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석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2
시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chan 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Bart’s syndrome is a rare hereditary mechanobullous disorder, first described by Bart et al in 1966. It is characterized by clinical manifestations: aplasia cutis congenita (ACC) over the lower extremities, epidermolysis bullosa (EB), and nail abnormalities. Previous genetic study revealed glycine substitution mutation in type VII collagen gene (COL7A1) indicated that Bart’s syndrome is a clinical variant of dominant dystrophic EB. The patient was a 1-day-old male newborn who presented with well-demarcated absence of skin over both lower extremities and erosive patches with blisters on nostril, lip, and hand since birth. He was born by Cesarean section at the 37th weeks of gestation. There was no family history of genetic disorder. There was no systemic involvement such as pyloric atresia, renal abnormalities, or arthrogryposis. Histopathologic findings from blister on hand showed subepidermal blister formation, and electron microscopy showed separation of below lamina densa layer. We performed mutation analysis of 118 exons of COL7A1. These result disclosed two novel heterogenous frameshift mutations (c.3841_3843delGGTinsTGGGG in exon 31 and c.8109_81014delGGTGAG in exon 109). Therefore, he was diagnosed as Bart’s syndrome with recessive dystrophic EB. Herein, we report a very rare case of Bart' syndrome which is clinical variant of recessive dystrophic EB, and review genetic mutation in this syndrome.
[P113] Clinical and histopathologic features of 4 cases of adult-onset Still`s disease
( Sang-jin Cheon ),( Sung-min Park ),( Hyun-joo Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disorder characterized by classic clinical triad of persistent high spiking fever, arthralgia, and typical salmon colored maculopapular rash. Recently, comprehensive review of literature showed that cutaneous involvement occurs in about 80% of AOSD patients. However, clinical and histopathologic characteristics of skin lesion of AOSD are rarely reported in dermatologic literature. We experienced 4 cases of AOSD (M:F=1:3). The diagnosis is based upon the clinical and laboratory criteria. Among them, 2 patients clinically showed multiple persistent pruritic erythematous papules and plaque. Histopathologic examination of erythematous plaque revealed multiple dyskeratotic keratinocytes in the upper epidermis. The other 2 patients presented with disseminated pruritic urticarial rash. Histopathologic examination of urticarial lesion revealed perivascular and interstitial infiltrates with neutrophils and a few mononuclear cells in the dermis. Diagnosing of AOSD is difficult due to nonspecific symptoms and absence of characteristic laboratory test. Herein, we report rare cases of AOSD presenting with persistent pruritic papules and plaques and urticarial rash. And we considered that dyskeratotic keratinocytes in upper dermis of pruritic plaques and neutrophils infiltration in perivascular and interstitial infiltration may be clue for a suspicious of AOSD.
Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition
Moon Kyung Joo,Chan Hyuk Park,Joon Sung Kim,Jae Myung Park,Ji Yong Ahn,Bong Eun Lee,Jeong Hoon Lee,Hyo-Joon Yang,Yu Kyung Cho,Chang Seok Bang,Beom Jin Kim,Hye-kyung Jung,Byung-Wook Kim,Yong Chan Lee,K 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.6
Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology. However, the previous guidelines were based mainly upon a review of the relevant literature and expert opinion. Therefore, the guidelines need to be revised. We organized a guideline Development Committee for drug-related peptic ulcer under the auspices of the Korean College of Helicobacter and Upper Gastrointestinal Research in 2017 and developed nine statements, including four for NSAIDs, three for aspirin and other antiplatelet agents, and two for anticoagulants through a de novo process founded on evidence-based medicine that included a literature search and a meta-analysis, A consensus was reached through the application of the modified Delphi method. The primary target of these guidelines is adult patients undergoing long-term treatment with NSAIDs, aspirin or other antiplatelet agents and anticoagulants. The revised guidelines reflect the expert consensus and is intended to assist clinicians in the management and prevention of druginduced peptic ulcer and associated conditions.
Endophthalmitis due to Streptococcus agalactiae of a serotype V strain in a healthy adult
( Sang Hyun Kim ),( Yu Ra Sim ),( Yea Jin Lee ),( Min Ja Kim ),( Jang Wook Sohn ),( Jae Moon Ahn ),( Young Kyung Yoon ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Streptococcus agalactiae, a group B streptococcus (GBS), is a normal flora. Endogenous endophthalmitis caused by GBS is an extremly rare but visually devastating disease. Here, we describe the first-reported Korean case of GBS infective endocarditis presenting as endogenous endophthalmitis and skin and soft tissue infection. Case Report: A 43-year old female without any underlying medical condition visited our emergency room complaining of a 10-hour history of decreased visual acuity with ocular pain on the right eye. Physical examination revealed a 3 cm-sized skin swelling with purulent discharge on right buttock area which was tender and erythematous. Ophthalmic examination revealed endogenous endophthalmitis on the right eye. Penicillin-susceptible S. agalactiae, sequence type 1 associated with a serotype V, was identified as the causative organism on the specimens from the eyeball, blood, and skin pus of right buttock. For the first 12 days of hospitalization, intravenous ceftriaxone (2 g/day) was prescribed with the regimen of intravitreal vancomycin (1 mg/0.1 mL) and ceftazidime (2.25mg/0.1 mL). However, her visual acuity rapidly deteriorated to light perception within a day. On the third day of hospitalization, she underwent a therapeutic vitrectomy of right eye. Ten days after initially normal transthoracic echocardiography, transesophageal echocardiography revealed a 5 mm-sized vegetation attached to anterior mitral leaflet. The patient was finally diagnosed as invasive GBS infection with infective endocarditis presented as endogenous endophthalmitis and skin and soft tissue infection. At the 6-month follow-up visit after completion of antibiotic therapy for 40 days, the patient remained free of any complications, except phthisis bulbi of the right eye without perception to light and visual acuity. Conclusions: In conclusion, this case suggests that GBSinfections should be added to the list for differential diagnosis of endogenous endophthalmitis even in healthy adults. Our report also highlights the requirement of a high index of suspicion for infective endocarditis among them.
Associations between Nutritional Risk and Mental Health in an Elderly Korean Population
Sung-Jin Kim,Im-Gyu Kim,Do-Un Jung,Jae-Hong Park,Young-Soo Seo,Jung-Joon Moon,Dong-Wook Jeon 대한노인정신의학회 2020 노인정신의학 Vol.24 No.1
Objective:Older adults are at greater risk for malnutrition than younger adults, and malnutrition can be associated with a variety of mental problems. This study was undertaken to investigate differences in mental health indicators according to nutritional risk administered to elderly people living in the community. Methods:Nutritional risk score was assessed using the ‘Determine Your Nutrition Health’ checklist, developed by the Nutritional Screening Initiative. The study enrolled 400 elderly people living in the community. Study subjects were divided into 3 groups based on their nutritional risk score: good nutrition (score ≤2; n=275), moderate nutritional risk (score 3-5; n=63), and high nutritional risk (score ≥6; n=62). The General Health Questionnaire-12 (GHQ-12), suicide risk screening tool, memory decline awareness, sleep disorder questionnaire, and health-related quality of life (EuroQoL-5 dimension, EQ-5D) were used to assess mental health problems. Statistical analyses were performed using chi-square test, analysis of variance, and Pearson correlation analysis. Results:In the high nutrition risk group, GHQ-12 score was highest. In the good nutrition group, subjective memory impairment score and sleep difficulty were lowest, and EQ-5D index was highest. The risk of suicide tended to increase with increasing nutritional risk. Nutritional risk score was significantly correlated with GHQ-12, subjective memory impairment, sleep latency time, total sleep duration, sleep difficulty, and EQ-5D index. Conclusion:This study confirms that nutritional risk in the elderly is related to various psychological symptoms and low quality of life. High nutritional risk in the elderly warrants clinical attention to mental health and quality of life.
[P402] Primary milium of the nipple
( Sung-min Park ),( Hak-jun Kim ),( Hyun-joo Lee ),( Hyunju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Milia are very common, benign, keratin-filled, small epidermal inclusion cysts measuring 1-2 mm in diameter that may arise from the pilosebaceous apparatus or the eccrine sweat ducts. They occur either spontaneously (primary milia) or secondary to various processes (secondary milia). Primary milia are common in newborns, and resolve spontaneously within weeks to several months. They can be found anywhere, but usually occur on the face, upper trunk, and extremities. However, milia occurring on the nipple are rare. Herein, we present an interesting case of primary milium of nipple. A 6-year-old boy presented with a solitary, pearly, dome-shaped nodule on the left nipple. His mother stated that the lesion had been present at birth, and there was no history of trauma, and prior skin lesions. There were no associated signs or symptoms, and his contralateral breast was normal. Cyst was excised under local anesthesia, and histopathologic findings were consistent with milium.