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Lee, Se-Ra,Mun, Jeong-Yeon,Jeong, Mi-So,Lee, Hyun-Hee,Roh, Yun-Gil,Kim, Won-Tae,Kim, Min-Hye,Heo, Jeonghoon,Choi, Yung Hyun,Kim, Su Jin,Cha, Hee-Jae,Jun, Mira,Leem, Sun-Hee MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.11
<P>Tristetraprolin (TTP), a well-characterized AU-rich element (ARE) binding protein, functions as a tumor suppressor gene. The purpose of this study was to investigate whether a bioactive substance derived from a natural medicinal plant affects the induction of TTP and to elucidate its mechanism. We examined the effects of natural bioactive materials including Resveratrol (RSV), thymoquinone (TQ) and curcumin on the expression of TTP in cancer cell. TQ derived from a natural plant Nigella sativa increased the expression levels of TTP mRNA and proteins in a dose-dependent manner in gastric and breast cancer cells. TQ-induced TTP increased the instability of MUC4 mRNA by direct binding of TTP to ARE in the 3′UTR of MUC4 mRNA. The induction of TTP by TQ also reduced the proliferation, migration and invasion of cancer cells. The expression of the epithelial-mesenchymal (EMT)-related genes, which were target genes of TTP, was also decreased by the TQ treatment. In the in vivo experiments using mouse melanoma cells, TQ-induced TTP inhibited metastasis of tumor cells. We have found that TQ-induced TTP might inhibit metastasis by reducing tumor cell migration and invasion through destabilization of MUC4 mRNA, which suggest the MUC4 as a novel target to TTP.</P>
Lee, Ju Hee,Yu, Jae Yong,Shim, So Yun,Yeom, Kyung Mi,Ha, Hyun A,Jekal, Se Yong,Moon, Ki Tae,Park, Joo Hee,Park, Sook Hyun,Hong, Jeong Hee,Song, Mi Ra,Cha, Won Chul 한국성인간호학회 2024 성인간호학회지 Vol.36 No.3
Purpose: The purposes of this study were to develop a prediction model for pressure injury using a machine learning algorithm and to integrate it into clinical practice. Methods: This was a retrospective study of tertiary hospitals in Seoul, Korea. It analyzed patients in 12 departments where many pressure injuries occurred, including 8 general wards and 4 intensive care units from January 2018 to May 2022. In total, 182 variables were included in the model development. A pressure injury prediction model was developed using the gradient boosting algorithm, logistic regression, and decision tree methods, and it was compared to the Braden scale. Results: Among the 1,389,660 general ward cases, there were 451 cases of pressure injuries, and among 139,897 intensive care unit cases, there were 297 cases of pressure injuries. Among the tested prediction models, the gradient boosting algorithm showed the highest predictive performance. The area under the receiver operating characteristic curve of the gradient boosting algorithms pressure injury prediction model in the general ward and intensive care unit was 0.86 (95% confidence interval, 0.83~0.89) and 0.83 (95% confidence interval, 0.79~0.87), respectively. This model was integrated into the electronic health record system to show each patients probability for pressure injury occurrence, and the risk factors calculated every hour. Conclusion: The prediction model developed using the gradient boosting algorithm exhibited higher performance than the Braden scale. A clinical decision support system that automatically assesses pressure injury risk allows nurses to focus on patients at high risk for pressure injuries without increasing their workload.
고추잎 열수추출물로부터 보체계 활성화 다당의 분리 및 특성
나경수,정상철,서형주,박희성,백형석,최장원,이용세 부산대학교 유전공학연구소 2002 분자생물학 연구보 Vol.18 No.-
고추잎의 열수추출을 행하여 추출물의 보체계 활성을 측정한 결과 열수추출물에서 높은 항보체 활성이 나타나 고추잎이 열수추출물을 대상으로 활성 다당을 분리하여 특성을 조사하였다. 즉 열수추출물의 메탄올 환류, 에탄올 침전, 투석 및 동결건조를 통하여 고추잎 600 g으로부터 186 g의 조다당(CAL-0)을 얻었다. CAL-0는 당 51.8%, 산성당 8.2%, 단백질 16.2%를 함유하고 있었으며 주로 arabinose, glucose, galactose로 구성되어 있었다. 조다당 CAL-0는 pronase 처리에서 활성의 변화가 없었으나 과요오드산 산화에 의해서 급격히 활성이 감소하였다. 또한 CAL-0의 항보체 활성은 Ca^2+이온 존재 유무시의 항보체 활성과 교차 면적 전기영동 결과 고전경로와 부경로를 통하여 보체계를 활성화하는 것이 관찰되었다. 이 조다당 CAL-0를 DEAE Sepharose CL-6B을 사용하여 0→1 M NaCl로 이온교환 크로마토그래피를 행하여 1개의 비흡착획분과 6개의 흡착획분을 얻었다. 이중 증류수(CAL-1)와 0.1 M NaCl에서 용출된 획분(CAL-2)이 다른 획분들에서는 주로 arabinose, galactose, glucose가 다양한 비율의 몰비로 구성되어 있었다. CAL-2획분은 Sepharose CL-6B의 gel filtration에서 고분자 peak와 저분자 peak로 분리되었으며 항보체 활성은 분자량 61,000 정도의 고분자 획분에서 높게 나타났다. It was observed that the hot water extract of the leaves of Capsicum annuum L., a Korean edible plant, had a potent anti-complementary activity. Crude polysaccharide fraction(CAL-0) was obtained by methanol reflux, ethanol precipitation, dialysis and lyophilization. CAL-0 contained 51.8% of total sugar, 8.2% of uronic acid and 16.8% of protein, and consisted of mainly arabinose, galactose and glucose as neutral sugars and galacturonic acid as uronic acid. The anti-complementary activity of CAL-0 decreased greatly by periodate oxidation, but was not changed by pronase treatment. Also, the anti-complementary activity of CAL-0 was reduced partially in the absence of the Ca^2+ ion. The crude polysaccharide CAL-0 was found to activate the C3 component both the presence and in the absence of Ca^2+ through the crossed- imminoelectrophoresis suggesting that those involved in both classical and alternative complement pathway. CAL-0 was further separated to an unabsorbed fraction(CAL-1) and six absorbed fractions(CAL-2→CAL-7) on DEAE Sepharose CL-6B ion exchange column. Among them four major fractions in activity and yield were obtained, and consisted mainly of arabinose, galactose and glucose with various molar ratios. The major fraction, CAL-2, was purified to give a high molecular fraction(CAL-2-Ⅰ) and a low molecular fraction(CAL-2-Ⅱ) on Sepharose CL-6B column. The anti- complementary activity of CAL-2-Ⅰ, a molecular weight of about 61,000, was higher than it of CAL-2-Ⅱ.
Deletion Polymorphism of UGT2B17 and Its Relation to Lung Cancer
Se-Ra Lee(이세라),Myoung Hyun Ahn(안명현),So-Young Seol(설소영),Ji-Sun Lee(이지선),Chung-Nam Chung(정정남),Sun-Hee Leem(임선희) 한국생명과학회 2010 생명과학회지 Vol.20 No.5
Glucuronidation은 NNAL [4-(methylnitrosamno)-1-(3-pyridyl)-1-butanol]의 주요 pathway이며, UGT2B의 family인 UGT2B17 (UGT, uridine diphospho-glucuronosyltransferase) 유전자는 발암원의 glucuronidation에 관여한다. UGT2B17 결손은 NNAL의 감소 수준과 특정 암에 있어 위험도를 증가시킨다. UGT2B17 유전자의 copy 수는 사람에서 개인별로 0∼2로 다양하다. 본 연구에서는 UGT2B17 결손이 폐암의 위험도와 연관성을 가지는 가를 알아보기 위해 한국인인 271명의 대조군과 176명의 폐암환자의 샘플로 PCR 방법으로 CNV를 조사하였다. 그 결과, 현재까지 보고된 백인과 흑인에 비해 한국인에서 결실 대립형질이 현저히 높게 나타났다. 백인에서 유전자 두 개 모두가 결실된 0 copy 수가 약 10%를 나타낸 것에 비해, 본 연구의 한국인에서는 0 copy 수가 약 74%를 나타내었다. 더욱이 양 쪽 결실이 여성그룹에서 전반적으로 남성그룹에 비해 높게 나타났다. 그러나 UGT2B17 유전자가 CNV와 폐암과의 연관성은 찾을 수 없었다. 이러한 결과는 UGT2B17 유전자의 결실이 폐암의 감수성과는 연관되어 있지 않으나, UGT2B17 CNV 다형성이 인종간의 진화적 분석의 유용한 마커로 사용이 가능할 것으로 사료된다. Glucuronidation is a major pathway for NNAL [4-(methylnitrosamno)-1-(3-pyridyl)-1-butanol] and UGT2B17 (UGT, uridine diphospho-glucuronosyltransferase) is from the UGT2B family that glucuronidates carcinogens. UGT2B17 deletion was associated with decreased levels of NNAL and with increased risk of some cancers. The UGT2B17 gene varies in copy number from zero to two per individual in humans. To examine whether UGT2B17 gene deletion is associated with the risk of lung cancer, we investigated copy number variants (CNV) in 271 cancer-free controls and 176 cases of lung cancer in Koreans by a PCR-based method. The frequency of the UGT2B17 deleted alleles was much higher than in other Caucasian and African-American groups which have already been reported. While only up to 10% of Caucasians have zero copies of the gene, up to 74% of Koreans in this study showed that both copies of the gene were deleted. Furthermore, the overall frequency of this dual deletion in female groups was higher than in male groups. However, there was no association between CNV in UGT2B17 and lung cancer. This result suggested that the UGT2B17 deletion allele was not associated with the susceptibility of lung cancers in the Korean group. However, this UGT2B17 CNV polymorphism may be a useful marker for evolutionary analysis among races.