) and healthy controls (HC). Methods : Eighty-six subjects were divided into two groups seeking outpatient treatment, one for IGD (n=37) and the second for AD (n=21), as well as a HC group (n=28) which was age-matched to the IGD group. Participants completed the World Health Organization’s Quality of Life assessment - Brief Form (WHOQOL-BREF) and the Psychosocial Well-being Index (PWI) questionnaire, which measures levels of distress. Results : Both addiction groups had lower scores in all WHOQOL-BREF domains (general, psychological, physical health, social relationships, and environmental) com pared with the HC group. Additionally, both addiction groups showed higher PWI scores than the HC group, indicating higher levels of distress in the former groups. However, no significant difference in PWI was found between the IGD and AD groups. Conclusion : Those with IGD reported poorer QOL and higher levels of distress compared with HCs, but their QOL and dis-tress scores were comparable to those of AD subjects. Thus, individuals with IGD require assistance to manage their distress.
Developing a Decision Making Model for Selecting an IT Post-Merger Integration Strategy
Suh, Byung-Wan,Baek, Seung-Ik Korea Data Strategy Society 2012 Journal of information technology applications & m Vol.19 No.3
M&A (Merger and Acquisitions) is a standard corporate strategy frequently used by companies seeking to secure new growth engines and gain a solid foothold in their markets in order to become more globally competitive. To achieve the original goals of M&A, the two involved parties need to invest significant time and resources in integrating all aspects of the companies. A well-planned post-merger integration of information technology (IT PMI) by the two M&A parties is considered a crucial and difficult process because IT provides a fundamental infrastructure for integration. Considering various internal and external factors, the two parties normally formulate an IT PMI strategy. The many IT PMI strategies can be categorized into four major types: Renewal, Takeover, Standardization, and Synchronization. This study aims to develop a decision making model to help merger company and IT managers select the proper IT PMI strategy. More specifically, we identify key determinants that need to be considered when selecting a proper IT PMI strategy. The relative importance of each determinant is defined by analytic hierarchy process (AHP) analysis. Finally, this study evaluates each IT integration strategy under the identified determinants.
Suh, Jae Wan,Lee, Jin Woo,Park, Jun Young,Choi, Woo Jin,Han, Seung Hwan Elsevier 2018 The Journal of foot and ankle surgery Vol.57 No.3
<P><B>Abstract</B></P> <P>Chronic peroneal tendon dislocation is an uncommon disorder that frequently presents with concomitant pathology. Posterior fibular groove deepening and retinaculum repair have been increasing in popularity for treatment of peroneal tendon dislocations. The purpose of the present study was to introduce a posterior fibular groove deepening procedure using low-profile snap-off screws to securely and simply fix the fibrocartilaginous flap to facilitate faster rehabilitation and to assess the clinical outcomes of patients with chronic peroneal tendon dislocation and associated pathologic features. In the present retrospective case series, 34 ankles in 34 patients underwent the fibular groove deepening procedure using low-profile screws with superior peroneal retinaculum repair. The clinical outcomes were evaluated using the American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot scale and patient subjective satisfaction rate. The time of return to recreational and sports activities was also assessed. Weightbearing ankle radiographs were evaluated to assess the stability of the flap by checking the screws. The mean follow-up period was 47.96 (range 12 to 142) months. The mean AOFAS scale score for all patients improved from 69.96 ± 13.14 to 87.72 ± 10.13 at the last follow-up examination (<I>p</I> < .001). Overall, 85.3% of patients subjectively rated their operative outcomes as excellent or good. The 18 (52.9%) patients with an isolated peroneal tendon dislocation had a faster return to recreational or sports activities than the 16 (47.1%) patients with concomitant pathologic features (2.95 ± 0.19 versus 4.14 ± 1.34 months; <I>p</I> = .002). No patient experienced residual dislocation, screw loosening, or irritation from the screws. The fibular groove deepening procedure using low-profile screws is be a simple procedure that offers rigid fixation. This leads to relatively fast rehabilitation and resumption of recreational or sports activities.</P>