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Myung-Eun Jung,Hyuck-Se Kwon,Se-Gye Shin,Yong-Xie Jin,Eun-Kyung Han,Seung-Shi Ham,Il-Jun Kang,Cha-Kwon Chung 한국영양학회 2006 Nutritional Sciences Vol.9 No.4
??The effect of methanol extract from Agaricus blazei Murill on the hepatotoxicity was investigated CCl₄is one of the oldest and most widely used toxins for the induction of hepatic damages and fibrosis in experimental animals. In this study, male Sprague-Dawley(SD) rats were randomly divided into 6 groups of the control(C), CCl₄(T), CCl₄and high fat group(TL) with matching sub-groups of Agaricus blazei Murill extract-fed groups of CA, TA and TLA. Methanol extracts of Agaricus blazei Murill were fed 50 ㎎/㎏ B.W daily via drinking water. A 1.2 ㎖ of CCl₄/㎏ body weight was administered by oral intubation twice a week for total of six times. The levels of total-cholesterol, TG, LDL and LDL-phospholipids were elevated by CCl₄treatment as compared to the control(C). However, Agaricus blazei Murill methanol extract feeding in the group of TA and TLA significantly(p<0.05) decreased TG by 53.1% and 17.9% compared to the internal control of T and TL, respectively. Triglyceride of TL was increased by 3.33 times(p<0.05) compared to the control(C) with CCl₄and high fat administration from 3.78 ㎎/g to 12.60㎎/g liver. The extract(CA) also reduced kidney weight compared to the control(C). With the administration of high fat and CCl₄(TLA), the extract reduced the organ weight of both liver and kidney and further, significantly reduced TG, total cholesterol and GTP activity. Hepatoprotective effects of Agaricus blazei Murill on GOT, GPT, AP and LDH activities were enhanced by the extract feeding. Electronmicrograph showed that CCl₄deteriorated the structure of cytoplasmic matrix with its uneven distribution. However, the extract reconstituted the damaged cytoplasm and stimulated mitochondriogenesis. The above results suggest that Agaricus blazei Murill may have a possible protective effect against chemically induced liver damage and further help to reduce the symptoms of fatty liver.
Yoon-Hee Choi,Hyuck-Se Kwon,Se-Gye Shin,Cha-Kwon Chung 한국식품영양과학회 2014 Preventive Nutrition and Food Science Vol.19 No.4
The present study investigated the effects of Vaccinium uliginosum L. (bilberry) on the learning and memory impairments induced by amyloid-β protein (AβP) 1-42. ICR Swiss mice were divided into 4 groups: the control (Aβ40-1A), control with 5% bilberry group (Aβ40-1B), amyloid β protein 1-42 treated group (Aβ1-42A), and Aβ1-42 with 5% bilberry group (Aβ1-42B). The control was treated with amyloid β-protein 40-1 for placebo effect, and Alzheimer’s disease (AD) group was treated with amyloid β-protein 1-42. Amyloid β-protein 1-42 was intracerebroventricular (ICV) micro injected into the hippocampus in 35% acetonitrile and 0.1% trifluoroacetic acid. Although bilberry added groups tended to decrease the finding time of hidden platform, no statistical significance was found. On the other hand, escape latencies of AβP injected mice were extended compared to that of Aβ40-1. In the Probe test, bilberry added Aβ1-42B group showed a significant (P<0.05) increase of probe crossing frequency compared to Aβ1-42A. Administration of amyloid protein (Aβ1-42) decreased working memory compared to Aβ40-1 control group. In passive avoidance test, bilberry significantly (P<0.05) increased the time of staying in the lighted area compared to AD control. The results suggest that bilberry may help to improve memory and learning capability in chemically induced Alzheimer’s disease in experimental animal models.
들쭉이 약물에 의해 유도된 당뇨 및 지질대사에 미치는 생리활성 효과
한은경(Eun-Kyung Han),권혁세(Hyuck-Se Kwon),신세계(Se-Gye Shin),최윤희(Yoon-Hee Choi),강일준(Il-Jun Kang),정차권(Cha-Kwon Chung) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.12
본 연구는 들쭉을 투여한 흰쥐를 대상으로 고지방과 당뇨를 유발시킨 후의 생리활성 변화를 조사하였다. 수컷 SD rat를 정상군, 고지방군, 당뇨군으로 분류, 들쭉투여군과 대조군으로 분류하였다. 들쭉은 식이 5% 첨가의 경우 식이 섭취량이 증가하였으나, 체중증가량은 감소시켰다. 들쭉의 투여는 또한 STZ에 의해 유발된 당뇨대조군의 증가된 혈청 중성지질 수준을 감소시켰고, HDL-cholesterol 수준을 유의적(p<0.05)으로 증가시켰으며, 당뇨로 증가된 동맥경화지수 수치를 유의적(p<0.05)으로 감소시켰다. 간 지질의 경우 고지방 식이로 인해 증가된 총지질량과 총콜레스테롤, 중성지질을 감소시켰다. 이는 들쭉의 투여가 지질대사를 촉진하는 것으로 사료된다. 지질 과산화물은 고지방의 투여와 당뇨 유발로 증가하였고 들쭉의 병용투여가 이를 감소시켰으나 유의성은 없었다. Oral glucose tolerance test(경구당부하 검사)에서 정상군에서는 혈당의 변화가 거의 관찰되지 않았으며, 당뇨유발쥐의 포도당 투여 후 30분에서 261.20 mg/dL로 높은 혈당을 들쭉 투여로 약 27% 정도 감소시키고, 120분 후에는 공복 수준으로 혈당 수준을 회복시키는 것으로 나타났다. 따라서 들쭉의 투여는 당뇨쥐의 혈청과 지질대사를 개선하고 당대사를 촉진하여 혈당을 강하시키며, 간의 항산화효소 활성을 증가시킴과 동시에 지질과산화량을 감소시켜 간 기능을 개선시키는 것으로 사료되며 고지방으로 지방간을 유도한 흰쥐의 혈청과 간 지질대사를 촉진함으로써 당뇨발생 시 간기능 보호와 더불어 당뇨의 예방에 도움을 줄 수 있을 것으로 사료된다. This study was conducted to investigate the effects of Vaccinium uliginosum L. (bilberry) on chemically induced diabetes and hypercholesterolemia. Sprague Dawley (SD) rats were divided into six groups, control (CON), bilberry added group (CBB), streptozotocin (STZ)-induced diabetic group (STZ), STZ and bilberry added group (SBB), high fat fed group (HFF) and high fat and bilberry added group (HFB). Diabetes was chemically induced by intravenous injection of 45 mg/kg body weight STZ in citrate buffer (pH 4.5). Serum triglycerides decreased significantly (p<0.05) in the STZ group that was fed bilberry. Additionally, the athrogenic index (AI) decreased significantly (p<0.05) when compared to the STZ group, while the liver triglycerides tended to decrease in the STZ group. HDL-cholesterol also increased significantly in response to bilberry. When compared to the STZ group, steady attenuation of the blood glucose level was observed upon fasting, 15 min, 30 min, 60 min and 120 min after oral glucose administration. The blood glucose level in the bilberry fed group decreased by 24% when compared to STZ group, while the superoxide dismutase (SOD) became significantly higher (p<0.05) in the STZ group when compared to the CON group. Overall, the results of this study suggest that bilberry stimulates lipid metabolism in both the serum and liver and has a positive effect on glucose metabolism in chemically induced diabetic rats.