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RISS 인기검색어
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- 저자 : Seol Yong-Geon (검색결과 5 건)
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정정명,임대건,이원식,최봉기,장윤식,이연재,이상혁,설상명,최하진 인제대학교 1996 仁濟醫學 Vol.17 No.2
1991년 1월부터 1993년 12월까지 인제의대 부산백병원에서 6개월 이상 HBsAg 및 HBeAg 양성이며 간조직 검사상 만성간염을 보인 환자들(활동성;26례, 지속성;3례)을 대상으로 알파 인터페론 치료시 혈청 전환 및 간기능 정상화율과 인터페론 투여에 따른 효과에 대해 분석하여 보았다. In order to evaluate the therapeutic efficacy and safety of recombinent alpha-interferon, we studied 29 patients proven to have chronic hepatitis B(CAH : 26 cases, CPH : 3 cases) through biopsy from January 1991 to December 1993. All patients were seropositive for HBeAg and HBsAg, and recieved alpha-interferon with tonal dosage up to 120 million units. The results were as follows ; 1) HBeAg sero-conversion rate was 51.7%(Total 15 cases including 3 cases in chronic per-sistant hepatitis group), and all these patients have showed normalized transaminase levels continously. 2) In response group, the serum transaminase level began to decrease at average 4.7th week after initiation of interferon. But in non-response group, the serum transaminase level began to decrease at 2nd to 4th week transiently after interferon, and then increased again. 3) Several adverse effects were noted during interferon treatment. General ache and myalgia were most common(65.5%), followed by fever and chillness(37.9%), headache(37.9%), leukopenia(17.2%) etc. But they were relatively tolerable. 4) Peripheral blood leukocyte counts showed slight reduction within 1 week after initiationof interferon treatment but rapidly recovered to normal level within 5 days after temporary withdrawal. And after completion of interferon treatment, no significant differences were remained compared with initial level. With these results, it suggests that α-interferon therapy may be effective and safe in chronic hepatitis B. However, further study will be required in non-responsive group thereafter.
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저온소결용 (Ba, Sr)$TiO_3$-Glass계 세라믹스의 유전특성
구자원,설용건,최승철,Gu, Ja-Won,Seol, Yong-Geon,Choe, Seung-Cheol 한국재료학회 1995 한국재료학회지 Vol.5 No.2
$(Ba, Sr)TiO_{3}$계에 저융점의 Glass물질을 첨가하여 저온소결이 가능하며, 고유전율을 갖는 유전체 재료를 제조하여, 그 특성을 조사하였다. 본 연구에서는 고유전율의 $(Ba, Sr)TiO_{3}$계에 PbO함량이 서로 다른 Glass물질을 첨가하여 조성변화에 따른 저온소결거동 및 유전특성을 조사하였으며, 적층형 세라믹 Capacitor(MLCC)에 응용하기 위하여 다양한 조성으로 제조하였다. $PbO-ZnO-B_{2}O_{2}$계 Glass 성분을 첨가하여 소결온도를 $1350^{\circ}C$에서 $1050^{\circ}C$까지 낮출수 있었으며, 4wt% glass 첨가로 $1150^{\circ}C$ 이하에서 2시간 소결한 저온소결용 재료는 실온에서 8000정도의 높은 비유전율과 0.005의 낮은 유전손실 그리고 광역온도범위에서 유전상수의 안정성을 가진 우수한 특성을 나타내며, 입자크기가 1~3 $\mu$m 정도로 치밀한 미세구조를 가지고 있다. 본 연구의 저온소결용 유전체 재료는 Z5U 규격을 만족시키고 기존의 $BaTiO_{3}$계 재료에 비해 낮은 소결온도를 가지므로 MLCC에 응용시 내부전극으로 Ag-Pd alloy 사용이 가능한 것으로 밝혀졌다. Low temperature firing $(Ba, Sr)TiO_{3}$ dielectrics were successfully prepared with lead based glass and those electrical properties were investigated. Different amount of PbO content glass materials were added to dielectrics to investigate the sinterability and its dielectric properties. Also, various compositions of ceramic capacitors were prepared to applicate in multilayer ceramic capacitors. A large amount of experiment has been done with various Pb contented glasses and different sintering temperatures. The sintering temperature of $(Ba,Sr)TiO_{3}$can be reduced from $1350^{\circ}C$to as low as $1050^{\circ}C$ with 4wt% addition of $PbO-ZnO-B_{2}O_{2}$ glass materials. Its dielectric constant at room temperature was up to 8100 with low dielectric loss, 0.005. This ceramic capacitor showed fully fired microstructures with its grain size of 1-3$\mu \textrm{m}$. The sintered body which was sintered at $1150^{\circ}C$ for 2hr with 4wt% $PbO-ZnO-B_{2}O_{2}$ glass material addition satisfied the Z5U specification of the EIAS.
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김규환,옥승철,이영민,임대건,이상혁,설상영,정정명,최하진 인제대학교 1995 仁濟醫學 Vol.16 No.2
대장 흑피증은 매우 드문 질환으로 anthraquinone 제제의 지속적인 복용과 관련되어 있다고 알려져 있는데 저자 등은 본원에서 대장 내시경을 통한 조직검사나 수술을 통해 확진된 대장 흑피증 환자 5명을 대상으로 그 임상적 특징을 관찰하고 문헌 고찰과 함께 보고하는 바이다. Melanosis coli is the brownish black pigmentation of the colon associated with prolonged ingestion of anthraquinone compounds as laxatives. This condition is so rare that a few cases have been reported in Korea and its pathophysiology has not been understood clearly Many studies have suggested that the brownish discoloration of the colon mucosa is due to accumulation of macrophage containing lipofuscin pigment. We report 5 cases of melanosis coli histologically confirmed by colonoscopic biopsy or by operation from January, 1992 to September, 1994 in this hospital with a review of the literature.
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Duodenal amyloidosis secondary to ulcerative colitis
Seung Woon Park,Sam Ryong Jee,김지현,Sang Heon Lee,Jin Won Hwang,Ji Geon Jang,Dong Woo Lee,Sang Yong Seol 대한장연구학회 2018 Intestinal Research Vol.16 No.1
Amyloidosis is defined as the extracellular deposition of non-branching fibrils composed of a variety of serum-protein precursors. Secondary amyloidosis is associated with several chronic inflammatory conditions, such as rheumatologic or intestinaldiseases, familial Mediterranean fever, or chronic infectious diseases, such as tuberculosis. Although the association of amyloidosis with inflammatory bowel disease is known, amyloidosis secondary to ulcerative colitis (UC) is rare. A 36-year-old malepatient with a 15-year history of UC presented with nausea, vomiting, and abdominal pain. He had been treated with infliximabfor 6 years. At the time of admission, he had been undergoing treatment with mesalazine and adalimumab since the preceding5 months. Esophagogastroduodenoscopy showed mucosal erythema, edema, and erosions with geographic ulcers at the 2ndand 3rd portions of the duodenum. Duodenal amyloidosis was diagnosed using polarized light microscopy and Congo red stain. Monoclonal gammopathy was not detected in serum and urine tests, while the serum free light chain assay result was notspecific. An increase in plasma cells in the bone marrow was not found. Secondary amyloidosis due to UC was suspected. Thesymptoms were resolved after glucocorticoid therapy.
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