한국인 제2형 당뇨병 환자에 있어 지속적 피하 인슐린 주입법 치료시 Lispro insulin와 Regular insulin의 효과 비교

유재등,박봉안,류하근,류주성,김정수,김치훈,박선민,최수봉 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Objective: The Lispro insulin has faster onset of effects and shorter duration than the human regular insulin, an analog of human insulin. The differences in the pharmacodynamics between the two types of insulin in the continuous subcutaneous insulin infusion(CSII) with insulin pump for treating the Korean Type 2 DM patients were analyzed. The effects on the regulation of blood sugar, the amount of insulin injected, and the frequency of hypoglycemia were compared between the lispro insulin and the regular human insulin. Method and Material: One hundred and three Korean Type 2 DM patients were randomly divided into two groups, 49 Lispro insulin and 54 Regular insulin.(Table 1) Both groups were treated for 14 days. Also at a set time before meal, insulin was injected as bolus, using a portable insulin pump, in both groups, 15 minutes before for lispro insulin and 30 minutes before for human insulin The HbA1C, C-peptide, AC/PC, height and weight were measured for each patients at the time of admission. The peripheral blood sugar level and insulin injection profile were recorded 7 times per day for each patients. Results: After treating for 7 days and 14 days, the blood sugar level normalized in both groups. There weren't any significant differences in blood sugar levels in both groups at point of the study, and also there weren't any differences in the frequency of hypoglycemia. In order to maintain the normalized blood sugar level, the lispro insulin group had higher total daily insulin requirement than the regular insulin group after 14 days of treatment (0.90±0.35 vs 0.73±0.39u/kg/day, p<0.05) This difference is probably due to the difference in basement insulin requirements rather than prandial insulin requirements (0.32±0.1 vs 0.43± 0.09u/kg/day, p<0.001). Discussion: In the hospitalized Korean Type 2 DM patients with CSII treatment, continuous subcutaneous insulin infusion therapy using lispro insulin has convenience in usage compared to the regular insulin. However, there were not any differences in the blood sugar levels. Also lispro insulin requires more insulin in order to maintain normal blood sugar level, which is probably due to the increase in the basal requirement. Also there were not any difference in the frequency of hypoglycemia.

우발성으로 투여된 척수강내 고용량 모르핀에 의한 호흡정지 : 증례보고

성상훈,유수봉,류시정 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Epidural or intrathecal morphine injection is a useful method for management of postoperative pain and cancer pain. But the effect of intrathecal morphine is ten to twenty times more potent than epidural morphine. So inadvertent intrathecal injection of morphine during epidural injection can induce serious side effect. The authors report a patient who experienced respiratory arrest and loss of consciousness due to inadvertent intrathecal injection of high dose morphine during epidural injection for management of cancer pain. The patient was treated with intravenous bolus and infusion of naloxone for 8 hours and assisted ventilation with Ambu and she was recovered completely without any sequela.

수분에 불안정한 2-(Trimethylsilyloxy)furan의 수용체에서의 카르보닐 부가반응 연구

柳燦模,李宗昊,李晟洙,尹淑卿 성균관대학교 기초과학연구소 1995 論文集 Vol.46 No.2

The irreversible addition of 2-(trimethylsilyloxy)furan to various aldehydes in the presence of catalytic amount of alkali metal carbonate in aqueous media is described. Even though alkli metal enolates have many synthetic advantages of applicability and high selections of (E)- and (Z)- enolate geometry, their application to carbonyl addition have been utilized in limited purpose mainly due to the low stereoselectivity resulted from the equilibrium between retroaldol and realdol. The addition of 2-(trimethylsilyloxy)furan to the aldehyde in the presence of K_2CO_3 in aqueous media(THF : H_2O = 9 : 1) at -20℃ resulted in the formation of addition product in high yield and moderate good stereo selection (3-15:1).

건설산업의 성과지수 개발을 위한 핵심성과지표 : 건설기업 대상 KPI를 중심으로

유일한,김경래,정영수,진상윤 대한건축학회 2005 大韓建築學會論文集 : 構造系 Vol.21 No.2

The Performance Measurement in the construction industry is more important recently. Various researches about PMS (Performance Measurement Systems), such as the government-oriented PMS in U.K. have been done. As growing concern at new vision and target in the Korean construction industry, it is needed to manage the growth of the construction industry using performance measurement. The purpose of this study is to recommend the framework for development of PI(Performance Index) and KPIs(Key Performance Indicators) focusing on the Korean construction industry. First, the framework for development of PI is suggested through literature survey and studying cases performed in the U.K. Second, KPls are suggested through analyzing limitations and problems appeared in the existing researches, questionnaire survey, and interviews to verify and supplement limitations and problems. Finally, the validity of the proposed KPIs are validated by three case studies. This study also suggests the expected effects and further research fields.

폐흡충증으로 확진된 고립성 폐결절 1예

유영권,김규식,김윤현,나국주,김경수,임성철,김영철,박경옥 全南大醫大 2001 전남의대학술지 Vol.37 No.2

저탁도시 PAC와 Ca-PAX의 입자제거 및 슬러지 탈수성 비교

심유섭,유명진,조희경,이상수,곽종운 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

This study was accomplished to evaluate the characteristics of particle removal and sludge dewatering and to find out the optimal condition of coagulation depending on the dosage of different coagulants (PAC, Ca-PAX) in low turbidity water. The experiments were carried out at a pilot plant of conventional rapid sand filtration system using artificial raw water. There was no large difference in the removal efficiencies of turbidity and total particle counts for both coagulants. However, Ca-PAX was required less than PAC to obtain the same efficiency of removal, and the initial head loss in a filter increased more fastly in case of PAC. The results on the evaluation of sludge from settling tank indicated that specific resistance of sludge was decreased inversely to the dose of both coagulant and specific resistance of Ca-PAX sludge was lower than that of PAC, therefore dewatering of sludge in case of Ca-PAX was better.

자동차 배기정화용 촉매에 관하여 : NO와 CO제거를 위한 촉매제

박유철,오상오,김창수,구본권 경북대학교 교육대학원 1980 논문집 Vol.12 No.-

The reactions of nitric oxide with hydrogen, carbon monoxide and hydrogen-carbon monoxide mixture have been investigated over the catalysts supported on alumina. In NO-H_2 System the relative activity of catalysts was decreased in the order as Pd>Ru>Pt>Os, while it was Ru>Pd<Pt<Os in NO-CO system. The relative activity sequence of catalysts in NO-H_2-CO system was similiar to that in the mixture of nitric oxide and carbonmonoxide. The inverstigation on the effectiveness of air-fuel ratio for the purification of exhaust gases has also been carried out over alumina supported ruthenium and palladium. Of exhaust gases the nitric oxide conversions were decreased slowly with increasing the air-fuel ratio, while the carbon monoxide conversions were increased slowly under the same condition. In this experiment the best value of air-fuel ratio was 14.5. In the nitric oxide conversions, the ruthenium and palldium of catalysts used were not so much inhibited by carbon monoxide.

Nitrilotriacetatonickelate(Ⅱ)와 Copper(Ⅱ)간에 금속이온 치환반응속도

吳相牛,朴裕哲,金昌洙 경북대학교 교육대학원 1974 논문집 Vol.5 No.-

The reactions between copper (Ⅱ) and nitrilotriacetatonickelate (Ⅱ) have been studied from pH 2.6 to 3.5 at an ionic strength of 1.0 and a temperature of 50℃. The reaction order in copper (Ⅱ) concentration is first order. The pseudo-first order rate constant is given by the expression k_0=k_1+k_1'[H^+]+k_2'[H^+]/[Ni^+2]. The expression is similiar to that for metal-exchange reaction between metal ion and polyaminocarboxlylate. The values of rate constants k_1, k_1' and k_2' were 1.02×10 exp(-3) sec^-1, 0.43 mole^-1 ℓ sec^-1 and 4.41×10 exp(-3) sec^-1, respectively. And also the mechanisms of copper (Ⅱ) and nickel (Ⅱ) exchange-reaction are discussed. The equation of the exchange reaction can be expressed by three pathways.

화상환자에서 혈청중 가용성 Interleukin-2 Receptor의 변동

이희성,이유진,이종량,백광진,하재성,전건수 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.2

Cell-mediated immunity frequently becomes severely impaired after burn. However, the cause of postburn immune dysfunction is unclear and controversy exists over both pathophysiology and clinical relevance of these abnormalities. This study was undertaken to invstigate the immune responses in vivo of patients with burn. Levels of soluble IL-2R, a sensitive marker of T-cell activation, were measured in 26 patients with burn. Serum soluble IL-2R levels in patients with burn were significantly higher than those of normal controls. Serum soluble IL-2R levels were correlated closely with the severity of the burn. The burn patients were classified according to the outcome. Patients with fatal outcom always showd a higher soluble IL-2R levels than survivors. Postburn sera significantly suppressed mitogen-indeced lymphocyte proliferation. These data indicate that soluble IL-2R might be useful parameters for monitoring of the clinical course in burn patients.

만 19세 남자의 근시성 굴절이상 결정요인

이상준,안기수,유병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : Myopia is common condition affecting a significant proportion of the population, particularly in East Asian countries. Although the causes of myopia are unclear, evidence supports both genetic and environmental components among which are higher amounts of near work, years of education and intelligence. We conducted this study in order t o find i nfluencing f actors for myopia of 1 9 years old men who lived i n Busan, Ulsan and Gyeongsangnam-do using health checkup data of conscription. Methods : We screened 66,915 nineteen-years-old conscripts who lived in Busan, Ulsan and Gyeongsangnam-do using subjective visual activity test and noncycloplegic autorefraction test. All refractive data were converted into spherical equivalents and we finally diagnosed 21,445 myopia which defined under -0.5 diopter. At the same time we measured biometric data and collected informations of social factors such as education level and residence area. We estimated influencing factors on myopic refractive error using social factors and biometric factors. Data analysis was performed with descriptive analysis, ANOVA and multiple regression analysis using SPSS Win(ver 12.0K) program. Results : Refractive errors of study subjects are -4.62 ± 1.95D(OD) and -4.36 ± 2.20D(OS). Refractive errors were significantly high in conscripts who lived in small cities(p=0.000), had high education level(p=0.000) and high in stature(p=0.047), -5.10 ± 2.13D, -4.79 ± 1.95D and 4.66 ± 1.94D respectively. The influencing factors of myopic refractive error in 19 years old men who lived in Busan, Ulsan and Gyeongsangnam-do were educational level, residence area, stature and systolic blood pressure(p=0.000). Conclusion : Although genetic factors are significant in the development and progression of myopia, environmental factors are important in prevention of myopia. Our study showed that degrees of myopic refractive error in 19 years old conscripts were influenced by education level, residence area, stature and systolic blood pressure.