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Chanmuang Saoraya,Meemalai Orawan,Promyo Kitipong,Park Kyung-Hee,Pongworn Suthipong,Gong Dal-Seong,Oak Min-Ho,Cho Jeong-Yong,Kang Seong-Gook,Ham Kyung-Sik 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.6
Endothelial dysfunction is directly involved in consequence of various metabolic syndromes such as diabetes and hypertension. In this study, we investigated the preventive efects of two ark clams [ark shell (AS, Scapharca subcrenata) and granular ark (GA, Tegillarca granosa)] on endothelial dysfunction induced by a high-fat diet. Wistar rats were divided into four groups as follows: control (normal diet), HF (high-fat diet), AS (high-fat diet+5% AS powder), and GA (high-fat diet+5% GA powder) for 12 weeks. AS and GA diets enhanced vascular reactivity of the rat thoracic aorta and signifcantly increased expression levels of vascular relaxation-related proteins (p-Akt-ser473 and p-eNOSser1177). Ark clam supplement reduced endothelin-1 expression level, as compared to the HF group. Additionally, AS and GA showed a trend of improving insulin sensitivity compared to HF. Our results suggest that AS and GA enhance vascular reactivity and ameliorated endothelial dysfunction induced by a high-fat diet.