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Quantitative Measurement of Serum Allergen-Specific IgE on Protein Chip
Tae-EunKim,Seok-WonPark,Nam-YunCho,Seung-YoungChoi,Tai-SoonYong,Baek-HieNahm,이상선,GeunwoongNoh 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.2
Type I allergy is an immunoglobulin E (IgE)-medi-ated hypersensitivity disease inflicting more thanquarter of the world population. In order to identifyallergen sources, skin provocation test and IgEserology was performed using allergen extracts.Such process identifies allergen-containing sourcesbut cannot identify the disease-eliciting allergenicmolecules. Recently, microaray technology hasbeen developed for allergen-specific IgE detectionusing rolling circle amplification. This study wascarried out to evaluate protein chip technology forthe quantitative measurement and limits of sensitivityof multiple allergen-specific IgE by an immunofluores-cence assay. Significance of positive calibrators wastested using purified human IgE. Dermatophagoidespteronyssinus (Dp), egg white, milk, soybean, andwheat were used as allergens and human serumalbumin as negative control. Sensitivity and clinicalefficacy of protein chip were evaluated using allergyimmune serum for Dp. The fluorescent intensitiesfor purified human IgE as calibrator were wel core-lated with the concentrations of human IgE. Two-fold dilution of serum allowed an optimal reactionwith Dp (1 mg/ml) at which serum Dp-specific IgElevels by protein chip were compatible with those byUniCap. The sensitivity of protein chip in thisstudy was found at level of 1 IU/ml of IgE. Dp-spe-cific IgE levels by protein chip corelated wel withthose of UniCap by comparing 10 atopic dermati-tis. Aditional 18 sera were tested for above multipleantigens other than Dp and significant results wereobtained for many antigens as well as Dp. Theseresults indicated that spotting of heterogeneousprotein mixture on protein chip and the quantitativemeasurement of serum allergen-specific IgE levelsusing immunofluorescence assay can be success-fully applied in the clinical laboratory for the diagno-sis of allergy and could be applied to diagnosis ofautoimmune and infectious diseases
이인국,이혁희,조용인,최영주,허병욱,이병완,강은석,Seok-WonPark,차봉수,이은직,이용호,허갑범 한국지질동맥경화학회 2020 지질·동맥경화학회지 Vol.9 No.1
Objective: This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM). Methods: This observational study included 1,381 subjects with T2DM in whom serial measurements of carotid intima-media thickness (CIMT) were made at 1- to 2-year intervals for 6–8 years. The progression of carotid atherosclerosis was defined as newly detected plaque lesions on repeat ultrasonography. After dividing total serum bilirubin levels into tertiles, the association between total serum bilirubin at baseline and plaque progression status was analyzed. Results: Among 1,381 T2DM patients, 599 (43.4%) were categorized as having plaque progression in their carotid arteries. Those with plaque progression were significantly older; showed a higher prevalence of hypertension, abdominal obesity, and chronic kidney disease; and had a longer duration of T2DM, higher levels of total cholesterol (TC), triglycerides, and insulin resistance, and lower total bilirubin concentrations than those with no plaque progression. When total serum bilirubin levels were divided into tertiles, the highest tertile group was younger than the lowest tertile group, with higher levels of TC and high-density lipoprotein cholesterol. Multiple logistic regression analysis demonstrated that higher serum bilirubin levels were associated with a significantly lower risk of CIMT progression (odds ratio, 0.584; 95% confidence interval, 0.392–0.870; p=0.008). Age (p<0.001), body mass index (p=0.023), and TC (p=0.019) were also associated with the progression of carotid atherosclerosis in T2DM patients. Conclusion: Total serum bilirubin is independently associated with progression of atherosclerosis in the carotid arteries in T2DM patients.
The development of waste cathode ray tube (CRT) recycling technology to concrete and clay bricks
( Jang Soo Lee ),( Heung Min Yoo ),( Won Seok Yang ),( Jun Kyung Park ),( Se Wonpark ),( Yong Chil Seo ),( Bo Saeng Kim ),( Ki Bae Lee ),( Sang Bae Le ),( Yoon Soo Kim ),( Seong Hoon Jeon ),( Jeon Sik 한국폐기물자원순환학회(구 한국폐기물학회) 2013 한국폐기물자원순환학회 심포지움 Vol.2013 No.2