지역사회 연계를 고려한 진주종합경기장 활용방안 연구

강석진(Kang, Seok-Jin),안재우(Ahn, Jae-Woo),김지희(Kim, Ji-Hee),이현진(Lee, Hyun-Jin) 대한건축학회 2013 대한건축학회 학술발표대회 논문집 Vol.33 No.2

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

Ketoprofen 첩포제(Ketotop : )의 경피적용에 따른 혈장농도 및 피부자극의6 검토

임동석,장인진,신상구,유재학,은희철 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

공매도의 수익률예측성과 미래이익반응계수에 관한 연구

이용석(Lee, Yong-Seok),박희진(Park, Hee-Jin),김범준(Kim, Bum-Joon) 한국국제회계학회 2018 국제회계연구 Vol.0 No.78

본 연구의 목적은 기업별 공매도 체결내역을 기초로 공매도 거래와 회계정보의 유용성 간의 관련성을 분석하는 것이다. 일반적인 주식투자에 비해 공매도는 상대적으로 위험이 큰 투자안이므로 공매도 투자자는 위험을 회피하기 위하여 보다 적극적으로 회계정보를 활용할 가능성이 높다. 이에 본 연구에서는 공매도 투자자가 공매도 거래시 기업의 영업성과와 관련된 회계정보를 어떻게 활용하는지를 살펴보았으며, 추가적으로 FERC 모형을 이용하여 거래비중이 높은 기업에서 당기 주식수익률이 미래이익을 보다 정확하게 반영하고 있는지를 분석하였다. 분석결과, 투자자가 공매도 거래시 기업의 영업성과와 관련된 회계정보를 이용하여 추가적인 양(+)의 초과수익을 달성할 수 있음을 확인하였으며, 이를 통해 공매도 투자시 회계정보를 활용할 충분한 유인이 존재함을 보였다. 아울러 공매도 거래비중이 높은 기업에서 당기주식수익율과 미래이익간의 양(+)의 관련성이 더 높은 것으로 나타나, 공매도 거래비중이 높은 기업일수록 당기수익율이 보다 정확하게 미래이익을 반영하고 있다는 점을 실증적으로 제시하였다. 공매도는 전문적 투자자가 투자대상기업의 내재가치 변경을 예상할 때 발생한다는 선행연구의 결과와 유사하게 본 연구는 공매도 투자시 투자기업의 회계정보가 투자의사 결정의 유용한 정보가 될 수 있음을 보였으며, 공매도 투자자가 기업의 미래수익률을 보다 정확하게 예측한다는 Drake et al.(2011)의 연구결과가 국내 주식시장에서도 일관되게 나타난다는 점을 확인하였다. 공매도 거래비중이 높은 기업일수록 기업의 미래이익반응계수가 상대적으로 높은 것으로 나타났는데 이는 공매도 투자자들이 자본시장에서 회계정보를 잘 이용하게 할 수 있는 정보 촉매제 역할을 하고 있음을 시사하는 것으로 Pownall and Simko(2005)의 주장과도 일치되며, 직접적인 공매도거래가 아닌 대차잔고를 이용하여 연구를 실시한 Drake et. al.(2015)의 연구결과와도 유사한 결과이다. 본 연구는 자본시장에서 공매도 투자자가 정보중개인의 역할을 수행하고 있다는 점을 밝혔으며, 아직까지 공매도에 대한 인식에 차이가 존재하는 금융당국 · 투자자 및 기업들에게 공매도에 대한 유용한 새로운 시각을 제공한다. The purpose of our study is to analyze the relationship between the short sale transaction and the usefulness of accounting information based on the short sales transaction data. Since short selling is relatively high risk compared to stock trading, short selling investors are more likely to actively use accounting information to avoid risk. In this study, we investigate whether short selling investors use accounting information related to the company"s performance when doing short selling. In addition, we use the FERC model to analyze whether the current profitability is more accurately reflect future profit. According to the result of our analysis, investors can obtain additional positive earnings by using the accounting information related to the performance of the company during the short sale. Therefore, we find that there is sufficient incentive to utilize the accounting information in the short sale investment. In addition, the relationship between the future profit and the stock return is higher in companies with a high volume of short selling, suggesting that firms with higher volume of short selling would likely to reflect future earnings more accurately in the current stock return. Based on the prior research that short selling can be occurred when a professional investor expects to change the intrinsic value of firm, this study shows that the accounting information can be useful for investment decision. In addition, we also find that short-selling investors, who can be regarded as professional investors, predict the firm’s future returns more accurately, confirming that the empirical results of Drake et al. (2011) consistently apply in Korea stock market. Our results are consistent with the finding of Pownall and Simko (2005), which shows that firms with high short-sale volume have relatively high future earning-response coefficients, suggesting that short-selling investors have a role as information catalysts. We find that short selling investors play the role of information intermediaries in the capital market and provide a new insight on short selling to financial authorities and investors who still have differences perspectives in short selling transaction.

삭골(Bone shaving)한 골의 재생에 골막이 미치는 영향

강진성,권건영,송중원,오석희,한기환 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

Many orientals have a more prominent malar eminence and mandibular angle than westerners so their faces often look rough and unattracive. In recent years more people want to have a more attractive and beautiful face due to economic prosperity and westernization. Therefore people receiving bone shavings or osteotomies for cosmetic purposes are increasing. The effects of the periosteum on lay bone grafts were investigated but the effect of the periosteum after bone shaving or osteotomy is little known. The authors investigated the effect of the periosteum on the regeneration of bone in membranous and endochondral bone of rabbits. Bony defects each measuring about 5.0×5.0×1.5mm were made on the left and right sides of the parietal bones of 15 rabbits and femurs of 15 other rabbits respectively. The periosteum was preserved on the left and removed on the right. The following results were obtained: 1) The average thickness of the regenerated bones in groups 2 δ4 were thinner than those in groups 1 δ 3 at 4, 8 and 12 weeks postoperatively but the differences of thickness were statistically significant at onl 4weeks postoperatively(P<0.05). 2) The histological findings in groups 2 δ 4 showed lesser regeneration of the shaved bone than those in groups 1 δ 3 at 4, 8 and 12weeks postoperatively. 3) There was no significant increase in the thickness of the regenerated bone after 8 weeks postoperatively in all groups. 4) At 12 weeks postoperatively, the thickness of the regenerated bone in all groups was over 70% of the thickness of the resected bone. In summary, the authors found that it is important to perform overcorrection and resect the periosteum simultaneously in bone shaving to prevent the unwanted regeneration.

제7차 교육과정에 따른 고등학교 과학(화학단원) 교과서 STS 내용분석

이영진,이석희,문성배 부산대학교 사범대학 과학교육연구소 2002 科學敎育硏究報 Vol.29 No.-

The purpose of this study is to provide the basic data of educational activities on the school scene, by finding the extent of agreement between the educational purposes o high school science textbooks by the 7th curriculum and by dividing the contents of STS into the subject and activity area. In the study, the contents of STS were analyzed by the topics of Piel, and student activities of SATIS. The STS contents in textbooks showed average value of 50.7%, which was increased in quantity in comparison with the 6th curriculum, and as contents in detail by the distributional order of subject matter, environmental quality and natural source takes 39.2%, sociology of science 34.7%, effect of technological development 19.0%, human technology 5.0%, population 2.2%, space research and national defense 0.2% and energy 0.0%. As the order of activity areas, case study takes 40.1%, investigation study 16.1%, data analysis 13.0%, structured discussion 8.2%, simulation 6.5%, practice activity 5.1%, problem solving and decision making 4.8% research design 4.8%, and role play 1.0%.

구강 편평세포암종에서 E-cadherin 및 β-catenin 발현의 변화 : Correlation with Histologic Features and p53 Expression

서진건,권창석,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Altered expression of cell adheion molecules is associated with biologic behavior of tumor. The aim of this study is to evaluate the expression pattern of E-cadherin, β-catenin and p53 protein according to histologic grade and invasion pattern of squamous cell carcinoma of the oral cavity and the relationship between E-cadherin, β-catenin and p53 protein expression. Methods and Material : The materials were fifty seven cses of squamous cell carcinoma, and clinicl parameers such as age, sex, tumor location, stage and recurrence were recorded. Histologic review was done based on histologic grade and invasion pattern(nodular vs infiltrative). Immunohistochemical stains for E-cadherin and β-ca tenin were interpreted based on staining pattern as los of membranous expression and cytoplasmic expression and p53 protein expression was defined as positive if more than 10% of nuclei were reactive. Statistical analysis between E-cadherin, β-catenin and p53 protein expressions and histologic grade and invasion pattern and the relationship between E-cdherin, β-catenin and p53 protein expressions were perfomed. Results : There wa positive correlation between higher histologic grade and infiltrative pattern. Loss of membranous expression and cytoplasmic expression of E-cadherin were noted in 33.3% and 57.9%, respectively, and loss of membranous expression of E-cadherin showed increaing tendency in poorly differentiated carcinomas, however, there was no significant difference of cytoplasmic expression rate of E-cadherin according to histoogic grade. Altered expression of E-cadherin was more frequent in poorly differentiated carcinomas. Loss of membranous expression and cytoplasmic expression of E-cadherin were more frequent in carinomas with infiltrative pattern than in carcinomas with nodular pattern, but their diferences were not significant, Loss of membranous expression and cytoplasmic expression of β-catenin were observed in 19.3% and 80.7%, respectively. Loss of membranous expression of β-catenin howed no positive correlation according to histologic grade and invasion pattern, but cytoplasmic expression rate of β-catenin was higher in poorly differentiated carcinomas and in carcinomas with infiltrative pettern. p53 protein expression rate was 45.6%, and showed invreasing tendency in poorly differentiated carcinomas, but no significant relationship with invasion pattern. There was an inverse relationship of loss of membranous expression and cytoplasmic expression of E-cadherin and β-catenin. Altered expression of E-cadherin was related to cytoplasmic expression of β-catenin, however, there were no significant relationship between altered expressions of E-cadherin and β-catenin and p53 protein expression. Conclusion : In squamous cell carcinomas of the oral cavity, altered expression of E-cadherin and β-catenin was more frequent in poorly differentiated carcinomas and in carcinomas with infiltrative pattern and there was positive correlation betwween altered expression of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cadherin and β-catenin may have a role in the development of squamous cell carcinomas with aggressive biologic behavior. but altered explosions of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cdherin and β-catenin my have a role in the development of squmaous cell carcinomas with aggressive biologic behavior. But altered expression of E-cadherin and β-catenin might not be related to p53 protein expression. Further study on genetic mutation related to altered expression of E-cadherin and β-catenin will be needed

고압 커패시터의 고장 분석을 통한 신뢰도 예측

양석준,김진우,신승우,이희진,신승훈,유동수,장석원 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.6

본 논문은 고압 커패시터의 고장분석과 신뢰성 예측 결과를 다루고 있다. 부품의 수명과 고장률을 예측하기 위해서 두 가지 방법으로 고장 모드와 고장 메커니즘을 연구하였다. 에폭시 수지로 성형된 고압 커패시터가 절연내압 시험 하에서 저항이 제로로 되는 고장에 대하여, 근본원인 고장분석 체계를 효과적으로 수립함으로써 고장 메커니즘의 원인을 분석하였다. 특히 세라믹-에폭시 계면에서의 절연파괴 고장 현상이 강조되었으며, 본 연구에서 얻어진 결과의 타당성은 마그네트론에 장착된 고압 커패시터의 열사이클 시험 수행에 의한 가속시험 결과로부터 입증되었다. 시험 결과들은 결함이 있는 로트를 신속히 규명하고 B10수명을 결정하는데 유용하게 사용할 수 있다. 또한, 유전체의 절연파괴에 대해서 부하-강도 간섭모델을 이용하여 고장률을 예측하였다. This paper presents a result of failure analysis and reliability evaluation for high voltage ceramic capacitors. The failure modes and failure mechanisms were studied in two ways in order to estimate component life and failure rate. The causes of failure mechanisms for zero resistance phenomena under withstanding voltage test in high voltage ceramic capacitors molded by epoxy resin were studied y establishing an effective root cause failure analysis. Particular emphasis was placed on breakdown phenomena at the ceramic-epoxy interface. The validity of the results in this study was confirmed by the results of accelerated testing. Thermal cycling test for high voltage ceramic capacitor mounted on a magnetron were implemented. Delamination between ceramic and epoxy, which might cause electrical short in underlying circuitry, can occur during curing or thermal cycle. The results can be conveniently used to quickly identify defective lots, determine B10 life estimation each lot at the level of inspection, and detect major changes in the vendors processes. Also, thd condition for dielectric breakdown was investigated for the estimation of failure rate with load-strength interference model.