필리핀 여행 후 발생한 쯔쯔가무시병 1예

김계형,김낙현,김문석,김충종,전재현,박완범,장원종,박상원,김익상,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6

Infectious diseases imported from other countries have increased as more and more Koreans are going abroad for various purposes. Tsutsugamushi disease from other endemic area such as Southeast Asia is important, because it can occur in any season and eschar may be absent. We report a case of imported tsutsugamushi disease acquired in the Philippines. A patient presented with fever, headache, and maculopapular skin rash. However, eschar was absent. Polymerase chain reaction (PCR) for 56-kDa gene of Orientia tsutsugamushi using buffy coat was positive. Serum indirect immunofluorescent antibody assay was initially negative but became positive with a titer of 1:320 at follow-up, Sequencing analysis revealed the strain to be 100% identical to the TW73R strain identified in Taiwan. After the patient received doxycycline, body temperature normalized in 12 hours. Tsutsugamushi disease is one of the differential diagnoses that should be included for patients with fever who have recently returned from Southeast Asian countries. PCR for O. tsutsugamushi using patient's buffy coat was useful for early diagnosis.

C₄유분을 이용한 옥텐류의 합성에 있어서 1,3-Butadiene의 함량에 따른 이량화 촉매의 수명에 관한 연구

전종기,한원희,조정호,고승태,노상균 동양대학교 2001 동양대학교 논문집 Vol.7 No.1

Selective hydrogenation of 1,3-butadiene in C4 raffinate was carried out in fixed bed reactor using Pd/a1unina catalysts, Concentration of 1,3-butadiene in C4 raffinate could be reduced under 100 ppm.The life of dimerization catalyst using C4 raffinate after selective hydrogenation was longer than that of dimerization catalyst without selective hydrogenation.It was found that dilution of olefin concentration in feed was effective to increase dimerization catalyst life.

두부 위치 변화에 따른 파노라마 방사선사진상의 치축각도의 왜곡

전현상,최갑림,임성훈,김광원 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.4

본 연구는 파노라마 방사선사진에서 두부 위치 변화에 따라 인접 치아장축 사이에 이루는 각도가 어떻게 변화되는 지 알아보기 위해 시행하였다. 정상교합자의 모델을 기초로 하여 3차원 solid 모델을 구성하고 이를 신속 조형모델(rapid prototyping, RP)로 제작하였다. 다음 9가지 두부위치들을 5주 동안 일주일 간격으로 재위치시키고 촬영하였다: ideal head position, 5^(o), 10^(o) up, 5^(o), 10^(o) down, 5^(o), 10^(o) right up, and 5o,^(o) 10^(o) right rotation. 파노라마 방사선사진 촬영은 디지털 방사선 촬영기(Planmeca ProMax)를 이용하였고 모니터상에서 직접 인접 치아장축을 표시하고 그 사이 각도를 계측하였다. 그 결과 이상적인 두부 위치와 다양한 두부 위치 변화에 따라 촬영한 파노라마 방사선사진 사이에 인접 치아장축 사이의 각도가 대부분 유의한 차이를 보였다. 수평축(X축)을 중심으로 고개를 든 경우, 각 치아 들의 장축이 교합평면을 향하여 수렴하는 경향을 보였고 고개를 숙인 경우에는 치근단측을 향하여 수렴하는 경향을 보였으며, 이는 특히 전치부에서 가장 큰 차이를 보였다. 전후방축(Y축)을 중심으로 좌우측으로 고개를 기울인 경우, 교합평면이 올라간 쪽의 치아장축은 치근단측을 향하여 수렴하는 경향을 보였고 교합평면이 내려간 쪽은 교합평면을 향하여 수렴하는 경향을 보였다. 수직축(Z축)을 중심으로 고개를 좌우로 회전시킬 때, 고개를 돌린 쪽의 측절치와 견치는 치근단측을 향하여 수렴하고 반대측의 측절치와 견치는 교합평면을 향하여 수렴하였다. 이상의 결과들로 볼 때 파노라마 방사선사진 촬영 시 두부의 위치 변화에 따라 치근 평행도가 달라지기 때문에 환자를 올바르게 위치시키는것이 중요하며, 교정 환자에서 파노라마 방사선사진을 이용하여 치근 평행도를 평가할 때 교합평면의 경사(전후방,좌우측방)나 악궁의 비대칭 등이 반드시 고려되어야 할 것이다. Objective: The purpose of this study was to evaluate the effect of head position changes on the root parallelism between adjacent teeth on panoramic radiographs. Methods: A model with normal occlusion was constructed in the SolidWorks program, then RP (rapid protyping) model was fabricated. The model was repeatedly imaged and repositioned five times at each of the following nine positions: ideal head position, 5^(o), 10^(o) up, 5^(o), 10^(o) down, 5^(o), 10^(o) right up, and 5o,^(o) 10^(o) right rotation. Panoramic radiographs were taken by Planmeca ProMax and the angle between the long axes of adjacent teeth was directly measured in the monitor. Results: Axes of adjacent teeth tended to converge toward the occlusal plane when the head tilted up and converged in the opposite direction to the occlusal plane when the head tilted down. Anterior teeth showed the most notable differences. When one side of the head tilted up 5o and 10o along the anteroposterior axis (Y axis), tooth axes of the same side tended to converge toward the occlusal plane and tooth axes of the opposite side tended to converge in the opposite direction to the occlusal plane. When the head rotated to one side along the vertical axis (Z axis), the canine and lateral incisor of the same side converged in the opposite direction to the occlusal plane and the canine and lateral incisor of the other side converged toward the occlusal plane. Conclusions: When assessing the root parallelism on panoramic radiographs, the occlusal plane cant (anteroposterior or lateral) or asymmetry of the dental arch should be considered because these can cause distortion of tooth axes on panoramic radiographs.

加減茵蔯蒿湯 水鍼液이 膽道結紮로 유도된 肝損傷에 미치는 영향

成樂箕,金元信,田炳薰,李建穆 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 肝癌 및 肝硬變은 韓國人의 疾病으로 인한 중요한 喪亡原因의 하나이며, 특히 우리나라 B型肝炎의 流行地域으로 急慢性 肝炎이나 肝經辨證, 肝癌의 發病率이 높다. 그리하여 肝硬變症을 寢具治療法중 水鍼을 이용하여 肝의 募穴인 期門穴에 投與하면 治療效果가 있는지에 대하여, 그리고 藥量에 따라 治療效果가 달라지는 지에 대하여 알아보기 위하여 본 연구를 시행하였다. 방법 : 加減茵蔯蒿湯 水鍼液을 膽道를 結紮한 白鼠에 26guage의 1ml 주사기를 이용하여 투여하였다. 經穴은 人體의 期門에 相應하는 左石部位와 腹部內의 任意의 部位를 設定하여 매일 1회 7주간 수침하였다. 결과 : 體重과 Total Bilirubin은 實驗群 A, C에서 有意性 있는 增加와 減少를 보였고, WBC·ALT·AST·ALT 및 Cholesterole은 全實驗群에서 有意性 있는 減少를, Albumin은 全實驗群에서 有意性 있는 增加를 각각 나타내었으며, 組織學的 觀察도 全實驗群에서 有意性을 나타내었다. 또한 Hydroxyproline도 實驗群 A, B에서 有意性있는 減少를 보였다. 결론 : 加減茵蔯蒿湯 水鍼液을 膽道를 結紮한 白鼠의 期門穴에 投與한 缺課 有意한 효과를 보였으나 水鍼量에 따라 有意性의 차이가 있어 敵意한 水鍼量을 투여하는 것이 治療시 重要하다고 思料되며, 또한 水鍼에 대한 安全性 問題에 대하여서도 더욱 硏究할 필요가 있다. In order to study the effects of the water extract of Gagaminjinhotang in the Meridian points Liv 14 on the liver damage indued by bile duct ligation during 7 weeks after the operation of bile duct ligation, blood was taken from the heart and body weight, WBC, RBC, hemoglobin, hematocrit, total bilirubin, ALT, AST, ALP, cholesterol, albumin and hydroxyproline were in each experimental apparatus. The results of this study were as follows; 1. Body weight of EXA, C were significantly increased by the water extract of Gagaminjinhotang. 2. WBC of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 3. RBC, hemoglobin and hematocrit of EXA,B,C were not significantly influenced by the water extract of Gagaminjinhotang. 4. Total bilirubin of EXA,C and direct bilirubin of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 5. ALT, AST,ALP of EXA,B,C were significantly decreased by the water extract of Gagaminjinhotang. 6. Cholesterol of EXA,B,C, were significantly decreased by the water extract of Gagaminjinhotang. 7. Albumin of EXA,B,C, were significantly increased by the water extract Gagaminjinhotang. 8. Hydroxyproline of EXA,B were significantly decreased by the water extract Gagaminjinhtang. 9. On the histological observation, the results of the experimental groups showed significant hepatoprotective effects compared with control group from 3 weeks after the administration of the water extract of Gagaminjinhotang. According to the above result, it is suggested that the water extract Gagaminjinhotang was significantly effective in WBC, bilirubin, ALT, AST, ALP, cholesterol, albumin and hydroxyproline level and then it seems to be applicable to the fibrosis or cirrhosis of liver.

생쥐 중이와 상기도 점막의 섬모세포운동

정하원,오승하,유원석,이강수,모지훈,전상준,김인상,김종선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

汗出의 病因病機에 對한 文獻的 小考

田炳薰,陸相元,李光揆 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

땀이란 人體內에서 體溫을 調節하고 老廢物을 排泄하는 등의 중요한 生理作用을 한다고 알려져있다. 韓醫學에서는 津液의 一種이라하여 汗出에 대한 警覺心을 强調하기도 하였으며 發汗法에 대한 重要性과 이것으로 因한 後遺症을 警告하기도 하였다. 이에 筆者는 正常的인 新陳代謝로서의 땀이 生理機能失調로 인한 非正常的인 땀이나 汗蒸 혹 찜질방 등의 人爲的인 發汗으로 인한 땀과는 本質的으로 差異點이 있을 것으로 思料되어 땀에 대한 여러 가지 文獻을 整理하여 발표하고자 한다. It is known sweat plays important roles in temperature regulation and secretion as phtsical action. In oriental medicine, it is regarded as a kind of dody fluids, and the importance and the side effects of excessive eprspiration were emphasized. The objective of this study is to investigate literature and introduce the results because there will be the difference between the usual sweat for metastasis and the extraordinary sweats by failure of physical funciton, sauna and other artificial perspiration. The results of this study are summarized as follows: 1. Swteat is a kind of body fluid and the sweat for physical is considered to be made up of water component and made by the weakness of defensive energy of lung. 2. The function of activity of gi by triple heater brings about the thin and clear fluid and the fluid is made by the opening and closing function of defensive energy. 3. The disorder of opening and closing function comes about sponataneous perspiration and night sweats, spontaneous perspiration is divided into disharmony between Ying and Wei, insufficiency of both the spleen and the lung of gi and so on, and night sweats is divided into deficiency of the heart blood and deficiency of Yin brings about interior heat-syndrome. 4. Swear is named variously. 1) By the time and feeling : spontaneous perspiration, night sweats. 2) By the perts of body : perspiration on the forehead, chest, nose, groin, hand and foot and so forth. 3) By the color : yellow, red, green sweat. 4) By the condition : perspiration after shivering, hot and cold sweats and so on.

환경회계정보 공시수준과 기업특성과의 관계에 관한 연구 : 우리나라 상장기업을 중심으로 한 실증연구

田雄秀,尹祥源 한국기업윤리학회 2003 企業倫理硏究 Vol.7 No.-

Recently, environmental aspect of coporates' activities becomes a very important social problem. And the needs of the environmental accounting informations are growing rapidly. It is the purpose of this paper to examine the factors which affect the disclosure level of coporates evironmental accounting information. Some researches were conducted on this topic and they had measured the amount of information disclosed by the physical measures such as the number of words, lines or pages. But we have measured it by the amount of messages(contents) in the disclosed information. By the results of the analysis, we have found some significant relationships between the level of disclosure of environmental accounting informations and characteristics of firms. There are statisticaly significant positive relationships between the each of following three variables-the environmental friendliness of a firm, the size of a firm and the ratio of minority shareholders - and the disclosure level of environmental accounting information. But we could not find any significant relationships by using the number of words. lines or pages as measures of disclosure level.

흰쥐에 Xylene 반복 투여가 Xylene의 대사에 미치는 영향

전태원,이혜자,윤종국,이상일,조현국 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

실험동물에 xylene의 반복 투여가 이물질의 대사에 어떠한 영향을 미치는지를 알아보기 위하여 흰쥐에 m-xylene과 olive oil의 동량혼합액을 체중 100g당 0.25ml씩 2일 간격으로 1, 4, 8, 12 및 16회 복강으로 투여한 다음 마지막 투여 24시간 후에 처치하여 다음과 같은 결과를 얻었다. 요 중 m-methylhippuric acid 함량은 m-xylene 4회 투여군의 경우 1회 투여군에 비하여 약 56%의 유의한 증가를 보였으며 이후 12회 투여까지 유사한 결과를 나타내었으나 m-xylene 16회 투여시에는 xylene 1회 투여군 치와 유사한 치로 감소되었다. 그리고 간조직의 microsomal aniline hydroxylase와 alcohol dehydrogenase 활성은 m-xylene 12회 투여시 까지는 대체적으로 점진적인 증가를 보였으나 이후 16회 투여시에는 12회 투여군에 비하여 유의한 감소를 보였다. 또한 aldehyde dehydrogenase 활성은 m-xylene 투여 회수에 비례해서 전 실험기간 동안 감소되었으며 특히 16회 투여군에서 본 효소활성의 현저한 감소를 보였다. 한편 본 실험조건에서 투여기간에 따른 진자현미경적 미세구조의 변화는 초기에 활면소포체의 증식이 보이다가 16회 투여군에서는 활면소포체가 감소되고 조면소포체가 증가되었다. 이상 실험결과는 흰쥐에 있어서 xylene 투여 회수에 따라서 요 중 m-methylhippuric acid의 농도 변동이 초래되며 이는 효소단백 유도에 따른 xylene 대사효소 활성 변동에 기인된 결과로 생각된다. To evaluate the effect of repeated treatment of xylene on its metabolism, m-xylene (0.25ml of 50% in olive oil/100 g body weight) has been intraperitoneally given to the rats 1, 4, 8, 12 and 16 times every other day. m-Xylene was once more administered to the animals after 24 hrs since last injection of it. And then the animals were sacrificed after 24 hrs. Four times xylene treated rats showed the significantly elevated urinary m-methylhippuric acid, compared to those treated with the singe dose of m-xylene with the continued similiar high levels of urinary m-methylhippuric acid up to the animals pretreated 12 times and then those treated 16 times defined the significantly decreased urinary m-methylhippuric acid compared to those treated 12 times. On the other hand, hepatic aniline hydroxylase and alcohol dehydrogenase activities demonstrated a gradual increase from the first group to the 12 times xylene-treated animals, but those treated 16 times showed the significantly decreased value compared with the 12 times treated-group. And aldehyde dehydrogenase activities in rats treated with m-xylene 8, 12 or 16 times were significantly decreased compared to those pretreated one or four times. In the early stage of xylene administration, proliferation of SERs were seen whereas SERs were decreased and RERs were clearly increased in xylene-treated rats 16 times. These results indicate that the frequency of xylene injection may influence upon the changes in xylene metabolite, m-methylhippuric acid and it may be due to induction of xylene metabolizing enzymes.

직장암에서 자율신경보존술후 배뇨기능의 변화에 대한 요역동학적 연구

조원상,이상전,송영진 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.4

흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.