허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

거대고리 착이온 (NiL²)의 낮은 스핀상태(D)와 높은 스핀상태(O)간의 평형

卞鍾轍,韓性彬 제주대학교 1989 논문집 Vol.29 No.-

물, 아세토니트릴, 아세톤 및 니트로메탄에서 Ni(Ⅱ)-tetraamine 착물의 화학평형을 분광착이온의 낮은 스핀(??) 구조와 높은 스핀(??) 구조간의 평형이 니트로메탄을 제외한 물, 아세토니트릴, 아세톤 용액에서 나타났다. 각 용액에서 온도와 〔NaClO₄〕가 증가할수록 이 반응의 평형상수는 감소하였다. 각 용매에서 반응엔탈피와 반응엔트로피는 착물의 전자 스펙트럼에 대한 온도의 영향을 분석하므로써 결정하였다. ??구조인 triplet 화학종의 형성시, 아세토니트릴과 아세톤 용액에서 반응엔탈피(???)와 반응엔트로피(???)는 각각 1.26, 1.32, 그리고 25.01, 54.90이었다. The chemical equilibria of Ni(Ⅱ) - tetraamine(tetraamine = L,2,12 -dimethyl - 3,7,11,17-tetraazabicyclo - 11,3,1-heptadeca-1(17), 2,11,13,15-pentaene) complex ion in water, acetonitrile, acetone and nitromethane were investigated using spectrophotometric method, respectively. The equilibria between low-spin(??) and high-spin(??) structures of Ni-tetraamine complex ion were presented in water, acetonitrile and acetone, but not in nitromethane. The equilibrium constants, the reaction enthalpies and the reaction entropies were determined from analysis of the temperature dependence of the electronic spectra. The formation of the triplet species (??) was found to be exothermic. The solvent and electrolyte spectra. The formation of the triplet species (??) was found to be exothermic. The solvent and electrolyte effects on the equilibrium constants could be explained by the dielectric constants of solvents and the reaction entropries.

[cis-Cr(III)(5,5,7,12,12,14-hexamethy1-1,4,8,11-tetraazacyclotetradecane)(L_(a))_(n)]CLO_(4)(n = 1 or 2)합성과 성질

변종철,한성빈,정덕상,임희정,한충훈 濟州大學校 師範大學 科學敎育硏究所 1995 科學敎育 Vol.12 No.1

rac-5.5.7.12.12.14-hexamethy1-1,4,8,11-tetraazacyclotetradecane hydrate : Lm·H_(2)O was prepared and separated from the corresponding meso-isomer dihydrate according to the Curtis method. The racisomer was confirmed by spectroscopic data of NMR and IR spectroscopy. To synthesize the [CrL_m(OH)₂] complex. the racemic compound purified from meso and racemic mixture was reacted with Cr(II1) salt. The complx ion species {[SrL_m(OH)_(2)]^(+): λ_(max) = 613.0(ε_(max) = 116 M^(-1)cm^(-1)), {[CrLm(OH)(H_(2)O)]^(2+) : λ_(max) = 575.0nm(ε_(max) = 133M^(-1)cm^(-1)). [CrLm(H_(2)O)_(2)]^(3+) : λ_(max) = 532.0nm (ε_(max) = 172M^(-1)cm^(-1))} obtained from pH change of [CrLm(OH)_(2)(OH)_(3)]^(+) solution were confirmed from an electron absorption spectra. The result of the distribution diagram of chemical species proves that main products in the range of solution pH ≤ 3.5 . 3.5 <pH <7, and pH ≥ 7. are [CrLm(H_(2)O)_(2)]^(3+). [CrL_(m)(OH) (H_(2)O)^(2+). and [CrL_m(OH)_(2), respectively. At P~ 2.0, we synthesized several Cr(III)-macrocyclic complexes containing various axial ligands (L_(a) : I, Br^(-), CI^(-), S_(2)O_(3)^(2-), F^(-), malonate, NCS^-, oxalate) instead of H_(2)O. [CrL_m(OH_(2))]^(3+) + L_(a) →[CrL_(m)(L_(a))_(n)]^(+)(n = 1 or 2) Cr(III)-macrocyclic complexes combined with vaious ligands on the axial position were primarily confirmed with the mass spectrum. Especially, when the axial ligands are malonate, oxalate, and S_(2)O_(3)^(2-), a possible thermal decomposition reaction and redox potential are considered as follows: ◁표삽입▷(본문을 참조하세요) As well, a spectrochemical series was drawn up on the basis of the ligand field strength obtained from electron absorption spertra of the complexes, [CrL_(m)(La)_(n)]^(p+) F^(-), CI^(-) ~Br^(-)<I^(-)<S_(2)O_(3)^(2-)<OH^(-)<H_(2)O<mal~NCS^(-) We can expect that there is three d-d transition d^(3) ion Tanabe-Sugano diagram. ◁표삽입▷(본문을 참조하세요) However, we found only two trasitions because the other transition {^(4)A_(2)_g(F)→^(4)T_lg(P) : v_(3)} is obscured by absorption arising from charge transfer transition. ◁표삽입▷(본문을 참조하세요)

Wavelet 변환을 이용한 고저항 지락사고의 고장 검출 및 고장점 추정

변성현,김현,고영훈,김철환 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

High Impedance Fault (HIF) defined as fault that general overcurrent relay can not detect or interrupt. Especially when HIF occur in residential areas, energized high voltage conductor results in fire hazard, equipment damage or personal threat. This paper proposes modeling the high impedance fault in transmission line using the ZnO arrester which can be implemented within EMTP. The performance of the proposed model is tested under a variety of fault conditions on a typical 345[kV] korean transmission line system. Wavelet transform is efficient and useful for the detection of HIF in power system because it uses short windows at high frequencies and long windows at low frequencies. HIF detection method using wavelet transform must distinguish HIF from similar fault like arcfurnace load, capacitor bank switching and line switching. With comparison in detetion characteristic of similar fault, we represents the efficiency of that in HIF detection. Moreover, this new technique can implement fault location computation using fundamental frequency component of wavelet analysis.

거대괴 착이온(NiL²+)의 낮은 스핀상태(D4h)와 높은 스핀상태(Oh)간의 평형

卞鐘轍,韓性彬 濟州大學校 基礎科學硏究所 1990 基礎科學硏究 Vol.3 No.1

물, 아세토니트릴, 아세톤 및 니트로메탄에서 Ni(II)-tetraamine 착물의 화학평형을 분광광도법을 이용하여 각각 관찰하였다. Ni(II)-tetraamine 착이온의 낮은 스핀(??)구조와 높은 스핀(??) 구조간의 평형이 나트로메탄을 제외한 물, 아세토니트릴, 아세톤 용액에서 나타났다. 각 용액에서 온도와 [NaClO₄]가 증가 할수록 이 반응의 평형상수는 감소하였다. 각 용매에서 반응엔탈피와 반응엔트로피는 착물의 전자 스펙트럼에 대한 온도의 영향을 분석하므로써 결정하였다. ?? 구조인 triplet 화학종의 형성시, 아세토니트릴과 아세톤 용액에서 반응엔탈피(??)와 반응엔트로피(??)는 각각 1.26, 1.32 그리고 25.01, 54.90이었다. The chemical equilibria of Ni (II)-tetraamine (tetraamine=L, 2, 12-dimethyl-3, 7, 11, 17-tetraazabicyclo-11, 3, 1-heptadeca-1(17), 2, 11, 13, 15-pentaene) complex ion in water, acetonitrile, acetone and nitromethane were investigated using spectrophotometric method, respectively. The equilibria between low-spin(??) and high-spin(??) structures of Ni=tetraamine complex ion were presented in water, acetonitrile and acetone, but not in nitromethane. The equilibrium constants, the reaction enthalpies and the reaction entropies were determined from analysis of the temperature dependence of the electronic spectra. The formation of the triplet species (??) was found to be exothermic. The solvent and electrolyte effects on the equilibrium constants could be explained by the dielectric constants of solvents and the reaction entropies.

Ru(Ⅲ) : 거대고리 착물의 합성과 이를 촉매제로 이용한 올레핀의 산화반응 Macrocyclic Complexes and Catalytic Oxidation of Olefins

朴裕哲,金聖洙,申相姬,卞鍾轍 慶北大學校 1992 論文集 Vol.52 No.-

The complexes were prepared by the controlled dropwise addition method . Reactions of K_2[RuCl_2·H_2O] with cyclam, meso, and rac (cyclam=1,4,8,11- tetraazacyclotetradecane, meso =C-meso-5, 7, 7, 12, 14, 14-hexamethyl-1,4,8,11-tetraazacyclotrtradecane, rac=C-rac-5, 7, 7,12, 14,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane) in ethanol yielded trans-[RuLCl_2]Cl (L= cyclam, meso, rac) complexes. The ligand-to-metal charge-transfer transition in the UV vis spectrum of trans-[Ru(meso)Cl_2] Cl determined at 20℃ has been appeared at 370nm and 314㎚, while the spectrum for trans-[Ru(cyclam)Cl_2]Cl complex is considerably red-shifted. Oxidation of olefins using trans-[RuLCl_2]Cl complexes as catalyst was investigated in dichloroethane, in with sodium hypocholrite, hydrogen peroxide and tert-butyloxide were used as terminal oxidant and olefins were styrene,cyclohexene, 1-hexene, cyclooctene, and 1-octene. In this experimental condition, sodium hypochlorite was rather efficient terminal oxidant than hydrogen peroxide and tert-butylperoxide. In addition trans-[Ru(meso)Cl_2]Cl complex was rather efficient catalyst than trans-[Ru(cyclam) Cl_2]Cl complex, when sodium hypocholrite was used as terminal oxidant.

담낭종양에서 CD24의 역할

임성철,이용,김동출,강길,변익건,박정희,최석민 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

CD24 is a small heavily glycosylated glycosylphosphatidylinosito-linked cell surface protein, which is expressed in hematologic malignancies as well as in a large variety of solid tumors, It appears to function as a ligand of PUselectin, an adhesion molecule that is present in activated platelets and endothelial cells. The authors aimed to evaluate CD24 protein expression in adenoma and adenocarcinoma of gallbladder to correlate to clinicopathologic data. The staining- was evaluated as stainability (negative, weak-, moderate-, strong-positive) and staining' patterns (membranous vs. intracytoplasmic) for statistical analysis. A highly significant association of cytoplasmic CD24 expression with adenocarcinoma compared to the adenoma of gallbladder was demonstrated. The present study demonstrates that CD24 was abundantly expressed on adenocarcinoma rather than on adenoma, but it was not statistically significant, Interrelation between the stainability or intracytoplasmic staining of CD24 and lymph node metastasis was not statistically significant. The authors conclude that CD24 is involved in tumorigenesis of gallbladder mucosa and intracytoplasmic expression of CD24 is an important molecular marker for malignant transformation.

정신분열병 환자에서의 한국어판 사회적응 척도의 개발 : 신뢰도 및 타당도 연구

김철권,서지민,김상수,조진석,하준선,김정옥,변원탄 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 정신분열병 환자의 사회적응 정도를 측정하는데 사용되는 사회적응 척도의 한국어판을 개발하기 위함이다. 방 법: 사회적응 척도를 번역한 후 정신분열병 환자 67명과 정상인 78명을 대상으로 신뢰도와 타당도를 검증하였다. 결 과: 자료분석 결과 검사-재검사 신뢰도는 0.85, 검사자간 신뢰도는 0.89, 내적 일치도는 0.87로 높은 수치였다. 변별 타당도를 검증하기 위하여 정신분열병 환자군과 정상 대조군을 비교한 결과 정신분열병 환자군에서 사회적응 정도가 유의하게 낮았다. 구성 타당도를 알아보기 위하여 10개 영역간의 상관관계를 측정한 결과 성적적응 영역을 제외한 모든 영역들에서 유의한 상관관계를 보였다. 본 척도의 전반적 평가 영역 결과와 GAF 결과간의 상관성을 통해 간접적으로 검증한 공존 타당도 역시 유의하였다. 결 론: 한국판 사회적응 척도는 우수한 신뢰도와 타당도가 입증되었고 나아가 정신분열병 환자의 사회적응 정도를 평가하는데 유용하게 사용되어질 수 있을 것이다. Objectives: The purpose of this study was to develop the Korean version of the Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) in the schizophrenics. Methods: KSAS Ⅱ-RV was administered to 67 schizophrenic patients and 78 matched normal controls for examining the reliability and validity. Results: Data analysis showed statistically significant reliabilities and validities of KSAS Ⅱ-RV. The test-retest reliability, inter-rater reliability, and internal consistency for total scores of KSAS Ⅱ-RV were 0.85, 0.89. and 0.87, respectively. Evidence for discriminant validity of KSAS Ⅱ-RV comes from the results that the mean scores of schizophrenic patients were significantly high than those of normal controls. Construct validity was assessed by calculating the 10 inter-subareas correlations of the KSAS Ⅱ-RV, and all except the sexual adjustment area were statistically significant. Significant correlations between the global area scores of KSAS Ⅱ-RV and those of Global Assessment of Functioning Scale lend support for the concurrent validity of this instrument indirectly. Conclusions: KSAS Ⅱ-RV was found to be a valid and reliable instrument which can be used to evaluate the degree of social adjustment in the schizophrenic patients.

정신분열병 외래환자에서 사회기능, 정신병리, 그리고 주의력 결손간의 관계

김철권,정순민,김진원,김상수,변원탄 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

본 연구의 목적은 증상이 안정된 83명의 정신분열병 외래 환자들을 대상으로 증상, 사회적응, 그리고 주의력간의 연관성을 알아보기 위한 것이다. 정상 대조군은 정신분열병 환자군과 교육수준, 나이, 성별등이 비슷한 60명으로 하였다. 증상은 양성 및 음성증상 증후군 척도(PANSS)를 이용하여 평가하였고, 사회적응은 한국판 사회적응 척도를 이용하였다. 그리고 주의력은 지속수행 검사(Continuous Performance Test)와 정보 감지능력검사(Span of Apprehension Task)를 사용하였다. 그 결과는 다음과 같다. 1) 정신분열병 환자군이 정상 대조군에 비해 지속수행 검사와 정보 감지능력 검사 모두에서 유의한 결손을 보였다. 또 사회적용 척도의 총 점수와 10개 소영역의 점수에서도 정신분열병 환자군이 정상 대조군에 비해 유의하게 낮았다. 2) 사회기능과 증상군의 연관성에서는 양성증상, 음상증상, 일반증상 모두 사회기능의 총 점수와 연관성이 없었다. 그러나 사회적 여가활동 소영역에서는 음성증상과 유의한 상관성이 있었다. 3) 사회적응 척도의 총 점수와 지속수행 검사에서 가장 중요한 변인인 민감도와의 상관관계에서는 유의한 상관성을 보였다. 그러나 사회적응 척도의 총 점수와 정보 감지능력 검사에서 가장 중요한 변인인 정답반응 횟수간에는 유의한 상관성을 보이지 않았다. 사회적응 척도중 도구적 역할 소영역은 민감도 및 정답반응 횟수와 상관성이 있었다.그리고 친구관계 소영역은 민감도와 유의한 상관성을 보였다. 4) 증상과 주의력과의 상관관계에서는 지속수행 검사의 민감도와 음성증상간에 유의한 상관성을 보였다. 이러한 결과는 증상이 안정된 정신분열병 외래환자에서 지속적 주의력이 전반적인 사회 기능을 예측하는 한 인자가 될 수 있음을 시사한다. In order to study the relations between attentional deficits and social functioning of the schizophrenia, 83 stable outpatients with DSM-Ⅳ schizophrenia and matched 60 normal controls were examined for their sustained attention, sensory register, and social functioning by means of Continuous performance test(CPT), Span apprehension task(SPAN), and Korean version of Social Adjustment Scale Ⅱ-Revised Version(KSAS Ⅱ-RV) respectively. Psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS). The results were as follows. 1) Schizophrenic patients showed a significant deficit in the sustained attention and sensory register as manifested in the data of CPT and SPAN, compared with the matched normal controls. Schizophrenic patients also showed a significantly poor social functioning in measure of KSAS Ⅱ-RV compared with the matched normal controls. 2) There was no correlation between three type of symptoms(positive/negative/general) and total scores of social functioning. But negative symptoms was correlated with the social leisure subarea of KSASⅡ-RV. 3) CPT was correlated with total scores of social functioning including the instrumental role and friend relation subareas of KSASⅡ-RV, whereas SPAN was only correlated with instrumental role subarea of social functioning. 4) In the relations between attention and symptoms, CPT was correlated with negative symptoms. These results suggest that the deficit of the sustained attention may be a predictive factor of social functioning in the schizophrenic outpatients.

운동형태가 청소년의 상태불안 감소에 미치는 영향

류호상,염민선,변재철,박승한 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.2

과거의 운동심리학(exorcise psychology) 문헌들은 일회(acute) 운동 후에 상태불안이 감소되어 기분이 좋아지는 효과를 얻을 수 있다고 밝혀왔다. 이 연구의 목적은 어떤 형태(유산소 대 무산소)의 일회 운동이 청소년의 상태불안과 그에 관련된 생리변인들에 보다 긍정적인 영향을 미치는 지를 비교하고자 하는 것이었다. 12명의 남자중학교 학생들을 6명씩 두 집단으로 나누어 한 집단에게는 유산소운동을 다른 집단에게는 무산소운동을 시킨 후, 1주일 후에는 서로 역할을 교대시키는 반복측정을 하였다. 유산소운동은 심박수를 이용하여 최대운동능력(VO_2peak)의 75%강도로 트레드밀에서 20분간 달리기를 하는 것이었고, 무산소운동은 5개의 웨이트트레이닝을 십회반복최대(10RM)의 75% 강도로 돌아가며 20분간 실시하는 것이었다. 각 운동 전·후에는 20분 동안 안정을 취한 뒤 상태불안, 체온, 그리고 혈압을 차례로 측정하였다. 각 운동조건의 평균을 비교하기 위한 통계분석을 사전점사 결과를 공변인으로 하고 사후점사 결과를 종속변인으로 하는 공변량분석(ANCOVA)을 실시하였다. 자료처리 결과, 유산소운동과 무산소운동 후 어떤 변인들에도 유의한 차이가 나타나지 않았다(p<.05). 따라서 청소년의 상태불안을 감소시키는 데는 운동형태간에 차이가 없으며 그러한 연구에 대해 지속적인 관심과 필요성이 강조되었다. The purpose of this study was to examine aerobic versus anaerobic exercise effect on state anxiety reduction and related physiological variables in middle school students. A total of twelve male subjects were assigned to 20-minute condition in each exercise with the intensity of 75% of VO_2peak and 75% of 10 Repetition Maximum. State anxiety(Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), body temperature, and blood pressure were assessed 20-minute before and after each exercise. One-way analysis of covariance(ANCOVA) indicated that the self-reported state anxiety, the body temperature, and the blood pressure were not significantly different between the 2 types of exercise. In conclusion, it is too premature to state that aerobic exercise is better than anaerobic exercise on state anxiety reduction in adolescents.