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( Ji Seok Kim ),( Chan Hee Nam ),( Ji Yeon Yoo1 ),( Hyun Jung Kim ),( Se Kyoo Jeong ),( Sung Ku Ahn ),( Seung Phil Hong ) 한국피부장벽학회 2014 한국피부장벽학회지 Vol.16 No.2
Purpose: There are researches indicating that in human skin, the cannabinoid receptors exist, which take a part of endocannabinoid system. Nonetheless, the possible association of cannabinoid receptors with the pathogenesis of psoriasis has not yet been fully elucidated. Through this research, we tried to document the association between cannabinoid system, epidermal differentiation and psoriasis. Methods: Using human keratinocyte (KC), the expression of cannabinoid receptor-1 (CB1R) and -2 (CB2R) was analyzed according to the degree of differentiation. Also we examined for changes in differentiation marker of KC after application of CBR agonist. In addition, murine model applied with imiquimod to induce psoriasis symptoms was used to evaluate the effect of topical CBR agonist on inflammation and skin barrier function. Results: Compared to normal human skin, CBR expression was reduced in epidermis of psoriasis skin. Western blotting revealed the expression of both CB1R and CB2R in undifferentiated KC. The expression level of CB1R increased as the differentiation progressed in KC as with involucrin, K1 and K10. On the other hand, there was no change of CB2R in the process of differentiation. Furthermore, CB1R agonist partly increased expression of proteins associated with epidermal differentiation. Through this we could speculate that the CB system may be associated with proteins related to epidermal differentiation. Moreover, inflammation and barrier function in murine models with psoriasis symptoms were improved after 3 days-application of topical CB1R agonist. Conclusion: Cannabinoid receptors in human skin might be related to the differentiation of KC, and since its activation could improve skin barrier condition in murine psoriasis model, it can be expected to be a new therapeutic target for treatment of psoriasis.
(Sang Ah Chang),(Bong Yun Cha),(Soon Jib Yoo),(Yo Bae Ahn),(Ki Ho Song),(Je Ho Han),(Jong Min Lee),(Hyun Sik Son),(Kun Ho Yoon),(Moo Il Kang),(Kwang Woo Lee),(Ho Young Son),(Sung Ku Kang) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2
N/A Background : It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. Methods : About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. Results : In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. Conclusion : These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.
Protective effect of bovine milk against HCl and ethanol–induced gastric ulcer in mice
Yoo, Jeong-Hyun,Lee, Jeong-Sang,Lee, You-Suk,Ku, SaeKwang,Lee, Hae-Jeung Elsevier 2018 Journal of dairy science Vol.101 No.5
<P>The purpose of this study was to investigate the gastroprotective effects of bovine milk on an acidified ethanol (HCl-ethanol) mixture that induced gastric ulcers in a mouse model. Mice received different doses of commercial fresh bovine milk (5, 10, and 20 mL/kg of body weight) by oral gavage once a day for 14 d. One hour after the last oral administration of bovine milk, the HCl-ethanol mixture was orally intubated to provoke severe gastric damage. Our results showed that pretreatment with bovine milk significantly suppressed the formation of gastric mucosa lesions. Pretreatment lowered gastric myeloperoxidase and increased gastric mucus contents and antioxidant enzymes catalase and superoxide dismutase. Administration of bovine milk increased nitrate/nitrite levels and decreased the malondialdehyde levels and the expression of proinflammatory genes, including transcription factor nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase in the stomach of mice. These results suggest that bovine milk can prevent the development of gastric ulcer caused by acid and alcohol in mice.</P>
( Sung Jay Choe ),( Jiyeon Yoo ),( Seung Phil Hong ),( Sung Ku Ahn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The various beneficial effects of moisturizer have been well established. However, it remains still unknown whether daily-used moisturizer can affect the photoaging process over a long period or not. Objectives: To investigate the effect of long-term use of moisturizer on the skin changes induced by long-term repeated exposure to suberythemal UV radiation. Methods: Hairless mice were divided into 4 groups according to the application time of moisturizer and UV exposure status: untreated control, UV exposure only (UV only), application of moisturizer 2 hour before UV radiation (Before), and application 1 hour after UV radiation (After) group. TEWL and SC hydration weremeasured every 6 weeks. After 18 weeks, Epidermal thickness (ET) and dermal thickness (DT), density of dermal fibrous components (DD) was measured from skin biopsy samples. Also, mRNA expression of MMP-13 and procollagen was quantified by real time RT-PCR. Results: After 18 weeks, all UV exposed groups showed increased ET and TEWL. The Before group had a lower margin of increase in ET and TEWL. DT and DD in the Before group was similar to the control group, whereas that of the UV only group was most reduced. Also, UV induced reduction of type 1 procollagen and rise of MMP-13 expression were alleviated in the Before group. Conclusion: Long-term application of moisturizer before UV exposure may have another beneficial role in the prevention against photo-aging, aside from its protective effect on the barrier function.
( Sung Eun Kim ),( Moo In Park ),( Seun Ja Park ),( Won Moon ),( Youn Jung Choi ),( Ji Hyun Cheon ),( Hye Jung Kwon ),( Ki Hwan Ku ),( Chang Hun Yoo ),( Jae Hyun Kim ),( Gyu Won Lee ),( Sung Eun Song 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6
Background/Aims: Trends in successful eradication of Helicobacter pylori using first-line triple therapy, consisting of a proton pump inhibitor, amoxicillin, and clarithromycin, have been understudied. We evaluated H. pylori eradication rates at a single center over the last 10 years and identified risk factors related to eradication failure. Methods: This study included 1,413 patients who were diagnosed with H. pylori infection and received 7 days of triple therapy between January 2003 and December 2012. We investigated H. pylori eradication rates retrospectively with respect to the year of therapy, as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 weeks after the completion of triple therapy. Results: The overall H. pylori eradication rate was 84.9%. Annual eradication rates from 2003 to 2012 were 93.5%, 80.0%, 87.2%, 88.5%, 92.0%, 88.3%, 85.7%, 84.1%, 83.7%, and 78.8%, respectively, by per-protocol analysis. The eradication rate with first-line triple therapy decreased during the last 10 years (p = 0.015). Multivariate analysis showed that female gender (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.12 to 2.55) and smoking (OR, 1.61; 95% CI, 1.05 to 2.47) were associated with the failure of H. pylori eradication therapy. Conclusions: The efficacy of first-line triple therapy for H. pylori infection has decreased over the last 10 years, suggesting an increase in antibiotic-resistant H. pylori strains. Thus, other first-line therapies may be necessary for H. pylori eradication in the near future.
Sung Ku Kwon,김병환,박종문,김보우,Seong Wook Yoo,Kun Sik Park,Yoon Kyu Bae,Kwang Ho Kwon 한국전자통신연구원 2002 ETRI Journal Vol.24 No.3
This study characterizes an oxide etching process in a magnetically enhanced reactive ion etching (MERIE) reactor with a CHF3/CF4 gas chemistry. We use a statistical 24-1 experimental design plus one center point to characterize the relationships between the process factors and etch responses. The factors that we varied in the design include RF power, pressure, and gas composition, and the modeled etch responses were the etch rate, etch selectivity to TiN, and uniformity. The developed models produced 3D response plots. Etching of SiO2 mainly depends on F density and ion bombardment. SiO2 etch selectivity to TiN sensitively depends on the F density in the plasma and the effects of ion bombardment. The process conditions for a high etch selectivity are a 0.3 to 0.5 CF4 flow ratio and a –600 V to –650 V DC bias voltage according to the process pressure in our experiment. Etching uniformity was improved with an increas e in the CF4 flow ratio in the gas mixture, an increase in the source power, and a higher pressure. Our characterization of via etching in a CHF3/CF4 MERIE using neural networks was successful, economical, and effective. The results provide highly valuable information about etching mechanisms and optimum etching conditions.