조선대학교 의과대학 유급제도 개선을 위한 예비조사

박종,박상기,박상학,도남용,송창훈,이승일,임성철 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

This is a pilot study to improve the flunk system, a self-reported questionnaire survey was done by 58 professors among a total of 94 professors at Chosun University Medical School in December 1997. The results were as follows : 1. In regard to the student's residence, 69% of professors answered that the current system was appropriate. For a proper method of flunking. 46.6% of the professors agreed to the introduction of retesting by the Academic Affairs Department and 44.8% of the professors agreed to the evaluation of academic achievement of each subject. 2. Sixty-seven point two percents of professors agreed to the changing of time of flunk. 43.1% felt at the end of course, 24.1% felt at midterm, and 25.9% felt that the current system. 3. In regard to flunking, 34.5% of professors thought the current system-if a student receives an F grade in to be one subject, he/she was flunked-was sufficient, but 65.6% of the professors felt needed there improvement. The method of improvement was considered was losing more than two credits-fail(32.8%), and losing more than four credits-fail(10.3%). 4. Eighty-four point five percent of the professors agreed to the necessity of flunking by grade point average(GPA) and 77.6% of the professors answered that the students who must re-register should take all designated subjects. 5. Seventy-two point four percent of the professors opposed summer or winter courses for students who flunk and 51.7% of the professors opposed the necessity of a management system for students. In conclusion, the professors in Chosun University Medical College recognized the necessity of improving the flunk system, especially, the time, method and record keeping. So a concrete follow-up study needed to improve the flunk system.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

의과대학 인성교육 모델개발을 위한 예비연구

송창훈,임성철,박종,이승일,도남용,박상기,박상화 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

논문 : 국립공원 탐방로 내 위험 급경사지 유지관리 방안 연구

김홍균 ( Hong Gyun Kim ),김태호 ( Tae Ho Kim ),김재학 ( Jae Hak Kim ),곽재환 ( Jae Hwan Kwak ),박성욱 ( Sung Wook Park ),최수원 ( Soo Won Choi ),송영갑 ( Young Karb Song ) 대한지질공학회 2016 지질공학 Vol.26 No.1

국립공원은 주로 산악 지형 내 조성되어 있으므로 산사태에 의한 피해 가능성을 항상 내포하고 있다. 본 연구는 산사태 연구의 일환으로 국립공원 탐방로 내 위험 급경사지를 체계적으로 유지관리하기 위한 방안을 마련하는데 목적이 있다. 국립공원에 특화된 자체 체크리스트를 제작하였으며, 전국 19개 국립공원 183개소 급경사지에 대한 실태조사가 이루어졌다. 실태조사의 최종 목적은 위험 급경사지에 대한 안정화 대책을 마련하는 것으로 현장조사와 안정해석의 과정을 거친다. 일부 급경사지에서는 위험성 판단을 위해 지상라이다 등 특수 장비를 이용한 조사를 시도하였다. 중장기 정비계획을 위한 투자우선순위 공식을 개발하였으며, 현장자료를 이용한 순위 및 위험등급을 산출하였다. 최종적으로 위험 급경사지의 향후 체계적인 관리를 위해 “국립공원 급경사지 유지관리시스템”을 개발하였으며, 모든 현장자료들은 시스템 내 DB화 되었다. National parks, which are located mainly in mountainous areas, are always at risk of damage by landslides. The goal of this study is to establish a method for systematically maintaining hazardous steep slopes along trails in national parks. We produced a checklist suitable for each of the 19 national parks nationwide and investigated 183 slopes. The aim of these investigations is to recommend appropriate slope-stability countermeasures, including field investigations and stability analysis. We made preliminary investigations at specific sites, evaluating the slope hazard using specialized equipment such as terrestrial LiDAR. An investment priority formula was developed, and ranking and hazardous grades were calculated as part of a long-term maintenance plan. Finally, to systematically manage dangerous slopes and to house all the field data within one system, we developed the “Slope Maintenance System in National Parks” based on web server that can show various information for slopes.

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12

C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]

정규화 반경벡터 함수에 기반한 2D-형태 정보검색

박혜진,이상학,이광재,장민혁,박종안 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2

형태 정보는 컨텐츠 기반 하의 시각적 특징 중의 하나이며 영상 정보검색에서 광범위하게 사용된다. 본 연구에서는 물체 윤곽선의 반경 벡터함수를 이용한 스타형 및 비스타형 2D 형태인식을 위한 효과적인 알고리즘을 제안한다. 알고리즘에서 무게중심은 형태의 기준점이 되며 축의 중심으로부터 반경벡터는 주요 특징벡터가 된다. 이를 위한 코너 포인트는 노드로 표시되고, 정규화 거리는 중심점에서 노드까지의 상대적 거리비로 규정한다. 데이터베이스에서 유사 물체와 조회 물체 사이의 중심에서 코너 거리까지의 기하학적 거리가 형상 정합을 위한 유크리드 거리 값으로 정합평가에 이용된다.

PC12세포에서 Reserpine에 의한 Preproenkephalin 유전자 발현의 조절

박석호,임동윤,최철희,김상훈,박상학,김학렬 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

In cultured PCl2 celIs, prepronkephalin gene expression was studied by measuring preproenkephalin mRNA levels as well as enkephalin content after the treatment of reserpine. Reserpine(0.5 uM) elicited and increased enkephalin peptide levels within 6-24 hrs, which was not inhibited by cycloheximide(2ug /ml), a protein synthesis inhibitor. In addition, reserpine-induced increase of enkephalin was not inhinited by dactinomycin(5ug / ml), which was found to decrease preproenkephalin mRNA. When preproenkephalin mRNA was measured by Northern blot hybridization with cDNA probe, reserpine elicited a slightly increased preproenkephalin mRNA in PCl2 cells as well as in the rat adrenal glands. From the present experimental data it is thought that reserpine-induced enhancement of cellular enkephalin content in cultured PCl2 cells may be mediated through the post translational processing along with a slightly increased transcription.

역압력구배하에서 윗벽면 및 평판슬릿흡입이 난류경계층의 구조에 미치는 영향

박계향,이학성,윤명식,유상신 한국항공대학교 1994 論文集 Vol.32 No.-

역압력 구배하에서 벽면흡입과 모델 평판의 슬릿흡입이 난류 경계층구조에 미치는 영향에 대하여 실험적으로 연구하였다. 압력탭이 설치된 평판을 실험부에 설치한 후 평판위에 역압력구배가 작용되도록 하고 경계층 내의 속도 분포와 난류강도를 열선유속계로 측정하였다. 역압력구배가 커지면 경계층의 천이점은 평판의 상류쪽으로 이동하며 평판의 벽면에서 슬릿흡입을 하면 경계층내의 난류강도가 감소하고, 흡입량을 증가하면 난류 강도는 더욱 감소한다. An experimental study on the boundary layer structure on the flat plate with upper wall and slit suction under adverse pressure gradients is presented. Velocity profiles and turbulent intensities in the boundary layer are measured by hot-wire anemometer system. The transition point of a bondary layer moves upstream direction as the adverse pressure gradient increases. Slit suction causes a reduction of turbulent intensity of boundary layer. Reduction of trubulent intensity increases as the suction coefficient increases.

초기 성공적인 심폐소생술후 혈청 Interleukin-6 농도의 발현양상

박규남,박승현,황두영,김형국,이환,최경호,이원재,정욱성,김학주,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Objective : To investgate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL-6 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR). Methods : We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2, 4, 12, 24, 48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay. Results : Serum IL-6 concentrations in the severe neurolgically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurolgic disabled group showed dual peak at 4 and 24 hours. Conclusion : Our study demonstrates significant increase of serum IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.