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RISS 인기검색어
- 검색키워드
- 저자 : Saulo R. Tintino (검색결과 3 건)
- 무료
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Anti-Candida activity of Mentha arvensis and Turnera ulmifolia
Karla K.A. Santos,Edinardo F.F. Matias,Celestina E.S. Souza,Saulo R. Tintino,Maria F.B.M. Braga,Glaucia M.M. Guedes,Lavouisier F.B. Nogueira,Edson C. Morais,Jose´ G.M. Costa,Irwin R.A. Menezes,Henriqu 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
Candidiasis is the most frequent infection by opportunistic fungi, frequently caused by Candida albicans, Candida tropicalis, Candida parapsilosis, Candida glabrata, and Candida krusei. Mentha arvensis L. is a herbaceous plant that occurs throughout South America and is used as a tea and in the folk medicine. Turnera ulmifolia L. is already known to be of medicinal value. Ethanol extracts from M. arvensis and T. ulmifolia were assayed for antifungal activity against strains of C. albicans, C. tropicalis, and C. krusei. No clinically relevant antifungal activity was demonstrated by the extracts;however, a potentiation effect was observed when the extracts were applied with metronidazole against C. tropicalis. M. arvensis and T. ulmifolia could represent a source of natural products with modifying antifungal activity.
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Enhancement of the Antifungal Activity of Antimicrobial Drugs by Eugenia uniflora L.
Karla K.A. Santos,Edinardo F.F. Matias,Saulo R. Tintino,Celestina E.S. Souza,Maria F.B.M. Braga,Glaucia M.M. Guedes,Jose´ G.M. Costa,Irwin R.A. Menezes,Henrique Douglas Melo Coutinho 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.7
Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.
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Cytotoxic, Trypanocidal, and Antifungal Activities of Eugenia jambolana L.
Karla K.A. dos Santos,Edinardo F.F. Matias,Saulo R. Tintino,Celestina E.S. Souza,Maria F.B.M. Braga,Gla´ucia M.M. Guedes,Miriam Rolo´n,Celeste Vega,Antonieta Rojas de Arias,Jose´ G.M. Costa,Irwin A. M 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1
Chagas’ disease, caused by Trypanosoma cruzi, is considered a public health problem. Nowadays, chemotherapy is the only available treatment for this disease, and the drugs currently used, nifurtimox and benzonidazole, present high toxicity levels. Alternatives for replacing these drugs are natural extracts from Eugenia jambolana, a plant used in traditional medicine because of its antimicrobial and biological activities. An ethanol extract from E. jambolana was prepared. To research in vitro anti-epimastigote activity, T. cruzi CL-B5 clone was used. Epimastigotes were inoculated at a concentration of 1 · 105/mL in 200 lL of tryptose-liver infusion. For the cytotoxicity assay J774 macrophages were used. To examine antifungal activity, Candida albicans, Candida tropicalis, and Candida krusei were used. This is the first record of trypanocide activity for E. jambolana. The effective concentration capable of killing 50% of the parasites was 56.42 lg/mL. The minimum inhibitory concentration was £ 1,024 lg/mL. Metronidazole showed a potentiation of its antifungal effect when combined with the ethanol extract of E. jambolana. Thus our results indicate that E. jambolana could be a source of plantderived natural products with anti-epimastigote and antifungal modifying activity with moderate toxicity.
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