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Genome-wide gene expression analysis in the fetal trisomy 21 placenta
( Yj Han ),( Ej Choi ),( Jm Lee ),( Dw Kwak ),( Sw Lee ),( Mh Kim ),( Jh Chung ),( Hk Ahn ),( Js Choi ),( Jy Han ),( My Kim ),( Jh Lim ),( Hyun Mee Ryu ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To gain new insight of gene expression into the pathogenesis of trisomy 21 (T21) placenta, we performed whole human genome expression analysis in placenta tissue (normal and T21) samples. 방법: We profiled whole human genome expression of placenta samples from normal and T21 fetuses using GeneChip Human Genome U133 plus 2.0 array and predicted the functions of differentially expressed genes using bioinformatics tools. 결과: One hundred-ten genes were significantly differentially expressed in the T21 placenta compared with the normal placenta (33 down-regulated and 77 up-regulated). Among them, some genes were significantly associated with focal adhesion, Alzheimer's disease, and Parkinson's disease pathway. The down-regulated genes in the T21 placenta were distributed on various chromosomes. The down-regulated genes were significantly associated with cystitis, metaplasia, pathologic neovascularization, airway obstruction, and diabetes mellitus type 2. None of down-regulated genes were on chromosome 21 causing T21, whereas over half (59.7%) of up-regulated genes were located on chromosome 21. The up-regulated genes were significantly associated with T21 and T21-related disorders, such as mental retardation, neurobehavioral manifestations, and congenital abnormalities. 결론: Our findings provide a broad overview of whole human genome expression in the placentas of fetuses with T21 and could contribute to future research efforts concerning genes involvement in disease pathogenesis.
한상철(SC Han),진형수(HS Jin),박용환(YH Park),한창황(CH Han),이근영(KY Lee),강성원(SW Kang) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.1
Since the initial report of leukemia in a pregnant woman was made by Virchow in 1845. Acute leukemias are among the most common malignant neoplasms of young adult women. The eincidence in pregnancy is not accurately known. The leukemias are a heterogenous group of neoplasms arising from the malignant transformation of hematopoietic (blood-forming) cells. Leukemic cells proliferate primary in the bone marrow and lymphoid tissues where they interfere with normal hematopoiesis and immunity. Leukemias are classified according to the types primarily involved (myeloid or lymphoid) and as acute and chronic based upon the natural history of the disease. The cause of leukemia is not known in most patient although both benetic and environmental factors may be important. Acute leukemia occurs with an increased frequency in a variety of congenital factors. Leukemia is the second most common malignancy in women in the reproductive age group, the true incidence of acute leukemia during pregnancy is not known. The diagnosis of acute leukemia is suggested by the clinical manifestations of marrow dysfunction-pallor, diminshed resistance to infection, bleeding diathesis, and bone pain, peripheral blood smear and bone marrow examination establish the diagnosis. Treatment decisions for each patient must be based on several factors, including the stage of gestation and the maternal and fetal health at the time of diagnosis, themothers prognosis and her likehood of pregnancy after treatment, and the known carcinogenic potential of the drug in question. Recently, we experienced a case of AML(M3) in a 26 years old pregnant woman. We present this case with a brief view of literature.
난구를 형성하고 있는 과립성세포 ( 난구세포 ) 가 생쥐배아 난할율에 미치는 영향
한혁동(HD Han),권장연(JY Kwon),한상원(SW Han),이영진(YJ Lee),차동수(DS Cha),김대현(TH Kim) 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.4
To study the effect of cumulus cells on the development of mouse embryos, one cell stage zygotes with cumulus cells(one cell stage zygotes-cumulus mass) and one cell stage zygotes without cumulus cells, which were treated with hyaluronidase, were cultured in Ham`s F-10 and Ham`s F-10 with 10% cord serum. Development of the blastocyst of one cell stage zygotes with cumulus cells was significantly higher than development of the blastocyst of one cell stage zygotoes without cumulus cells in Ham`s F-10 and Ham`s F-10 with 10% cord serum(P<0.05, P<0.017). In our results, cumulus cells which surround one cell zygotes promote the development of embryos.
정동원(DW Jung),한상원(SW Han),김남식(NS Kim),홍순원(SW Hong),양석우(SW Yang),홍민(M Hong) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9
Primary endometrial squamous cell carcinoma is extremely rare, with only 64 cases repo- rted in the literature. In 1928 Fluhmann proposed three criteria for differentiating primary from secondary endometrial squamous cell carcinoma:(1) no coexisting endometrial adenocarcinoma (2) no connection between the endometrial tumor and the squamous epithelium of the cervix, and (3) no squamous cell carcinoma of the cervix present. Several authors have modified these criteria in their case presentations. Kay accepts the presence of an in situ cervical carcinoma, if there is no connection between cervical carcinoma in situ and the endometrial tumors. We have experienced a case of simultaneous carcinoma in situ of the cervix and endomet- rial squamous cell careinoma. This case was treated with chemotherapy(cisplatin, 5-fluoruracil) and external radiation following extended hysterectomy and bilateral salpingooophorectomy We report this case with a review of the concerned literatures.
한상원 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.11
임신의 성공적 유지가 모체와 태아간의 면역의 조화에 의한 것으로 생각할 때 임신중독증의 원인인자를 모체 태아사이의 면역부조화로 설명하려는 연구가 금세기초부터 활발히 진행되고 있는데 그 하나는 태아항원에 대한 모체의 동종면역에 의해 형성된 동종항체는 모체 세포성면역에 의해 태아에게 미칠 악영향을 미연에 방지할 수 있다는 것으로 이러한 동종항체의 형성 감소가 임신중독증의 원인일 것으로 추측하는 가설이고, 다른 하나는 다량의 태아항원에 노출됨에 따라 모체의 면역반응에 변화가 와서 면역복합체가 형성되어 각종 조직에 침착됨으로써 임신중독증이 야기된다는 가설이다. 임신중독증의 원인인자로서 면역학적 측면이 매력적이긴 하나 정상임신의 면역학적 측면이 완전히 밝혀지기 전까지는 확실한 결론을 내릴 수 없다. 오로지 태아 동종이식에 대한 관용의 기전이 완전히 이해될 때 임신중독증의 비정상적 상황을 이해할 수 있을 것이다.