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RISS 인기검색어
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- 저자 : Seo Hyang-Hee (검색결과 193 건)
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Seo, Hyang-Hee,Kim, Sang Woo,Lee, Chang Youn,Lim, Kyu Hee,Lee, Jiyun,Choi, Eunhyun,Lim, Soyeon,Lee, Seahyoung,Hwang, Ki-Chul BioMed Central 2017 BIOLOGICAL RESEARCH Vol.50 No.-
<P><B>Background</B></P><P>Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberrant proliferation and migration of VSMCs can be a potential therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. To find an anti-proliferative chemical agent for VSMCs, we screened an in-house small molecule library, and the selected small molecule was further validated for its anti-proliferative effect on VSMCs using multiple approaches, such as cell proliferation assays, wound healing assays, transwell migration assays, and ex vivo aortic ring assay.</P><P><B>Results</B></P><P>Among 43 initially screened small molecule inhibitors of kinases that have no known anti-proliferative effect on VSMCs, a spleen tyrosine kinase (Syk) inhibitor (BAY61-3606) showed significant anti-proliferative effect on VSMCs. Further experiments indicated that BAY61 attenuated the VSMC proliferation in both concentration- and time-dependent manner, and it also significantly suppressed the migration of VSMCs as assessed by both wound healing assays and transwell assays. Additionally, BAY61 suppressed the sprouting of VSMCs from endothelium-removed aortic rings.</P><P><B>Conclusion</B></P><P>The present study identified a Syk kinase inhibitor as a potent VSMC proliferation and migration inhibitor and warrants further studies to elucidate its underlying molecular mechanisms, such as its primary target, and to validate its in vivo efficacy as a therapeutic agent for restenosis and atherosclerosis.</P>
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Seo, Hyang-Hee,Kim, Sang Woo,Lee, Chang Youn,Lim, Kyu Hee,Lee, Jiyun,Lim, Soyeon,Lee, Seahyoung,Hwang, Ki-Chul Elsevier 2017 european journal of pharmacology Vol.798 No.-
<P>Excessive vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury significantly contributes to the development of occlusive vascular disease. Therefore, inhibiting the proliferation and migration of VSMCs is a validated therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. In the present study, we screened chemical compounds for their anti -proliferative effects on VSMCs using multiple approaches, such as MTT assays, wound healing assays, and trans -well migration assays. Our data indicate that 7-cyclopenty1-5-(4-phenoxypheny1)-7H-pyrrolo[2,3-d] pyrimidin-4-ylamine, a lymphocyte -specific protein tyrosine kinase (Lck) inhibitor, significantly inhibited both VSMC proliferation and migration. 7-cyclopenty1-5-(4-phenoxypheny1)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine suppresses VSMC proliferation and migration via down -regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and cyclin Dl and, the phosphorylation of retinoblastoma protein (pRb). Additionally, 7-cyclopenty1-5-(4phenoxypheny1)-7H-pyrrolo[2,3-d] pyrimidin-4-ylamine suppressed the migration of VSMCs from endothelium -removed aortic rings, as well as neointima formation following rat carotid balloon injury. The present study identified 7-cyclopenty1-5-(4-phenoxypheny1)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine as a potent VSMC proliferation and migration inhibitor and warrants further studies to elucidate its more detailed molecular mechanisms, such as its primary target, and to further validate its in vivo efficacy as a therapeutic agent for pathologic vascular conditions, such as restenosis and atherosclerosis.</P>
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Seo, Hyang-Hee,Lee, Se-Yeon,Lee, Chang Youn,Kim, Ran,Kim, Pilseog,Oh, Sekyung,Lee, Hojin,Lee, Min Young,Kim, Jongmin,Kim, Lark Kyun,Hwang, Ki-Chul,Chang, Woochul S. Karger 2017 Journal of vascular research Vol.54 No.2
<P>Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of the damaged heart. In the present study, a strategy for enhancing the angiogenic efficacy of human mesenchymal stem cells (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSC<SUP>miR-146a</SUP>) decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1 (PAK1). miR-146a also increased the expression of Ras-related C3 botulinum toxin substrate 1 and PAK1, which are known to induce VEGF expression, and the formation of vascular branches was increased in hMSC<SUP>miR-146a</SUP> compared to hMSCs treated with VEGF. VEGF and p-Akt were increased in hMSC<SUP>miR-146a</SUP>. Furthermore, injection of hMSC<SUP>miR-146a</SUP> after ischemia/reperfusion (I/R) injury led to a reduction of fibrosis area and increased VEGF expression, confirming the regenerative capacity such as reparative angiogenesis in the infarcted area. Cardiac functions in I/R injury were improved following injection of hMSC<SUP>miR-146a</SUP> compared to the I/R group. Taken together, these data suggest that miR-146 is a novel microRNA that regulates VEGF expression, and its use may be an effective strategy for enhancing the therapeutic efficacy of hMSC transplantation into the I/R-injured heart.</P>
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만 5세 쌓기놀이 갈등해결에서 유아 또래 간 친사회적 행동 발생맥락에 관한 문화기술적 연구
서향희(Seo Hyang Hee) 학습자중심교과교육학회 2015 학습자중심교과교육연구 Vol.15 No.6
본 연구는 만 5세 쌓기놀이 갈등해결에서 유아 또래 간 친사회적 행동의 발생맥 락이 무엇인지를 문화기술적 연구방법으로 탐색함으로써, 쌓기놀이 갈등해결에서 유아 또래 간 친사회적 행동 지원을 위한 기초자료를 제시하고자 하였다. 이를 위한 연구 참여자는 서울특별시 S구에 소재한 D대학교 부속유치원 지혜반 담임 현 교사 1명과 지혜반 만 5세 유아(남: 12명, 여: 8명) 총 20명이며, 2013년 8월부터 2014년 2 월까지 참여관찰과 심층면담을 실시하였다. 연구결과, 만 5세 쌓기놀이 갈등해결에서 유아 또래 간 친사회적 행동의 발생맥 락은 친구관계를 유지하기 위하여 갈등해결에서 또래 간 우정 나누기의 친사회적 행동을 보였으며, 친구관계의 유지는 또래 간 깊은 우정과 애정을 의미하였다. 또한 자신 때문에 생긴 문제해결의 상황은 협동하기의 친사회적 행동을 더욱 촉진하는 맥락이었으며, 협동하기는 어떠한 보상을 바라는 것이 아닌 공동의 목표를 위한 것 이었다. 유아들은 갈등해결에서 자신의 감정에 상처받지 않기 위해 위로하기의 친사 회적 행동을 하였으며, 이는 자신으로 인한 타인의 고통과 어려움에 대한 인식, 동 정, 공감을 의미하는 것으로써 감정 이입 능력과 관련이 있음을 제시하였다. 본 연 구결과는 만 5세 쌓기놀이에서 유아 또래 간 갈등을 통해 친사회적 행동을 실제로 해 볼 수 있는 기회를 제공하여 자발적인 지식을 습득할 수 있는 교육적 환경과 지 원이 지속적으로 필요함을 시사하고 있다. This study was conducted in order to examine the context for occurrence of young children s prosocial behavior among peers in block play conflict resolution using ethnographic methodology and to provide basic data for promoting young children s prosocial behavior among peers in five-years-old block play conflict resolution. The participants of this study were the class teacher of the Wisdom Class and 20 five?year?old children of the class (12 boys and 8 girls) at the kindergarten attached to D University at S District in Seoul, and participant observation and in depth interviews were performed during the period from August 2013 to February 2014. The results of this study were as follows. As to the context for the occurrence of young children’s prosocial behavior among peers in five-years-old block play conflict resolution, the children showed the prosocial behavior of friendship sharing in conflict resolution in order to maintain friends relationship, and the maintenance of friends relationship meant close friendship and deep affection. In addition, the situation of solving a problem caused by the self was a context promoting the prosocial behavior of cooperation, and cooperation was not for expecting any reward but for achieving common goals. Young children did the prosocial behavior of comforting in conflict resolution in order to keep their emotion from being hurt, and this meant the awareness of, sympathy with, and empathy with others’ pain and difficulty induced by themselves, suggesting its relationship with empathy. The results of this study suggest the necessity of educational environment and support that provide young children with opportunities to practice prosocial behavior through five-years-old block play conflict resolution so that they can acquire knowledge spontaneously.
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결혼이주여성에 대한 다문화교육의 방향과 내용; 이혼의 원인 분석을 기초로 하여
윤향희 ( Hyang Hee Yun ) , 서은숙 ( Eun Sook Seo ) 한국윤리학회 2014 倫理硏究 Vol.99 No.1
본 연구의 목적은 결혼이주여성의 이혼 원인에 대한 기존 연구와 상담을 활용한 사례연구를 통해 결혼이주여성에 대한 다문화교육의 방향과 내용을 제시하고자 하였다. 기존의 연구에서 밝혀진 결혼이주여성의 주요 이혼원인은 성격차이, 경제적 무능력, 음주 및 도박, 배우자 가족과의 갈등 등이었으며, 본 연구에서 결혼이주여성의 이혼상담 사례를 통해 밝혀진 주요 이혼 및 갈등원인은 성격차이와 배우자 가족과의 갈등이었다. 그러나 결혼이주여성들을 대상으로 우리 사회에서 수행되고 있는 다문화교육은 그 내용과 방향이 결혼이주여성의 한국 사회 정착에 초점이 맞추어져 있어 이들의 가족 내 갈등을 해결하기에는 다소 무리가 있어 보인다. 따라서 본 연구에서는 결혼이주여성의 이혼 요인을 기초로 하여 다음과 같은 다문화교육의 방향과 내용을 제시하였다. 첫째, 국제결혼에 대한 다문화교육의 선제적 접근이 필요하다. 우리 사회에서 국제결혼 이전에 시행되고 있는 다문화교육을 국제결혼 당사자들뿐만 아니라 시부모 등을 포함한 다문화가족 구성원에 대해 확대 실시하고 다양한 교육 프로그램을 마련할 필요성이 있다. 둘째, 개별성에 기초한 다문화교육을 실시할 필요가 있다. 다문화가족의 개별 구성원에 대한 교육을 의무화하고 개별적 다문화가족에 대한다문화교육을 실시할 필요가 있다. 셋째, 다문화 사회?가족 윤리의 재정립을 통한다문화교육을 실시할 필요가 있다. This article aim at suggesting direction and contents of multi-cultural education for married immigrant women based on analyzing Causes of their divorce. In previous studies, the major causes of married immigrant women`s divorce were personality differences, economic incompetence, their husband`s drinking and gambling, conflict with their husband`s family, etc but according to consulting with married immigrant women in this study, personality differences and conflict with their husband`s family are major causes of married immigrant women`s divorce. However, Content and direction of multi-cultural education being performed on married immigrant women has focused on their settlement in our society and seems to be impossible to solve the conflict with their husband`s family. So, this study suggests following the direction and content of multi-cultural education. First, Proactive approach to international marriage is necessary. Multi-cultural education being implemented before international marriages is carried out for international wedding parties as well as multi-cultural family members, including parents-in-law and there is a need to provide a variety of educational programs for them. Second, it is necessary to perform a multi-cultural education based on individuality. It is necessary to mandate training for individual members of multi-cultural families and perform a multi-cultural education for multi-cultural families individually. Third, multi-cultural education through re-tailoring of a multi-cultural society and family ethics needs to be done.
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