http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shim, Jae-Hyuck,Greenblatt, Matthew B,Singh, Anju,Brady, Nicholas,Hu, Dorothy,Drapp, Rebecca,Ogawa, Wataru,Kasuga, Masato,Noda, Tetsuo,Yang, Sang-Hwa,Lee, Sang-Kyou,Rebel, Vivienne I,Glimcher, Laurie American Society for Clinical Investigation 2012 The Journal of clinical investigation Vol.122 No.1
<P>Mutations in the coactivator CREB-binding protein (CBP) are a major cause of the human skeletal dysplasia Rubinstein-Taybi syndrome (RTS); however, the mechanism by which these mutations affect skeletal mineralization and patterning is unknown. Here, we report the identification of 3-phosphoinositide-dependent kinase 1 (PDK1) as a key regulator of CBP activity and demonstrate that its functions map to both osteoprogenitor cells and mature osteoblasts. In osteoblasts, PDK1 activated the CREB/CBP complex, which in turn controlled runt-related transcription factor 2 (RUNX2) activation and expression of bone morphogenetic protein 2 (BMP2). These pathways also operated in vivo, as evidenced by recapitulation of RTS spectrum phenotypes with osteoblast-specific Pdk1 deletion in mice (Pdk1osx mice) and by the genetic interactions observed in mice heterozygous for both osteoblast-specific Pdk1 deletion and either Runx2 or Creb deletion. Finally, treatment of Pdk1osx and Cbp+/- embryos with BMPs in utero partially reversed their skeletal anomalies at birth. These findings illustrate the in vivo function of the PDK1-AKT-CREB/CBP pathway in bone formation and provide proof of principle for in utero growth factor supplementation as a potential therapy for skeletal dysplasias.</P>
남궁혁준(Hyuck-Joon Namkoung),심창열(Chang-yol Shim),이재호(Jae-ho Lee),박순상(Sun-sang Park) 한국추진공학회 2011 한국추진공학회 학술대회논문집 Vol.2011 No.11
이젝터 시스템은 주유동 제트에 발생되는 전단 응력과 압력차에 의해 흡입 챔버 압력에 영향을 미치거나 이차 흡입 유동을 유도한다. 이젝터는 터빈 기반 복합사이클 추진기관 및 로켓엔진의 고고도 모사 설비, 압력회복장치, 담수화 시스템, 이젝터 램젯시스템과 같이 많은 분야에 적용되어 널리 사용된다. 본 연구에서는 다양한 고고도 환경 모사를 위한 멀티 이젝터의 형상 및 운전 조건을 결정하는 설계 절차를 수립하고자 하였다. Ejector system can induce the secondary flow or affect the secondary chamber pressure by both shear stress and pressure drop which are generated in the primary jet boundary. Ejectors are widely used in a range of applications such as a turbine-based combined-cycle propulsion system and a high altitude test facility for rocket engine, pressure recovery system, desalination plant and ejector ramjet etc. The primary interest of this study is to set up an design procedure on the configuration and operating condition of multi-ejector for the various high altitude simulation.
Esophageal Squamous Cell Carcinoma Recurring as a Solitary Renal Mass
임도형,Sang Hoon Ji,박병배,이지연,Keun Woo Park,Joon-Oh Park,Kihyun Kim,정철원,Young Suk Park,Won Ki Kang,Kwanmien Kim,Young Mog Shim,Young-Hyuck Im,Mi Jung Oh,Se-Hoon Lee,Won Seog Kim,Mark H Lee,Keunchil Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.4
Herein, a case of solitary, unilateral renal metastasis in a patient with curatively resected thoracic esophageal carcinoma, who achieved a pathological complete remission after neoadjuvant concurrent chemoradiotherapy, is reported. The kidney is the 4th or 5th most common visceral metastasis site of a primary esophageal carcinoma. More than 50& of renal metastases typically show bilateral involvement. Solitary, unilateral renal metastasis is extremely rare. Renal metastases from a primary esophageal carcinoma are usually latent and its diagnosis is very unusual in a live patient. The solitary renal metastasis in this case was not accompanied by metastases to other sites. The value of a nephrectomy in solitary renal metastasis of esophageal cancer is not known due to the rarity of such cases. A nephrectomy could be justified in limited situations, such as with uncertainty of histological diagnosis, severe life-threatening hematuria, which cannot be controlled by embolization, or solitary renal metastasis with a long disease-free interval.(Cancer Res Treat. 2004;36:271-274)
왕성우 ( Sung Woo Wang ),이동혁 ( Dong Hyuck Lee ),심일출 ( Eel Chul Shim ),최승철 ( Seung Churl Choi ),김윤두 ( Yoon Doo Kim ) 한국식품유통학회 2006 食品流通硏究 Vol.23 No.1
The study aims to suggest an implementing strategy of packing shipment of radish and Chinese cabbage. To do this, we survey marketers who participated in collecting and distributing the produce, then analyze the preferences of them in those shipment system. Also, we estimate the cost of dealing with the produce and the benefit of it in standardization packing. This is to provide relevant intuition and direction for a step-by-step strategy of shipping produce, especially radish and Chinese cabbages, as well as for public aid. Improved system of the shipment would reduce the waste at the point of wholesale markets and currently occurring costs.
최혁재(Hyuck Jai Choi),심상범(Sang Bum Shim),김남재(Nam Jae Kim),김종우(Jong Woo Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
Propolis is a lipophilic, natural product prepared by mixing the exudates collected from various plants by honeybees with beeswax for the purpose of using to seal hive walls and to strengthen the borders of combs. Because of its versatile bioactivities, propolis has been attracting many investigators` interest. But the pharmacological studies on propolis has, to date, been exclusively performed for an alcohol extract, there is few information of water extract. Therefore, in this study, we investigated the various effects of water extract of Chinese propolis. The water extract of propolis and its fractions of organic solvents showed strong antioxidative activities, especially ether and ethylacetate fractions, and reduced the lipid peroxidation of rat liver in vitro. Additionally the ether fraction of propolis (10 mg/ml) inhibited the activity of hyaluronidase by 50%. In vivo, the water extract of propolis considerably decreased s-GOT, s-GPT and s-LDH activities which represent for the hepatotoxicity induced by CCl₄4 in rats, and prolonged the MST (Medium sevival tinme) and ILS (Increasing in MST over control) by 18% in mice which inoculated with sarcoma 180 ascites cells. These results suggest that the water extract of propolis has various bioactivities as well as the alcohol extract.