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안의환,정인환,오정환,이성태,김선남 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
Early diagnosis is the key of proper management and reducing of complication in infectious condition of pelvic area. It is difficult to diagnose differentially between pyogenic arthritis of hip joint and osteomyelitis of pelvic bone around hip joint by bone scan that shows only 2 dimensional plane. But it is possible to differnetiate two lesions by SPECT that shows 3 dimensional plane. We report a case of osteomyelitis of ischium around the hip joint in a five year old girl who had severe painful swelling of left buttock, hip and thigh and fever for 2 days. Bone scan showed diffusely increased activity on left hip joint and also pelvic bone surrounding hip joint. But SPECT could visualize increased activity not on left hip joint but only on left ischium. So pyogenic arthritis of hip joint could be ruled out. The patient was cured without any complication by only administration of adequate antibiotics, under the diagnosis of acute osteomyelits of left ischium.
김상철,강경화,오승환,이인성,김선영 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.5
빠르며 정확하고 안전한 치아이동을 목표로 삼고 있는 교정치료에서 새로운 패러다임이라고 여겨지는 피질골 절제술과 견인 골형성술을 응용한 구치의 원심직립이동에 대하여 알아보았다. 일반적인 방법으로는 어렵거나 치료 기간이 길어질 것으로 판단되는 구치의 원심직립 이동을 피질골 절제술과 견인 골형성술을 응용하여 도모하였다. 각각의 원심직립 증례를 통해 피질골 절제술과 견인 골형성술의 적용 술식, 견인장치 등을 논하고 그 효과를 파악하였다. 빠른 치아이동과 이에 따른 교정치료 기간의 단축이 가능하고 통상의 교정치료로는 이동에 한계가 있었던 치아이동을 구치의 정출이나 고정원의 상실 없이 도모할 수 있었다. Tooth movement facilitated by corticotomy and distraction osteogenesis, a new paradigm in orthodontics, was discussed. Molar uprighting was thought to be either difficult or nearly impossible. In this study, a section of cortical bone. which may act as resistance to tooth movement in alveolar bone, was removed. Active bone deposition was also made possible in the tension side. This forms the main concept of tooth movement facilitated by corticotomy and distraction osteogenesis. Molars in two cases were uprighted at such a speedy rate as we could not Imagine in conventional tooth movement, which lead to reduction of the total treatment period. And molar uprighting was possible without side effects, for example, supraversion of the tooth or anterior anchorage loss. These were the superior aspects to conventional orthodontics.
오선환 ( Seon Hwan Oh ),배정은 ( Jung Eun Bae ),김인섭 ( In Seop Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2012 한국미생물·생명공학회지 Vol.40 No.4
동물세포배양 유래 생물의약품 생산 공정에서 다양한 외래성 바이러스가 오염된 사례가 있기 때문에 바이러스 안전성 보증을 위한 바이러스 검출시험이 필수적이다. Reovirus (Reo), bovine viral diarrhea virus (BVDV), bovine parainfluenza virus (BPIV)는 동물 세포주와 동물 세포 배양 공정에 오염되는 대표적인 RNA 바이러스이다. 세포배양 유래 생물의약품의 안전성을 확보하기 위해, 세포주, 원료물질, 제조공정, 완제품에서 Reo, BVDV, BPIV를 동시에 검출할 수 있는 Multiplex Reverse Transcription (RT)-PCR 시험법을 확립하였다. Reo, BVDV, BPIV에 특이적인 primer를 선별하였으며, multiplex RT-PCR 시험법을 최적화하였다. Reo, BVDV, BPIV를 동시에 검출할 수 있는 multiplex RT-PCR 시험법의 민감도는 각각 7.76×102 TCID50/ml, 7.44×101 TCID50/ml, 6.75×101 TCID50/ml이었다. 확립된 multiplex RT-PCR을 생물의약품 제조공정 검증에 적용할 수 있는지 확인하기 위하여 인위적으로 각 바이러스를 오염시킨 CHO 세포에서 검출 시험을 실시한 결과 각 바이러스를 감염시킨 CHO 세포와 세포배양 상청액에서 각 바이러스를 검출할 수 있었다. 위와 같은 결과에서 확립된 multiplex RT-PCR시험법은 세포주, 원료물질, 제조공정, 완제품에서 Reo, BVDV, BPIV를 동시에 검출할 수 있는 특이성과 민감성이 우수한 시험법임을 확인하였다. Viral safety is an important prerequisite for clinical preparations of mammalian cell culture-derived biopharmaceuticals, because numerous adventitious viruses have been contaminated during the manufacturing process. In particular, Chinese hamster ovary (CHO) cells are highly susceptible to several RNA viruses including reovirus (Reo), bovine viral diarrhea virus (BVDV), and bovine parainfluenza virus (BPIV) and there have been reports of such viral contaminations. Therefore, viral detection during the CHO cell process is necessary to ensure the safety of biopharmaceuticals against viruses. In this study, a multiplex reverse transcription (RT)-PCR assay was developed and subsequently evaluated for its effectiveness as a means to simultaneously detect Reo, BVDV, and BPIV during the manufacture of cell culture-derived biopharmaceuticals. Specific primers for Reo, BVDV, and BPIV were selected, and a multiplex RT-PCR was optimized. The sensitivity of the assay for simultaneous amplification of all viral target RNAs was 7.76×102 TCID50/ml for Reo, 7.44×101 TCID50/ml for BVDV, and 6.75×101 TCID50/ml for BPIV. The multiplex RT-PCR was proven to be very specific to Reo, BVDV, and BPIV and was subsequently applied to the validation of CHO cells artificially infected with each virus. It could detect each viral RNA from CHO cells as well as culture supernatants. Therefore, it was concluded that the multiplex RT-PCR assay can be applied to detection of the adventitious viruses during the manufacture of cell culture-derived biopharmaceuticals.
증 례 : 자가면역성 췌장염과 감별이 어려웠던 췌장 림프종 1예
박진오 ( Jin Oh Park ),오동욱 ( Dong Wook Oh ),정민선 ( Min Seon Cheong ),김지윤 ( Ji Yoon Kim ),오진선 ( Jin Sun Oh ),송태준 ( Tae Jun Song ),홍승모 ( Seung Mo Hong ),김명환 ( Myung Hwan Kim ) 대한췌장담도학회 2015 대한췌담도학회지 Vol.20 No.4
Accurate diagnosis of autoimmune pancreatitis (AIP) is important to clinicians since it is difficult to differentiate AIP from pancreatic malignancies. Furthermore, unlike pancreatic malignancies, AIP has dramatic response to steroids. A 61-years-old man presented with acute pancreatitis. Imaging studies showed two separate pancreatic masses, irregular narrowing of main pancreatic duct, and a renal mass that highly suggested AIP. Endoscopic ultrasound-guided core needle biopsy of the pancreatic masses and ultrasound-guided biopsy of the renal mass revealed peripheral T-cell lymphoma. The patient is currently undergoing chemotherapy. We present a case of pancreatic lymphoma masquerading as AIP with literature review.
Shin, Kyong-Oh,Seo, Cho-Hee,Cho, Hyo-Hyun,Oh, Seikwan,Hong, Seon-Pyo,Yoo, Hwan-Soo,Hong, Jin-Tae,Oh, Ki-Wan,Lee, Yong-Moon 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Ginsenoside compound K (CK) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes. This study examined the anti-angiogenic properties of CK against sphingosine 1-phosphate (S1P)-induced cell migration via regulation of sphingosine kinase 1 (SPHK1) in human umbilical vein endothelial cells (HUVEC). Studies on S1P-induced cell migration, expression of SPHK1 and MMPs and analysis of sphingolipidmetabolites by LC-MS/MS were examined after the treatment of CK (2.5, 5, $10{\mu}g/mL$) in HUVEC. S1P produced by SPHK1 is also involved in cell growth, migration, and protection of apoptosis; therefore, we sought to investigate whether ginsenosides are able to regulate SPHK1. For this purpose, we developed an inhibitory assay of SPHK1 activity and an analytical method for detection of S1P and other sphingolipid metabolites in HUVEC. Ginsenoside CK inhibited 100 nM S1P-induced cell migrations in a dose-dependent manner. Among tested ginsenosides, CK exclusively inhibited S1P production, SPHK1 activity and SPHK1 expression in HUVEC, whereas expression of the pro-apoptotic sphingolipids, sphingosine and ceramide, was increased in response to CK. The major subspecies of the increased ceramide was C24:0-ceramide. CKalso disrupted the sphingolipid rheostat, which ultimately influences cell fate, and dose-dependently inhibited HUVEC migration by reducing expression of metalloproteinases (MMPs). Ginsenoside CK acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites.
Sphingosine 1-Phosphate and Sphingosine Kinase Activity during Chicken Embryonic Development
Choi, Chang-Hwan,Jeong, Ji-Seon,Yoo, Bo-Im,Jin, You-Xun,Moon, Dong-Cheul,Yoo, Hwan-Soo,Oh, Seik-Wan,Hong, Seon-Pyo,Lee, Yong-Moon 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
The chicken embryo has been weil used in studies of the developmental process, and during development sphingosine and sphingosine 1-phosphate (So1P) are considered critical mediators of cell death and survival. In this study, we compared the sphingolipid contents of chicken embryos during the early embryonic development period from day 3 to day 6. HPLC analyses of sphingosine and So1P in chicken embryos revealed that sphingosine levels were greatly reduced on day 4 whereas So1P levels were not significantly changed. Sphingosine kinase(Sphk) activities, which require sphingosine as substrate to produce So1P, were also greatly reduced on day 4. Collectively, we found sphingosine levels and Sphk activities, but not So1P levels are changed in early stage of chicken embryos development.