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Role of Coagulation Factor 2 Receptor during Respiratory Pneumococcal Infections
Shin, Seul Gi,Bong, Younghoon,Lim, Jae Hyang The Korean Society for Microbiology 2016 Journal of Bacteriology and Virology Vol.46 No.4
Coagulation factor 2 receptor (F2R), also well-known as a protease-activated receptor 1 (PAR1), is the first known thrombin receptor and plays a critical role in transmitting thrombin-mediated activation of intracellular signaling in many types of cells. It has been known that bacterial infections lead to activation of coagulation systems, and recent studies suggest that PAR1 may be critically involved not only in mediating bacteria-induced detrimental coagulation, but also in innate immune and inflammatory responses. Community-acquired pneumonia, which is frequently caused by Streptococcus pneumoniae (S. pneumoniae), is characterized as an intra-alveolar coagulation and an interstitial neutrophilic inflammation. Recently, the role of PAR1 in regulating pneumococcal infections has been proposed. However, the role of PAR1 in pneumococcal infections has not been clearly understood yet. In this review, recent findings on the role of PAR1 in pneumococcal infections and possible underlying molecular mechanisms by which S. pneumoniae regulates PAR1-mediated immune and inflammatory responses will be discussed.
COVID-19 예방을 위한 시설 관리 스마트 도어록 시스템
신슬기 ( Seul-gi Shin ),신슬비 ( Seul-bi Shin ),유기원 ( Ki-won Yoo ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
본 논문은 COVID-19 유증상자를 사전에 판별해 유증상자의 시설 출입을 제한하고, 비접촉 인증 방식인 RFID, 얼굴인식을 사용해 시설 내 COVID-19 집단 감염을 예방하는 시설 관리 스마트 도어록을 제안한다. 기존 디지털 도어록 및 스마트 도어록은 가정용으로 개발되어 많은 사람이 이용하는 다중 시설에서 사용하기에 불편하다. 본 연구에서 구현한 도어록은 아두이노 센서를 통해 시설 사용자의 체온과 산소 포화도 값을 받아 사용자의 COVID-19 증상 유무를 판단한다. 유증상자의 경우 경고음을 울려 시설 출입을 사전에 제한한다. 체온과 산소포화도 측정 후 비접촉 인증 방식인 RFID, 얼굴인식을 통해 시설 출입을 통제한다. 시설 관리자는 RFID, 얼굴인식, 도어록 전용 애플리케이션을 사용해 시설에 출입할 수 있다. 본 시스템을 통해 시설 관리가 편리해지고, 증가하고 있는 스마트 빌딩 및 무인 시설에 활용할 수 있다.
Seul Gi Oh,Shin Hwang,Suhyeon Ha,Heewon Kim,Lee Na Ryu 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.3
When the liver is divided into the right and left halves after central hepatectomy, a serious injury to the one half of the liver can destroy the ipsilateral half. We report a case showing total necrosis of the hepatic left lateral section (LLS) caused by blunt abdominal trauma in a patient who had undergone central hepatectomy and bile duct resection for perihilar cholangiocarcinoma. A 47-year-old female patient was transferred because of postoperative status following blunt abdominal trauma. Five years before, she had been diagnosed with perihilar cholangiocarcinoma. Since the tumor extent was compatible with Bismuth-Corlette type IV, she underwent central hepatectomy and bile duct resection. After five years, she experienced an industrial safety accident, in which a heavy refrigerator fell over her body. She underwent emergency duodenal diversion surgery with distal gastrectomy and Roux-en-Y gastrojejunostomy. During this surgery, serious ischemic injury of the LLS with occlusion of the left portal vein and hepatic artery was identified, but not treated. After three weeks, LLS necrosectomy with repair of the jejunal limb was done. Postoperative bile leak developed and required supportive care for two months for its healing. She is currently doing well without any physical discomfort four months after the necrosectomy. Our experience with this case suggests that an injury to the afferent jejunal limb requires an individualized treatment strategy including long-standing waiting with effective drainage for spontaneous healing. The experience of this case appears to be theoretically matched with late-stage resection of LLS following central hepatectomy and bile duct resection.
Shin, Yun Hee,Choi, Jihea,Margaret J. Storey,Lee, Seul Gi 기본간호학회 2017 기본간호학회지 Vol.24 No.3
Purpose: Competency in physical assessment is an important component of nursing practice. However, some physical assessment skills are not being utilized within the current teacher-centered, content-heavy curriculum. This study was conducted to identify the effects of student-centered, self-directed learning in the physical assessment class. Methods: An experimental study with a post-test only control group design was used to compare an intervention group that was provided self-directed learning classes and a control group that was provided traditional lecture and practice classes. Competency in physical assessment, academic self-confidence, and learning satisfaction were evaluated. Collected data were analyzed using x<SUP>2</SUP>-test (Fisher"s exact test) and independent t-test. Results: Competency in physical assessment was significantly higher in the experimental group. However, academic self-confidence and learning satisfaction were not significantly different between the groups. Conclusion: The findings in this study indicate that self-directed learning can improve nursing students competency in physical assessment and that self-directed learning is a good education method to improve nursing students" competency in physical assessment during clinical practice and perform quality patient care by making active use of physical assessment skills.