서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예

배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2

Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.

소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.

산소 혼합비에 따른 Ba_(0.7)Sr_(0.3)TiO₃박막의 유전체 특성

홍석민,임성민,김호건,김옥경 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-

Ba과 Sr의 화학당량비를 조절하여 Ba_(0.7)Sr_(0.3)TiO₃분말 시료를 제조하여 각각 1,200℃와 1,300℃에서 calcining과 sintering을 실시한 후 3 inch 성형틀로 Ba_(0.7)Sr_(0.3)TiO₃인 sputtering target를 제작하였다. MIM구조의 capacitor를 위하여 하부전극을 Pt(1500Å)/TiN(2000Å)/SiO₂/Si로 하고, 제작한 target를 이용하여 RF sputtering방법으로 BST박막을 증착하였다. 제작한 박막의 결정구조를 X-선 회절계(XRD)로 분석한 후 Al을 상부전극으로 증착하여 축전기구조로 C-V와 I-V의 전기적 특성을 얻었다. 제작된 박막의 결정구조를 XRD 측정으로 확인한 결과 550℃ 이상의 기판온도에서 결정성장이 양호함을 보였다. 유전상수와 유전손실이 기판온도와 sputtering 가스의 산소 혼합비에 영향을 받는 것으로 확인되고 I-V를 통한 전기적 특성에서 전도기구가 Schottky 장벽에 의한 것과 높은 인가전압에서 space charge limited (SCL) 전도 특성을 보였고, 누설전류의 값은 표면구조의 영향으로 산소가스의 증가에 따라 감소하였다. Ba_(0.7)Sr_(0.3)TiO₃powders were prepared by changing stoichiometry of Pb and Ba. After they were calcined and sintered at 1200℃ and 1300℃ respectively, BST sputtering targets were made in 3 inch mould. For MIM structure capacitors, Pt(1500Å)/TiN(2000Å)/SiO₂/Si were used for bottom electrodes and the BST thin films were sputtered on bottom electrodes. After we analysed their structures by XRD, Al was evaporated on the BST films for MIM capacitor and we investiaged the electrical properties by measuring of C-V and I-V. We found that the structures of the films showed good crystalllinity above 550℃ from the results of XRD measurements. We supposed that the dielectric constant and dielectric loss of films were affected with substrate temperature and oxygen ratio of sputtering gas. In I-V behavior, we supposed that the conduction mechanism was Schottky conduction and space charge limited(SCL) conduction in high voltage range.

RF 마그네트론 스퍼터링 방법에 의한 (Ba, Sr)TiO₃박막의 특성

홍석민,조정희,김호건,김옥경 漢陽大學校 工學技術硏究所 1996 工學技術論文集 Vol.5 No.1

A sputtering target(BaxSr1-xTiO3) is obtained by changing the mol% of Ba and Sr. Pt is evaporated on the SiO2/Si substrate as a bottom electrode, and subsequently the BaxSr1-xTiO3 thin film is sputtered. Or, for obtaining the MIS structure Pt is not used, and directly thin film is sputtered on the Si substrate. Then, the capacitor structures(MIM, MIS) have been obtained by evaporating Al as a top electrode after post-annealing. Our results show that produced thin firm is found to have Perovskite structure according to the XRD measurement and shows better crystal growing phenomena on SiO2/Si substrate than those on Si substrate. And, the existence of polarization is recognized by the hysteresis loop. The capacitor(MIM) structure of BaxSr1-xTiO3 thin film shows that the dielectric constant is increased as the mol% of Ba and the post-annealing temperature increase. MIS structure shows a increase of capacitance with increasing the mol% of Ba.

중이 수술후 청력 변화에 대한 임상적 고찰

홍석찬,강성호,이광희 건국대학교 의과학연구소 1994 건국의과학학술지 Vol.4 No.-

statistical analysis of bone conduction loss in chronic otitis media has not been exactly reported until now. Authors studied the relationship between the preoperative bone conduction hearing level and age, nature of middle ear and temporal bone pathology, pneumatization of mastoid in 97 ears of chronic uppurative otitis media performed middle ear surgery at Konkuk University Hospital from March 1992 to December 1992. The results were as following: The mean bone conduction threshold was 16.2±12.4dB. In the cases of ossicular defect, bone conduction loss was greater in total destruction than in partial destruction with statistical significance. Among ossicular defect, incus destruction group showed more bone conduction loss than intact incus group with statistical significance. There was no difference of bone conduction loss according to pathologic findings in middle ear cavity and mastoid antrum, but pathologic groups showed more bone conduction loss than control group with normal temporal bone pneumatization with statistical significance. Comparing pneumatization of mastoid antrum and mastoid process, there was statistically significant bone conduction loss in orders of pneumatic type, diploic type, sclerotic type, cholesteatoma cavity. There was no difference of bone conduction hearing level according to age, sex, and duration of disease process with statistical significance. The results suggest that the bone conduction threshold in chronic otitis media is influenced by artificial elevation due to conductive defect and can be improved by reconstructive surgery.Many patients being followed for chronic suppuration of the middle ear were observed to have sensorineural or mixed type hearing loss. The major cause of this bone conduction loss might be secondary to cochlear biochemical changes occuring through the round window membrane. But, clinical and statistical analysis of bone conduction loss in chronic otitis media has not been exactly reported until now. Authors studied the relationship between the preoperative bone conduction hearing level and age, nature of middle ear and temporal bone pathology, pneumatization of mastoid in 97 ears of chronic suppurative otitis media performed middle ear surgery at Konkuk University Hospital from March 1992 to December 1992. The results were as following: The mean bone conduction threshold was 16.2±12.4dB. Inthe cases of ossicular defect, bone conduction loss was greater in total destruction than in partial destruction with statistical significance. Among ossicular defect, incus destruction group showed more bone conduction loss than intact incus group with statistical significance. There was no difference of bone conduction loss according to pathologic findings in middle ear cavity and mastoid antrum, but pathologic groups showed more bone conduction loss than control group with normal temporal bone pneumatization with statistical significance. Comparing pneumatization of mastoid antrum and mastoid process, there was statistically significant bone conduction loss in orders of pneumatic type, diploic type, sclerotic type, cholesteatoma cavity. There was no difference of bone conduction hearing level according to age, sex, and duration of disease process with statistical significance. The results suggest that the bone conduction threshold in chronic otitis media is influenced by artificial elevation due to conductive defect and can be improved by reconstructive surgery.

전두-사골동 점액낭종의 비내시경 수술 치험 1례

홍석찬,김진국,강성호 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Frontoethmoidal sinus mucocele usually presents with frontal headache, exophthalmos and diplopia. Over the years it has necessitated either a conservative or a radical procedure. However, recently endoscopic sinus surgery has afforded to decrease the operative morbidity, and image the sinus postoperatively without problem. We have experienced a case of frontoethmoidal sinus mucocele which was satisfactorily treated with endoscopic marsupialization. Till now, no disease recurrence has been noted with endoscopic follow-up for 5 months. The etiology, characteristic features, and treatment of frontoethmoidal mucocele were reviewed.

안와 내벽 외향 골절의 내시경적 비내 재건술

홍석찬,진정언,강성호 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-

The orbital blowout fracture occurs when a convex object(usually a baseball and a fist) larger in diameter than orbital rim strikes the orbit, increasing intraorbital pressure and producing hydraulic forces in all directions, which explodes the bony margin. The most frequently site of fracture is the bony floor in the region of the infraorbital canal, less frequently medial orbital wall, that is, lamina papyracea. Medial orbital wall fractures are also seen with other types of facial fractures such as frontal, nasoethmoid, and maxillary injuries. With the advent of nasal endoscope, endoscopic intranasal reconstruction has substituted for external approach. We experienced a case of blowout fracture of left medial orbital wall, which was treated with endoscopic intranasal reconstruction method and report this case with the review of the literature.

급성 A형 간염에 병발한 급성신부전 2 례

홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.

한국형 후각검사 KVSS Test의 개발

홍석찬,유영석,김은서,김석천,박수홍,김진국,강성호 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.7