한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

BTX에 의한 2-프로판을 액-액 추출계의 상평형에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.1

The experimental binodal curves and tie line data were determined for ternary systems of 2-propanol-water with benzene, toluene and o-xylene as solvents at 25℃, and those tie line data were used to examine thermodynamic consistency. The experimental tie line data were correlated with UNIQUAC and modified UNIQUAC model and the parameters in each model and the calculated values of tie lines were predicted. The distribution curves in the equilibrium of ternary systems were determined to find the extraction effect.

Candida albicans에 의한 허리근 농양 1예

정승기,김수연,봉정민,백은기,이규훈,이상오,서일혜,조용균 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

칸디다는 우리 몸의 여러 곳에서 발견되는 상재 진균으로 Candida albicans가 가장 흔히 질병을 일으킨다. 대부분 표재성 감염을 일으키며 칸디다에 의한 심부 감염은 드물다. 심부 감염은 주로 면역약화 환자에서 혈류를 따라 여러 장기에 퍼지는 파종성 칸디다증으로 발생하며, 한 곳의 심부 장기에만 농양을 형성하는 경우는 상대적으로 덜 흔하다. 저자들은 당뇨병과 알코올성 간경변을 가진 환자에서 혈액 및 농 배양 검사에서 C. albicans가 동정된 허리근 농양 1예를 경험하였고 배농과 amphotercin-B, fluconazole로 성공적으로 치료하였기에 문헌고찰과 함께 보고하는 바이다. Candida species are ubiquitous human commensals, of which Candida albicans is most commonly associated with human disease. Candida infections usually involve superficial tissues, but the infections of deep tissues are relatively uncommon. Among the Candida infections of deep organs, disseminated candidiasis is the most common presentation particularly in immunosuppressed patients, however, a single abscess formation in deep organ is rare. We experienced a case of psoasabscess by C. albicans in a patient who had diabetes and alcoholic liver cirrhosis, which was treated successfully by drainage of the abscess and administration of amphotericin-B, followed by fluconazole. We report this case with review of the pertinent literatures.

평면 구성 및 공간 분석을 위한 프로그램 개발

정상규,박우장,이요희,이훈 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

This paper aims at developing a program for the composition of plan and the analysis of space. This program is able to draw plans more easily and quickly, and to seek a proper design solution by analyzing the topology of space based on Space Syntax(Hillier & Hanson, 1984). The program includes the Algorithms united some theories such as Shape Grammar(Stiny & Mitchell, 1980). Dimensionless Representation, Space Syntax and so on. Therefore we exhibit developing tools for modifying, editing and analyzing architectural plans.

에스테르류에 의한 2-프로판올의 액-액 추출에 관한 연구

鄭詳勳,申鉉心,朴東源 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2

The experimental binodal curves and tie-line data were determined for ternary systems of 2 propanol-water with ethylacetate, butylacetate and isoa-mylacetate as solvents at 25℃, and those tie-line data were used to examine thermodynamic consistency. The experimental tie line data were correlated with UNIQUAC and modified UNIQUAC model and the parameters in each model and the calculated values of tie line were predicted. The distribution and selectivity curves in the equilibrium of ternary systems were determined to find the extraction effect.

제2형 당뇨병 환자에서 Voglibose와 Acarbose의 비교임상연구

정인경,정재훈,민용기,이명식,이문규,김광원,정윤이,박중열,홍성관,이기업 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:아카보스와 보글리보스는 ­glucosidase inhibitors로써 비록 약리학적 작용이나 부작용에 있어서 두 약물간에 차이가 있다는 것은 잘 알려져 있으나 당뇨병 환자를 대상으로 아직 이에 대한 두 약물간에 직접적인 비교에 대해 연구된 바는 없었다. 이에 저자등은 국내 2형 당뇨병 환자에 대해 유효성과 부작용 발현에 대해 두 약제를 비교하고자 무작위법에 의한 위약 대조군의 이중 맹검법 연구를 시행하였다. 방법:시험 약제 투여 4주간의 관찰기를 설정하여 공복혈당의 변화가 30㎎/dL 이하이고, 식후 혈당이 200㎎/dL 이상인 환자로 기타 제외 기준에 해당하지 않은 환자 53명을 대상으로 하여 보글리보스 군(24명)과 아카보스 군(29명)으로 무작위로 나누었다. 치료기간은 총 8주로 하였으며, 4주간 간격으로 혈청학적 검사와 부작용을 분석하여 치료 효과가 부작용을 평가하였다. 결과:1)혈당 변화:보글리보스군은 식후 1시간 혈당이 치료 후 4주, 8주째 의미 있게 감소하였도, 아카보스군은 식후 1시간과 2시간 혈당이 치료 후 4주, 8주째 의미있게 감소하였다. 또한 관찰기 혈당에 대한 치료 4주째 감소량은 아카보스군에서 더 큰 경향을 보였으나, 치료 8주째에는 두 군 간의 강하정도에 의미있는 차이가 없었다(p=0.569). 2)인슐린 치의 변화:보글리스 군은 식후 1시간 인슐린 치가 치료 전에 비해 치료 4주, 8주째 감소하는 경향을 보였고, 공복 인슐린이나 식후 2시간 인슐린치는 치료전 후에 의미 있는 차이가 없었다. 아카보스군에서는 치료 전후로 공복 인슐린, 식후 1시간과 2시간 인슐린치에 의미 있는 차이를 보이지 않았다. 두약제 간에 치료 전과 치료 8주사이의 식후 2시간 인슐린의 감소량이 보글리보스 군에서 의미있게 높았다(p=0.040). 3)당화혈색소:보글리보스 군은 치료 전에 비해 치료후 당화혈색소가 감소하는 경향을 보였고, 아카보스군은 치료 전에 비해 의미있게 감소하였다. 당화혈색소 변화량은 두 군간에 의미 있는 차이는 없었다(p=0.412). 4)지질대사의 변화:중성지방, 콜레스테롤, 고밀도 진단백 콜레스테롤에 대해 두 군간에 의미 있는 차이는 없었다. 5)부작용:소화기계 부작용의 빈도는 치료 4주째 보글리보스 군에서 의미 있게 낮았으나(p=0.028), 치료 8주째 부작용의 빈도는 두 군간에 의미 있는 차이가 없었다(p=0.215). 결론:2형 당뇨병 환자에서 보글리보스와 아카보스의 두 약제의 임상적 유효성과 부작용발현에 대해 비교한 결과 치료 후 8 주 후 혈당강화효과는 두 약제간에 유사한 효과를 보였으나 보글리보스군에서 4주째의 초기 위장관 부작용이 적었다. Background : Acarbose and voglibose are alpha-glucosidase inhibitors. Although different pharmacological effects and adverse abdominal events associated with the two drugs have been reported, no study directly compared acarbose and voglibose in diabetes has been undertaken. To compare the pharmacological effects and gastrointestinal adverse events between two drugs, a randomized, placebo-controlled, double-bind study was performed in type 2 diabetes patients. Methods : The period of study was 12 weeks(observation period: 4 weeks; treatment period: 8 weeks). Fifty-three patients were randomized into two groups(the acarbose group: 24 patients; the voglibose group: 29 patients). The serum glucose, insulin, fructosamine, HbA_1c, cholesterol, triglyceride and the incidence of adverse events were measured. Results : 1) The reduction of glucose from before treatment to 4 weeks after treatment was significantly higher in the acarbose group, but the change before treatment and 8 weeks after treatment in the two groups was similar(p=0.569). 2) The insulin significantly decreased after voglibose treatment(p=0.040). 3) HbAa_1c level tended to decrease in voglibose group, and there was a significant decrease after acarbose treatment. However, the change in HbA_1c level before and after treatment was similar between the two groups(p=0.412). 4) The two drugs did not cause any other changes in the total, HDL-cholesterol and triglyceride. 5) The number of patients with gastrointestinal adverse events was significantly low 4 weeks after voglibose treatment (p=0.049), but the incidence in the two groups was similar after 8 weeks(p=0.215). Conclusions : Acarbose and voglibose significantly improved postprandial hyperglycemia in diabetes. The incidence of gastrointestinal adverse events was low 4 weeks after voglibose treatment(J Kor Diabetes 26:134~145, 2002).

백서에서 Chlorpromzaine,Haloperidol,Clozapine이 뇌파에 미치는 영향

정성훈,박영남,이만기,박진숙 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

To evaluate the differential elects of chlorpromazine, haloperidol, and clozapine on electroencephalographic (EEG) changes, EEG findings were compared in normal, relaxant, and schizophrenic animal models produced with MK-801 by using power spectral EEG analysis. Under pentobarbital anesthesia, the screw electrodes were implanted on the skull over the frontal cortex for EEG recording. The EEG was recorded before and after intraperitoneal administration of clozapine(5mg/kg), chlorpromazine(5mg/kg) and haloperidol(1mg/kg) in rats while awake(the normal group), rats pretreated with a relaxant pancuronium bromide(the relaxant group) and rats pretreated wish MK-801(0.2mg/kg, i.p., the MK-801 group). Spectrum analysis of the EEG was used to calculate the powers of each band (delta 1-4Hz; theta 4-8Hz; alpha 8-l3Hz; beta L 13-21Hz; beta H 21-30Hz; gamma 30-50Hz; and total 1-50Hz). The EEG activity was presented as the log value of the relative band power. In the relaxant group, clozapine increased the activity of the delta, theta and alpha bands. Chlorpromazine increased the activity of the betaL band as well as the delta, theta and alpha bands and it decreased the activity of the gamma band. However, haloperidol did not change the activity of all bands significantly. In the MK-801 group, clozapine increased the activity of the delta and gamma bands and chlorpromazine increased the activity of the delta, betah and gamma bands significantly, Haloperidol increased the activity of the alpha and betaL bands significantly. To evaluate the differential effects of antipsychotics on EEG between the groups, the ratio of power change after a drug as referenced to pre-drug power in each group was calculated and compared between the groups and was represented by star-like display. In the star-like display, clozapine showed the smallest change and caused a slight shift upwards and to the left, chlorpromazine showed irregular changes, haloperidol showed similar increases along each band.

모멘트 변화에 따른 브라켓과 교정용 선재 사이의 마찰력 변화

정혜진,임성훈,김광원 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.2

본 연구의 목적은 모멘트 변화에 따른 건조 환경과 타액 환경에서의 스테인리스강 브라켓과 여러 종류의 교정용 선재 사이의 마찰력을 비교하는 것이었다. 실험에는 0.022" × 0.028" 스테인리스강 브라켓과 0.019" × 0.025" 스테인리스강, 베타-티타늄, 니켈-티타늄 선재가 사용되었다. 활주 이동될 브라켓에는 0.9 mm 직경의 스테인리스강 선재로 제작된 길이 10 mm의 레버를 부착하였으며 레버에 100 g, 200 g의 추를 부착함으로써 브라켓에 각각 1000 g·mm (100 g × 10 mm), 2000 g·mm (200 g × 10 mm)의 모멘트를 가하고 만능시험기를 이용하여 마찰력을 측정하였다. 모든 조건에서 스테인리스강 선재가 가장 작은 마찰력을 보였으며 베타-티타늄과 니켈-티타늄 선재 사이에서는 2000 g·mm 모멘트의 인공타액 하의 조건에서를 제외하고는 마찰력의 유의한 차이가 없었다. 모든 선재에서 모멘트가 1000 g·mm인 때보다 2000 g·mm일 때 마찰력이 더 컸다. 건조 환경과 타액 환경의 비교에 있어서 1000 g·mm의 모멘트 하에서 인공타액에 의해 스테인리스강 선재의 마찰력은 증가하였으나 베타-티타늄과 니켈-티타늄의 마찰력은 증가하지 않았으며, 2000 g·mm의 모멘트 하에서 인공타액에 의해 모든 종류의 선재에서 마찰력이 증가하였다. Objective: The purpose of this study was to compare changes in frictional resistance between the bracket and wire under dry and wet conditions according to a change in moment. Methods: A stainless steel bracket of 0.022" × 0.028" slot, and 0.019" × 0.025" stainless steel, beta-titanium, and nickel-titanium wires were used. A 10 mm length lever was attached to the test (sliding) brackets to generate a moment. The experimental model was designed to allow tipping until contacts were established between the wire and the mesiodistal edges of the bracket slot. The moment was generated by suspending a 100 g or 200 g weight on the end of the lever. The moments applied were 1000 g·mm (100 g × 10 mm) and 2000 g·mm (200 g × 10 mm). The test brackets were ligated with elastomeric ligature for a constant ligation force and the fixed brackets were ligated with stainless steel ligature. Brackets were moved along the wire by means of an universal testing machine, and maximum frictional resistances were recorded. Results: Stainless steel wire showed least frictional resistance and there was no significant difference between beta-titanium and nickel-titanium except at 2000 g·mm moment in wet conditions. Frictional resistance of all wires increased as the moment increased from 1000 g·mm to 2000 g·mm. Under wet conditions, the frictional resistance of stainless steel wires increased in both 1000 g·mm and 2000 g·mm moment conditions, but frictional resistance of nickel-titanium and beta-titanium increased only in 2000 g·mm conditions. Conclusion: These results indicated that various conditions influence on frictional resistance. Therefore, laboratory studies of frictional resistance should simulate clinical situation.

역사적 도심지구의 집주모델시안에 나타난 전통성과 지역성의 표현 : 건축설계경기의 제안작품을 통하여

정세림,원세용,반상철,이훈,김태영 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

The purpose of this paper is to analyze and evaluate the tendency of collective habitat model in traditional urban area proposed by the architectural competition. The analysis and evaluation of these works is made by reference-frame such as community, locality, and economy. As results, the summaries of findings are as follows: 1. In the tentative plan of the collective habitat models, these have a tendency to encourage community life as the characteristic of traditionality and locality. That is, these concepts are represented by the consideration of environs, the positive use of site conditions, and so on. 2. In evaluation of these works, the critics are composed of these groups-specialist, developer, residents. The specialist groups make an emphasis on the community life and environs, the developer groups on the plan and structure system, and the residents on the present life-cycle and conditions. 3. The collective habitat models find their traditional and local expression in the alley, court, arrangement, exterior space, and traditional space.