Consideration of Diluents Selection and Input Amounts of the Hunter Process for Tantalum Production

Jae‑Jin Sim,Sang‑Hoon Choi,Yong‑Kwan Lee,Sung Gue Heo,Taek‑Soo Kim,Seok‑Jun Seo,Kyoung‑Tae Park 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.7

Tantalum (Ta) is a heavy refractory metal with an atomic weight of 180.95 g/mol, a density of 16.6 g/cm3, and a high meltingpoint of 3017 °C. With its refractory characteristics, it shows excellent chemical and physical stability as well as corrosionand heat resistance at elevated temperatures. The demand for Ta metal and related compounds is increasing with the expansionof the electronics and chemical industries. The Hunter process was proven to be effective in producing Ta powder in1953. Hunter proposed a method in which potassium heptafluorotantalate (K2TaF7) was reduced by sodium (Na). Thus far,this process has been the primary commercial method to produce Ta powder. In this study, quantitative differences wereanalyzed for diluent selection. Additionally, consideration was given to changes in the caloric value depending on the inputamount of diluents. Finally, the optimum material input and the properties of the prepared Ta were analyzed. Stoichiometricratios of K2TaF7(1 mol), NaCl (6.2–6.7 mol), Na (5–7 mol) were weighed, to perform a metallothermic reduction reaction. After the reaction, the tantalum powder was recovered and the flush process was carried out. After that, it was dried in avacuum atmosphere. Physical properties such as oxygen concentration, PSA, ICP-OES, and XRD of powder were conductedto evaluate the characteristics of Ta powder that was finally manufactured.

Nanogenerators: Fully Rollable Transparent Nanogenerators Based on Graphene Electrodes (Adv. Mater. 19/2010)

Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19

<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>

Poster Session : PS 1400 ; Hemato-Oncology(Hematology) : The Impact of Oliguria in Patients with Multiple Mye-loma Presenting with Renal Impairment

( Seo Yeon Ahn ),( Sung Hoon Jung ),( Jae Sook Ahn ),( Deok Hwan Yang ),( Min Seok Cho ),( Yeo Kyeoung Kim ),( Hyeoung Joon Kim ),( Je Jung Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Recently, change of urine output is valuable biomarker of acute kidney injury associated with mortality in critically ill patients. This study investigated the prognostic impact of oliguria for survival outcomes in patients with multiple myeloma (MM) presenting with renal impairment (RI). Methods: Retrospective data for 98 patients with MM and RI who were treated upfront with a novel agent containing regimen were analyzed. Oliguria was defined as a urine output that is less than 0.5ml/kg/hours. Results: Baseline median eGFR was 39.7 ml/min (range 5.1-59.8). Achievement of renal complete response (renalCR) was observed in 39.8% of patients. Nine patients (9.2%) presented with oliguria at initial diagnosis, and four initially required dialysis. Over follow-up for a median of 17.1 (range 1.7-100.0) months and median OS was 38.7 months (95% CI 25.0-52.5). On multivariate analysis, oliguria at diagnosis (hazard ratio [HR] 3628, 95% CI 1.366-9.849, P = 0.011) and thrombocytopenia < 100ⅹ 109/ L (HR 2.534, 95% CI 1.068-6.015, P = 0.035) at diagnosis were significantly associated with overall survival. Conclusions: Oliguria was significantly associated with high mortality in MM patients with RI. Therefore, close monitoring of urine output could be important in MM patients with RI.

Development of a Low Cost VI-Tracer for PV System using LabVIEW and DSP

Sang-Yong Kim(김상용),Sangsoo Park(박상수),Seong-Jae Jang(장성재),Gyeong-Hun Kim(김경훈),Hyo-Ryong Seo(서효룡),Minwon Park(박민원),In-Keun Yu(유인근) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

This paper deals with development of a low cost VI(Voltage-Currrent)-tracer for PV(Photovoltaic) system using LabVIEW and DSP(Digital Signal Processor). Although the conventional VI-tracer is a high cost equipment, it can't abstract the detailed parameters of solar cell. To overcome above mentioned disadvantages, in this paper, a converter type VI-tracer is developed. The DSP, which controls the buck-boost DC-DC converter, is used to implement the proposed VI-tracer algorithm. The proposed VI-tracer can abstract more detailed parameters of solar cell; A(temperature constant), Rs(series resistance), and Rsh(parallel resistance). The authors emphasize that the proposed VI-tracer can satisfy the users who need to get various parameters. A comparison between the proposed VI-tracer and the conventional VI-tracer is presented to show the effectiveness of the proposed system.

Poster Session:PS 1085 ; Gastroenterology (Gastrointestinal Tract) : A Case of Intestinal Amyloidosis in Multiple Myeloma Appeared as Ischemic Colitis

( Jae Hyuck Jun ),( Hyun Il Seo ),( Yang Hee Han ),( Jun Sung Kwon ),( Jong Kyu Park ),( Sang Jin Lee ),( Koon Hee Han ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Amyloidosis is a group of diseases caused by abnormal deposition of insoluble amyloid fi brils in various tissues of the body. Diagnosis of gastrointestinal amyloidosis is difficult by reason of various symptoms and nonspecific endoscopic fi ndings. Here, we report a case of small and large intestine amyloidosis in multiple myeloma appeared as ischemic colitis. Case Report: A 67-year-old female was admitted due to hematochezia with abdominal pain. Immediate lower gastrointestinal endoscopy was done and showed necrotic colonic mucosa on transverse colon (fig. 1 A). Contrast-enhanced computed tomography revealed ischemic colitis with intramural hematoma (fig. 1 B). Thus,she had emergency right hemicolectomy for necrotizing ischemic colitis. After operation, she took ordinary postoperative care and discharged. After 1 month, she was admitted again due to abdominal pain and melena. There was no evidence of bleeding on upper gastrointestinal endoscopy. Lower gastrointestinal endoscopy revealed multiple ulcer of various size and shape in distal ileum and biopsy was done (fig. 1 C). Histopathologic exam exhibited green birefringence under polarized light microscopy (fig. 1 D). Therefore we could diagnose ileal amyloidosis. We reviewed surgically resected colonic tissue and had same result. Additional test, serum and urine protein electrophoresis, provided clues to multiple myeloma. Subseqent bone marrow biopsy confi rmed multiple myeloma. finally, we diagnosed intestinal amyloidosis in multiple myeloma which presented as necrotizing ischemic colitis. She took chemotherapy for multiple myeloma in oncology and has improved gradually until now 18 month after diagnosis. Conclusion: We report a case of a small and large intestinal amyloidosis fi rst presented with hematochezia and abdominal pain as typical ischemic colitis and showed necrotizing ischemic colitis in endoscopy. Gastroenterologist and endoscopist have to be aware of possibility of intestinal amyloidosis in case of ischemic colitis. Key word: Amyloidosis, Ischemic colitis, Hematochezia, Endoscopy.

A non-human primate model for stable chronic Parkinson’s disease induced by MPTP administration based on individual behavioral quantification

Seo, Jincheol,Lee, Youngjeon,Kim, Bom Sahn,Park, Junghyung,Yang, Sejung,Yoon, Hai-Jeon,Yoo, Jang,Park, Hyun Soo,Hong, Jung-Joo,Koo, Bon-Sang,Baek, Seung Ho,Jeon, Chang-Yeop,Huh, Jae-Won,Kim, Young-Hyu Elsevier 2019 Journal of neuroscience methods Vol.311 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The guidelines for applying individual adjustments to macaques according to the severity of behavioral symptoms during 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment were provided to reproduce stable chronic Parkinsonism in a recent study (Potts et al., 2014). But, since there are insufficient guidelines regarding objective severity criteria of individual symptoms for adjustments of MPTP treatment, it is difficult to develop MPTP-induced chronic non-human primate (NHP) models with stable symptoms.</P> <P><B>New method</B></P> <P>The individual adjustments of MPTP administration based on results of automatic quantification of global activity (GA) using a video-based tracking system were applied to develop MPTP-PD model. Low-dose (0.2 mg/kg) intramuscular injection was repeated continuously until GA was lower than 8% of baseline Parkinsonian behavior scores. The positron emission tomography imaging were used to follow the longitudinal course of Parkinson’s disease (PD).</P> <P><B>Results</B></P> <P>Significant reductions in GA and dopamine transporter activity, along with significant increases in Parkinsonian behavior scores were found from 4 to 48 weeks following the first administration. GA was correlated with the Parkinsonian behavior score. The dopamine transporter activity was correlated with GA and the Parkinsonian behavior score. However, it was not correlated with the total dose of MPTP. Damage of dopaminergic neuronal systems in the basal ganglia was confirmed by immunohistochemistry and Western blot.</P> <P><B>Comparison with existing method</B></P> <P>This study reinforces previous guidelines regarding production of NHP models with stable Parkinsonian symptoms.</P> <P><B>Conclusions</B></P> <P>This novel strategy of MPTP administration based on global activity evaluations provides an important conceptual advance for the development of chronic NHP Parkinsonian models.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We provide a conceptual advance of the method to produce stable Parkinsonian models. </LI> <LI> Individual MPTP dose adjustments according to the severity of symptoms are needed. </LI> <LI> Global activity using a video tracking system is useful in evaluating Parkinsonism. </LI> <LI> Global activity provides an objective and accurate evaluation of symptom severity. </LI> <LI> Global activity provides the objective criteria for adjustments of MPTP treatment. </LI> </UL> </P>

Poster Session:PS 0229 ; Gastroenterology : Acute Viral Hepatitis after Recovering from Neutropenic Fever

( Sang Jun Suh ),( Young Kul Jung ),( Sun Young Yim ),( Ji Hye Je ),( Yang Jae Yoo ),( Hae Rim Kim ),( Sung Hee Kang ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Soon Ho 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Among the patients with hematologic malignancy, hepatitis occurs after recovering from neutropenic fever. Clinical course is decided according to appropriate treatment to causative pathogen. Various organisms can cause acute hepatitis in immunecompromised host, early inspection to the causative pathogen is essential. We investigated which pathogen cause acute hepatitis after recovering from neutropenic fever in patients with hematologic malignancy. Methods: From January 2011 to april 2014, we included the patients with acute hepatitis (elevated Aspartate transaminase and/or total bilirubin above 2 times upper limit of normal range) within two weeks after recoverinig from neutropenic fever. We excluded the patients with acute hepatitis within two weeks after infused by chemoagent or hepatotoxic drugs. Results: Neutropenic fever was occurred in 173 patients, and 43 patients were appropriate to acute hepatitis of above criteria. Male gender was 28 patients, mean age was 51 years. Causative pathogen was identifi ed in 22 patients. The pathogen was aspergillus 5, infl uenza 4, O.tsutsugamushi 2, varicella zoster virus 1, hepatitis E virus 1 pateint, and other 9 patients were bacterial infection. Among 43 patients, 13 patients occurred septic shock and 11 patients were died. Among survived 2 patients, 1 patient was diagnosed as pulmonary aspergillosis and recovered after therapy with voriconazole, other 1 patients was recovered after therapy with broad-spectrum antibiotics under diagnosis of unknown origin pathegen. Conclusions: Acute hepatitis occur in about 25% after recovering from neutropenic fever, and mortality rate was 25% in the patients with acute hepatitis. Early investigation is essential to such patients, and test for aspergillus and infl uenza would be essential.

A Clinical Analysis of Gastrointestinal Stromal Tumors in Small Intestine: Comparison of Bleeding and Non-bleeding Group

( Sang Jin Lee ),( Jong Kyu Park ),( Hyun Il Seo ),( Koon Hee Han ),( Young Don Kim ),( Woo Jin Jeong ),( Gab Jin Cheon ),( Jae Seok Song ) 대한장연구학회 2013 Intestinal Research Vol.11 No.2

Background/Aims: Gastrointestinal stromal tumors (GIST) in the small intestine are rare and can cause bleeding. The study investigated the clinical characteristics of GIST in the small intestine and to determine the factors related to gastrointestinal bleeding. Methods: We retrospectively evaluated the clinical outcomes of 22 patients with small bowel GIST who were pathologically diagnosed at Gangneung Asan Hospital between March 1997 and August 2012. Results: The median age was 63.5 (38-82) years. Nine patients (40.9%) had gastrointestinal bleeding, five patients (22.7%) had abdominal pain, two patients (9%) had palpable mass. The site of tumor was the duodenum in nine cases (40.9%), jejunum in 7 cases (31.8%), and ileum in six cases (27.3%). Most patients underwent small bowel resection or wedge resection but three patients underwent pancreaticoduodenectomy. Tumor size ranged from 1.6 to 19 cm (median 6.5 cm). The median mitotic rate was 2 (0-50)/50 high power fields (HPF). The median mitotic rate was 2 (0-50)/50 HPF. Five patients (25%) showed recurrence. Gender, aspirin or warfarin use, size and mitotic index of tumor, hospital stay, recurrence and survival were not significantly different between bleeding and non-bleeding group. Bleeding group showed older age, proximal location in small intestine and mucosal ulceration significantly. Conclusions: Small bowel GISTs with bleeding were marked by older age, mucosal ulceration and location of proximal small bowel (duodenum and jejunum) rather than distal small bowel (ileum). (Intest Res 2013;11:113-119)

Human platelet lysate as a novel bioink for 3D bioprinting

Sung Jun Min,Jae Seo Lee,Seung Yeon Lee,Ji Hye Yoo,Ho-Jin Moon,Il Keun Kwon 대한치과재료학회 2022 대한치과기재학회 학술대회 Vol.2022 No.11

Poster Session : PS 0695 ; Rheumatology ; Sarcoid Like Granuloma Developed during Adalimumab Therapy in Ankylosing Spondylitis

( Jae Hoon Kim ),( Jae Kyeom Shim ),( Young Ho Seo ),( Sung Jae Choi ),( Young Ho Lee ),( Jong Dae Ji ),( Kyung Ho Kang ),( Gwan Gyu Song ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Adalimumab is a full human monoclonal antibody that inhibits tumor necrosis factor-alpha (TNF-a). It has recently been shown to be effective in the treatment of rheumatoid arthritis, ankylosing spondylitis (AS). As the pulmonary complication of TNF-a antagonist, infection, interstitial pneumonitis, sarcoidosis and pulmonary vasculitis has been reported. Sarcoidosis is a rare complication among them. Here, we report a patient who has developed sarcoid like granuloma confi rmed by lung biopsy following adalimumab therapy for AS. Case Description: The patient is a 26-year-old man with a history of ankylosing spondylits evolving over the previous 9 years, who had received treatment with non-steroid anti-infi ammatory drugs and sulfasalazin. Adalimumab was injected at a dose of 40 mg twice a month for 9 months with a very positive clinical response. He is admitted due to the patch opacity showed on the right upper and middle lobe at chest radiograph in annual medical checkup. Computed tomography (CT) of the chest revealed various sized multiple nodules on the right upper and middle lobe and lymph node enlargement in both hilum and right paratracheal area. The blood analysis determined ESR 19 mm/hr, CRP 2. 16 mg/L with normal renal and hepatic function. The levels of the angiotensin-converting enzyme were 95. 7 U/L (normal value 9. 0~47. 0). The tuberculosis skin test and the interferon gamma releasing assay were negative. Blood cultures and sputum analysis were negative. The microbiological analysis of the bronchoalveolar lavage were negative. CT guided lung biopsy was carried out and demonstrated the presence of granulomas with histiocytic cells and giant multinucleatedcells, with neither necrosis nor caseum. Conclusion: Sarcoid-like granulomatosis is rare but not exceptional in patients treated with TNF antagonist. It is important for clinicians to be aware of this potential and uncommon complication of TNF antagonist.