연관규칙 데이터마이닝 기법을 이용한 전문 검색엔진 설계 및 구현

승현우,황정민,박미영 서울여자대학교 컴퓨터과학연구소 2003 정보기술논문지 Vol.1 No.-

본 논문에서는 검색엔진의 효율성을 높이기 위해서 연관규칙 데이터마이닝 기법을 이용한 전문 검색엔진을 설계 및 구현하였다. 연관규칙 탐사 기법인 Apriori 알고리즘을 이용하여 전문 용어별로 의미적으로 연관된 용어들을 클러스터로 구성해서 지식베이스 테이블을 구축하였다. 그리고 지식베이스 테이블을 이용하여 사용자가 제시한 키워드와 연관 정도가 높은 전문 용어를 포함한 문서를 검색하였다. 제안된 방법의 효율성을 검증하기 위하여 문헌정보학 전문 검색엔진을 구현하여 기존의 상용 검색엔진과 동일 키워드를 대상으로 검색 결과를 비교하였다. 비교 결과 기존의 검색엔진의 출력 결과보다 정확한 지식 정보를 포함한 문서를 효율적으로 검색할 수 있었다. In this research, we designed and implemented an expert search engine using the association rules which is one of the typical data mining techniques in order to enhance the efficiency of the search engine. First, we gathered technical terminologies and grouped them into clusters according to their association, and built a knowledge base. Second, using the knowledge base table, we tried to retrieve documents including terms highly associated with the keyword given by the user. In order to verify the efficiency of the proposed method, we constructed a search engine for the area of the library and information science, and compared it with the existing engines. As a result, we found the proposed engine search more accurate documents more efficiently than the existing engines.

장내의 탄수화물과 지방 흡수 억제를 통한 체지방 및 비만 개선 효과에 관한 연구

정은희,윤승원,이홍석,윤유식,유경미,황인경 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

In a previous study, a dietary supplement was developed in our lab using natural herbal extracts against digest enzyme activity in GI tract for weight control. This natural herbal extracts could regulate absorption of glucose and lipid by the inhibition of digest enzyme activity. In this study, we screened the natural herbs that inhibit glucoamylase activity and developed an water extract of cinnamon. The cinnamon extract delayed and decreased the increment of carbohydrate degradation through the inhibition of glucoamylase activity in vitro. Fifty volunteers were subjected to the intake of the herbal extracts by taking twice a day for 60 days. As a result, the treated subjects lost 3kg of body weight and 3.5kg of body fat mass after the treatment. Furthermore, the body mass index and waist size were significantly decreased during the experimental period. Above results suggested that the administration of the dietary additives composed of cinnamon and natural herbal extract improves the obesity by the decrement of body weight and body fat mass.

미치광이풀 모상근 배양에서 Tropane Alkaloid 생산성 증진을 위한 최적 생물학적 엘리시터 선발

정희영,강승미,강영민,김용덕,양재경,정영관,최명석 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Scopolamine and hyoscyamine which belong to tropane alkaloids are the pharmaceutically valuable anticholinergic drugs. In order to increase the productivities, the effects of elicitation were investigated during hairy root cultures of Scopolia parviflora. Biotic elicitors originated from 3 fungi and 1 yeast were prepared as homogenate and supernatant and added to 3-week-old cultures. Both of homogenate and supernatant of Candida albicans elicitors increased the scopolamine production. The production of hyoscyamine was enhanced by homogenate of Fusarium solani and supematant of C. albicans. Most of the other fungal elicitors were also improved on the tropane alkaloid production compared to non-treatment. Among the elicitors tested, C. albicans was proved the optimal biotic elicitor on tropane alkaloids production. These results will be served mass production of tropane alkaloids by large-scale production.

N-nitrosodiethylamine을 투여한 쥐의 간조직에서 polyamine과 c-AMP의 생성에 관한 연구

鄭夏承,金瑛洙,李美景,朴澤奎 建國大學校基礎科學硏究所 1990 理學論集 Vol.15 No.-

쥐에 N-nitrosodiethyamine을 복강주사하여 간조직에서의 polyamine과 c-AMP의 변화에 대하여 연구하였다. HPLC로 분석한 결과, polyamine과 c-AMP의 농도는 복강주사후 3일에 대조군에 비해 약 1.2배 증가하는 현상을 나타내었으며, 10일에 각각 3.6배와 1.2배 증가하였다. spermidine과 spermine농도의 증가는 c-AMP와 관련이 있는 것으로 보이며, 조직에서 polyamine과 c-AMP측정으로 종양의 임상화학적 진단에 유용하게 활용될 것으로 기대된다. The change of polyamine and c-AMP content in the liver of rat were investigated after a single intra peritoneal injection of N-nitrosodiethylamine. These compounds were analyzed quantitatively by HPLC. Both polyamine and c-AMP concentrations showed a slight increase at 3days after injection and elevated to a level about 1.2 times higher than of control value. Polyamine and c-AMP concentrations increased to 3.6 and 1.2 fold of control at 10 days after the N-nitrosodiethylamine injection. An increase in spermidine and spermine concentration may be related to c-AMP. The data suggested that the determination of polyamine and c-AMP level may have clinical utility for tumor monitoring.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

진피내 모반, 경계 모반 및 악성 흑생종에서 p53과 Ki-67의 발현 양상

이정훈,양승하,오미혜,김의한 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The authors analyzed immunohistochemical expression of mutant p53 and Ki-67 in eleven cases of intradermal nevus, 7 cases of junctional nevus and 6 cases of malignant melanoma, so following results were obtained. Results: 1. The positive reaction of p53 protein was 0%(0/11) in intradermal nevus, 43%(3/7) in junctional nevus and 83%(5/6) in malignant melanoma. 2. The positive reaction of Ki-67 was 9%(1/11) in intradermal nevus and 14%(1/7) in junctiona nevus, but the labelling index were below 10% in both nevi. In malignant melanoma, the positive reaction of Ki-67 was appeared in 50% (3/6). but the labelling index were below 20% in all positive cases Above results suggested that the p53 expression was stronger in poor differentiated tumors, so the p53 protein expression appeared to be related to the histological differentiation degree. But the Ki-67 expression appeared to be more related to the prognosis according to tumor growth rate than histological differentiation degree Because the Ki-67 labelling index was low in malignant melanoma as expected, it was difficult to justify the idea that the growth and prognosis of malignant melanoma were justified only by the Ki-67 positive reaction and labelling index. But the Ki-67 positive cells were not almostly observed in intradermal nevus and junctional nevus, So the differnetial diagnosis between benign and malignant melanocytic tumors were appeared to be possible by Ki-67 positive reaction and labelling index.

다입력 계통에 대한 새로운 최적 슬라이딩 모드제어기

박승규,남징락,진미정 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

In this paper, a novel sliding surface is proposed by defining a novel virtual state. This sliding surface has nominal dynamics of an original system and makes it possible that the Sliding Mode Control(SMC) technique is used with the various types of controllers. Its design is based on the augmented system of which dynamics have a higher order than that of the original system. The reaching phase is removed by using an initial virtual state which makes the initial sliding function equal to zero.

지역문화 교육을 위한 콘텐츠 개발과 활용 방안

백승국,이미정 경북대학교 사범대학부속 중등교육연구소 2006 중등교육연구 Vol.54 No.2

폐 활성 슬러지의 납 흡착에 따른 기초 요소의 영향

강미영,서정호,이창한,이송우,나영수,송승구 부산대학교 환경문제연구소 1998 環境硏究報 Vol.16 No.-

본 연구에서는 하수 처리장에서 발생되는 상당량의 폐 슬러지를 전처리 없이 중금속 제거에 사용하였다. 본 연구의 목적은 폐 슬러지를 이용하여 중금속을 제거하는 것이다. 온도와 pH, 초기 농도의 영향과 보관 시간에 따른 납 흡착량의 영항을 흡착등온 모델과 흡착속도 모델에 적용시켜 활성슬러지의 납 흡착 특성을 고찰하였다. 납, 카드뮴, 크롬, 니켈 중 슬러지는 납을 가장 많이 제거하였고, pH 4.5~5.5에서 최대의 흡착량을 나타냈으며, 온도가 증가할수록 흡착량은 증가하였고, Langmuir model에 잘 적용되었으며, 초기 최대 흡착속도도 Michaelis-Menten 형태 식으로부터 구하였다. In sewage treatment plant, waste sludge was one of bothering thing to be treated. The objective of this study was to examine the removal of heavy metal by waste sludge. The effect of factors such as temperature, pH, storage time, initial concentration of lead, and initial amount of biomass on adsorption of lead was investigated. And the biosorption model, adsorption isotherm, and initial adsorption rate model were evaluated. Waste sludge was proved to have an excellent ability to remove lead than other heavy metals such as cadmium, chromium, nickel in pure and mixed solution. The optimum pH of biosorption with waste sludge was 4.5~5.5, and the amount of adsorption was increased with increasing temperature. The adsorption isotherm of lead to waste sludge followed to Langmuir model. The initial adsorption rate of lead to waste sludge followed to Michaelis-Menten type kinetic.