Slide Session : OS-ONC-05 ; Oncology : Preoperative Chemotherapy or Upfront Liver Resection in Managing Colorectal Liver Metastasis: Which is Better?

( Sang Il Choi ),( Sun Young Kim ),( Ji Yeon Baek ),( Sung Chan Park ),( Jae Hwan Oh ),( Dae Yong Kim ),( Hee Jin Jang ),( Min Jung Kim ),( Seung Duk Lee ),( Sung Sik Han ),( Seoung Hoon Kim ),( Sang 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: Perioperative chemotherapy is the standard treatment option for resectable colorectal liver metastasis (CRLM), but the optimal sequence of surgical and systemic treatment has been debated. We retrospectively examined progression free survival (PFS) and postoperative complications between patients who received preoperative chemotherapy and upfront surgery for resectable CRLM. Methods: Patients who underwent surgical resection for CRLM from Aug. 2001 to Apr. 2012 in National Cancer Center, Korea were identifi ed and their medical records were reviewed. They were classifi ed into two groups: patents who had preoperative chemotherapy (preCTx) and who underwent upfront liver resection (UFLR). Patients with < 6 liver metastases were included. Those who had major vessel invasion, extrahepatic metastasis, prior liver resection or other advanced malignancy were excluded.Results: Of the 451 patients who underwent liver resection, 333 who met above criteria were analyzed. 50 (15%) patients received preoperative chemotherapy followed by liver resection and 283(85%) patients underwent upfront surgery. Among those who had upfront surgery, 231(81.7%) patients received post-operative chemotherapy. There was no signifi cant difference in baseline characteristics including number and distribution of metastases, CEA, and proportion of patients who received prior or adjuvant chemotherapy, while R0 resection rate was higher in preCTx group (98% vs 89%, p = 0.04). 3-year PFS in preCTx and UFLR group were 22% versus 37% (p value = ). In multivariate analysis, number of liver metastasis, incomplete resection and synchronicity of metastasis were associated with poor PFS. There was no statistical difference in post-operative complications. Conclusions: Although R0 resection rate in preCTx group was signifi cantly higher than UFLR group, it did not affect PFS. Preoperative chemotherapy did not offer benefi t in terms of PFS and post-operative complications compared to upfront surgery.

Differential Gene Expression Analysis in K562 Human Leukemia Cell Line Treated with Benzene

Choi, Sul-Ji,Kim, Ji-Young,Moon, Jai-Dong,Baek, Hee-Jo,Kook, Hoon,Seo, Sang-Beom Korean Society of ToxicologyKorea Environmental Mu 2011 Toxicological Research Vol.28 No.1

Even though exposure to benzene has been linked to a variety of cancers including leukemia, the detailed molecular mechanisms relevant to benzene-induced carcinogenesis remain to be clearly elucidated. In this study, we evaluated the effects of benzene on differential gene expression in a leukemia cell line. The K562 leukemia cell line used in this study was cultured for 3 h with 10 mM benzene and RNA was extracted. To analyze the gene expression profiles, a 41,000 human whole genome chip was employed for cDNA microarray analysis. We initially identified 6,562 genes whose expression was altered by benzene treatment. Among these, 3,395 genes were upregulated and 3,167 genes were downregulated by more than 2-fold, respectively. The results of functional classification showed that the identified genes were involved in biological pathways including transcription, cell proliferation, the cell cycle, and apoptosis. These gene expression profiles should provide us with further insights into the molecular mechanisms underlying benzene-induced carcinogenesis, including leukemia.

A Study on Energy Saving System Utilizing Sewage Tank Heat Source

Sang Haw Baek,Gye Woon Choi 위기관리 이론과 실천 2019 Crisisonomy Vol.15 No.5

생활 오폐수 열원이 고온임에도 불구하고 활용하지 않은 이유에는 경제성 부족과 시스템에 대한 신뢰성 부족이다. 본 연구는 기존 시스템의 문제점을 보완하여 오폐수열원을 이용하여 건축물의 냉난방 시스템으로 적용될 수 있도록 연구하였다. 기존 오폐수 열 교환 시스템의 구조적인 문제점인 Slime과 Scale에 대하여 많은 어려움을 보여주고 있으며 본 연구는 다른 획기적인 방법을 제시하였 다. 그것은 워터케이싱 이라는 열 회수기술과 복합열원 축⋅열 수조라는 열 축전 방식을 제안하였다. 그리고 생활 오폐수라는 특수한 조건의 열원을 사용하면서 외기온도와의 상관관계를 밝혀내었다. 이러한 연구를 통해 이제까지 버려왔던 생활 오폐수와 같은 소규모 미활용에너지를 축⋅열하여 유 효의 에너지로 변환시킴으로써 에너지 재활용에 대한 인식 변화는 물론 냉난방시스템으로 적용함으 로써 제로에너지건축물 인증 의무화 제도 및 신재생 설비 설치 의무화 제도에 기여할 수 있다고 본다. A reason for not using the heat source of waste water despite the high temperature of life is that a lack of economic efficiency and a lack of trust in the system. This study has been studied so that problems in the existing system can be supplemented and applied to the heating and cooling system of buildings using a waste water source. The structural problems of the existing waste water heat exchange system, Slime and Scale, show a lot of difficulties. Because of these difficulties, this study suggested other innovative methods. It proposed a heat recovery technique called water casing and a heat accumulator called combined heat source heat accumulator water tube. It also found a correlation with ambient air temperature by using a special condition of heat source by life sewage. Through these studies, we will convert the amount of small, unused energy such as living sewage that we have throw away throw away throw awaythrowed out into effective energy by accumulating heat. Also, not only do we change our perception of energy recycling, but also apply it as a heating and cooling system. We believe that these efforts can contribute to the mandatory certification of zero-energy buildings and the mandatory installation of new and renewable facilities.

Genetic Variations of the Apolipoprotein B Gene in Korean People and Its Association with Hypercholesterolemia

Sung Han Kim,Un Kyung Kim,Jae Jin Chae,Jeong In Baek,Soo Young Choi,Jae Woong Bae,Sang Hyun Kim,Hyo Soo Kim 한국유전학회 2008 Genes & Genomics Vol.30 No.5

Genetic polymorphisms at the apolipoprotein B have been associated with elevated plasma concentrations of LDL, atherosclerosis and increased risk of coronary artery disease. 106 individuals composed of 46 hypercholesterolemic patients and 60 controls were analyzed with Ins/Del length polymorphism, four RFLPs (HincII, PvuII, AluI, EcoRI) and 3`-VNTR to clarify the characteristics of the apolipoprotein B gene and to determine their influence on the lipid profile of hypercholesterolemic patients and controls in Korea. A total of 212 apolipoprotein B alleles from six markers were identified in this study. Heterozygosityranges from zero to 0.32, and the genotyope frequencies in the case of 3`-VNTR are significantly different between two groups. Analysis of linkage disequilibrium revealed paired nonrandom associations between four pairs of polymorphic sites of the apolipoprotein B gene (p<0.05). Moreover, addition of all 4 polymorphic sites provided the highest PIC value. This study also investigated the association of these polymorphisms with the patients and with variation in lipid levels. A significant association between 3`-VNTR genotypes and Lp(a) was observed in hypercholesterolemic patients (p<0.05). The results suggest that genotypes of six polymorphic markers were not significantly associated with TC, TG or LDL-chol level between the patients and controls in the Koreans.

Classification of maturity group in 100 Korea soybean varieties

Sang-Ouk Shin,Tae-Joung Ha,Seong-Hyu Shin,Sea-Gyu Lim,Kyung-Jin Choi,In-Yeul Baek,Keum-Yong Park,Sang-Chul Lee 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10

This study was carried out to classify Korean soybean varieties based maturity group. One hundred (100) domestic soybean varieties ( 56 for fermentation, 26 for sprouting, 17 for mixed with rice) were used and seeding date was scheduled at April 30. This experiment carried out at Yeongnam Agricultural Research Institute, NICE situated at Miryang from 2005 to 2006. Classification of maturity group in 100 soybeans was followed by Kweon et al's method (1974) The main difference between this experiment and that of Kweon et al's method (1974) were the planting region and planting date. This experiment was conducted on April 30 at Miryang while Kweon et al. was conducted on May 23 in Seoul. Results of maturity grouping of Korean soybean varieties showed that Keunol, which was represented among 3 varieties, belonged to Group 0, Seonnok and Danmi in GroupⅡ, Shinrok in GroupⅢ, Seonyu, represented by 17 cultivars, in GroupⅣ, Taekwang, having 44 cultivars in GroupⅤ, Daewon, represented by 25 cultivars in GroupⅥ, and Kwangdu and Keumdu in GroupⅦ.

Effects of combination therapy of docetaxel with selenium on the human breast cancer cell lines MDA-MB-231 and MCF-7

Sang O Park,Young Bum Yoo,Yong Hun Kim,Kwang Je Baek,Jung-Hyun Yang,Pil Cho Choi,Jeong Hun Lee,Kyeong Ryong Lee,Kyoung Sik Park 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.2

Purpose: The anticancer property and cytoprotective role of selenium in chemotherapy have been reported. However, the combination effects of selenium on chemotherapy for advanced breast cancer have not yet been clearly defined. The purpose of this study was to investigate the combined effects of selenium on chemotherapy using docetaxel on breast cancer cell lines. Methods: Under adherent culture conditions, two breast cancer cell lines, MDA-MB-231 and MCF-7, were treated with docetaxel at 500pM and selenium at 100nM, 1μM, or 10μM. Changes in cell growth, cell cycle duration, and degree of apoptosis after 72 hours in each treated group were evaluated. Results: In the MDA-MB-231 cells, the combination therapy group (docetaxel at 500pM plus selenium at 10mM) showed a significantly decreased percentage of cell growth (15% vs. 28%; P = 0.004), a significantly increased percentage of late apoptosis (63% vs. 26%; P = 0.001), and an increased cell cycle arrest in the G2/M phase (P = 0.001) compared with the solitary docetaxel therapy group. Isobologram analysis demonstrated the synergistic effect of the combination therapy in the MDA-MB-231 cells. However, in the MCF-7 cells, no significant differences in the percentage of cell growth apoptosis, the percentage of apoptosis, and the pattern of cell cycle arrest were noted between the combination therapy groups and the solitary docetaxel therapy group. Conclusion: Our in vitro study indicated that the combination of selenium with docetaxel inhibits cell proliferation through apoptosis and cell arrest in the G2/M phase in MDA-MB-231 breast cancer cells.

Relationships comparision of major agronomic characteristics for high quality soybean seed production

Sang-Ouk Shin,Sea-Gyu Lim,Tae-Joung Ha,Seong-Hyu Shin,Kyung-Jin Choi,In-Yeul Baek,Keum-Yong Park,Sang-Chul Lee 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10

This study was carried out to obtain general agronomic characteristics and identify its relationship with seeding date for high quality soybean seed production. One hundred(100) domestic soybean varieties were used and seeding date were scheduled at April 30 and May 30. This experiment was carried out at YARI, NICE situated at Miryang from 2005 to 2006. Maturity Group(MG) was classified by Kweon et al's method (1974). Correlation analysis of major agronomic characters showed positive relationship between days to flowering and growth days, seed weight and lodging in MG ,seed crack and growth days in Ⅳ~Ⅴ MG0~Ⅲ,seed crack and days to flowering in MGⅣ~Ⅴ and MGⅥ~Ⅶ, seed crack and lodging in MGⅣ~Ⅴ and MGⅥ~Ⅶ, seed crack and seed weight in MGⅣ~Ⅴ and MGⅥ~Ⅶ, purple seed and growth days in MGⅣ~Ⅴ , purple seed and seed weight in MGⅥ~Ⅶ, phomopsis and growth days in MGⅣ~Ⅴ and MGⅥ~Ⅶ, and phomopsis and purple seed in MGⅣ~Ⅴ and MGⅥ~Ⅶ. In contrast, a negative relationship was observed between seed weight and lodging in MG0~Ⅲ. Correlating yield and major characters revealed negative relationship between days to flowering and growth days in MG0~Ⅲ and MGⅣ~Ⅴ, whereas positive relationships were obtained on MGⅥ~Ⅶ seeded on April 30. Lodging, seed weight and seed crack were all negatively correlated with yield in MGⅣ~Ⅴ and MGⅥ~Ⅶ

A Standardized Pathology Report for Gastric Cancer: 2nd Edition

Sung Hak Lee,Mee-Yon Cho,Young Soo Park,Myeong-Cherl Kook,Baek-Hui Kim,Hye Seung Lee,Dong-Wook Kang,Mi-Jin Gu,Ok Ran Shin,Younghee Choi,Wonae Lee,Hyunki Kim,In Hye Song,Kyoung-Mee Kim,Hee Sung Kim,Guh 대한위암학회 2023 Journal of gastric cancer Vol.23 No.1

The first edition of ‘A Standardized Pathology Report for Gastric Cancer’ was initiated by the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists and published 17 years ago. Since then, significant advances have been made in the pathologic diagnosis, molecular genetics, and management of gastric cancer (GC). To reflect those changes, a committee for publishing a second edition of the report was formed within the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists. This second edition consists of two parts: standard data elements and conditional data elements. The standard data elements contain the basic pathologic findings and items necessary to predict the prognosis of GC patients, and they are adequate for routine surgical pathology service. Other diagnostic and prognostic factors relevant to adjuvant therapy, including molecular biomarkers, are classified as conditional data elements to allow each pathologist to selectively choose items appropriate to the environment in their institution. We trust that the standardized pathology report will be helpful for GC diagnosis and facilitate large-scale multidisciplinary collaborative studies.

Increased prevalence of transfusion-transmitted diseases among people with tattoos: a systematic review and meta-analysis

( Sung Ha Lim ),( Solam Lee ),( Young Bin Lee ),( Chung Hyeok Lee ),( Jong Won Lee ),( Sang Hoon Lee ),( Ju Yeong Lee ),( Joung Soo Kim ),( Mi Youn Park ),( Sang Baek Koh ),( Eung Ho Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Whether having a tattoo increases the risk of transfusion transmitted diseases (TTDs) is controversial. Objectives: To identify prevalence and risk of TTDs in people with tattoos as compared with the general population. Methods: A systematic review of the studies published before September 2019 was performed by using the Medline, Embase, and Web of Science databases. Observational studies on hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and syphilis infections in people with and without tattoos were included. Studies that reported disease status without serological confirmation were excluded. Results: A total of 115 studies were quantitatively analyzed. HCV (odd ratio [OR], 2.94; 95% confidence interval [CI], 2.52-3.44), HBV (OR, 1.53; 95% CI, 1.34-1.76), and HIV infections (OR, 3.42; 95% CI, 2.16-5.41) were more prevalent in the tattooed population. In subgroup analyses, after the adjustment of possible publication bias, the prevalence of HCV infection was significantly elevated in the community-dwelling, hospital patient, intravenous (IV) drug user, and prisoner groups. IV drug users and prisoners showed high prevalence rates of HBV infection. The prevalence of HIV infection was significantly increased in the prisoner group. Conclusion: Having a tattoo is associated with an increased prevalence of TTDs. Our approach clarifies in depth and supports a guideline for TTD screening in the tattooed population.

A Characteristics Experimental of Robot Joint Torque Sensor by Using Carbon Nanotube Strain Sensor

Baek Gyu Choi,Se Hoon Park,Sung Yong Kim,Jae-Bok Song,Inpil Kang 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.춘계 No.-