단상 유도형 동기 전동기(LSPM)의 특성해석에 관한 연구

정대성,김승주,이진헌,최재학,이주,Jung, Dae-Sung,Kim, Seung-Ju,Lee, Jin-Hun,Choi, Jae-Hak,Lee, Ju 한국조명전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.3

가전분야에서의 전동기 효율향상을 통한 에너지 소비절감 효과는 상당히 크지만 이를 위한 전동기의 설계/해석 기술 확보가 아직은 미흡한 상태이다. 이에 따라 유도형 동기전동기가 제안되었지만, 유도형 동기 전동기는 유도전동기와 통기전동기의 특성을 동시에 가지고 있어, 해석 및 설계가 쉽지 않다. 따라서 본 논문에서는 기존의 냉장고 압축기용 전동기인 단상유도전동기를 대처할 수 있는 단상 유도형 동기전동기를 이용해 파라미터에 따라 특성이 어떻게 바뀌는가에 대해 서술하였다. 그에 따라 단상유도전동기의 정상상태 특성을 해석하고 제안모델의 성능을 기존모델과 비교하고 실험하여 해석결과의 신뢰성을 검증한다. 또한 본 논문에서는 제안모델의 기존 고정자 형상이나 권선 스팩을 유지하고 회전자의 형상이나 구조만을 변경시켜 성능향상을 도모하였다. 해석방법으로는 전자장 수치 해석적인 방법으로 널리 이용되고 있는 유한요소법(Finite Element Method : FEM)을 이용하였다. Electric motor efficient improvement from home appliance field is important to the effect reducing the energy consumption. But the electric motor design/analysis technology is still insufficient. Specially the electric motor design/analysis technology of satisfying characteristic of both the induction motor and the synchronous motor such as Line start permanent motor. Therefore the electric motor design/analysis technology is urgently demanded reliability. This paper proposes the sing1e-phase line-start permanent magnet motor to develop the motor it with be able to alternate the sing-phase induction motor it is a refrigerator compressor motor. The sing-phase induction motor is analyzed in the steady state. And we have a certification test to compare our single-phase line-start permanent magnet motor with the sing-phase induction motor. In order to improve the performance, the stator of the single-phase line-start permanent magnet motor is same as the stator of the sing-phase induction motor and changes the rotor form and has the permanent magnet. It used the Finite Element Method(FEM) which is widely used with electronic-magnetic field numerical analysis method.

Loganin Ameliorates Acute Kidney Injury and Restores Tofacitinib Metabolism in Rats: Implications for Renal Protection and Drug Interaction

Choi Hyeon Gyeom,Park So Yeon,Bae Sung Hun,Chang Sun-Young,Kim So Hee 한국응용약물학회 2024 Biomolecules & Therapeutics(구 응용약물학회지) Vol.32 No.5

Tofacitinib, a Janus kinase (JAK) inhibitor used to treat rheumatoid arthritis, is metabolized through hepatic cytochrome P450 (CYP), specifically CYP3A1/2 and CYP2C11. Prolonged administration of rheumatoid arthritis medications is generally associated with an increased risk of renal toxicity. Loganin (LGN), an iridoid glycoside, has hepatorenal regenerative properties. This study investigates the potential of LGN to mitigate acute kidney injury (AKI) and its effects on the pharmacokinetics of tofacitinib in rats with cisplatin-induced AKI. Both intravenous and oral administration of tofacitinib to AKI rats significantly increased the area under the plasma concentration-time curve from time 0 to infinity (AUC) compared with control (CON) rats, an increase attributed to the decelerated non-renal clearance (CLNR) and renal clearance (CLR) of tofacitinib. Administration of LGN to AKI rats, however, protected kidneys from severe impairment, restoring the pharmacokinetic parameters (AUC, CLNR, and CLR) of tofacitinib to those observed in untreated CON rats, with partial recovery of kidney function, as evidenced by an increase in creatinine clearance. Possible interactions between drugs and natural components should be considered, especially when co-administering both a drug and a natural extract containing LGN or iridoid glycosides to patients with kidney injury.

Severity of COVID-19 Pneumonia in Kidney Transplant Recipients According to SARS-CoV-2 Vaccination

Choi Seunghyeok,Lee Hanbi,Eum Sang Hun,Min Ji-Won,Yoon Hye Eun,Yang Chul Woo,Chung Byung Ha 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.4

We reviewed 24 kidney transplantat recipients (KTRs) who had radiologically confirmed coronavirus disease 2019 (COVID-19) pneumonia. Enrolled KTRs were divided into a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-vaccination (+) group (n = 18) and a vaccination (-) group (n = 6). Clinical outcomes of the two groups including death, pulmonary outcome, and renal outcome were compared. COVID-19 pneumonia was worse in vaccination (-) KTRs. Two out of six vaccination (-) KTRs needed continuous renal replacement therapy (CRRT) and mechanical ventilator (MV) and expired. In contrast, only one KTR expired and required CRRT and MV out of 18 vaccination (+) KTRs. Our results suggest that SARS-CoV-2 vaccination attenuates severity of COVID-19 pneumonia in KTRs.

Investigation of Single Nucleotide Polymorphisms in Porcine Candidate Gene for Growth and Meat Quality Traits in the Berkshire Breed

Sang Wook Kim(김상욱),Ji Hye Jung(정지혜),Kyung Tag Do(도경탁),Kwan Suk Kim(김관석),Chang Hee Do(도창희),Jun kyu Park(박준규),Young Kuk Joo(주영국),Tae Suk Kim(김태숙),Bong Hwan Choi(최봉환),Tae Hun Kim(김태헌),Ki Duk Song(송기덕),By 한국생명과학회 2007 생명과학회지 Vol.17 No.12

4개의 후보 유전자를 분석해본 결과, 돼지의 주요 염색체 부위 및 유전자들이 주요 경제성 요인들과 관계가 있는 것으로 확인됐다. 양돈업계에서 DNA 기술을 이용한 염색체 정보를 활용하기 위해 본 연구에서는 4개의 후보 유전자에서 생성된 중합효소연쇄반응(PCR) 생성물을 비교 재 서열 함으로써 단일염기변이(SNP) 표지들을 개발했다. 또한 이들 4개의 SNP에 대해 PCR 제한효소 절편길이 다형 성(RFLP) 분석을 전개한 후, 이를 대한민국내 버크셔 종 돼지 개체군의 유전자형을 분석하는데 활용했다. 본 연구는 유용한 단일염기변이를 식별하고 돼지개체군 내 경제적으로 중요한 특성들과 SNP의 연관성을 확인하는 데 그 목적이 있다. This study was conducted to identify useful single nucleotide polymorphisms (SNPs) and determine their association with economically important traits in pig population. Four candidate gene analyses have identified important chromosomal regions and major genes associcated whit economic traits of the pig. For application of the chromosomal information to the pig industry using DNA technology, SNP markers were developed by comparative re-sequencing of polymerase chain reaction (PCR) products of 4 candidate genes (CSF2, IL4, MYOD, RIP140). PCR restriction fragment length polymorphism (PCR-RFLP) assays were developed for these 4 SNPs and used to genotype Berkshire pig populations in Korea.

Investigation of Single Nucleotide Polymorphisms in the Adipocyte Fatty-Acid Binding Protein (FABP4) Gene

Sang Wook Kim(김상욱),Ji Hye Jung(정지혜),Kwan Suk Kim(김관석),Cheol Koo Lee(이철구),Jong Joo Kim(김종주),Bong Hwan Choi(최봉한),Tae Hun Kim(김태헌),Ki Duk Song(송기덕),Byung Wook Cho(조병욱) 한국생명과학회 2007 생명과학회지 Vol.17 No.11

본 연구는 돼지 4번 염색체에서 FAT1 좌위의 후보유전자인 Adipocyte Fatty-Acid 결합단백질 (FABP4) 유전자에서 8개의 Single Nucleotide Polymorphisms (SNPs) 를 발견하였다. Duroc, Landrace, Berkshire, Yorkshire를 기초 축으로 이용한 800두에 대해 FABP4 유전자의 단일염기 분석과 PCR-RFLP를 이용하여 그 다형성을 조사하고 돼지의 일당증체량, 등지방두께, 사료요구율, 정육율과 그 유전자형 간의 연관성을 규명하고자 실시하였다. FABP4 유전자에 대해 각 단일염기에 관한 PCR-RFLP를 이용하여 400~800 bp 산물을 증폭한후 각각의 제한효소로 사용하여, 얻어진 FABP4 유전자의 빈도는 품종별로 다르게 나타났다. 통계적 분석을 통하여 각 유전자형에 대한 경제형질과 연관성을 분석한 결과 일당증체량, 등지방두께, 정육율, 사료요구량은 다른 유전자형을 가진 개체들이 유의적으로 우수한 능력을 보였다 (P<0.05). FABP4유전자는 일당증체량, 정육율, 등지방두께 에 높은 연관성이 있음을 관찰하였다. 따라서 돼지의 성장과 정육율에 관련된 선발력을 높이기 위해서 FABP4 유전자의 다형성 분석에서 검증된 PCR marker를 우량돼지육종 계획에 있어 분자생물학적 선발 marker로 사용할 수 있을 것으로 사료된다. We found 8 single nucleotide polymorphisms (SNPs) in adipocyte fatty acid bonding protein (FABP4) gene as candidate gene of FAT1 locus on pig chromosome 4. With over 800 heads of major commercial pig breeds including Duroc, Landrace, Berkshire and Yorkshire, we analyzed SNPs of FABP4 gene to determine possible effects of FABP4 genotype to economically important traits. 400~800 bp amplicons in FABP4 gene were used PCR-RFLP for each SNPs and we found that the frequency of some SNPs of this gene was different among the breeds. According to the statistical analyses to determine possible associations of each genotype with economic traits, it was found that subgroup with different genotypes showed significant differences in daily gain, backfat thickness, lean percentage and feed conversion ratio (P<0.05). Thus, as a part of enhancing the selection competence related to swine growth rate and lean percentage, it is expected that FABP4 gene markers verified in this study will be useful to use for Korean commercial pig industry.

New Simulation Method of Flashover Rate by Connection of EMTP and MATLAB

Hun-Chul Seo,Joon-Han,Sun-Kyu Choi,Byung-Sung Lee,Chul-Hwan Kim 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.3

Because of the random characteristics of lightning, the Monte Carlo method is applied to estimate the flashover rate due to lightning, however, the simulations using previous methods are difficult to both beginner and expert in power corporations. Therefore, this paper proposes the new and easy method to simulate the flashover rate by connection of electromagnetic transients program (EMTP) and MATLAB. The magnitude of a lightning strike is based on a curve measured in the field, while the classification of direct and indirect lightning depends on the striking distance. In a Korean distribution system, the flashover rate induced by lightning is simulated using proposed method. Simulations of the footing resistance according to the existence of an overhead ground wire (OHGW) are performed and the simulation results are discussed. The simulation results are compared with findings obtained with the IEEE Flash 2.0 program.

Distribution of human rotaviruses in children with acute gastroenteritis

( Sang Hun Park ),( Se Ah Oh ),( Seok Ju Cho ),( Jib Ho Lee ),( Seung Hee Ryu ),( Sun Hee Park ),( Sung Kook Jung ),( Gun Yong Park ),( Sung Min Choi ),( Young Zoo Chae ) 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-

[연구배경] Rotaviruses (RoVs) are recognized as the major etiological agents among infants and young children. [연구목적] The aims of this study were to investigate the detection rate of RoV infections and the prevalence of the G and P genotypes of RoV strains detected in children hospitalized with acute gastroenteritis. [연구방법] Between January and December 2009, stool samples were collected from 1,423 patients 650 females, 773 males) presenting to five referral hospitals for the treatment of acute gastroenteritis in Seoul. [연구결과] In total, 1,423 stool samples collected in 2009 were tested by RT-PCR. 269 (18.9%) samples were positive by RT-PCR. The 269 positive samples were identified as either G or P genotypes (242 samples, 90.0% = G type and 251 samples, 93.3% = P type).

The Relationship Between the Acute Changes of the Systolic Blood Pressure and the Brachial-Ankle Pulse Wave Velocity

( Hun Jun Park ),( Tai Ho Rho ),( Chan Seok Park ),( Sung Won Jang ),( Woo Seung Shin ),( Yong Seog Oh ),( Man Young Lee ),( Eun Ju Cho ),( Ki Bae Seung ),( Jae Hyung Kim ),( Kyu Bo Choi ) 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3

Background: The brachial-ankle pulse wave velocity (baPWV) is a useful parameter to assess arterial stiffness. However, it is difficult to evaluate arterial stiffness in hypertensive patients because the baPWV is affected by the blood pressure itself. This study was designed to estimate the relationship between the change of the blood pressure parameters and the baPWV (ΔbaPWV) when hypertensive patients were subjected to an acute reduction of blood pressure. Methods: Thirty patients with essential hypertension and whose blood pressure was higher than 140/90 mmHg were enrolled. In all the patients, the blood pressure and baPWV were measured using an automatic waveform analyzer with the patients at a resting state. When the reduction of blood pressure was more than 10 mmHg after sublingual administration of nifedipine 10 mg, then the blood pressure and baPWV were measured again in the same manner and then they were compared with the baseline values. Spearman`s correlation and multiple linear regression tests were performed to estimate the relationship between the change of the blood pressure parameters (ΔSBP, ΔDBP, ΔMAP and ΔPP) and the ΔbaPWV. Results: The baPWV was significantly decreased shortly after the administration of nifedipine (1903.6±305.2 cm/sec vs. 1716±252.0 cm/sec, respectively, p<0.01). The ΔbaPWV was correlated with the ΔSBP (r=0.550, p<0.01), ΔDBP (r=0.386, p<0.05), ΔMAP (r=0.441, p<0.05), and ΔPP (r=0.442. p<0.05). On the multiple regression analysis, the ΔSBP was the only significant variable for predicting the ΔbaPWV, and the linear equation was ΔbaPWV=8.7×SBP-48. Conclusions: The baPWV is affected by the systolic blood pressure level to a large degree and careful attention must be paid to the blood pressure level when evaluating arterial stiffness with using the baPWV.

Porcine LMNA Is a Positional Candidate Gene Associated with Growth and Fat Deposition

Choi, Bong-Hwan,Lee, Jung-Sim,Lee, Seung-Hwan,Kim, Seung-Chang,Kim, Sang-Wook,Kim, Kwan-Suk,Lee, Jun-Heon,Seong, Hwan-Hoo,Kim, Tae-Hun Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.12

Crosses between Korean and Landrace pigs have revealed a large quantitative trait loci (QTL) region for fat deposition in a region (89 cM) of porcine chromosome 4 (SSC4). To more finely map this QTL region and identify candidate genes for this trait, comparative mapping of pig and human chromosomes was performed in the present study. A region in the human genome that corresponds to the porcine QTL region was identified in HSA1q21. Furthermore, the LMNA gene, which is tightly associated with fat augmentation in humans, was localized to this region. Radiation hybrid (RH) mapping using a Sus scrofa RH panel localized LMNA to a region of 90.3 cM in the porcine genome, distinct from microsatellite marker S0214 (87.3 cM). Two-point analysis showed that LMNA was linked to S0214, SW1996, and S0073 on SSC4 with logarithm (base 10) of odds scores of 20.98, 17.78, and 16.73, respectively. To clone the porcine LMNA gene and to delineate the genomic structure and sequences, including the 3'untranslated region (UTR), rapid amplification of cDNA ends was performed. The coding sequence of porcine LMNA consisted of 1,719 bp, flanked by a 5'UTR and a 3'UTR. Two synonymous single nucleotide polymorphisms (SNPs) were identified in exons 3 and 7. Association tests showed that the SNP located in exon 3 (A193A) was significantly associated with weight at 30 wks (p<0.01) and crude fat content (p<0.05). This association suggests that SNPs located in LMNA could be used for marker-assisted selection in pigs.

Proton Transfer Reactions and Ion-Molecule Reactions of Ionized XCH₂CH₂Y (X and Y = OH or NH₂)

Choi, Sung-Seen,So, Hun-Young Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.4

Proton transfer reactions and ion-molecule reactions of bifunctional ethanes of $H_2NCH_2CH_2NH_2$, $H_2NCH_2CH_2OH$, and $HOCH_2CH_2OH$ were studied using Fourier transform mass spectrometry (FTMS). The rate constants for proton transfer reactions between the fragment ions and neutral molecules were obtained from the temporal variation of the ion abundances. The rate constants were consistent with the heats of reaction. The fastest proton transfer reactions were the reactions of $CH_2N^+$, $CHO^+$, and $CH_3O^+$ for $H_2NCH_2CH_2NH_2$, $H_2NCH_2CH_2OH$, and $HOCH_2CH_2OH$, respectively. The $[M+13]^+$ ion was formed by the ion-molecule reaction between $H_2C=NH_2 ^+$ or $H_2C=OH^+$ and the neutral molecule. The major product ions generated from the ion-molecule reactions between the protonated molecule and neutral molecule were $[2M+H]^+$, $[M+27]^+$, and $[M+15]^+$.