열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

원발성 유방암에서 Sodium Iodide Symporter의 발현과 ^(99m)Tc-MIBI 유방스캔의 관계

석주원,김성장,곽희숙,이창훈,김인주,김용기,배영태,김동수 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.6

목적: hNIS는 갑상선 조직 외에 다른 조직들에서도 발현된다고 알려져 있다. 유방암 세포는 그런 조직들 중에 하나이며, 그에 의한 유방암의 방사성옥소치료의 가능성이 제시되고 있다. 본 연구에서는 유방암 조직에서 hNIS의 발현정도를 알아보고, ^99mTc-MIBI 유방스캔과 hNIS의 발현 정도와의 관계를 조사하여 보았다. 대상 및 방법: 본 연구에서는 유방암으로 수술을 시행했던 56명의 환자를 대상으로 하였다. hNIS의 발현은 면역조직화학염색에 의해서 평가되었으며, 그 결과를 ^99mTc-MIBI 유방스캔의 판정 결과와 비교하였다. 결과: 전체 56명의 환자에서 hNIS의 발현율은 41.1%였다. 병리학적 진단에 의해 침윤성관상피암종이었던 49명에서의 발현율은 42.9%, 관상피내암종이었던 7명에서의 발현율은 28.6%였다. ^99mTc-MIBI 유방스캔에서 국소섭취 소견이 관찰되었던 41명에서의 hNIS의 발현율은 31.7%였다. 비정상적인 섭취 소견이 관찰되지 않았던 15명의 환자에서의 hNIS의 발현율이 의미있게 높게 관찰되었다(66.7%, p>0.05). 결론: 유방암 환자에서의 hNIS의 발현율은 그다지 높지 않았다. ^99mTc-MIBI 유방스캔에서 섭취증가 소견이 없을 때 hNIS의 발현율이 더 높았다. Purpose: Human Na^+/I- symporter (hNIS) is known to be expressed in many tissues other than thyroid gland. The breast cancer cells are one of them and the possibility of radioiodine therapy in treatment of the breast cancer may be suggested. We investigated the expression rate of hNIS and the relationship between the expression of hNIS and the finding of 99mTc-MIBI scintimammography in the breast cancer. Materials and Methods: Surgically proved 56 patients with breast cancer were the subjects of this study. The expression of hNIS were evaluated by immunohistochemistry and the results were compared to the findings of 99mTc-MIBI scintimammography. Results: Overall expression rate of hNIS was 41.1% in 56 patients. According to the pathologic diagnosis, it was 42.9% in 49 patients with invasive ductal carcinoma and 28.6% in the 7 patients with ductal carcinoma in situ. The expression rate of hNIS in the 41 cases with a focal increased uptake at he breast lesion on 99mTc-MIBI scintimammogram was 31.7%. That in the 15 cases without any abnormal uptake on the scan was significantly higher(66.7%, p<0.05). Conclusion: The expression rate of hNIS in the patients with breast cancer was not so high. The rate was higher in the patients with no increased uptake at the breast lesion on 99mTc-MIBI scintimammography. (Korean J Nucl Med 2002;36;325-32)

염수의 담수화를 위한 막분리 장치 설계제작 및 성능

배성렬,김영채,이종일 한양대학교 에너지·환경기술연구소 1997 에너지·環境技術論文集 Vol.3 No.-

폐수의 처리와 해수의 담수화에 사용되는 막분리장치의 효율을 증가시키기 위하여 새롭게 설계, 제작하였다. 유체의 흐름을 개선하여 염수를 사용한 실증 실험으로 상업용 제품과 비교하여 10%의 향상된 분리성능을 갖은 장치를 개발하였다.

전이금속촉매에 의한 환상중합고분자의 합성에 관한 연구

김윤희,문성배,김영인,정경규 부산대학교 1997 科學敎育硏究報 Vol.24 No.-

The cyclopolymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne was carried out by transition metal catalysts such as MoCl_(5) or WCl_(6)-based catalysts. The catalytic activity of MoCl_(5) for this cyclopolymerization was greater than that of WCl_(6). The polymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne by MoCl_(5) alone gives a quantitative yield of polymer. WCl_(6)-based catalyst system was not effective in this polymerization. The obtained polymer was generally insoluble in common organic solvents. The IR spectrum of poly (EHH) showed the stretching band of the carbon-carbon double bond at 1590-1650 cm^(-1) indicate a high conjugation. The thermal properties and oxidative stability of poly(EHH) were also studied. The electrical conductivity of the I2 doped poly(EHH) was 1.2 - 2.5 × 10^(-4) Scm^(-1). 본 연구에서는 4-위치에 에틸기와 히드록실기를 동시에 갖는 1,6-heptadiyne 유도체를 합성하여 이를 여러가지 전이 금속 촉매를 사용하여 합성하였다. MoCl_(5) - 단독 촉매를 사용할 경우 가장 높은 중합수율을 보였으며 WCl_(6)- 계 촉매의 경우 중합체가 얻어지지 않았다. 합성된 고분자는 여러 가지 분광 법으로 확인한 결과 주 사슬에 6각형 고리 구조를 가지면서 공액이중결합을 구조를 갖는 것으로 확인되었다. 중합된 고분자는 치환기의 효과로 여러 용매에 쉽게 용해되었으며 산화안정성도 높은 것으로 확인되었다. 합성된 고분자를 요오드로 도핑 시켜 전도도를 조사한 결과 1.2 - 2.5×10^(-4) Scm^(-1)를 갖는 것으로 확인되었다.

제6차 교육과정에 따른 중학교 과학(화학)의 STS 수업모형에 대한 적용

김재표,이석희,문성배 부산대학교 사범대학 과학교육연구소 2000 科學敎育硏究報 Vol.27 No.-

Science Education has been mainly concerned with teaching scientific knowledge and method at class. And its focus on the conveyance of scientific knowledge itself resulted in the limited understanding of science to the students. So the Science-Society(STS) has put more emphasis on the understanding of science, technology, and society rather than the science knowledge only. The goal of STS education is to develop students to understand how science, technology and society interrelate and to use the knowledge they learned in everyday decision making. The purpose of this study was to evaluate the effect of the STS Model in chemistry chapter of Third Grade students' Science textbook in Middle School. 1. In the scholastic achievement, the experimental class showed higher scores by 12.8% points in the rate of correction especially in the problems which were demanding scientific inquiries. This indicated problem-solving through discussion could help the students have correct understanding of science. 2. In pretest, there were no statistically significant differences between 2 classes in the improvement of scientific inquiry abilities. However, in posttest, the experimental class showed higher scores by 2.0% points. 3. In the analysis of science-related attitude, students didn't take much interest in the science subject itself. The didn't prefer the jobs which are related with the science, either. But the STS teaching model received so much recognition that 63.8% of the showed their favor of the teaching method which required discussion in relation between science and society in their science class. And 80.7% of them believed that it would be more interesting when the contents of science textbooks would be changed about those of their authentic lives. 4. About the STS teaching method, 85.0% of the students become more interested n the group discussion and presentation. However, 55.0% of them complained about the lack of little time in preparing material and teachers' enough explanation.

CO₂고정을 위한 화학독립영양미생물 Aeromonas sp. strain JS-1의 분리 및 특성

배상옥,곽경오,이용운,김성준,정선용 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

The increase of CO2 in the atmosphere by fossil-fuel combustion has been recognized as a major cause of global warming. Thus many studies on CO2 removal from the combustion gas have been performed, and recently the techniques for biological CO2 fixation by photoautotrophs have also been developed, In this study, extensive screening was conducted to obtain micoorganism with high capability in fixing CO2, and its characteristics was investigated. As a result, a chemoautotrophs identified as a Aeromonas sp. strain JS-1 was isolated from the fresh water. The isolated strain used the molecular hydrogen and CO2 as an energy and a carbon source, respectively. Growth characteristics, which will be used in the development of a continuous culture system related in CO2 fixation, were examined in batch cultivation under conditions of various CO2 and NaCl concentrations, temperature, and pH. The results of the examination showed that the isolated strain had a good growth to high CO2 concentration(40%), indicating applicable in removing CO2 discharged from industries.

회분식 반응기에서 ABS 수지의 열분해특성에 관한 연구

김지태,곽현,류한영,배성렬 漢陽大學校 工學技術硏究所 2002 工學技術論文集 Vol.11 No.-

본 연구는 앞으로 폐플라스틱 뿐 아니라 다른 폐기물에도 보편화될 것으로 예상되는 열분해공정을 이용하여 ABS 수지(Acrylonitrile-Butadiene-Styrene resign)에 대해 열분해 실험을 행하였다. 교반기가 달린 회분식 반응기에서 5대범용수지(PS, PP, PE, PVC, ABS)중 전기부품과 자동차 부품 등으로 많이 사용되고 있는 ABS 수지 100g을 400, 420, 440℃ 의 분해온도에서 등온 열분해실험을 행하였다. 대부분 고분자의 열분해 반응은 1차이므로 1차반응으로 가정하고 속도록적 해석과 함께 활성화에너지를 구하였다. 실험변수인 분해온도가 오일, 가스 및 잔류물질의 수율과 오일 생성물의 성분분포에 미치는 영향을 관찰하였다. 분해온도에 따라 약간의 차이가 나긴 하지만 주성분은 styrene, benzenebutanenitrile, ethylbenzene 등의 성분으로 이루어져 있었고, 생성오일의 양은 분해 온도가 높을수록 증가했으며, 부가가치가 큰 styrene 단량체 역시 400℃ 일 경우 32.6wt%였으나 440℃일 경우 45.8wt%까지 크게 증가하였다. Isothermal pyrolysis experiment was performed on ABS resign 100g in batch reactor. The temperature was varied from 400℃ to 440℃ at intervals of 20℃. Because most plastic degradation reaction was first order, it assumed first order and elucidated the kinetics. This was the basis of characteristics analysis of ABS resign degradation mechanism. Also, the effect of temperature on the yield of oil, gas and char product change was observed, and the distribution of oil product components was observed. Main components of oil product were a little difference with degradation temperature, but they consist of styrene, benzenebuttanenitrile, ethylbenzene etc. and their yield increased along with degradation temperature. Particularly, high value added styrene yield 32.6wt% at 400℃ but increased to 45.8wt% at 440℃.

베이스 구조물 진동을 고려한 스테이지 입력성형기법 적용에 관한 연구

김형기,권오영,배규현,홍성욱 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

A base structure which mounts positioning stages is often subjected to vibration due to the reaction force against the stage motions. This paper deals with an input shaping method for positioning stage in consideration of vibration base structures along with the stage vibration. A dynamic model is established to investigate the vibration of positioning stage and base structure. Two input shapers, a conventional input shaper and a new input shaper, are applied to eliminate both the residual vibrations in base structure as well as positioning stage. Simulations show that the input shaping methods effectively remove the residual vibrations.

본태성 고혈압에서 염산에포니디핀 (NZ-105, 핀테20정�)의 유효성 및 안전성 : 제3상 다기관 임상시험 The phaseⅢ multicenter open trial

배종화,손일석,강흥선,조정휘,강재헌,김성원,이선영,양윤준,김영식,선우성 대한간질학회 2003 대한간질학회지 Vol.9 No.1

적외선 열화상 카메라를 이용한 고속가공에서의 열 발생 특성

김흥배,이우영,최성주,유중학 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

The term 'High Speed Machining' has been used for many years to describe end milling with small diameter tools at high rotational speeds, typically 10,000 - 100,000 rpm. The process was applied in the aerospace industry for the machining of light alloys, notably aluminium. In recent year, however, the mold and die industry has begun to use the technology for the production of components, including those manufactured from hardened tool steels. With increasing cutting speed used in modern machining operation, the thermal aspects of cutting become more and more important. It not only directly influences in rate of tool wear, but also will affect machining precision recognized as thermal expansion and the roughness of the surface finish. Hence, one needs to accurately evaluate the rate of cutting heat generation and temperature distributions on the machining surface. To overcome the heat generation, we used to cutting fluid. Cutting fluid play a roles in metal cutting process. Mechanically coupled effectiveness of cutting fluids affect to friction coefficient at tool-work-piece interface and cutting temperature and chip control, surface finish, tool wear and form accuracy. Through this study, we examined the behavior of heat generation in high-speed machining and the cooling performance of various cooling methods.